Protein Alignment SCNN1D and Nach

DIOPT Version :10

• Sequence 1: NP_001123885.2
• Gene: SCNN1D / 6339
• HGNCID: 10601
• Length: 802
• Species: Homo sapiens
• Sequence 2: NP_001334724.1
• Gene: Nach / 36864
• FlyBaseID: FBgn0024319
• Length: 553
• Species: Drosophila melanogaster
• Alignment Length: 633
• Identity: 116/633 - (18%)
• Similarity: 215/633 - (33%)
• Gaps: 197/633 - (31%)

Human   208 GHQEGL----VELPAS-----FRELLTFFCTNATIHGAIRLVCSRGNRLKTTSWGLLSLGALVAL 263
            ||||.|    |:|..:     .|...:.||..::|||.........|::....|.|:|:...:..
  Fly     2 GHQEELKPEQVDLKVTPFVGYLRRTWSDFCATSSIHGLKYTRDEDTNKIVHLVWLLISVVMFICA 66

Human   264 CWQLGLLFERHWHRPVLMAVSVHS---ERKLLPLVTLCDG---NPRRPSPVLRHLEL-------- 314
            .......:..:...|..|.|...:   .|...|.||:|..   |.::....|..|.|
  Fly    67 VVMARTFYMDYRSSPTRMNVESDNTPVNRLYFPPVTICPDVLFNMQKSEAFLNTLRLPKGAELRG 131

Human   315 ------------LDE--FARENIDS----LYNVNLSKGRAALSATVPRHEPPFHLDREIRLQRLS 361
                        ||:  ::.|:|:.    |:..||         |:|........:.:..|.|..
  Fly   132 ILRKLHIFYGFMLDDERYSAEDIEQMEALLFLNNL---------TIPEFVEHLRWNCDEILYRCR 187

Human   362 HSG-----SRVRVGFRLCNSTGGDCFYRGYTSGVAAVQDWYHFHYVDILALLPAAWEDSHGSQDG 421
            .:|     |::   |:|..:..|.|
  Fly   188 FNGEIMDCSKI---FQLSKTFFGHC---------------------------------------- 209

Human   422 HFVLSCSYDGLDCQARQ-------------FRTFHHPTYGSCYTVDGVWTAQRP--GITHGVGLV 471
                 ||::     .||             |:.||..:..        :||||.  |:.:|:.:|
  Fly   210 -----CSFN-----LRQKGWVNNKLNNLESFKVFHLNSLN--------FTAQRAIGGLRYGLSVV 256

Human   472 LRVEQQPHLPLLSTLAGIRVMVHGRNHTPFLGHHSFSVRPGTEATISIREDEVHRLGSPYGHCTA 536
            :|.:...:.||.|...|:::::...:..|.....:..:...:|...::|..|.        .|::
  Fly   257 VRYKDDNYDPLQSYSYGVKLLIQEADAFPSAHSAAKFIAFNSETFAAVRPQET--------FCSS 313

Human   537 GGEGVEVE-----------LLHNTSYTRQACLVSCFQQLMVETCSCGYYLHPLPAGAE-YCSSAR 589
            ..:.:.:|           :.:.:.|....|.::|....||:.|.|..|.......:: .|:...
  Fly   314 AVKALIIEERNCVFQNEFPMRYFSDYVYPNCELNCRVTNMVKFCGCHTYFFDFNRTSDRICTFRD 378

Human   590 HPAWGHCFYRL------YQDLE--------THRLPCTSRCPRPCRESAFKLSTGTSRWPSAKSAG 640
            .|.....|.||      |.|..        |.:......||..|....:.:.  .:.:|.
  Fly   379 IPCLVDNFGRLLLICSKYSDFNRLLSANIITRKKSTQCYCPLTCEHIDYDVQ--LTNFPL----- 436

Human   641 WTLATLGEQGLPHQSHRQRSSLAK----INIVYQELNYRSVEEAPVYSVPQLLSAMGSLCSLWFG 701
                   |..:| .:.:..|.|||    :::.....:||.:....:.::..|:|.:||..||:.|
  Fly   437 -------ELNMP-VADKFYSGLAKNDGVLHVFINSFSYRRLRRDLLSNMVTLVSNLGSAFSLFVG 493

Human   702 ASVLSLLELL---------ELLLDASALTLVLGGRRLRRAWFSWPRAS 740
            .|:||::|::         ...|:....:.:|.    ::..|:||:|:
  Fly   494 MSMLSVVEIIYYFSVILRKNYKLECETRSQMLH----KKPKFAWPKAN 537

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SCNN1D	NP_001123885.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	145..211		2/2 (100%)
		ENaC	219..784	CDD:273304	109/618 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	738..777		1/3 (33%)
Nach	NP_001334724.1	ASC	30..505	CDD:459966	102/567 (18%)