Protein Alignment SCNN1D and ppk7

DIOPT Version :10

• Sequence 1: NP_001123885.2
• Gene: SCNN1D / 6339
• HGNCID: 10601
• Length: 802
• Species: Homo sapiens
• Sequence 2: NP_609016.2
• Gene: ppk7 / 33886
• FlyBaseID: FBgn0031802
• Length: 573
• Species: Drosophila melanogaster
• Alignment Length: 636
• Identity: 129/636 - (20%)
• Similarity: 197/636 - (30%)
• Gaps: 237/636 - (37%)

Human   203 PPPKEGHQEG-------LVELPASFRELLTFFCTNATIHGAIRLVCSRGNRLKTTSW--GLLS-- 256
            ||.|...|:.       ..:|..|..:|...|....||||..||:.::.:|.:...|  ..:|
  Fly     7 PPSKLQQQQQPSRSSRLAQQLAQSSWQLALRFGKRTTIHGLDRLLSAKASRWERFVWLCTFVSAF 71

Human   257 LGALVALCWQLGLLFERHWHRPVLMAVSVHSERKLLPLVTLCDGNPRRPSPVLRHLELLDEFARE 321
            ||| |.:|..|...:.....:.|:.:......|...|::|:|:.|
  Fly    72 LGA-VYVCLILSARYNAAHFQTVVDSTRFPVYRIPFPVITICNRN-------------------- 115

Human   322 NIDSLYNVNLSKGRAALSATVPRHEPPFHLDREIRLQRLSHSGSRVRVG---------FRLCNST 377
                                            .:..|||:.:.||....         |.|...|
  Fly   116 --------------------------------RLNWQRLAEAKSRFLANGSNSAQQELFELIVGT 148

Human   378 GGDCFYRGYTS---------------GVAAVQDWYHFHYVDILALLPAAWEDSHGSQDGHFVLSC 427
            ..|.::..:.|               ..:.|.|:..:...::||  ...|.        |....|
  Fly   149 YDDAYFGHFQSFERLRNQPTELLNYVNFSQVVDFMTWRCNELLA--ECLWR--------HHAYDC 203

Human   428 --------SYDGLDCQARQFRTFHHPTYGSCYTVDGVWTAQRPGITHGVG----LVLRVEQQP-- 478
                    |.:|| |.|  |.:...........:|.:|    |..|...|    |.:||..||
  Fly   204 CEIFSKRRSKNGL-CWA--FNSLETEEGRRMQLLDPMW----PWRTGSAGPMSALSVRVLIQPAK 261

Human   479 HLP---LLSTLAGIRVMVHGRNHTPFLGHHS-FSVRPGTEATISIR------EDEVHRLGSPYGH 533
            |.|   ..:.:.||.|||    ..||:.|:: |.|...||.|:.|.      :::...:.|....
  Fly   262 HWPGHRETNAMKGIDVMV----TEPFVWHNNPFFVAANTETTMEIEPVIYFYDNDTRGVRSDQRQ 322

Human   534 CTAGGEGVEVELLHNTS---------YTRQACLVSCFQQLMVETCSCGYYLHPLPAGAEYCSSAR 589
            |....|       ||:.         |..:.|...|.|:.:|..|:|...|...|.....|.:
  Fly   323 CVFDDE-------HNSKDFKSLQGYVYMIENCQSECHQEYLVRYCNCTMDLLFPPGQYRSCRA-- 378

Human   590 HPAWGHCFYRLYQDL----ETHRLPCTSRCPRPCRESAFKLSTGTSRWPSAKSAGWTLATLGE-- 648
                        |||    |.:.|...|..|                              ||
  Fly   379 ------------QDLLCLAEHNDLLIYSHNP------------------------------GEKE 401

Human   649 ------QGLPHQSHRQRSSLAKINIV--------------YQELN----------YRSVEEAPVY 683
                  ||:..:..|...||..|:.|              |.:|:          ||:   :.|:
  Fly   402 FVRNQFQGMSCKCFRNCYSLNYISDVRPAFLPPDVYANNSYVDLDVHFRFETIMVYRT---SLVF 463

Human   684 SVPQLLSAMGSLCSLWFGASVLSLLELLELL-LDASALTLVLGGRRLRRAW 733
            ....|:.:.|.:..|:.|.|::|.:||...| ::..|    .|...|||.|
  Fly   464 GWVDLMVSFGGIAGLFLGCSLISGMELAYFLCIEVPA----FGLDGLRRRW 510

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SCNN1D	NP_001123885.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	145..211		3/7 (43%)
		ENaC	219..784	CDD:273304	124/613 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	738..777
ppk7	NP_609016.2	ASC	38..493	CDD:459966	115/582 (20%)