Protein Alignment SCNN1D and ppk28

DIOPT Version :10

• Sequence 1: NP_001123885.2
• Gene: SCNN1D / 6339
• HGNCID: 10601
• Length: 802
• Species: Homo sapiens
• Sequence 2: NP_573169.2
• Gene: ppk28 / 32671
• FlyBaseID: FBgn0030795
• Length: 606
• Species: Drosophila melanogaster
• Alignment Length: 635
• Identity: 128/635 - (20%)
• Similarity: 228/635 - (35%)
• Gaps: 177/635 - (27%)

Human   218 ASFRELLTFFCTNATIHGAIRLVCSRGNRL-KTTSWGLLSLGALVALCWQLGLLFERHWHRPVLM 281
            |:.:..:.::..|:|:|| ::.:......: :...:||..:..::...:.:..::.:....|::
  Fly    34 AAIKRSVVYYLKNSTLHG-LKYIAEESITIPERIFFGLAFVLVVILSVFFISNVYVKWSASPII- 96

Human   282 AVSVHSERKL-----LPLVTLCDGNPRRPSPVLRHLELLDEFARENIDSLYNVNLSKGRAALSAT 341
             :|..:::||     .|.:|:|                             |:|    :|.||
  Fly    97 -ISTSAKQKLTSNMPFPAITIC-----------------------------NLN----QALLS-- 125

Human   342 VPRHEPPFHLDREIRLQRLSHSGSRVRVGFRLCNSTGGDCFYRGYTSGVAAVQDWYHFHYVDILA 406
                          ::.|:..:.:...:...||:. |||       :.::.:..|.:|..:.:..
  Fly   126 --------------KVDRIGRTSTNFSLLMGLCDQ-GGD-------TTISYIGTWKYFKAILVDV 168

Human   407 LLPAAWED-----SHGSQDGHFVLSCSY--------DGLDCQARQFRTFHHPTYGSCYTVDGV-- 456
            ..|.  |.     |.||::.    .||:        |||.|.....    ||:|......|.|
  Fly   169 AQPC--EKMLLYCSFGSREE----DCSWLFTSILTDDGLCCNFNAL----HPSYLIRNYSDDVRL 223

Human   457 -------------WTAQR-----------------PGITHGVGLVLRVEQQPHLPLLSTLAGIRV 491
                         ||.::                 .||..|:.:||......:....|...|.:|
  Fly   224 ETAHPNTRYELIDWTPEKGYARNLPEFYFPRTSGGTGIRMGLTVVLNASIAEYYCTKSMSVGFKV 288

Human   492 MVHGRNHTPFLGHHSFSVRPGTEATISIR---ED---EVHRLGSPYGHCTAGGEGVEVELLHNTS 550
            :||.....|.:.::.|.|..|.||.|.|.   ||   .:..:......|....|.   :|.:..:
  Fly   289 LVHNPAELPKVSNYGFVVTAGREARIPIEPVYEDALPTIRSIKKSVRRCLFSDEN---DLAYYRT 350

Human   551 YTRQACLVSCFQQLMVETCSCG-YYLHPLPAGAEYCSSARHPAWGHCFYRLYQDLETH--RLPCT 612
            |:|:.|.:.|..:|::..|||. |||..:...|..|.    |....|..|:..::|:.  .|.|
  Fly   351 YSRKNCELECEAKLLLRECSCVLYYLPRIDPLARVCG----PNDNQCTDRVQTEIESSLTNLSC- 410

Human   613 SRCPRPCRESAFK--LSTGTSRWPSAKSAGWTLATLGEQGLP----HQSHRQRSSLAKINIVYQE 671
            ..|...|.|..::  |||.:........||        :.||    |..:...|.::.::..|..
  Fly   411 ENCWPGCFELTYRATLSTASIVSDPRFQAG--------ENLPEYIFHGPYSNASEISILHFYYMT 467

Human   672 LNYRSVEEAPVYSVPQLLSAMGSLCSLWFGASVLSLLEL-LELLLDASALTLVLGGRRLRR---- 731
            ..:||..::.::...:.||..|.|..|:.|.|:.|::|: ..:.:.....:..|..|..||
  Fly   468 NIFRSTTKSEMFGFTEFLSNTGGLLGLFMGFSIFSVIEIFFYITVRPYCASRTLRQRHKRRLEQL 532

Human   732 AWFSWPRASPA-------SGASSIKPEASQMPPPA-------GGTSDDPE 767
            :|.: |...|.       .|.....|     ||||       .|..|.||
  Fly   533 SWLT-PIRMPVRRALRRNRGGLLRNP-----PPPAYSDLQKFRGKLDKPE 576

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SCNN1D	NP_001123885.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	145..211
		ENaC	219..784	CDD:273304	127/634 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	738..777		11/44 (25%)
ppk28	NP_573169.2	ASC	43..509	CDD:459966	110/551 (20%)