Protein Alignment SCNN1D and ppk8

DIOPT Version :10

• Sequence 1: NP_001123885.2
• Gene: SCNN1D / 6339
• HGNCID: 10601
• Length: 802
• Species: Homo sapiens
• Sequence 2: NP_001036260.3
• Gene: ppk8 / 318213
• FlyBaseID: FBgn0052792
• Length: 569
• Species: Drosophila melanogaster
• Alignment Length: 661
• Identity: 131/661 - (19%)
• Similarity: 228/661 - (34%)
• Gaps: 211/661 - (31%)

Human   218 ASFRELLT----FFCTNATIHGAIRLVCSRGNRLKTTSWGLLSLGALVALCWQLGLL---FERHW 275
            :::|.:|:    .||.|.||||   |.....::|:::......:..||.|...:.|:   |::..
  Fly    29 STWRRILSRNTDEFCRNTTIHG---LKYINNSKLRSSDRLFFGIALLVVLSLAIYLIQDAFDKWN 90

Human   276 HRPVLMAV-----SVHSERKLLPLVTLCDGNPRRPSPVLRHLELLDEFARENIDSLYNVNLSKGR 335
            ..||::.:     |:.:|.  .|.||:|:.|...       .|.::.|:.::::
  Fly    91 TNPVIVGIDPELTSIANEP--FPAVTICNLNQAL-------AERVEHFSNDSVE----------- 135

Human   336 AALSATVPRHEPPFHLDREIRLQRLSHSGSR-----VRVGFRLCNST------GGD---C---FY 383
            .|:...:.|        |::.::.:..:.||     :.:. :.|||.      |.|   |   |:
  Fly   136 FAMLQLLCR--------RKVDVELVKTNDSRWEEFILNIS-QPCNSMVIHCRFGADDYECARLFH 191

Human   384 RGYT-SGVAAVQDWYH---------------------FHYVDILALLPAAWEDSHGSQDGHFVLS 426
            ...| .|:..|.:..|                     ||.|:        |....|.:...|
  Fly   192 PIVTDEGLCCVFNMLHPRFMYRKRVPYSHRNISLPEGFHAVN--------WHAELGYRKRGF--- 245

Human   427 CSYDGLDCQARQFRTFHHPTYGSCYTVDGVWTAQRPGITHGVGLVLRVEQQPHLPLLSTLAGIRV 491
             ..||           .:|.|..        .||..|.:.|:.|.|.|:...:....|:..|.::
  Fly   246 -QPDG-----------DNPLYPR--------RAQGTGESLGLSLTLDVQADAYYCSSSSSIGFKI 290

Human   492 MVHGRNHTPFLGHHSFSVRPGTEATISI------REDEVHRLGSPYGHCTAGGEGVEVELLHN-- 548
            .:|..|.:|.:......:.||.|..:.|      .|..:..:......|          |.||
  Fly   291 ALHSPNESPNVRETGVLLAPGMETKLRIDPSKILTEKHLRNVDRRSRRC----------LFHNEL 345

Human   549 -----TSYTRQACLVSCFQQLMVETCSC-GYYLHPLPAGAEYCSSARHPAWGHCFYRLYQDLETH 607
                 ..||::.|:..|....::..|.| .:|:..|.|....|...:........:|....:|:
  Fly   346 KLRWFAHYTQRNCVAECLSGWLIRHCGCVTFYMPRLNANDTICPLHKRECVELIRFRTIIAMES- 409

Human   608 RLPCTSRCPRPCRE---SAFKLST-----GTSRWPSAKSAGWTLATLGEQGLPHQSHRQRSSLAK 664
               |...|...|.:   ||...||     |....||  :.||...         .::.:| |:|.
  Fly   410 ---CLDECLPSCFDLSFSAIAYSTRISLDGFRETPS--NGGWNFT---------DAYVER-SVAV 459

Human   665 INIVYQELNYRSVEEAPVYSVPQLLSAMGSLCSLWFGASVLSLLELLELLLDASALTLVLGGRRL 729
            :|:.:::..:|:.::.........||.:|.|..|:.|.|.||:.|.:
  Fly   460 VNMYFKDPTFRANKQTEFIGFSDFLSGVGGLMGLFLGFSFLSIAECV------------------ 506

Human   730 RRAWFSWPRASPASGASSIK----PEASQMPPPAGGTSDDPEPSGPHLPRVMLPGVLAGVSAEES 790
               :|:..|  |....|.|:    |...||                :|.|...||.:..:||.:
  Fly   507 ---YFALIR--PCRTCSEIRQLNQPRVHQM----------------NLKRSPTPGNIRYISAAD- 549

Human   791 W-----AGPQP 796
            |     |..||
  Fly   550 WFQAELAHQQP 560

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SCNN1D	NP_001123885.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	145..211
		ENaC	219..784	CDD:273304	125/641 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	738..777		9/42 (21%)
ppk8	NP_001036260.3	ASC	42..508	CDD:459966	111/575 (19%)