Protein Alignment SCNN1A and ppk26

DIOPT Version :9

• Sequence 1: NP_001153048.1
• Gene: SCNN1A / 6337
• HGNCID: 10599
• Length: 728
• Species: Homo sapiens
• Sequence 2: NP_648125.3
• Gene: ppk26 / 38835
• FlyBaseID: FBgn0035785
• Length: 597
• Species: Drosophila melanogaster
• Alignment Length: 686
• Identity: 144/686 - (20%)
• Similarity: 249/686 - (36%)
• Gaps: 207/686 - (30%)

Human    69 DSSPPQSTPGLMKGNKREEQGLGPEPAAPQQ-------------------PTAEEEALIEFHRSY 114
            ||:.|. ||.       .|..:.|.|.|..|                   ..:|:|...:....|
  Fly     4 DSTQPH-TPS-------HEVAVRPPPCAANQWKRAALMARMAPAFRETVSDDSEDEVDTKKQIKY 60

Human   115 -------RELFEFFCNNTTIHGAIRLVCSQHNRMKTAFW-AVLWLCTFGMMYWQFGLLFGEYFSY 171
                   :.:...:|:.|||||...|...:...::..|| :||.|..|..:..... ::.::.:.
  Fly    61 GSGFQAAKAIIHEYCDYTTIHGIRYLGEKKRPLLERLFWISVLVLSVFTCVKLTLN-IWDKWNNN 124

Human   172 PVSLNINLNSD---KLVFPAVTICTLNPYRYPEIKEELEELDRITEQTLFDL----YKYSSFTTL 229
            ||.::....|.   ::.|||||:|       ||.|         |.:.:|:.    ::...|.:.
  Fly   125 PVIVSFAEKSTPVWQIPFPAVTVC-------PETK---------TRREIFNFTDSYHQVRDFQSN 173

Human   230 VAG----SRSRRDLRGTLPHPLQRLRVPPPPH--------GARRARSVASSLRDNNPQVD----- 277
            |:|    |..::.|.|.:....:       ||        ..||...:..:|.:.:|..|
  Fly   174 VSGIVDLSDKQKGLYGAVSQVCE-------PHLHDVTLGNKTRRGMEIIDALTEVSPHFDDTYLN 231

Human   278 --WKDWKIGFQLCNQNKSDCFYQTYSSGVDAVREWYRFHYINILSRLPETLPSLEEDTLGNFIFA 340
              |::..:   .|    ||.|::..:.  |.|  .:.|   |.||  |..: ...|..:.:|||.
  Fly   232 CKWRNSPV---KC----SDIFHKFVTE--DGV--CFSF---NSLS--PAEI-FRAEGIIPDFIFR 279

Human   341 CRFNQVSCN---------QANYSHFHHPMYGNCYTFNDKNNSNLWMSSMPGINNGLSLMLRAEQN 396
             ..|::|.:         .|:.|.:.:.:.|                  ||...||.|.:...:.
  Fly   280 -EENRLSMDWNVEDGYSASADTSPYPNRVLG------------------PGARAGLYLFMGGAEI 325

Human   397 DFIPLL-STVTGARVMVHGQDEPAFMDDGGFNLRPGVETSISMRKETLDRLGGDYGDCTKNGSDV 460
            ||..:. ..|.|.::::|...:.|.:....|.:....|..||:|.:.:         .|.:|
  Fly   326 DFDDMCRGPVQGFKILLHTPGDVAQVSKQYFRIPFDQEVLISIRPKII---------TTSDG--- 378

Human   461 PVENLYPSK----------------YTQQVCIHSCFQESMIKECGCAYIFYPRPQNVEYCDYRKH 509
             :::..|::                |:|..|...|.....:.:|||.....||..|:..|.
  Fly   379 -LKHYEPNRRQCYFQKERELRYFNIYSQSNCELECLANFTLTKCGCVKFSMPRNVNMPVCG---- 438

Human   510 SSWGYCYYKLQVDFSSDHLGCFTKCRKPCSVTSYQ---LSAGYSR--------WPSVTSQEWVFQ 563
                        |.|   |.|:.:......:..:.   ::||.:.        .||.||..:..:
  Fly   439 ------------DAS---LKCYNQAEDELLLREFTQGLVNAGENTRGETECNCLPSCTSIAYEAE 488

Human   564 MLSRQNNY-TVNN-----------KRNG--VAKVNIFFKELNYKTNSESPSVTMVTLLSNLGSQW 614
            :.....:| ||.|           ||.|  :::|:|||||..:.|:..|........|:|.|...
  Fly   489 ISQADFDYKTVINTDSPEGKEEQSKRQGMKMSRVSIFFKEAQFLTSRRSELYGTTDFLANCGGLL 553

Human   615 SLWFGSSVLSVVEMAELVFDLLVIMFLMLLRRFRSR 650
            .|:.|.|:||:|   ||::...|.:...|..|.::|
  Fly   554 GLFMGVSMLSIV---ELIYFCTVRLISNLRMRRKTR 586

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SCNN1A	NP_001153048.1	ENaC	113..706	CDD:273304	132/623 (21%)
		deg-1	121..631	CDD:273309	125/587 (21%)
ppk26	NP_648125.3	ASC	74..570	CDD:279230	127/590 (22%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4294
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D303969at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X60
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.820