DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment SCN10A and NaCP60E

DIOPT Version :9

Sequence 1:XP_005265428.1 Gene:SCN10A / 6336 HGNCID:10582 Length:1959 Species:Homo sapiens
Sequence 2:NP_001261172.1 Gene:NaCP60E / 37981 FlyBaseID:FBgn0085434 Length:2896 Species:Drosophila melanogaster


Alignment Length:2621 Identity:832/2621 - (31%)
Similarity:1191/2621 - (45%) Gaps:794/2621 - (30%)


- Green bases have known domain annotations that are detailed below.


Human    25 EKQIAAKQ---GTKKAREKHREQKDQEEK-----PRPQLDLKACNQLPKFYGELPAELIGEPLED 81
            ||.:|..|   .|::::.||..:..|..:     ||.:..::..:.||:.:...|..:.|:|||:
  Fly    11 EKAVAKHQVVAYTQRSQVKHENRHIQLVREYGFHPRTKASVEDGDVLPRKFEPFPEHMYGKPLEE 75

Human    82 LDPFYSTHRTFMVLNK---GRTISRFSATRALWLFSPFNLIRRTAIKVSVHSYPLWFSLFITVTI 143
            :|.|. ...||.|::|   ...|.||:.|::|:||.|::..||..:.::.:.:   |...:..||
  Fly    76 IDTFI-YEETFCVVSKRFRKNYIHRFTGTKSLFLFYPWSPARRVCVYIATNQF---FDYCVMATI 136

Human   144 LVNCVCMTRTDLPEKIEYVFTVIYTFEALIKILARGFCLNEFTYLRDPWNWLDFSVITLAYVGTA 208
            |.||:.:..|:..|:.||:|..||:.|.:|||:|:||.||::||||:|||||||.|||..|....
  Fly   137 LFNCIFLAMTETVEEAEYIFLAIYSIEMVIKIIAKGFLLNKYTYLRNPWNWLDFVVITSGYATIG 201

Human   209 IDLRGISGLRTFRVLRALKTVSVIPGLKVIVGALIHSVKKLADVTILTIFCLSVFALVGLQLFKG 273
            :::..::|||||||||||||||::||||.|:.||:||.::||:|..||||||.||||..||::.|
  Fly   202 MEVGNLAGLRTFRVLRALKTVSIMPGLKTIINALLHSFRQLAEVMTLTIFCLMVFALFALQVYMG 266

Human   274 NLKNKCVKNDMAVNETTNYSSHRKPDIYINKRGT----SD--PLLCGNGSDSGHCPDGYICLKTS 332
            .|:||||:  ....:.||. ||....|::|....    .|  |:||||.:.:.|||..|:||...
  Fly   267 ELRNKCVR--QVPTDWTNV-SHTDWQIWVNDTDNWLYDEDELPVLCGNLTGARHCPFEYVCLCVG 328

Human   333 DNPDFNYTSFDSFAWAFLSLFRLMTQDSWERLYQQTLRTSGKIYMIFFVLVIFLGSFYLVNLILA 397
            :||:..||:||:|.|:.|:.|:|:|.|.||.:|...|.|.|.:.:.||.:|:|.|||||:||:||
  Fly   329 ENPNHGYTNFDNFMWSMLTTFQLITLDYWENVYNMVLATCGPMSVSFFTVVVFFGSFYLINLMLA 393

Human   398 VVTMAYEEQNQATTDEIEAKEKKFQEALEMLRKEQEVLAALGIDTTSLH-------------SHN 449
            ||.::|||:.:.|.:|    .||     ::|....:  :....|.:.|:             |..
  Fly   394 VVALSYEEEAEITNEE----RKK-----DLLDHRDD--STFSFDPSVLNVKKLNKNNKKKIDSRK 447

Human   450 GSPLTSKNASERRHRIKPRVSEGST---------EDNK------SPRSDPYNQ--RRMSFLGLAS 497
            |..|.|.:..:.|.:......||.|         :|||      ||...|.:.  .|.|.|.:.:
  Fly   448 GVLLASYSKKKTRRKKTKGGKEGGTNGNGNGSNGDDNKSHSATPSPGPSPRHSATERPSALTMQA 512

Human   498 GK------------RRASHGS----------VFHFRSPGRDISLPEGVTDDGVFPGDHESHRGSL 540
            .|            :..|.||          ...|:..|..:..|     :.::|.|   ::|.|
  Fly   513 QKQYQQMEQQHKLAKSGSGGSNNPMAPTPKGRISFQDSGMGVKNP-----NMLYPSD---YKGQL 569

Human   541 LLGGGAGQQGPLPRSPLPQPSNPDSRHGEDEHQPPPTSE-----------LAPGAVDVSAFDAGQ 594
            :...|   |.....|.:.:.|:.|.....|:|:...|:.           |:|..|.:...:...
  Fly   570 IANSG---QPSSNSSGVNRESSQDDSGVVDDHEEQDTTNDMGHVSTVELALSPREVRLIKCNGNI 631

Human   595 KKTFLSAEY-LDEPFRAQRAMSVVSIITSVLEELEESEQKCPPCLTSLSQKYLIWDCC--PMWVK 656
            .:......| |.:.|.::    ||     |:::|  .::.|..|:.        | |.  ..|::
  Fly   632 ARIKNHNVYALHQEFSSE----VV-----VIDDL--PDRNCDRCVH--------W-CTDYESWLQ 676

Human   657 LKTILFGLVTDPFAELTITLCIVVNTIFMAMEHHGMSPTFEAMLQIGNIVFTIFFTAEMVFKIIA 721
            .:..|:.:|.||..||.||||||:||.|:||||||||.:|...|.:||.|||..||.|.:.|::|
  Fly   677 FQNCLYKVVRDPLFELAITLCIVLNTAFLAMEHHGMSESFRNALDVGNKVFTSIFTFECIVKLMA 741

Human   722 FDPYYYFQKKWNIFDCIIVTVSLLELGVAKKGSLSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNS 786
            ... .:|...|||||.:|||.|||::.......|||||..|||||.|||:||.|:..|:.||.::
  Fly   742 LSK-DFFLCGWNIFDLLIVTASLLDIIFELVDGLSVLRGLRLLRVLKLAQSWTTMKVLLSIIIST 805

Human   787 VGALGNLTIILAIIVFVFALVGKQLLGENYRNNRKNISAPHEDWPRWHMHDFFHSFLIVFRILCG 851
            :|||||||:||.|::::||::|.||..::|...:.:    .:..|||:.:||||||:::||||||
  Fly   806 IGALGNLTLILVIVIYIFAVIGMQLFSKDYTPEKFD----PDPVPRWNFNDFFHSFMMIFRILCG 866

Human   852 EWIENMWACMEVGQK---SICLILFLTVMVLGNLVVLNLFIALLLNSFSADNLTAPEDD-GEVNN 912
            ||||.:|.||...::   |.|..:||..:|:||.:|||||:|||||||:::.|.:.::: ||.:.
  Fly   867 EWIEPLWDCMRAEEEQGASTCFAIFLPTLVMGNFMVLNLFLALLLNSFNSEELKSKKEEVGEESK 931

Human   913 LQVALARI-----------------------------------QVFGHR---------------- 926
            |..::.|:                                   |...|:                
  Fly   932 LARSIERVRDLIRKKRQERKDRKERKFAEKFQQIVLDAQQAHAQTLSHQAAVGLERGDKPGVLAE 996

Human   927 TKQALCSF--------------------------------------------------------- 934
            ||....|:                                                         
  Fly   997 TKFHRLSYQESMNRPVSGSDFGFQIPLHDGLHTIVDGLEYDDTGDLPEQIQLQAHPLPPTSDSMP 1061

Human   935 --------------FSR-----SC----PFPQP-------------------------------- 944
                          ||.     :|    ||.|.                                
  Fly  1062 PTYESAMMATTGGSFSSVNGNGTCQNLTPFVQAERRLQHQISSGVSTQQYDSREEATYTESIELL 1126

Human   945 ----------------------------------------------KAEPELVVKLP-------- 955
                                                          |.:..|:.:.|        
  Fly  1127 GQYNSTDTDPYANDQRSGCGSFNRGDSLQDNSSRRYGSEEHDEAFLKYQKSLLTRSPSYRKSLDR 1191

Human   956 LSSSKAENHIA------ANTARGSSG--------------------------------------- 975
            ||.|..::..:      |...|.|||                                       
  Fly  1192 LSQSSGQSQRSLLKSEEAEMRRHSSGQSLNSMSIEQDELLSQQGNLREELLNCDQKELFQFLQEE 1256

Human   976 -------------GLQAPRGPRD-----------EHSDF-------------------------- 990
                         .:...|.|..           |||:|                          
  Fly  1257 EELQKGTKLRRISNVMRSRRPSSQMGQPENETMVEHSEFDNIIQSFEKELEEIKRSTTSLERKLS 1321

Human   991 -IANPT---------VWVSVPIAEGES------------------DLDD---------------- 1011
             ::.|:         :...:.|..|.|                  ||..                
  Fly  1322 NLSEPSPAADEATKAIMEHIAIITGASERSAADEVVLPLNPYDSYDLSSVPRRSQSVSAAAQRQS 1386

Human  1012 -------------LEDD-----------------------------GGEDAQSFQQ--------- 1025
                         :::|                             ....||..|.         
  Fly  1387 VKLKRRSLEKQRKIDEDFSISNEIRKICDQIHAPFVAMEAMAVAATSASQAQPNQSPFLRRKVDP 1451

Human  1026 -----------------EVIPKGQQ--------------------EQLQ---------------- 1037
                             |.:|:.::                    :||:                
  Fly  1452 FTVQFDRFKRLSLIERVEEVPEEEKPISTLRIESEKMPRKFLHGPDQLRLDSLSLKSTNSYENLL 1516

Human  1038 -QVERCG---DHLTPRSPGTGTSSEDLAPSLGETWKDESVPQVPA-------------------- 1078
             |.::.|   ....|.:|.|...|....|:|.:....::.|.:.|                    
  Fly  1517 IQKQKLGMATPPAVPATPPTSLKSSIEPPTLAQISSLKTTPPLAALTEHQQHFHATSIQAAPTPA 1581

Human  1079 ------------------------------------------EGVDDTSS------------SEG 1089
                                                      .|..|.||            |:.
  Fly  1582 HTHAHSQAHAHSMAGQRRRMEHPQSTLDKAASFQSARTESHSSGAADASSALALAMAQKTEQSQS 1646

Human  1090 STVDCLDPEEILRKIPE--------LADDL---------------------------EEPDDCFT 1119
            :..|.........::.|        ..|||                           :.|||||.
  Fly  1647 TAPDATQKPSAFTRLTEKPWHCLVSYVDDLTVGGRRNSQGAYNDPMTFPSYGATKAAKVPDDCFP 1711

Human  1120 EGCIRH----CP----CCKLDTTKSPWDVGW-QVRKTCYRIVEHSWFESFIIFMILLSSGSLAFE 1175
            :.|..|    ||    |....:.|.     | :||.....:|:...||.|::.:|..||.:|.||
  Fly  1712 QKCYDHFYFRCPWFMSCMDTQSAKH-----WTRVRTAVLTVVDTPAFEWFVLVLIFASSITLCFE 1771

Human  1176 DYYLDQKPTVKALLEYTDRVFTFIFVFEMLLKWVAYGFKKYFTNAWCWLDFLIVNISLISLTAKI 1240
            |..||:..|:|.:|.:.:..|..|||.||:|||:|.||.||||:.|..|||:||.:|:.||.  |
  Fly  1772 DINLDKNKTLKRVLYWINFSFCLIFVVEMILKWLALGFSKYFTSFWTILDFIIVFVSVFSLL--I 1834

Human  1241 LEYSEVAPIKALRTLRALRPLRALSRFEGMRVVVDALVGAIPSIMNVLLVCLIFWLIFSIMGVNL 1305
            .|...:..:::||||||||||||:||::|||:||:||:.|||||.|||||||:||||||||||..
  Fly  1835 EENENLKVLRSLRTLRALRPLRAISRWQGMRIVVNALMYAIPSIFNVLLVCLVFWLIFSIMGVQF 1899

Human  1306 FAGKFWRCINYTDGEFSLVPLSIVNNKSDCKIQNSTGSFFWVNVKVNFDNVAMGYLALLQVATFK 1370
            |.|||::|:|.. ||  |:|::.||:|.||..||.|    |:|.|:.||:|.||||||||||||:
  Fly  1900 FGGKFFKCVNEM-GE--LLPITEVNDKWDCIEQNYT----WINSKITFDHVGMGYLALLQVATFE 1957

Human  1371 GWMDIMYAAVDSREVNMQPKWEDNVYMYLYFVIFIIFGGFFTLNLFVGVIIDNFNQQKKKLGG-- 1433
            |||::|..|||:|.|::||:.|.|:|.|:||||||:.|.|||||||:||||||||..|||..|  
  Fly  1958 GWMEVMADAVDARGVDLQPQREANLYAYIYFVIFIVCGSFFTLNLFIGVIIDNFNMLKKKYEGGV 2022

Human  1434 QDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKFQGFVFDIVTRQAFDITIMVLICLNMITMMV 1498
            .::|:||.||.||.||||||.|||||.|.||:|.|....:|:...:.|:|.|.|||.|||:||.:
  Fly  2023 LEMFLTESQKHYYTAMKKLGRKKPQKVIKRPINHFLAMFYDLSNSRRFEIAIFVLIFLNMLTMGI 2087

Human  1499 ETDDQSEEKTKILGKINQFFVAVFTGECVMKMFALRQYYFTNGWNVFDFIVVVLSIASLIFSAIL 1563
            |..||......||...|.||..||..|.::|:..||.:|||..||||||::|:.||..::...|:
  Fly  2088 EHYDQPHAVFFILEVSNAFFTTVFGLEAIVKIVGLRYHYFTVPWNVFDFLLVLASIFGILMEDIM 2152

Human  1564 KSLQSYFSPTLFRVIRLARIGRILRLIRAAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFG 1628
            ..|.  .||||.||:|:.|||||||||:||||||.|||||::|||||||||.||.|:.|||:|.|
  Fly  2153 IDLP--ISPTLLRVVRVFRIGRILRLIKAAKGIRKLLFALVVSLPALFNIGALLGLITFIYAILG 2215

Human  1629 MSSFPHVRWEAGIDDMFNFQTFANSMLCLFQITTSAGWDGLLSPILNTGPPYCDPNLPNSNGTRG 1693
            ||.|.:|:.:..:|||.|||||..||..||::.|||||:.:|..:: ..||.|||.:  ...|.|
  Fly  2216 MSLFGNVKLQGALDDMVNFQTFGRSMQLLFRLMTSAGWNDVLESLM-IQPPDCDPFI--HGHTNG 2277

Human  1694 DCGSPAVGIIFFTTYIIISFLIMVNMYIAVILENFNVATEESTEPLSEDDFDMFYETWEKFDPEA 1758
            :||.|.:.|.:||::||||::|::|||||:||||||.|.:|....:.|||.:|||..|.|:||.|
  Fly  2278 NCGHPLLAITYFTSFIIISYMIVINMYIAIILENFNQAHQEEEIGIVEDDLEMFYIRWSKYDPHA 2342

Human  1759 TQFITFSALSDFADTLSGPLRIPKPNRNILIQMDLPLVPGDKIHCLDILFAFTKNVLGESGELDS 1823
            ||||.||.||||..:|..||.|.|||...|:..:||:..|:||||||||.|..|:|||...|.|:
  Fly  2343 TQFIHFSQLSDFIASLDPPLGISKPNNVALVSFNLPISKGNKIHCLDILHALVKHVLGHVEETDN 2407

Human  1824 ---LKANMEEKFMATNLSKSSYEPIATTLRWKQEDISATVIQKAYRSYVLHRSMALSNTPCVPRA 1885
               |:..|:.||.....::...|.:::|..||:::.:|..||..::.|:..:           |.
  Fly  2408 FKQLQEQMDVKFKKQFPTRKELEIVSSTRIWKRQEKAAKTIQTGWKEYLRRK-----------RE 2461

Human  1886 EEEAASLPDEGFVAFTANENCVLPDKSETASATSFPPSYESVTRGL--------------SDRVN 1936
            :|.:.|                    .::|:.||.|..::|....|              |.|.:
  Fly  2462 KERSNS--------------------GDSATQTSSPGGWQSKLSALNFFHLQVSRRGTACSSRAS 2506

Human  1937 MRTSSSIQNEDEATSMELIAP 1957
            .|.||  :..|.:...||..|
  Fly  2507 SRKSS--RASDASDLSELAGP 2525

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SCN10AXP_005265428.1 Ion_trans 150..410 CDD:278921 131/265 (49%)
Na_trans_cytopl 466..>537 CDD:288761 21/109 (19%)
Ion_trans 685..897 CDD:278921 107/214 (50%)
Na_trans_assoc 907..1150 CDD:284034 80/825 (10%)
Ion_trans 1172..1430 CDD:278921 153/257 (60%)
Na_channel_gate 1422..1474 CDD:240441 31/53 (58%)
Ion_trans 1496..1735 CDD:278921 125/238 (53%)
GPHH 1745..1802 CDD:293510 30/56 (54%)
NaCP60ENP_001261172.1 Ion_trans 152..371 CDD:278921 111/221 (50%)
Ion_trans 705..902 CDD:278921 96/201 (48%)
Ion_trans 1768..2019 CDD:278921 155/259 (60%)
Na_channel_gate 2009..2063 CDD:240441 31/53 (58%)
Ion_trans 2085..2320 CDD:278921 126/239 (53%)
GPHH 2331..2386 CDD:293510 29/54 (54%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG2301
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D37221at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100419
Panther 1 1.100 - - LDO PTHR10037
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
54.820

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