| Sequence 1: | NP_001352465.1 | Gene: | SCN9A / 6335 | HGNCID: | 10597 | Length: | 1988 | Species: | Homo sapiens |
|---|---|---|---|---|---|---|---|---|---|
| Sequence 2: | NP_956426.2 | Gene: | scn1laa / 393101 | ZFINID: | ZDB-GENE-040426-751 | Length: | 1955 | Species: | Danio rerio |
| Alignment Length: | 2016 | Identity: | 1316/2016 - (65%) |
|---|---|---|---|
| Similarity: | 1572/2016 - (77%) | Gaps: | 98/2016 - (4%) |
- Green bases have known domain annotations that are detailed below.
|
Human 3 MLPPPGPQSFVHFTKQSLALIEQRIAERKSKEPK--EEKKDDDEEAPKPSSDLEAGKQLPFIYGD 65
Human 66 IPPGMVSEPLEDLDPYYADKKTFIVLNKGKTIFRFNATPALYMLSPFSPLRRISIKILVHSLFSM 130
Human 131 LIMCTILTNCIFMTMNNPPDWTKNVEYTFTGIYTFESLVKILARGFCVGEFTFLRDPWNWLDFVV 195
Human 196 IVFAYLTEFVNLGNVSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFA 260
Human 261 LIGLQLFMGNLKHKC-----FRNSLE---NNETLESIMNTLESEEDFRKYFYYLEGSKDALLCGF 317
Human 318 STDSGQCPEGYTCVKIGRNPDYGYTSFDTFSWAFLALFRLMTQDYWENLYQQTLRAAGKTYMIFF 382
Human 383 VVVIFLGSFYLINLILAVVAMAYEEQNQANIEEAKQKELEFQQMLDRLKKEQEEAEAIAAAAAEY 447
Human 448 TSIRRSRIMGLS----ESSSETSKLSSKSAKERRNRRKKKNQKKLSSGEEKGDAEKLSKSESEDS 508
Human 509 IRRKSFHLGVEGH-RRAHEKRLSTPNQSPLSIRGSLFSARRSSRTSLFSFKGRGRDIGSETEFAD 572
Human 573 DEHSIFGDNESRRGSLFVPHRPQERRSSNISQASRSPP-MLPVNGKMHSAVDCNGVVSLVDGRSA 636
Human 637 LMLPNGQLL----PEVIIDKATSDDSGTTNQIHKKRRCSSYLLSEDMLNDPNLRQRAMSRASILT 697
Human 698 NTVEELEESRQKCPPWWYRFAHKFLIWNCSPYWIKFKKCIYFIVMDPFVDLAITICIVLNTLFMA 762
Human 763 MEHHPMTEEFKNVLAIGNLVFTGIFAAEMVLKLIAMDPYEYFQVGWNIFDSLIVTLSLVELFLAD 827
Human 828 V-EGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKS 891
Human 892 YKECVCKINDDCTLPRWHMNDFFHSFLIVFRVLCGEWIETMWDCMEVAGQAMCLIVYMMVMVIGN 956
Human 957 LVVLNLFLALLLSSFSSDNLTAIEEDPDANNLQIAVTRIKKGINYVKQTLREFILKAFSKKPKIS 1021
Human 1022 REIRQAED----LNTKKENYISNHTLAEMSKGHNFLKEKDKISGFGSSVDKHLMEDSDGQSFIHN 1082
Human 1083 PSLTVTVPIAPGESDLENMNAEELSS-DSDSEYSKVRLN--RSSSSECSTVD-NPLPGEGEEAEA 1143
Human 1144 EPMNSDE--PEACFTDGCVWRFSCCQVNIESGKGKIWWNIRKTCYKIVEHSWFESFIVLMILLSS 1206
Human 1207 GALAFEDIYIERKKTIKIILEYADKIFTYIFILEMLLKWIAYGYKTYFTNAWCWLDFLIVDVSLV 1271
Human 1272 TLVANTLGYSDLGPIKSLRTLRALRPLRALSRFEGMRVVVNALIGAIPSIMNVLLVCLIFWLIFS 1336
Human 1337 IMGVNLFAGKFYECINTTDGSRFPASQVPNRSECFALMNVSQNVRWKNLKVNFDNVGLGYLSLLQ 1401
Human 1402 VATFKGWTIIMYAAVDSVNVDKQPKYEYSLYMYIYFVVFIIFGSFFTLNLFIGVIIDNFNQQKKK 1466
Human 1467 LGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPGNKIQGCIFDLVTNQAFDISIMVLICLNMVT 1531
Human 1532 MMVEKEGQSQHMTEVLYWINVVFIILFTGECVLKLISLRHYYFTVGWNIFDFVVVIISIVGMFLA 1596
Human 1597 DLIETYFVSPTLFRVIRLARIGRILRLVKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIF 1661
Human 1662 GMSNFAYVKKEDGINDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSKPPDCDPKKVHPGSSV 1726
Human 1727 EGDCGNPSVGIFYFVSYIIISFLVVVNMYIAVILENFSVATEESTEPLSEDDFEMFYEVWEKFDP 1791
Human 1792 DATQFIEFSKLSDFAAALDPPLLIAKPNKVQLIAMDLPMVSGDRIHCLDILFAFTKRVLGESGEM 1856
Human 1857 DSLRSQMEERFMSANPSKVSYEPITTTLKRKQEDVSATVIQRAYRRYRLRQNVKNISSIYIKDGD 1921
Human 1922 RDDDLLNKKDMAFDNVNENSSPEKTDATSSTTSPPSYDSVTKPDKEKYEQDRTEKE--DKGKDSK 1984
Human 1985 E 1985 |
| Gene | Sequence | Domain | Region | External ID | Identity |
|---|---|---|---|---|---|
| SCN9A | NP_001352465.1 | Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 26..55 | 14/30 (47%) | |
| I. /evidence=ECO:0000305 | 112..410 | 225/305 (74%) | |||
| Ion_trans | 125..410 | CDD:306908 | 215/292 (74%) | ||
| Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 461..543 | 37/82 (45%) | |||
| Na_trans_cytopl | 488..681 | CDD:314757 | 77/198 (39%) | ||
| Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 565..611 | 23/46 (50%) | |||
| II. /evidence=ECO:0000305 | 726..989 | 200/263 (76%) | |||
| Ion_trans | 743..956 | CDD:306908 | 167/213 (78%) | ||
| Na_trans_assoc | 982..1187 | CDD:310839 | 92/214 (43%) | ||
| Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 1102..1148 | 23/49 (47%) | |||
| III. /evidence=ECO:0000305 | 1180..1488 | 233/307 (76%) | |||
| Ion_trans | 1191..1466 | CDD:306908 | 205/274 (75%) | ||
| Na_channel_gate | 1458..1510 | CDD:240441 | 48/51 (94%) | ||
| IV. /evidence=ECO:0000305 | 1497..1795 | 246/297 (83%) | |||
| Ion_trans | 1514..1770 | CDD:306908 | 210/255 (82%) | ||
| GPHH | 1774..1837 | CDD:318993 | 47/62 (76%) | ||
| Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 1934..1988 | 27/54 (50%) | |||
| scn1laa | NP_956426.2 | Ion_trans | 150..416 | CDD:278921 | 205/272 (75%) |
| Na_trans_cytopl | 483..594 | CDD:288761 | 51/114 (45%) | ||
| Ion_trans | 749..945 | CDD:278921 | 153/195 (78%) | ||
| Na_trans_assoc | 972..1161 | CDD:284034 | 91/211 (43%) | ||
| Ion_trans | 1184..1438 | CDD:278921 | 189/256 (74%) | ||
| Na_channel_gate | 1430..1482 | CDD:240441 | 48/51 (94%) | ||
| Ion_trans | 1504..1742 | CDD:278921 | 195/237 (82%) | ||
| GPHH | 1752..1801 | CDD:293510 | 34/48 (71%) |
| Tool | Simple Score | Weighted Score | Original Tool Information | |||
|---|---|---|---|---|---|---|
| BLAST Result | Score | Score Type | Cluster ID | |||
| Compara | 0 | 0.000 | Not matched by this tool. | |||
| Domainoid | 0 | 0.000 | Not matched by this tool. | |||
| eggNOG | 0 | 0.000 | Not matched by this tool. | |||
| Hieranoid | 0 | 0.000 | Not matched by this tool. | |||
| Homologene | 0 | 0.000 | Not matched by this tool. | |||
| Inparanoid | 0 | 0.000 | Not matched by this tool. | |||
| NCBI | 0 | 0.000 | Not matched by this tool. | |||
| OMA | 1 | 1.010 | - | - | QHG52281 | |
| OrthoDB | 1 | 1.010 | - | - | D37221at33208 | |
| OrthoFinder | 0 | 0.000 | Not matched by this tool. | |||
| OrthoInspector | 0 | 0.000 | Not matched by this tool. | |||
| orthoMCL | 1 | 0.900 | - | - | OOG6_100419 | |
| Panther | 1 | 1.100 | - | - | O | PTHR10037 |
| Phylome | 1 | 0.910 | - | - | ||
| RoundUp | 0 | 0.000 | Not matched by this tool. | |||
| SonicParanoid | 1 | 1.000 | - | - | X214 | |
| SwiftOrtho | 0 | 0.000 | Not matched by this tool. | |||
| TreeFam | 0 | 0.000 | Not matched by this tool. | |||
| ZFIN | 0 | 0.000 | Not matched by this tool. | |||
| 6 | 5.930 | |||||