| Sequence 1: | NP_001352465.1 | Gene: | SCN9A / 6335 | HGNCID: | 10597 | Length: | 1988 | Species: | Homo sapiens |
|---|---|---|---|---|---|---|---|---|---|
| Sequence 2: | NP_001259619.1 | Gene: | para / 32619 | FlyBaseID: | FBgn0285944 | Length: | 2145 | Species: | Drosophila melanogaster |
| Alignment Length: | 2123 | Identity: | 945/2123 - (44%) |
|---|---|---|---|
| Similarity: | 1313/2123 - (61%) | Gaps: | 221/2123 - (10%) |
- Green bases have known domain annotations that are detailed below.
|
Human 12 FVHFTKQSLALIEQRIAERKSKEPKEEKK----------------------DDDEEAPKPSSDLE 54
Human 55 AGKQLPF-IYGDIPPGMVSEPLEDLDPYYADKKTFIVLNKGKTIFRFNATPALYMLSPFSPLRRI 118
Human 119 SIKILVHSLFSMLIMCTILTNCIFMTMNNPPDWTKNVEYTFTGIYTFESLVKILARGFCVGEFTF 183
Human 184 LRDPWNWLDFVVIVFAYLTEFVNLGNVSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDV 248
Human 249 MILTVFCLSVFALIGLQLFMGNLKHKCFRNSLENNETLESIMNTLESEE-DFR----KYFYYLEG 308
Human 309 SKDALLCGFSTDSGQCPEGYTCVK-IGRNPDYGYTSFDTFSWAFLALFRLMTQDYWENLYQQTLR 372
Human 373 AAGKTYMIFFVVVIFLGSFYLINLILAVVAMAYEE-QNQANIEEAKQKELEFQQMLDRLKKEQEE 436
Human 437 AEAIAAAAAEYTSIRRSRIMGLSESSSETSKLSSKSAKERRNRRKKKNQKKLSSGEEKG----DA 497
Human 498 EKLS------KSESEDSIRRKSFHLGVEGHRRAHEKRLSTPNQSPLSIRGSLFSARRSSRTS-LF 555
Human 556 SFK-GRGR-----------------DIGSETEFADDEHSIFGDNESRRGSLFVP---------HR 593
Human 594 PQERRSSNISQASRSPPM--LPVNG--------KMHSAVDCNGVVSLVDGRSALMLPNGQL-LPE 647
Human 648 VIIDKATSDDSGT----TNQIHKKRRCSSYLLSED--MLND-----PNLRQRAMSR-ASILTNTV 700
Human 701 EELEES----RQKCPPWWYRFAHKFLIWNCSPYWIKFKKCIYFIVMDPFVDLAITICIVLNTLFM 761
Human 762 AMEHHPMTEEFKNVLAIGNLVFTGIFAAEMVLKLIAMDPYEYFQVGWNIFDSLIVTLSLVELFLA 826
Human 827 DVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKS 891
Human 892 YKECVCKINDDCTLPRWHMNDFFHSFLIVFRVLCGEWIETMWDCMEVAGQAMCLIVYMMVMVIGN 956
Human 957 LVVLNLFLALLLSSFSSDNLTAIEEDPDANNLQIAVTRIKKGINYVKQTLRE-FILKAFSKKPKI 1020
Human 1021 SREIRQAEDLNTKKENYIS---------------NHTLAEMSKGHNFLKEKDKISGFGSSVDKHL 1070
Human 1071 MEDS-------DGQSF-IH------NPSLTVTVPIAPGESDLENMNA---------EELSSDSDS 1112
Human 1113 EYSKVRLNRSSSSECSTVDNPLPGEGEEAEAEPMNSD-------------EPEACFTDGCVWRFS 1164
Human 1165 CCQVNIESGKGKIWWNIRKTCYKIVEHSWFESFIVLMILLSSGALAFEDIYIERKKTIKIILEYA 1229
Human 1230 DKIFTYIFILEMLLKWIAYGYKTYFTNAWCWLDFLIVDVSLVTLVANTLGYSDLGPIKSLRTLRA 1294
Human 1295 LRPLRALSRFEGMRVVVNALIGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYECINTTDGSRF 1359
Human 1360 PASQVPNRSECFALMNVSQNVRWKNLKVNFDNVGLGYLSLLQVATFKGWTIIMYAAVDSVNVDKQ 1424
Human 1425 PKYEYSLYMYIYFVVFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQ-DIFMTEEQKKYYNAMKKL 1488
Human 1489 GSKKPQKPIPRPGNKIQGCIFDLVTNQAFDISIMVLICLNMVTMMVEKEGQSQHMTEVLYWINVV 1553
Human 1554 FIILFTGECVLKLISLRHYYFTVGWNIFDFVVVIISIVGMFLADLIETYFVSPTLFRVIRLARIG 1618
Human 1619 RILRLVKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFAYVKKEDGINDMFNFET 1683
Human 1684 FGNSMICLFQITTSAGWDGLLAPILNSK---PPDCDPKKVHPGSSVEGDCGNPSVGIFYFVSYII 1745
Human 1746 ISFLVVVNMYIAVILENFSVATEESTEPLSEDDFEMFYEVWEKFDPDATQFIEFSKLSDFAAALD 1810
Human 1811 PPLLIAKPNKVQLIAMDLPMVSGDRIHCLDILFAFTKRVLGESGEMDSLRSQMEERFMSANPSKV 1875
Human 1876 SYEPITTTLKRKQEDVSATVIQRAYRRYRLRQNVKNISSIYIKDGDRDDDLLNKKDMAFDNVNEN 1940
Human 1941 SSPEKTDATSSTTSPPSYDSVTKPDKEKYEQDRTEKEDKGKDS 1983 |
| Gene | Sequence | Domain | Region | External ID | Identity |
|---|---|---|---|---|---|
| SCN9A | NP_001352465.1 | Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 26..55 | 11/50 (22%) | |
| I. /evidence=ECO:0000305 | 112..410 | 173/304 (57%) | |||
| Ion_trans | 125..410 | CDD:306908 | 165/291 (57%) | ||
| Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 461..543 | 23/91 (25%) | |||
| Na_trans_cytopl | 488..681 | CDD:314757 | 56/247 (23%) | ||
| Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 565..611 | 12/54 (22%) | |||
| II. /evidence=ECO:0000305 | 726..989 | 164/262 (63%) | |||
| Ion_trans | 743..956 | CDD:306908 | 136/212 (64%) | ||
| Na_trans_assoc | 982..1187 | CDD:310839 | 54/256 (21%) | ||
| Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 1102..1148 | 13/54 (24%) | |||
| III. /evidence=ECO:0000305 | 1180..1488 | 186/308 (60%) | |||
| Ion_trans | 1191..1466 | CDD:306908 | 166/274 (61%) | ||
| Na_channel_gate | 1458..1510 | CDD:240441 | 35/52 (67%) | ||
| IV. /evidence=ECO:0000305 | 1497..1795 | 174/300 (58%) | |||
| Ion_trans | 1514..1770 | CDD:306908 | 155/258 (60%) | ||
| GPHH | 1774..1837 | CDD:318993 | 31/62 (50%) | ||
| Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 1934..1988 | 8/50 (16%) | |||
| para | NP_001259619.1 | Ion_trans | 165..436 | CDD:278921 | 156/276 (57%) |
| Na_trans_cytopl | 515..648 | CDD:288761 | 34/138 (25%) | ||
| Ion_trans | 835..1028 | CDD:278921 | 123/194 (63%) | ||
| Na_trans_assoc | 1054..1296 | CDD:284034 | 54/256 (21%) | ||
| Ion_trans | 1318..1571 | CDD:278921 | 160/258 (62%) | ||
| Na_channel_gate | 1561..1613 | CDD:240441 | 35/51 (69%) | ||
| Ion_trans | 1636..1871 | CDD:278921 | 145/241 (60%) | ||
| GPHH | 1880..1930 | CDD:293510 | 25/49 (51%) |
| Tool | Simple Score | Weighted Score | Original Tool Information | |||
|---|---|---|---|---|---|---|
| BLAST Result | Score | Score Type | Cluster ID | |||
| Compara | 0 | 0.000 | Not matched by this tool. | |||
| Domainoid | 1 | 1.000 | 342 | 1.000 | Domainoid score | I1069 |
| eggNOG | 1 | 0.900 | - | - | E1_KOG2301 | |
| Hieranoid | 1 | 1.000 | - | - | ||
| Homologene | 0 | 0.000 | Not matched by this tool. | |||
| Inparanoid | 1 | 1.050 | 1621 | 1.000 | Inparanoid score | I82 |
| Isobase | 0 | 0.000 | Not matched by this tool. | |||
| OMA | 1 | 1.010 | - | - | QHG52281 | |
| OrthoDB | 1 | 1.010 | - | - | D37221at33208 | |
| OrthoFinder | 1 | 1.000 | - | - | FOG0000268 | |
| OrthoInspector | 1 | 1.000 | - | - | otm41716 | |
| orthoMCL | 1 | 0.900 | - | - | OOG6_100419 | |
| Panther | 1 | 1.100 | - | - | O | PTHR10037 |
| Phylome | 1 | 0.910 | - | - | ||
| RoundUp | 0 | 0.000 | Not matched by this tool. | |||
| SonicParanoid | 1 | 1.000 | - | - | X214 | |
| SwiftOrtho | 0 | 0.000 | Not matched by this tool. | |||
| TreeFam | 0 | 0.000 | Not matched by this tool. | |||
| User_Submission | 0 | 0.000 | Not matched by this tool. | |||
| 12 | 11.880 | |||||