DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment SCN9A and nca-2

DIOPT Version :9

Sequence 1:NP_001352465.1 Gene:SCN9A / 6335 HGNCID:10597 Length:1988 Species:Homo sapiens
Sequence 2:NP_498054.2 Gene:nca-2 / 175674 WormBaseID:WBGene00003558 Length:1785 Species:Caenorhabditis elegans


Alignment Length:2099 Identity:401/2099 - (19%)
Similarity:725/2099 - (34%) Gaps:709/2099 - (33%)


- Green bases have known domain annotations that are detailed below.


Human   122 ILVHSLFSMLIMC---------------TILTNCIFMTMNNPPDWTKNVEYTFTGIYTFESLVKI 171
            :.|..|.||:.:|               .||.|.:.:|:                |:..|:.|.|
 Worm    78 VRVACLLSMISLCLHTPETIKMWPPLNYIILANDVIVTL----------------IFIGEAAVTI 126

Human   172 LARGFCVGEFTFLRDPWNWLDFVVIVFAYLTEFVN-------------------LGNVSALRTFR 217
            ...|....:.::|||.|...:|.:::...|:..::                   ||.:.:.|.|.
 Worm   127 NQNGLFDNQNSYLRDRWYQFEFFLLINHILSCVIHIYELCSIWFPALNFVYYPWLGALRSARPFI 191

Human   218 VLRALKTISVIPGLKTIVGALI-QSVKKLSDVMILTVFCLSVFALIGLQLFMGNLKHKCFRNSLE 281
            .||.:::|......|..:..:| :|.:::.:|.|..:|.:..:|::|:||| |.|.:.|..|..:
 Worm   192 FLRFIRSIVRFKLPKNRIKLIIKRSSQQIQNVTIFFMFFVFSYAIMGVQLF-GRLNYHCVVNGTD 255

Human   282 -NNETLE--SIMNTLESEEDFRKYFYYLEGSKDALLCGFSTDSGQCPEGYTCVKIGRNP-DYG-Y 341
             ||.|:.  :|.:|:.|::....|                    :||....|:::...| :.| |
 Worm   256 PNNVTIADLAIPDTMCSQKGAGGY--------------------ECPGNMVCMRLQLKPQEEGFY 300

Human   342 TSFDTFSWAFLALFRLMTQDYWENLYQQTLRAAGKTYMIF-FVVVIFLGSFYLINLILAVVAMAY 405
            ..|..|:.:...::...:|:.|..:....|.:.......| ||.:||..::.:.|:.:||:    
 Worm   301 GQFSDFASSLFTVYLAASQEGWVYVLYDCLDSLPSFLAFFYFVTLIFFLAWLVKNVFIAVI---- 361

Human   406 EEQNQANIEEAKQKELEFQQMLDRLKKEQEEAEAIAAAAAEYTSIRRSRIMGLSESSSE---TSK 467
                                           .|..|....:::.:.::|     |::::   |.|
 Worm   362 -------------------------------TETFAEIRVQFSEMWQTR-----EATTDHVYTQK 390

Human   468 LSSKSAKERRNRRKKKNQKKLSSGEEKGDAEKLSKSESEDSIRRKSFHLGVEGHRRAHEKRLSTP 532
            |                       |:..|..||               :.|:.:.|||       
 Worm   391 L-----------------------EKDEDGWKL---------------VEVDKYNRAH------- 410

Human   533 NQSPLSIRGSLFSARRSSRTSLFSFKGRGRDIGSETEFADDEHSIFGDNESRRGSLFVPHRPQER 597
                             |..|||                                          
 Worm   411 -----------------SNNSLF------------------------------------------ 416

Human   598 RSSNISQASRSPPMLPVNGKMHSAVDCNGVVSLVDGRSALMLPNGQLLPEVIIDKATSDDSGTTN 662
                                :|:.|......:::           |||                 
 Worm   417 --------------------LHTIVTSTAFQTVM-----------QLL----------------- 433

Human   663 QIHKKRRCSSYLLSEDMLNDPNLRQRAMSRASILTNTVEEL------EESRQKCPPWWYRFAHKF 721
                                            ||.|.:...      :||.|....|:|      
 Worm   434 --------------------------------ILANAIFHATFVFYHDESDQIRKIWYY------ 460

Human   722 LIWNCSPYWIKFKKCIYFIVMDPFVDLAITICIVLNTLFMAMEHHPMTEEFKNVLAIGNLVFTGI 786
                                   :|::..||                                 :
 Worm   461 -----------------------YVEVGFTI---------------------------------L 469

Human   787 FAAEMVLKLIAMDPYEYFQVGWNIFDSLIVTLSLVELFLADVEGLSVLRSFRLLRVFKLAKSWPT 851
            |..|:::|:.|.....|...|.:.||.::...|.:.......| .::...|::.|:.:|.|:.|.
 Worm   470 FNTEVIIKIYAFGWKAYIARGQHKFDCILCVGSSLNAIWVLYE-TNIFTYFQVFRIARLIKASPM 533

Human   852 L-NMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKINDDCTLPRWH-MNDFF 914
            | :.:.||.|.. ..||.|.:...|::.:.:.:.:|||              |.:|:.: ..:|.
 Worm   534 LEDFVYKIFGPG-KKLGGLVIFTGILLIVTSAISLQLF--------------CYVPKLNKFTNFA 583

Human   915 HSFLIVFRVLCGE-W----IETMWDCME--VAGQAMCLIVYMMVMVIGNLVVLNLFLALLLSSFS 972
            .:|:.:|:::..| |    ||.:..|.|  |...|:..:.|.:::   .|.||:||:|::|.:..
 Worm   584 VAFMSMFQIITQEGWTDVVIEILRACNEQAVPFVAIYFVAYHLLV---TLFVLSLFVAVILDNLE 645

Human   973 SD-------NLTAIEEDPDANNLQI-------------AVTRIKKGINYVKQTLREFILKAF--- 1014
            .|       .|.|.|:|.....|.:             .||..|....:....:|:...:.|   
 Worm   646 MDEELKKVKQLKAREQDTIKTTLPMRLRIFNRFPTAPTMVTMKKVSSEFPLPKIRDSFTRQFADE 710

Human  1015 -------------------------SKKPKISREIRQAEDLNTK----------KENYI----SN 1040
                                     ||:.:|:..||....|:.|          ..|..    ||
 Worm   711 FVETSDDTIQEIGFKVRSMLSGRGPSKETRITTTIRHVGQLSNKTILTSMLTESNRNRALFSESN 775

Human  1041 HTLAEMSKGHNFLK----------EKDKISGFGSSVDKHLMEDSDGQSFIHN----PSLTVTVPI 1091
            ..||.:::.:...|          .:.:..|..|...||::|     .|..|    |..|.....
 Worm   776 QHLASLTRSNTSSKHGKSGALSTNSRSRTRGLASLKGKHMVE-----GFKENGDLRPEDTARKVE 835

Human  1092 APGESDLENMNAEELSSDSDSEYSKVRLNRSSSSECSTVDNPLPGEGEEAEAEPMNSDEPEACFT 1156
            ..||.|.:.:..:.    :.:|.::.|:...........|.||...|.|:....|          
 Worm   836 KHGEIDFKALQMKR----AHAEITRNRIEEEMRENHPMFDRPLFLVGRESSLRRM---------- 886

Human  1157 DGCVWRFSCCQV------NIESGKGKIWWNIRKTCYKIVEHSWFESFI----------VLMILLS 1205
                     ||:      :.:...|:    .||...|   :..|..|:          ||:..||
 Worm   887 ---------CQLIAHSRHSYDQNDGQ----HRKHSNK---YKQFHDFLAIMTYMDWTMVLVTTLS 935

Human  1206 SGALAFEDIYIERKKTI---KIILEYADKIFTYIFILEMLLKWIAYGY----KTYFTNAWCWLDF 1263
            ..::.:|..:....:.:   ...|:.|:.||..:...|:::|.||.|.    |...|:....|..
 Worm   936 CCSMLWESPWPTTGENLIFNNFYLQIAEYIFVLVMSFELIVKCIANGLFFTPKALVTDVGDILTI 1000

Human  1264 LIVDVSLVTLV--ANTLGYSDLGPIKSLRTLRALRPLRALSRFEGMRVVVNALIGAIPSIMNVLL 1326
            .|...||:.|:  .|.:..:....:  |...||:||||..:....:|.||..|......|:.|.:
 Worm  1001 FIYITSLMFLIWMPNHIEINSWAQL--LMVCRAMRPLRVYALIPHIRRVVVELCRGFREILLVTI 1063

Human  1327 VCLIFWLIFSIMGVNLFAGKFYECINTTDGSRFPASQVPNRSECFALMNVSQNVR---------- 1381
            :.::...||:..||.|..||...|.:         ..:.:|..|..|.:|...|.          
 Worm  1064 LLVVLMFIFASFGVQLVGGKLASCND---------PMITSRENCTGLYDVKLFVTRMEVYGKNDN 1119

Human  1382 -----------WKNLK-VNFDNVGLGYLSLLQVATFKGWTI---IMYAAVDSVNVDKQPKYEYSL 1431
                       |.|.: .|||::|...|:|.:..::|||.:   ::|             ..:..
 Worm  1120 LMHPSIIVPRVWTNPRNFNFDHIGNAMLALFETLSYKGWNVVRDVLY-------------LRHGA 1171

Human  1432 YMYIYFVVFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNAMKKLGSKKPQKP 1496
            :..::..:::..|....|.||:||::.|:.:.:     ....:|.:|:::::...:|...:|...
 Worm  1172 WAVLFIHIYVFIGCMIGLTLFVGVVVANYTENR-----GTALLTVDQRRWHDLKARLKMAQPLHV 1231

Human  1497 IPRP--GNKIQGCIFDLVTNQAFDISIMVLICLNMVTMM----VEKEGQSQHMTEVLYWINVVFI 1555
            .|:|  ..|::..::||.|::.|.....||:.:|..|::    |.:|...:.....|..|:.:..
 Worm  1232 PPKPPESAKLRCYLYDLTTSRWFKQLFAVLVVVNSFTLVIPWNVSEEQDRKTFLLCLTVISAICN 1296

Human  1556 ILFTGECVLKLISLRHYYFTVG--W----NIFDFVVVIIS---IVGMFLADLIETYFVSPTL--- 1608
            ||||.||:||:|:     ||:.  |    |..||::.|:.   ||..||..| ..||.....   
 Worm  1297 ILFTLECLLKMIA-----FTLSGFWQSRRNRIDFIITILGINWIVFHFLFQL-PAYFAGGITEWK 1355

Human  1609 -------FRVIRLARIGRILRL--VKGAKG-IRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGM 1663
                   :.|:       |||.  :.|.|. ::.|:..::||:.....|...:||::..||..|:
 Worm  1356 RLTYTYGYLVV-------ILRFFTIAGRKSTLKMLMLTVVMSMVRSSFIIAAMFLLVLFYANAGV 1413

Human  1664 SNFAYVKKEDGINDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSKPPDCDPKKVHPGSSV-E 1727
            ..|..||....:....||.....:::.||:..|...|:.::...:.: ||.|:   .|||.|. :
 Worm  1414 VLFGMVKYGQAVGKHVNFRNGREALVVLFRSVTGEDWNDIMHDCMRA-PPFCN---WHPGLSYWQ 1474

Human  1728 GDCGNPSVGIFYFVSYIIISFLVVVNMYIAVILENFSV-ATEESTEPLSEDDFEMFYEVWEKFDP 1791
            .||||....|.||.|:.:|...:|:|:.:|:|:||||: .:.|....||..|...|..||...|.
 Worm  1475 TDCGNYVGAIVYFCSFYLIITYIVLNLLVAIIMENFSLFYSSEEDALLSYADIRNFQLVWNMVDI 1539

Human  1792 DATQFIEFSKLSDFAAALDPPLLIAKPNKVQLIAMDLPMVSGDRIHCLDILFAFTKRVLGESGEM 1856
            :..:.|...::.                                     .|....|..|..:.|.
 Worm  1540 EQKRSIPVRRVK-------------------------------------FLLRLLKGRLEVNDES 1567

Human  1857 DSL--RSQMEERFMSANPSKVSYEPITTTLKRKQEDVSAT-----VIQRAYRRYRLRQNV-KNIS 1913
            |.|  :....|.....|...||:..:...|..:..|:..:     ::||....|.:.:.| |:..
 Worm  1568 DGLLFKHMCHEMERLHNGDDVSFHDVLNMLSYRSVDIRKSLQLEELLQREELEYIIEEEVAKHTI 1632

Human  1914 SIYIKDGDRDDDLLNKKDMAFDNVNENSSPEKTDATSSTTS-PPSYDSVTK--------PDKEKY 1969
            ..::     ::.|.|.|      ..:|::..|..:..||.: |.|.:.:||        |:::..
 Worm  1633 RAWL-----ENCLKNIK------AKQNNTLGKMSSIGSTFAFPQSQEVLTKGVVLTEASPEEDSL 1686

Human  1970 EQDRTEKEDKGKDSKESKK 1988
            :      .|||...|::::
 Worm  1687 Q------GDKGSGKKKAQR 1699

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SCN9ANP_001352465.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 26..55
I. /evidence=ECO:0000305 112..410 68/328 (21%)
Ion_trans 125..410 CDD:306908 67/325 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 461..543 11/84 (13%)
Na_trans_cytopl 488..681 CDD:314757 17/192 (9%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 565..611 0/45 (0%)
II. /evidence=ECO:0000305 726..989 55/278 (20%)
Ion_trans 743..956 CDD:306908 43/221 (19%)
Na_trans_assoc 982..1187 CDD:310839 45/279 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1102..1148 8/45 (18%)
III. /evidence=ECO:0000305 1180..1488 74/351 (21%)
Ion_trans 1191..1466 CDD:306908 69/318 (22%)
Na_channel_gate 1458..1510 CDD:240441 8/53 (15%)
IV. /evidence=ECO:0000305 1497..1795 94/327 (29%)
Ion_trans 1514..1770 CDD:306908 80/283 (28%)
GPHH 1774..1837 CDD:318993 8/62 (13%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1934..1988 13/62 (21%)
nca-2NP_498054.2 Ion_trans 95..371 CDD:278921 65/347 (19%)
Ion_trans 444..649 CDD:278921 56/285 (20%)
Ion_trans 959..1202 CDD:278921 62/266 (23%)
Ion_trans 1288..1518 CDD:278921 73/246 (30%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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