DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SCN9A and scn1a

DIOPT Version :9

Sequence 1:	NP_001352465.1	Gene:	SCN9A / 6335	HGNCID:	10597	Length:	1988	Species:	Homo sapiens
Sequence 2:	XP_012826731.2	Gene:	scn1a / 100488621	XenbaseID:	XB-GENE-978019	Length:	2020	Species:	Xenopus tropicalis

Alignment Length:	2022	Identity:	1519/2022 - (75%)
Similarity:	1729/2022 - (85%)	Gaps:	40/2022 - (1%)

- Green bases have known domain annotations that are detailed below.

Human     2 AMLPPPGPQSFVHFTKQSLALIEQRIAERKSKEPKEEKKDDDEE-APKPSSDLEAGKQLPFIYGD 65
            |.|.||||.||.:|:::||..||:||||.|:|:||:|.:|||:: .|||||||||||.|||||||
Frog     4 ARLVPPGPDSFRYFSRESLEAIEKRIAEEKAKKPKQEHRDDDDDNGPKPSSDLEAGKSLPFIYGD 68

Human    66 IPPGMVSEPLEDLDPYYADKKTFIVLNKGKTIFRFNATPALYMLSPFSPLRRISIKILVHSLFSM 130
            |||||||||||||||||.::|||||||:||.||||:||.|||:|:||:|||:::||:||||||||
Frog    69 IPPGMVSEPLEDLDPYYMNQKTFIVLNRGKAIFRFSATSALYILTPFNPLRKVAIKVLVHSLFSM 133

Human   131 LIMCTILTNCIFMTMNNPPDWTKNVEYTFTGIYTFESLVKILARGFCVGEFTFLRDPWNWLDFVV 195
            ||||||||||:||||:|||:||||||||||||||||||:||||||||:.:|||||||||||||.|
Frog   134 LIMCTILTNCVFMTMSNPPEWTKNVEYTFTGIYTFESLIKILARGFCLEKFTFLRDPWNWLDFSV 198

Human   196 IVFAYLTEFVNLGNVSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFA 260
            ||.||:|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Frog   199 IVMAYVTEFVNLGNVSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFA 263

Human   261 LIGLQLFMGNLKHKCFR------NSLEN-----NETL---ESIMNTLESEEDFRKY------FYY 305
            |||||||||:|::||.:      ..|.|     |.|:   :...||..|..|:.:|      ||.
Frog   264 LIGLQLFMGHLRNKCLQWPPIDYFPLINIPPILNGTMNIHDPFGNTTNSTFDWEEYITDKNHFYK 328

Human   306 LEGSKDALLCGFSTDSGQCPEGYTCVKIGRNPDYGYTSFDTFSWAFLALFRLMTQDYWENLYQQT 370
            |||.||.||||.|:||||||:||.|||.|:||:||||||||||||||:|||||||||||||||.|
Frog   329 LEGQKDFLLCGNSSDSGQCPKGYICVKTGKNPNYGYTSFDTFSWAFLSLFRLMTQDYWENLYQLT 393

Human   371 LRAAGKTYMIFFVVVIFLGSFYLINLILAVVAMAYEEQNQANIEEAKQKELEFQQMLDRLKKEQE 435
            |||||||||||||:|||||||||:|||||||||||||||||.:|||:|||.||||||::|||:||
Frog   394 LRAAGKTYMIFFVLVIFLGSFYLVNLILAVVAMAYEEQNQATLEEAEQKEAEFQQMLEQLKKQQE 458

Human   436 EAEAIAAAA----AEYTSIRRSRIMGLSESSSETSKLSSKSAKERRNRRKKKNQKKLSSGEEKGD 496
            ||:|.|.||    .||:  .......|||||||.|||||||||:||||:||:.||:|....||||
Frog   459 EAQAAAVAALNMSREYS--EDGGFGPLSESSSEASKLSSKSAKDRRNRKKKRKQKELGEEYEKGD 521

Human   497 AEKLSKSESEDSIRRKSFHLGVEGHRRAHEKRLSTPNQSPLSIRGSLFSARRSSRTSLFSFKGRG 561
            .||..|||||.||:||.|...:||:|..:|.:.|:|:||.|||||||||.||:||.|||||:.|.
Frog   522 DEKFPKSESETSIKRKGFRFSIEGNRLTYENKFSSPHQSLLSIRGSLFSPRRNSRASLFSFRNRA 586

Human   562 RDIGSETEFADDEHSIFGDNESRRGSLFVPHRPQERRSSNISQASRSP---PMLPVNGKMHSAVD 623
            :|:|||.:|||||||.|.||||||||||||:|..|||:|||||.|:|.   .:||.||||||.||
Frog   587 KDVGSENDFADDEHSTFEDNESRRGSLFVPNRHGERRNSNISQVSKSSKTMTVLPANGKMHSTVD 651

Human   624 CNGVVSLVDGRSALMLPNGQLLPEVIIDKATSDDSGTTNQIH-KKRRCSSYLLSEDMLNDPNLRQ 687
            |||||||:.|.|....|.|.||||||:||..|||:|||.:.. :||:.|.|.:..|:|.||..||
Frog   652 CNGVVSLLGGPSVPTSPVGLLLPEVIVDKPASDDNGTTTETEIRKRKSSCYQVPMDLLEDPTARQ 716

Human   688 RAMSRASILTNTVEELEESRQKCPPWWYRFAHKFLIWNCSPYWIKFKKCIYFIVMDPFVDLAITI 752
            ||:|.||||||||||||||||||||.||:||:.||||:|...|:..|..:..|||||||||||||
Frog   717 RALSVASILTNTVEELEESRQKCPPCWYKFANTFLIWDCCENWLTVKHIVKLIVMDPFVDLAITI 781

Human   753 CIVLNTLFMAMEHHPMTEEFKNVLAIGNLVFTGIFAAEMVLKLIAMDPYEYFQVGWNIFDSLIVT 817
            |||||||||||||:|||:||.:||:||||||||||.||||.||||:|||.|||.||||||.:||:
Frog   782 CIVLNTLFMAMEHYPMTKEFNDVLSIGNLVFTGIFTAEMVFKLIALDPYYYFQEGWNIFDGIIVS 846

Human   818 LSLVELFLADVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAV 882
            |||:||.||:|||||||||||||||||||||||||||||||||||||||||||||||||||||||
Frog   847 LSLMELGLANVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAV 911

Human   883 VGMQLFGKSYKECVCKINDDCTLPRWHMNDFFHSFLIVFRVLCGEWIETMWDCMEVAGQAMCLIV 947
            |||||||||||||||||.::|.|||||||||||||||||||||||||||||||||||||:|||:|
Frog   912 VGMQLFGKSYKECVCKIAENCELPRWHMNDFFHSFLIVFRVLCGEWIETMWDCMEVAGQSMCLLV 976

Human   948 YMMVMVIGNLVVLNLFLALLLSSFSSDNLTAIEEDPDANNLQIAVTRIKKGINYVKQTLREFILK 1012
            :|:||||||||||||||||||||||||||||.::|.:.|||||||.||::||:|||:|:||.|.|
Frog   977 FMLVMVIGNLVVLNLFLALLLSSFSSDNLTATDDDNEMNNLQIAVGRIQRGIDYVKKTIRECIQK 1041

Human  1013 AFSKKPKISREIRQAEDLNTKKENYISNHTLAEMSKGHNFLK-EKDKISGFGSSVDKHLMEDSDG 1076
            ||.||.|...||:..|:|:.|:|:.:.||...|::|..::.| :....||.||||:|::::::|.
Frog  1042 AFVKKQKGLDEIKPLEELHNKRESCLFNHNAVEINKVLDYHKGDNGTTSGVGSSVEKYIIDENDY 1106

Human  1077 QSFIHNPSLTVTVPIAPGESDLENMNAEELSSDSDSEYSKVRLNRSSSSECSTVDNPLPGEGEEA 1141
            .|||||||||||||||.||||.||:|.|:.||:||.|.||.:||.:||||.||||...||...|.
Frog  1107 MSFIHNPSLTVTVPIAVGESDFENLNTEDFSSESDLEESKEKLNMTSSSEGSTVDIRPPGVVAEG 1171

Human  1142 EAEPMNSD-----EPEACFTDGCVWRFSCCQVNIESGKGKIWWNIRKTCYKIVEHSWFESFIVLM 1201
            |.||::.:     ||:||||:|||.||..|.||||..|||:||..|||||.||||:|||:||:.|
Frog  1172 EGEPIDIESEEALEPDACFTEGCVKRFPICYVNIEENKGKLWWTFRKTCYTIVEHNWFETFIIFM 1236

Human  1202 ILLSSGALAFEDIYIERKKTIKIILEYADKIFTYIFILEMLLKWIAYGYKTYFTNAWCWLDFLIV 1266
            ||||||||||||||||::||||.:||||||:|||||||||||||:|||:..||||||||||||||
Frog  1237 ILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTYIFILEMLLKWVAYGFVKYFTNAWCWLDFLIV 1301

Human  1267 DVSLVTLVANTLGYSDLGPIKSLRTLRALRPLRALSRFEGMRVVVNALIGAIPSIMNVLLVCLIF 1331
            |||||:||||.||||:||.||||||||||||||||||||||||||||||||||||||||||||||
Frog  1302 DVSLVSLVANALGYSELGAIKSLRTLRALRPLRALSRFEGMRVVVNALIGAIPSIMNVLLVCLIF 1366

Human  1332 WLIFSIMGVNLFAGKFYECINTTDGSRFPASQVPNRSECFALMNVSQNVRWKNLKVNFDNVGLGY 1396
            |||||||||||||||:|.|:|||.|.....:||.|||:|   ::::::.||||:||||||||.||
Frog  1367 WLIFSIMGVNLFAGKYYHCVNTTTGEMLLDTQVNNRSDC---LHLNESARWKNVKVNFDNVGAGY 1428

Human  1397 LSLLQVATFKGWTIIMYAAVDSVNVDKQPKYEYSLYMYIYFVVFIIFGSFFTLNLFIGVIIDNFN 1461
            |:||||||||||..||||||||..|::||:||.:||||:|||:||||||||||||||||||||||
Frog  1429 LALLQVATFKGWMDIMYAAVDSRKVEEQPRYEDNLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFN 1493

Human  1462 QQKKKLGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPGNKIQGCIFDLVTNQAFDISIMVLIC 1526
            |||||.|||||||||||||||||||||||||||||||||.||.||.:||.||.|||||.||:|||
Frog  1494 QQKKKFGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPPNKYQGLVFDFVTKQAFDIIIMILIC 1558

Human  1527 LNMVTMMVEKEGQSQHMTEVLYWINVVFIILFTGECVLKLISLRHYYFTVGWNIFDFVVVIISIV 1591
            |||||||:|.:.|||.|...|||||:||||||||||:||:|||||||||:|||||||||||:|||
Frog  1559 LNMVTMMIETDEQSQDMENNLYWINLVFIILFTGECILKIISLRHYYFTIGWNIFDFVVVILSIV 1623

Human  1592 GMFLADLIETYFVSPTLFRVIRLARIGRILRLVKGAKGIRTLLFALMMSLPALFNIGLLLFLVMF 1656
            ||||||:||.||||||||||||||||||||||:||||||||||||||||||||||||||||||||
Frog  1624 GMFLADMIEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMF 1688

Human  1657 IYAIFGMSNFAYVKKEDGINDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSKPPDCDPKKVH 1721
            ||||||||||||||||.||:||||||||||||||||||||||||||||||||||..|||||:..|
Frog  1689 IYAIFGMSNFAYVKKESGIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSGAPDCDPQMEH 1753

Human  1722 PGSSVEGDCGNPSVGIFYFVSYIIISFLVVVNMYIAVILENFSVATEESTEPLSEDDFEMFYEVW 1786
            |||||:|||||||||||:|||||||||||||||||||||||||||||||.|||.|||||||||||
Frog  1754 PGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVATEESAEPLGEDDFEMFYEVW 1818

Human  1787 EKFDPDATQFIEFSKLSDFAAALDPPLLIAKPNKVQLIAMDLPMVSGDRIHCLDILFAFTKRVLG 1851
            ||||||||||||:||||:||.||||||.|||||:|||||||||||||||||||||||||||||||
Frog  1819 EKFDPDATQFIEYSKLSNFADALDPPLRIAKPNRVQLIAMDLPMVSGDRIHCLDILFAFTKRVLG 1883

Human  1852 ESGEMDSLRSQMEERFMSANPSKVSYEPITTTLKRKQEDVSATVIQRAYRRYRLRQNVKNISSIY 1916
            |..|||:||..||||||::||||.||||||:||:||||::|..:|||.:|:|.||:.:|..|.:|
Frog  1884 EGDEMDALRLPMEERFMASNPSKASYEPITSTLRRKQEELSVVIIQRCFRKYLLRKTIKKASYLY 1948

Human  1917 IKDGDRDDDLLNKKDMAFDNVNENSSPEKTDATSSTTSPPSYDSVTKPDKEKYEQDRTEKEDKGK 1981
            .|:....:.|..|:||..|.:|.||:.||||.|.||||||||||||||:|||:|:|:.|||:|.|
Frog  1949 KKEKLGVNSLPIKEDMVIDKLNGNSTTEKTDMTPSTTSPPSYDSVTKPEKEKHEKDKAEKENKSK 2013

Human  1982 DSKESKK 1988
            |::|:||
Frog  2014 DARENKK 2020

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SCN9A	NP_001352465.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	26..55		19/29 (66%)
		I. /evidence=ECO:0000305	112..410		247/317 (78%)
		Ion_trans	125..410	CDD:306908	239/304 (79%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	461..543		51/81 (63%)
		Na_trans_cytopl	488..681	CDD:314757	119/196 (61%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	565..611		34/48 (71%)
		II. /evidence=ECO:0000305	726..989		221/262 (84%)
		Ion_trans	743..956	CDD:306908	188/212 (89%)
		Na_trans_assoc	982..1187	CDD:310839	115/210 (55%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1102..1148		25/45 (56%)
		III. /evidence=ECO:0000305	1180..1488		250/307 (81%)
		Ion_trans	1191..1466	CDD:306908	221/274 (81%)
		Na_channel_gate	1458..1510	CDD:240441	46/51 (90%)
		IV. /evidence=ECO:0000305	1497..1795		262/297 (88%)
		Ion_trans	1514..1770	CDD:306908	227/255 (89%)
		GPHH	1774..1837	CDD:318993	56/62 (90%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1934..1988		35/53 (66%)
scn1a	XP_012826731.2	Ion_trans	128..435	CDD:395416	241/306 (79%)
		Na_trans_cytopl	515..723	CDD:403218	126/207 (61%)
		Ion_trans	772..985	CDD:395416	188/212 (89%)
		Na_trans_assoc	1011..1222	CDD:399489	115/210 (55%)
		Ion_trans	1226..1498	CDD:395416	221/274 (81%)
		Na_channel_gate	1490..1542	CDD:240441	46/51 (90%)
		Ion_trans	1547..1802	CDD:395416	227/254 (89%)
		GPHH	1814..1861	CDD:407139	41/46 (89%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
NCBI	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG52281
OrthoDB	1	1.010	-	-		D37221at33208
OrthoFinder	1	1.000	-	-		FOG0000268
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10037
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X214
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	6.030