| Sequence 1: | NP_001352465.1 | Gene: | SCN9A / 6335 | HGNCID: | 10597 | Length: | 1988 | Species: | Homo sapiens |
|---|---|---|---|---|---|---|---|---|---|
| Sequence 2: | XP_031749252.1 | Gene: | scn2a / 100486750 | XenbaseID: | XB-GENE-6447552 | Length: | 1970 | Species: | Xenopus tropicalis |
| Alignment Length: | 1993 | Identity: | 1419/1993 - (71%) |
|---|---|---|---|
| Similarity: | 1624/1993 - (81%) | Gaps: | 61/1993 - (3%) |
- Green bases have known domain annotations that are detailed below.
|
Human 6 PPGPQSFVHFTKQSLALIEQRIAERKSKEPKEEKKDDDEEAPKPSSDLEAGKQLPFIYGDIPPGM 70
Human 71 VSEPLEDLDPYYADKKTFIVLNKGKTIFRFNATPALYMLSPFSPLRRISIKILVHSLFSMLIMCT 135
Human 136 ILTNCIFMTMNNPPDWTKNVEYTFTGIYTFESLVKILARGFCVGEFTFLRDPWNWLDFVVIVFAY 200
Human 201 LTEFVNLGNVSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQ 265
Human 266 LFMGNLKHKC----FRNSLENNETLESIMNTLESEEDFRK-YFYYLEGSKDALLCGFSTDSGQCP 325
Human 326 EGYTCVKIGRNPDYGYTSFDTFSWAFLALFRLMTQDYWENLYQQTLRAAGKTYMIFFVVVIFLGS 390
Human 391 FYLINLILAVVAMAYEEQNQANIEEAKQKELEFQQMLDRLKKEQEEAEAIAAAAAEY--TSIRRS 453
Human 454 RIMGL---SESSSETSKLSSKSAKERRNRRKKKNQKKLSSGEEKGDAEKLSKSESEDSIRRKSFH 515
Human 516 LGVEGHRRAHEKRLSTPNQSPLSIRGSLFSARRSSRTSLFSFKGRGRDIGSETEFADDEHSIFGD 580
Human 581 NESRRGSLFVPHRPQERRSSNISQASRSP---PMLPVNGKMHSAVDCNGVVSLVDGRSALMLPNG 642
Human 643 QLLPEVIIDKATSDDSGTTNQIHKKRRCSSYLLSEDMLNDPNLRQRAMSRASILTNTVEELEESR 707
Human 708 QKCPPWWYRFAHKFLIWNCSPYWIKFKKCIYFIVMDPFVDLAITICIVLNTLFMAMEHHPMTEEF 772
Human 773 KNVLAIGNLVFTGIFAAEMVLKLIAMDPYEYFQVGWNIFDSLIVTLSLVELFLADVEGLSVLRSF 837
Human 838 RLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKINDD 902
Human 903 CTLPRWHMNDFFHSFLIVFRVLCGEWIETMWDCMEVAGQAMCLIVYMMVMVIGNLVVLNLFLALL 967
Human 968 LSSFSSDNLTAIEEDPDANNLQIAVTRIKKGINYVKQTLREFILKAFSKKPKISREIRQAEDLNT 1032
Human 1033 KKENYISNHTLAEMSKGHNFLKEKDKI-SGFGSSVDKHLMEDSDGQSFIHNPSLTVTVPIAPGES 1096
Human 1097 DLENMNAEELSSDSDSEYSKVRLNRSSSSECSTVDNPLPGE---GEEAEAEPMNSDEPEACFTDG 1158
Human 1159 CVWRFSCCQVNIESGKGKIWWNIRKTCYKIVEHSWFESFIVLMILLSSGALAFEDIYIERKKTIK 1223
Human 1224 IILEYADKIFTYIFILEMLLKWIAYGYKTYFTNAWCWLDFLIVDVSLVTLVANTLGYSDLGPIKS 1288
Human 1289 LRTLRALRPLRALSRFEGMRVVVNALIGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYECINT 1353
Human 1354 TDGSRFPASQVPNRSECFALMNVSQNVRWKNLKVNFDNVGLGYLSLLQVATFKGWTIIMYAAVDS 1418
Human 1419 VNVDKQPKYEYSLYMYIYFVVFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFMTEEQKKYYN 1483
Human 1484 AMKKLGSKKPQKPIPRPGNKIQGCIFDLVTNQAFDISIMVLICLNMVTMMVEKEGQSQHMTEVLY 1548
Human 1549 WINVVFIILFTGECVLKLISLRHYYFTVGWNIFDFVVVIISIVGMFLADLIETYFVSPTLFRVIR 1613
Human 1614 LARIGRILRLVKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFAYVKKEDGINDM 1678
Human 1679 FNFETFGNSMICLFQITTSAGWDGLLAPILNSKPPDCDPKKVHPGSSVEGDCGNPSVGIFYFVSY 1743
Human 1744 IIISFLVVVNMYIAVILENFSVATEESTEPLSEDDFEMFYEVWEKFDPDATQFIEFSKLSDFAAA 1808
Human 1809 LDPPLLIAKPNKVQLIAMDLPMVSGDRIHCLDILFAFTKRVLGESGEMDSLRSQMEERFMSANPS 1873
Human 1874 KVSYEPITTTLKRKQEDVSATVIQRAYRRYRLRQNVKNISSIYIKDGDRDDDLLNKKDMAFD-NV 1937
Human 1938 NENS---SPEKTDATSSTTSPPSYDSVTKPDKEKYEQDRTEKE 1977 |
| Gene | Sequence | Domain | Region | External ID | Identity |
|---|---|---|---|---|---|
| SCN9A | NP_001352465.1 | Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 26..55 | 13/28 (46%) | |
| I. /evidence=ECO:0000305 | 112..410 | 234/302 (77%) | |||
| Ion_trans | 125..410 | CDD:306908 | 226/289 (78%) | ||
| Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 461..543 | 45/81 (56%) | |||
| Na_trans_cytopl | 488..681 | CDD:314757 | 105/195 (54%) | ||
| Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 565..611 | 28/48 (58%) | |||
| II. /evidence=ECO:0000305 | 726..989 | 212/262 (81%) | |||
| Ion_trans | 743..956 | CDD:306908 | 178/212 (84%) | ||
| Na_trans_assoc | 982..1187 | CDD:310839 | 94/208 (45%) | ||
| Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 1102..1148 | 21/48 (44%) | |||
| III. /evidence=ECO:0000305 | 1180..1488 | 247/307 (80%) | |||
| Ion_trans | 1191..1466 | CDD:306908 | 216/274 (79%) | ||
| Na_channel_gate | 1458..1510 | CDD:240441 | 47/51 (92%) | ||
| IV. /evidence=ECO:0000305 | 1497..1795 | 249/297 (84%) | |||
| Ion_trans | 1514..1770 | CDD:306908 | 215/255 (84%) | ||
| GPHH | 1774..1837 | CDD:318993 | 52/62 (84%) | ||
| Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 1934..1988 | 23/48 (48%) | |||
| scn2a | XP_031749252.1 | Ion_trans | 127..408 | CDD:395416 | 228/291 (78%) |
| Na_trans_cytopl | 488..678 | CDD:403218 | 113/205 (55%) | ||
| Ion_trans | 727..940 | CDD:395416 | 178/212 (84%) | ||
| Na_trans_assoc | 966..1175 | CDD:399489 | 94/208 (45%) | ||
| Ion_trans | 1179..1454 | CDD:395416 | 216/274 (79%) | ||
| Na_channel_gate | 1446..1498 | CDD:240441 | 47/51 (92%) | ||
| Ion_trans | 1503..1758 | CDD:395416 | 215/254 (85%) | ||
| GPHH | 1770..1817 | CDD:407139 | 37/46 (80%) |
| Tool | Simple Score | Weighted Score | Original Tool Information | |||
|---|---|---|---|---|---|---|
| BLAST Result | Score | Score Type | Cluster ID | |||
| Compara | 0 | 0.000 | Not matched by this tool. | |||
| Domainoid | 0 | 0.000 | Not matched by this tool. | |||
| eggNOG | 0 | 0.000 | Not matched by this tool. | |||
| Hieranoid | 0 | 0.000 | Not matched by this tool. | |||
| Homologene | 1 | 1.000 | - | - | H2237 | |
| Inparanoid | 0 | 0.000 | Not matched by this tool. | |||
| NCBI | 0 | 0.000 | Not matched by this tool. | |||
| OMA | 0 | 0.000 | Not matched by this tool. | |||
| OrthoDB | 1 | 1.010 | - | - | D37221at33208 | |
| OrthoFinder | 1 | 1.000 | - | - | FOG0000268 | |
| OrthoInspector | 0 | 0.000 | Not matched by this tool. | |||
| Panther | 1 | 1.100 | - | - | O | PTHR10037 |
| Phylome | 0 | 0.000 | Not matched by this tool. | |||
| RoundUp | 0 | 0.000 | Not matched by this tool. | |||
| SonicParanoid | 1 | 1.000 | - | - | X214 | |
| SwiftOrtho | 1 | 1.000 | - | - | ||
| TreeFam | 0 | 0.000 | Not matched by this tool. | |||
| 6 | 6.110 | |||||