DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment SCN9A and scn3a

DIOPT Version :9

Sequence 1:NP_001352465.1 Gene:SCN9A / 6335 HGNCID:10597 Length:1988 Species:Homo sapiens
Sequence 2:XP_012826714.1 Gene:scn3a / 100125099 XenbaseID:XB-GENE-5812330 Length:2019 Species:Xenopus tropicalis


Alignment Length:2018 Identity:1505/2018 - (74%)
Similarity:1705/2018 - (84%) Gaps:35/2018 - (1%)


- Green bases have known domain annotations that are detailed below.


Human     3 MLPPPGPQSFVHFTKQSLALIEQRIAERKSKE--PKEEKKDDDEEAPKPSSDLEAGKQLPFIYGD 65
            :||||||.|....|::|||::|:|.||.|:::  .|:.:.||||..|||:|||||||.|||||||
 Frog     5 LLPPPGPDSLRLLTRESLAVLEKRFAEEKARKASQKDRRDDDDENGPKPNSDLEAGKNLPFIYGD 69

Human    66 IPPGMVSEPLEDLDPYYADKKTFIVLNKGKTIFRFNATPALYMLSPFSPLRRISIKILVHSLFSM 130
            ||.|||:.|:|||||||:::|||||||:||.||||:||.|||:|:||:|||||||||||||||||
 Frog    70 IPQGMVAVPMEDLDPYYSNQKTFIVLNRGKAIFRFSATSALYILTPFNPLRRISIKILVHSLFSM 134

Human   131 LIMCTILTNCIFMTMNNPPDWTKNVEYTFTGIYTFESLVKILARGFCVGEFTFLRDPWNWLDFVV 195
            ||||||||||.||||:|||:|||||||||||||||||||||||||||:..|||||||||||||.|
 Frog   135 LIMCTILTNCFFMTMSNPPEWTKNVEYTFTGIYTFESLVKILARGFCLESFTFLRDPWNWLDFSV 199

Human   196 IVFAYLTEFVNLGNVSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFA 260
            ||.||:||||:||||||||||||||||||||||||||||||||||||||||||||||||||||||
 Frog   200 IVMAYVTEFVDLGNVSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFA 264

Human   261 LIGLQLFMGNLKHKCFRNSLENNETLESIMN---------TLE--SEEDF---RKYFYYLEGSKD 311
            |||||||||:|::||.|...|....:.|..|         ||.  :.|::   ...||:|.|::|
 Frog   265 LIGLQLFMGHLRNKCVRWPPEYEPNITSYFNETAGLYINVTLNPFNREEYILEETNFYFLPGTRD 329

Human   312 ALLCGFSTDSGQCPEGYTCVKIGRNPDYGYTSFDTFSWAFLALFRLMTQDYWENLYQQTLRAAGK 376
            |||||.|:|:||||:||.|:|.||||:||||||||||||||:||||||||:||||||.|||||||
 Frog   330 ALLCGNSSDAGQCPKGYVCLKTGRNPNYGYTSFDTFSWAFLSLFRLMTQDFWENLYQLTLRAAGK 394

Human   377 TYMIFFVVVIFLGSFYLINLILAVVAMAYEEQNQANIEEAKQKELEFQQMLDRLKKEQEEAEAIA 441
            |||||||:|||||||||||||||||||||||||||.:|||:|||.|||.|:::|||.|||.:|.|
 Frog   395 TYMIFFVLVIFLGSFYLINLILAVVAMAYEEQNQATLEEAEQKEAEFQLMMEQLKKHQEEIQAAA 459

Human   442 AAAAEYTSIRR----SRIMGLSESSSETSKLSSKSAKERRNRRKKKNQKKLSSGE-EKGDAEKLS 501
            .||......|.    :...||||||||.||.||||||||||||||:.||:  .|| ||.|.||..
 Frog   460 LAAETMDGSREFSGGTGYGGLSESSSEASKPSSKSAKERRNRRKKRKQKE--QGEDEKADDEKFH 522

Human   502 KSESEDSIRRKSFHLGVEGHRRAHEKRLSTPNQSPLSIRGSLFSARRSSRTSLFSFKGRGRDIGS 566
            ||.||.||:||.|...:||:|..:||:.|:|:||.||.|||||..||.||.||.||:|||:|:||
 Frog   523 KSASETSIKRKGFRFSIEGNRLTYEKKYSSPHQSRLSFRGSLFFPRRDSRASLCSFRGRGKDVGS 587

Human   567 ETEFADDEHSIFGDNESRRGSLFVPHRPQERRSSNISQ---ASRSPPMLPVNGKMHSAVDCNGVV 628
            |.:|||||||.|.||||||||||||||..|||:|||||   |||:.|:|||||||||.|||||||
 Frog   588 ENDFADDEHSTFEDNESRRGSLFVPHRHGERRNSNISQTSKASRTLPVLPVNGKMHSTVDCNGVV 652

Human   629 SLVDGRSALMLPNGQLLPEVIIDKATSDDSGTT--NQIHKKRRCSSYLLSEDMLNDPNLRQRAMS 691
            ||:.|.|....|.|.|||||||||..|||:||.  |:: :|||.|||.:|.|.|.||.|||||:|
 Frog   653 SLLGGPSGPTSPAGLLLPEVIIDKPASDDNGTNTENEL-RKRRLSSYHVSMDFLEDPILRQRALS 716

Human   692 RASILTNTVEELEESRQKCPPWWYRFAHKFLIWNCSPYWIKFKKCIYFIVMDPFVDLAITICIVL 756
            .||.||||:|||||||:||||.|.:||:.:|||:||..|:|.|..:..|||||||||||||||||
 Frog   717 IASNLTNTMEELEESREKCPPCWNKFANTYLIWDCSDSWLKIKHVVNLIVMDPFVDLAITICIVL 781

Human   757 NTLFMAMEHHPMTEEFKNVLAIGNLVFTGIFAAEMVLKLIAMDPYEYFQVGWNIFDSLIVTLSLV 821
            |||||||||:|:|:||...|.:|||||||||.||||.||||:|||.||||||||||.:||:|||:
 Frog   782 NTLFMAMEHYPITDEFAGALNVGNLVFTGIFTAEMVFKLIALDPYYYFQVGWNIFDGVIVSLSLM 846

Human   822 ELFLADVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQ 886
            ||.|:||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
 Frog   847 ELGLSDVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQ 911

Human   887 LFGKSYKECVCKI-NDDCTLPRWHMNDFFHSFLIVFRVLCGEWIETMWDCMEVAGQAMCLIVYMM 950
            ||||||||||||| .|||.|||||||||||||||||||||||||||||||||||||||||.|:||
 Frog   912 LFGKSYKECVCKIAPDDCELPRWHMNDFFHSFLIVFRVLCGEWIETMWDCMEVAGQAMCLTVFMM 976

Human   951 VMVIGNLVVLNLFLALLLSSFSSDNLTAIEEDPDANNLQIAVTRIKKGINYVKQTLREFILKAFS 1015
            ||||||||||||||||||||||||||.|.|:|.:.|||||||.|:.:||.|||:.:||||..||.
 Frog   977 VMVIGNLVVLNLFLALLLSSFSSDNLAATEDDNEMNNLQIAVARMHEGIAYVKRKMREFIQNAFV 1041

Human  1016 KKPKISREIRQAEDLNTKKENYISNHTLAEMSKGHNFLKEKD---KISGFGSSVDKHLMEDSDGQ 1077
            ||.|...|.:..||:..:|::.|||||..|:||.:::||:.:   ..||.||||:|:::::||..
 Frog  1042 KKQKALEETKPLEDMQNQKDSCISNHTTVEISKEYDYLKDGNVTTATSGIGSSVEKYIIDESDYM 1106

Human  1078 SFIHNPSLTVTVPIAPGESDLENMNAEELSSDSDSEYSKVRLNRSSSSECSTVDNPLPGEGEEA- 1141
            |||||||||||||||.||||.||:|.||.||:||.|.||.:||.|||||.||||....||||.. 
 Frog  1107 SFIHNPSLTVTVPIAVGESDFENLNTEEFSSESDLEESKEKLNSSSSSEGSTVDIRPAGEGEPVP 1171

Human  1142 EAEPMNSDEPEACFTDGCVWRFSCCQVNIESGKGKIWWNIRKTCYKIVEHSWFESFIVLMILLSS 1206
            :.|.....||:|||||||:.||.||.|::..||.|.|||:||||:.||||:|||:||:.|||:||
 Frog  1172 QVEVEEFQEPDACFTDGCIRRFPCCVVDVSHGKWKQWWNLRKTCFLIVEHNWFETFIIFMILMSS 1236

Human  1207 GALAFEDIYIERKKTIKIILEYADKIFTYIFILEMLLKWIAYGYKTYFTNAWCWLDFLIVDVSLV 1271
            |||||||||||::||||||||||||:|||||||||||||:|||::.|||||||||||||||||||
 Frog  1237 GALAFEDIYIEQRKTIKIILEYADKVFTYIFILEMLLKWVAYGFQKYFTNAWCWLDFLIVDVSLV 1301

Human  1272 TLVANTLGYSDLGPIKSLRTLRALRPLRALSRFEGMRVVVNALIGAIPSIMNVLLVCLIFWLIFS 1336
            :|:||.||||:||.|||||||||||||||||||||||||||||:|||||||||||||||||||||
 Frog  1302 SLIANALGYSELGAIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFS 1366

Human  1337 IMGVNLFAGKFYECINTTDGSRFPASQVPNRSECFALMNVSQNVRWKNLKVNFDNVGLGYLSLLQ 1401
            |||||:|:||:..|:|.||...|..:.|.|||:|..|::.::..||||:||||||||.|||:|||
 Frog  1367 IMGVNMFSGKYGYCVNYTDDVVFDYTIVNNRSQCMDLISENKTARWKNVKVNFDNVGFGYLALLQ 1431

Human  1402 VATFKGWTIIMYAAVDSVNVDKQPKYEYSLYMYIYFVVFIIFGSFFTLNLFIGVIIDNFNQQKKK 1466
            |||||||..||||||||...::|||||.:||||:|||:|||||||||||||||||||||||||||
 Frog  1432 VATFKGWMEIMYAAVDSRKQEEQPKYEDNLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKK 1496

Human  1467 LGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPGNKIQGCIFDLVTNQAFDISIMVLICLNMVT 1531
            .|||||||||||||||||||||||||||||:|||.||.||.:||.|:.|.|||:||:||||||||
 Frog  1497 FGGQDIFMTEEQKKYYNAMKKLGSKKPQKPVPRPDNKFQGAVFDFVSKQPFDIAIMILICLNMVT 1561

Human  1532 MMVEKEGQSQHMTEVLYWINVVFIILFTGECVLKLISLRHYYFTVGWNIFDFVVVIISIVGMFLA 1596
            ||:|.:.||......|||||.|||:|||||||||||||||||||:|||||||||||:||||||||
 Frog  1562 MMIETDDQSIETENNLYWINAVFIVLFTGECVLKLISLRHYYFTIGWNIFDFVVVILSIVGMFLA 1626

Human  1597 DLIETYFVSPTLFRVIRLARIGRILRLVKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIF 1661
            ||||.||||||||||||||||||||||:|||||||||||||||||||||||||||||||||||||
 Frog  1627 DLIEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIF 1691

Human  1662 GMSNFAYVKKEDGINDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSKPPDCDPKKVHPGSSV 1726
            |||||||||||.||:||||||||||||||||||||||||||||||||||..||||||..|.||||
 Frog  1692 GMSNFAYVKKEAGIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSGAPDCDPKAEHSGSSV 1756

Human  1727 EGDCGNPSVGIFYFVSYIIISFLVVVNMYIAVILENFSVATEESTEPLSEDDFEMFYEVWEKFDP 1791
            :|||||||||||:|||||||||||||||||||||||||||||||.|||.|||||||||||||||.
 Frog  1757 KGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVATEESAEPLGEDDFEMFYEVWEKFDS 1821

Human  1792 DATQFIEFSKLSDFAAALDPPLLIAKPNKVQLIAMDLPMVSGDRIHCLDILFAFTKRVLGESGEM 1856
            :|||||::.||:|||.||||||.:.|||..|||||||||||||||||||:|||||||||||..||
 Frog  1822 NATQFIQYVKLTDFADALDPPLRMPKPNNAQLIAMDLPMVSGDRIHCLDVLFAFTKRVLGEGDEM 1886

Human  1857 DSLRSQMEERFMSANPSKVSYEPITTTLKRKQEDVSATVIQRAYRRYRLRQNVKNISSIYIKDGD 1921
            |:||..||||||::||||.||||||:||:||||:::|.||||.||.|.||:.:|:.|.:|.::..
 Frog  1887 DNLRQPMEERFMASNPSKASYEPITSTLRRKQEELAAIVIQRCYRCYALRKGIKHASFMYNQEKG 1951

Human  1922 RD-DDLLNKKDMAFDNVNENSSPEKTDATSSTTSPPSYDSVTKPDKEKYEQDRTEKEDKGKDSKE 1985
            :| ..||.:|||..|.:|.||:.||.|.|.||||||||||||||||||:|:|:.||||:|||.:|
 Frog  1952 KDGGSLLTRKDMLSDRLNGNSTTEKADITPSTTSPPSYDSVTKPDKEKHEKDKIEKEDRGKDVRE 2016

Human  1986 SKK 1988
            .||
 Frog  2017 HKK 2019

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SCN9ANP_001352465.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 26..55 15/30 (50%)
I. /evidence=ECO:0000305 112..410 247/311 (79%)
Ion_trans 125..410 CDD:306908 235/298 (79%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 461..543 51/82 (62%)
Na_trans_cytopl 488..681 CDD:314757 126/198 (64%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 565..611 36/48 (75%)
II. /evidence=ECO:0000305 726..989 225/263 (86%)
Ion_trans 743..956 CDD:306908 190/213 (89%)
Na_trans_assoc 982..1187 CDD:310839 117/208 (56%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1102..1148 26/46 (57%)
III. /evidence=ECO:0000305 1180..1488 246/307 (80%)
Ion_trans 1191..1466 CDD:306908 217/274 (79%)
Na_channel_gate 1458..1510 CDD:240441 45/51 (88%)
IV. /evidence=ECO:0000305 1497..1795 257/297 (87%)
Ion_trans 1514..1770 CDD:306908 226/255 (89%)
GPHH 1774..1837 CDD:318993 49/62 (79%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1934..1988 36/53 (68%)
scn3aXP_012826714.1 Ion_trans 151..430 CDD:278921 217/278 (78%)
Na_trans_cytopl 512..627 CDD:288761 76/114 (67%)
Ion_trans 786..982 CDD:278921 172/195 (88%)
Na_trans_assoc 1008..1216 CDD:284034 116/207 (56%)
Ion_trans 1239..1496 CDD:278921 204/256 (80%)
Na_channel_gate 1488..1540 CDD:240441 45/51 (88%)
Ion_trans 1562..1800 CDD:278921 212/237 (89%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
NCBI 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG52281
OrthoDB 1 1.010 - - D37221at33208
OrthoFinder 1 1.000 - - FOG0000268
OrthoInspector 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR10037
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X214
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
66.030

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