DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SCN8A and scn8aa

DIOPT Version :9

Sequence 1:	NP_001317189.1	Gene:	SCN8A / 6334	HGNCID:	10596	Length:	1980	Species:	Homo sapiens
Sequence 2:	XP_005162325.1	Gene:	scn8aa / 58152	ZFINID:	ZDB-GENE-000828-1	Length:	1960	Species:	Danio rerio

Alignment Length:	1994	Identity:	1632/1994 - (81%)
Similarity:	1784/1994 - (89%)	Gaps:	50/1994 - (2%)

- Green bases have known domain annotations that are detailed below.

Human     1 MAARLLAPPGPDSFKPFTPESLANIERRIAESKLKKPPKADGSHREDDEDSKPKPNSDLEAGKSL 65
            |||.|||||||:|:|.||.|||..||:||.|.|.|.|||.|.|:|:||:::|||||.||||||||
Zfish     1 MAAPLLAPPGPNSYKYFTRESLREIEKRIEEEKAKPPPKPDNSYRDDDDENKPKPNGDLEAGKSL 65

Human    66 PFIYGDIPQGLVAVPLEDFDPYYLTQKTFVVLNRGKTLFRFSATPALYILSPFNLIRRIAIKILI 130
            ||||||||.|:||.|||||||:|:.||||||||:|||:||||||||||::|||||.|||||||||
Zfish    66 PFIYGDIPPGMVATPLEDFDPFYINQKTFVVLNKGKTIFRFSATPALYMISPFNLARRIAIKILI 130

Human   131 HSVFSMIIMCTILTNCVFMTFSNPPDWSKNVEYTFTGIYTFESLVKIIARGFCIDGFTFLRDPWN 195
            ||||||.||||||||||||||||||:|||.|||||||||||||.|||||||||||||||||||||
Zfish   131 HSVFSMFIMCTILTNCVFMTFSNPPEWSKQVEYTFTGIYTFESAVKIIARGFCIDGFTFLRDPWN 195

Human   196 WLDFSVIMMAYVTEFVDLGNVSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVF 260
            ||||.||.|||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Zfish   196 WLDFMVISMAYVTEFVDLGNVSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVF 260

Human   261 CLSVFALIGLQLFMGNLRNKCVVWPINFNESYLE-NGTKGFDWEEYINNKTNFYTVPGMLEPLLC 324
            ||||||||||||||||||.|||:||||..|.:.: ||::.|:|:|||.|:||||.:|..|:.|||
Zfish   261 CLSVFALIGLQLFMGNLRQKCVIWPINITEMFPDVNGSRAFNWDEYILNETNFYFLPDQLDALLC 325

Human   325 GNSSDAGQCPEGYQCMKAGRNPNYGYTSFDTFSWAFLALFRLMTQDYWENLYQLTLRAAGKTYMI 389
            |||||:|:|||||.||||||||||||||||:|.|||||||||||||:||||||||||||||||||
Zfish   326 GNSSDSGRCPEGYTCMKAGRNPNYGYTSFDSFGWAFLALFRLMTQDFWENLYQLTLRAAGKTYMI 390

Human   390 FFVLVIFVGSFYLVNLILAVVAMAYEEQNQATLEEAEQKEAEFKAMLEQLKKQQEEAQAAAMATS 454
            ||||||||||||||||||||||||||||||||:||||:|||||||||||||||||:|||.|||||
Zfish   391 FFVLVIFVGSFYLVNLILAVVAMAYEEQNQATMEEAERKEAEFKAMLEQLKKQQEDAQANAMATS 455

Human   455 AGTVSEDAIEEEGEEGGGSPRSSSEISKLSSKSAKERRNRRKKRKQKELSEGEEKGDPEKVFKSE 519
            |||||||.:|::|:..|....||||:||||||||||||||:||.:|||  :.:||||.||..|||
Zfish   456 AGTVSEDVVEDDGDGEGNLSCSSSEMSKLSSKSAKERRNRKKKWRQKE--QDKEKGDSEKFVKSE 518

Human   520 SEDGMRRKAFRLPDNRIGRKFSIMNQSLLSIPGSPFLSRHNSKSSIFSFRGPGRFRDPGSENEFA 584
            |:||.||: ||.||||:||:.|||||||||||||||.||.||||||||     |.:|.|||||||
Zfish   519 SDDGSRRR-FRFPDNRLGRRSSIMNQSLLSIPGSPFPSRRNSKSSIFS-----RCKDGGSENEFA 577

Human   585 DDEHSTVEESEGRRDSLFIPIRARERRSSYSGYSGYSQGSRSSRIFPSLRRSVKRNSTVDCNGVV 649
            |||||||||.:.||||...|    :|||||:|:.|                  ||||||||||||
Zfish   578 DDEHSTVEEYDERRDSFLSP----QRRSSYTGFYG------------------KRNSTVDCNGVV 620

Human   650 SLIGGPGSHIGGRLLPEA-----------TTEVEIKKKGPGSLLVSMDQL-ASYGRKDRINSIMS 702
            ||| |||.  |||||||.           ||::|||||..|||:||::|| .|:|||:|.||:||
Zfish   621 SLI-GPGP--GGRLLPEVIIDKAATDDSPTTDLEIKKKLSGSLMVSVEQLNTSFGRKERANSVMS 682

Human   703 VVTNTLVEELEESQRKCPPCWYKFANTFLIWECHPYWIKLKEIVNLIVMDPFVDLAITICIVLNT 767
            .:|||||||||||||||||||||||||||||||.|.|:.:|||||||||||||||||||||||||
Zfish   683 ALTNTLVEELEESQRKCPPCWYKFANTFLIWECGPLWMSIKEIVNLIVMDPFVDLAITICIVLNT 747

Human   768 LFMAMEHHPMTPQFEHVLAVGNLVFTGIFTAEMFLKLIAMDPYYYFQEGWNIFDGFIVSLSLMEL 832
            |||||||:||||||||||:|||||||||||||||.||:|||||||||||||||||||||||||||
Zfish   748 LFMAMEHYPMTPQFEHVLSVGNLVFTGIFTAEMFAKLVAMDPYYYFQEGWNIFDGFIVSLSLMEL 812

Human   833 SLADVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF 897
            .||:|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Zfish   813 GLANVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF 877

Human   898 GKSYKECVCKINQDCELPRWHMHDFFHSFLIVFRVLCGEWIETMWDCMEVAGQAMCLIVFMMVMV 962
            |||||:|||||.||||||||||:||||||||||||||||||||||||||||||||||||||||||
Zfish   878 GKSYKDCVCKIAQDCELPRWHMNDFFHSFLIVFRVLCGEWIETMWDCMEVAGQAMCLIVFMMVMV 942

Human   963 IGNLVVLNLFLALLLSSFSADNLAATDDDGEMNNLQISVIRIKKGVAWTKLKVHAFMQAHFKQRE 1027
            |||||||||||||||||||||||||:|||||||||||:|||||||:||.|.||...:.....::.
Zfish   943 IGNLVVLNLFLALLLSSFSADNLAASDDDGEMNNLQIAVIRIKKGIAWVKAKVRELVNIILGRKV 1007

Human  1028 ADEVKPLDELYEKKANCIANHTGADIHRNGDFQKNGNGTTSGIGSSVEKYIIDEDHMSFINNPNL 1092
            .||.||||::|::|.||||||||.||.|:.|:|||||||||||||||.||:||:||||||:||||
Zfish  1008 TDEAKPLDDMYDRKLNCIANHTGVDISRDLDYQKNGNGTTSGIGSSVGKYMIDDDHMSFIHNPNL 1072

Human  1093 TVRVPIAVGESDFENLNTEDVSSESDPEGSKDKLDDTSSSEGSTIDIKPEVEE-VPVEQPEEYLD 1156
            ||.|||||||||||||||||.||||:.||||: |||.|||||||||||||||| |.||..|||:|
Zfish  1073 TVCVPIAVGESDFENLNTEDFSSESEAEGSKE-LDDISSSEGSTIDIKPEVEEAVVVETVEEYVD 1136

Human  1157 PDACFTEGCVQRFKCCQVNIEEGLGKSWWILRKTCFLIVEHNWFETFIIFMILLSSGALAFEDIY 1221
            |:||:||.|:.|:|||.|.|.||.||:||.|||||:||||||||||.||||||||||||||||:|
Zfish  1137 PEACWTEACIARYKCCDVPITEGWGKNWWFLRKTCYLIVEHNWFETLIIFMILLSSGALAFEDVY 1201

Human  1222 IEQRKTIRTILEYADKVFTYIFILEMLLKWTAYGFVKFFTNAWCWLDFLIVAVSLVSLIANALGY 1286
            ||||||||.||||||.||||||||||||||.||||||:||||||||||.||.||:||||||||||
Zfish  1202 IEQRKTIRIILEYADMVFTYIFILEMLLKWVAYGFVKYFTNAWCWLDFFIVDVSIVSLIANALGY 1266

Human  1287 SELGAIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAG 1351
            |:||.||||||||||||||||||||||||||||||||||||||||||||||||||||||||:|||
Zfish  1267 SDLGPIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNMFAG 1331

Human  1352 KYHYCFNETSEIRFEIEDVNNKTECEKLMEGNNTEIRWKNVKINFDNVGAGYLALLQVATFKGWM 1416
            ||:||:|||.:..||::.||||:||..|:|.|.||:|||||||||||||||||||||||||||||
Zfish  1332 KYYYCYNETEKAYFELDVVNNKSECFALIEQNYTEVRWKNVKINFDNVGAGYLALLQVATFKGWM 1396

Human  1417 DIMYAAVDSRKPDEQPKYEDNIYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFM 1481
            ||||||||||:.::|||||||||||||||||||||||||||||||||||||||||||||||||||
Zfish  1397 DIMYAAVDSRRVEDQPKYEDNIYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFM 1461

Human  1482 TEEQKKYYNAMKKLGSKKPQKPIPRPLNKIQGIVFDFVTQQAFDIVIMMLICLNMVTMMVETDTQ 1546
            ||||||||||||||||||||||||||.||:||:||||||||.|||.||:||||||||||||||.|
Zfish  1462 TEEQKKYYNAMKKLGSKKPQKPIPRPQNKLQGMVFDFVTQQVFDISIMILICLNMVTMMVETDDQ 1526

Human  1547 SKQMENILYWINLVFVIFFTCECVLKMFALRHYYFTIGWNIFDFVVVILSIVGMFLADIIEKYFV 1611
            |::.||||||||.:|::.||.|.|||:|||||||||.||||||.||||||||||||||:||||||
Zfish  1527 SQETENILYWINFIFIVAFTSEFVLKLFALRHYYFTNGWNIFDCVVVILSIVGMFLADLIEKYFV 1591

Human  1612 SPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIFSIFGMSNFAYV 1676
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Zfish  1592 SPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIFSIFGMSNFAYV 1656

Human  1677 KHEAGIDDMFNFETFGNSMICLFQITTSAGWDGLLLPILNRPPDCSLDKEHPGSGFKGDCGNPSV 1741
            |.|:|||||:|||||||||||||.|||||||||||.||||.||||...||:||:..||:||||||
Zfish  1657 KRESGIDDMYNFETFGNSMICLFMITTSAGWDGLLAPILNYPPDCEPTKENPGTSVKGNCGNPSV 1721

Human  1742 GIFFFVSYIIISFLIVVNMYIAIILENFSVATEESADPLSEDDFETFYEIWEKFDPDATQFIEYC 1806
            ||||||.|||:||||||||||||||||||||||||||||.|||||:||||||||||.|:|||.:.
Zfish  1722 GIFFFVMYIIVSFLIVVNMYIAIILENFSVATEESADPLCEDDFESFYEIWEKFDPTASQFITFA 1786

Human  1807 KLADFADALEHPLRVPKPNTIELIAMDLPMVSGDRIHCLDILFAFTKRVLGDSGELDILRQQMEE 1871
            ||.||||.||||||||||||||||||||||||||||||||||||||||||||||:||::||||||
Zfish  1787 KLGDFADTLEHPLRVPKPNTIELIAMDLPMVSGDRIHCLDILFAFTKRVLGDSGDLDMMRQQMEE 1851

Human  1872 RFVASNPSKVSYEPITTTLRRKQEEVSAVVLQRAYRGHLARRGFICKK-TTSNKLENGGTHREKK 1935
            ||:|:||||||:||||||||||||.:||.|:|||:|.||.|:|||||: .:|::||||||:::||
Zfish  1852 RFIAANPSKVSFEPITTTLRRKQEHMSAGVIQRAFRAHLIRKGFICKRLLSSSRLENGGTNQDKK 1916

Human  1936 ESTPSTASLPSYDSVTKPEKEKQQRAEEGRRERAKRQKEVRESK 1979
            |.||||||||||||||||||||.:.: :.:.::.|.||:|:|||
Zfish  1917 EGTPSTASLPSYDSVTKPEKEKLEES-DSKGKKGKNQKDVKESK 1959

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SCN8A	NP_001317189.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..20		14/18 (78%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	28..62		21/33 (64%)
		I. /evidence=ECO:0000305	114..442		289/328 (88%)
		Ion_trans	131..421	CDD:395416	256/290 (88%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	446..530		55/83 (66%)
		Na_trans_cytopl	504..702	CDD:403218	123/209 (59%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	568..602		22/33 (67%)
		II. /evidence=ECO:0000305	735..1007		255/271 (94%)
		Ion_trans	752..965	CDD:395416	203/212 (96%)
		Na_trans_assoc	991..1192	CDD:399489	145/201 (72%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1107..1148		34/41 (83%)
		III. /evidence=ECO:0000305	1180..1495		278/314 (89%)
		Ion_trans	1197..1473	CDD:395416	243/275 (88%)
		Na_channel_gate	1465..1517	CDD:240441	48/51 (94%)
		IV. /evidence=ECO:0000305	1504..1801		256/296 (86%)
		Ion_trans	1522..1776	CDD:395416	219/253 (87%)
		GPHH	1788..1835	CDD:407139	39/46 (85%)
		IQ	1894..1915	CDD:197470	12/20 (60%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1922..1980		37/58 (64%)
scn8aa	XP_005162325.1	Ion_trans	151..423	CDD:278921	238/271 (88%)
		ATP-synt_B	363..>456	CDD:304375	87/92 (95%)
		Na_trans_cytopl	498..604	CDD:288761	78/117 (67%)
		Ion_trans	750..945	CDD:278921	185/194 (95%)
		Na_trans_assoc	971..1172	CDD:284034	145/201 (72%)
		Ion_trans	1195..1453	CDD:278921	226/257 (88%)
		Na_channel_gate	1445..1497	CDD:240441	48/51 (94%)
		Ion_trans	1519..1756	CDD:278921	205/236 (87%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C194329516
Domainoid	1	1.000	538	1.000	Domainoid score	I2274
eggNOG	1	0.900	-	-		E1_KOG2301
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H7927
Inparanoid	1	1.050	3246	1.000	Inparanoid score	I124
NCBI	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG52281
OrthoDB	1	1.010	-	-		D13170at7742
OrthoFinder	1	1.000	-	-		FOG0000268
OrthoInspector	1	1.000	-	-		otm27949
orthoMCL	1	0.900	-	-		OOG6_100419
Panther	1	1.100	-	-	LDO	PTHR10037
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X214
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	1	1.500	-	-
	16	16.270