DRSC/TRiP Functional Genomics Resources

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Protein Alignment SCN8A and NaCP60E

DIOPT Version :9

Sequence 1:NP_001317189.1 Gene:SCN8A / 6334 HGNCID:10596 Length:1980 Species:Homo sapiens
Sequence 2:NP_001261172.1 Gene:NaCP60E / 37981 FlyBaseID:FBgn0085434 Length:2896 Species:Drosophila melanogaster


Alignment Length:2658 Identity:823/2658 - (30%)
Similarity:1177/2658 - (44%) Gaps:871/2658 - (32%)


- Green bases have known domain annotations that are detailed below.


Human    53 PKPNSDLEAGKSLPFIYGDIPQGLVAVPLEDFDPYYLTQKTFVVLN---RGKTLFRFSATPALYI 114
            |:..:.:|.|..||..:...|:.:...|||:.|. ::.::||.|::   |...:.||:.|.:|::
  Fly    45 PRTKASVEDGDVLPRKFEPFPEHMYGKPLEEIDT-FIYEETFCVVSKRFRKNYIHRFTGTKSLFL 108

Human   115 LSPFNLIRRIAIKILIHSVFSMIIMCTILTNCVFMTFSNPPDWSKNVEYTFTGIYTFESLVKIIA 179
            ..|::..||:.:.|..:..|...:|.|||.||:|:..:   :..:..||.|..||:.|.::||||
  Fly   109 FYPWSPARRVCVYIATNQFFDYCVMATILFNCIFLAMT---ETVEEAEYIFLAIYSIEMVIKIIA 170

Human   180 RGFCIDGFTFLRDPWNWLDFSVIMMAYVTEFVDLGNVSALRTFRVLRALKTISVIPGLKTIVGAL 244
            :||.::.:|:||:|||||||.||...|.|..:::||::.||||||||||||:|::||||||:.||
  Fly   171 KGFLLNKYTYLRNPWNWLDFVVITSGYATIGMEVGNLAGLRTFRVLRALKTVSIMPGLKTIINAL 235

Human   245 IQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCV-----VWPINFNESYLENGTKGFDWEE 304
            :.|.::|::||.||:|||.||||..||::||.||||||     .|.   |.|:.       ||:.
  Fly   236 LHSFRQLAEVMTLTIFCLMVFALFALQVYMGELRNKCVRQVPTDWT---NVSHT-------DWQI 290

Human   305 YINNKTNFYTVPGMLEPLLCGNSSDAGQCPEGYQCMKAGRNPNYGYTSFDTFSWAFLALFRLMTQ 369
            ::|:..|:......| |:||||.:.|..||..|.|:..|.|||:|||:||.|.|:.|..|:|:|.
  Fly   291 WVNDTDNWLYDEDEL-PVLCGNLTGARHCPFEYVCLCVGENPNHGYTNFDNFMWSMLTTFQLITL 354

Human   370 DYWENLYQLTLRAAGKTYMIFFVLVIFVGSFYLVNLILAVVAMAYEEQNQATLEEAE------QK 428
            |||||:|.:.|...|...:.||.:|:|.|||||:||:|||||::|||:.:.|.||.:      :.
  Fly   355 DYWENVYNMVLATCGPMSVSFFTVVVFFGSFYLINLMLAVVALSYEEEAEITNEERKKDLLDHRD 419

Human   429 EAEF---------KAMLEQLKKQQEEAQAAAMATSAGTVSEDAIEEEGEEGGGSPR---SSSEIS 481
            ::.|         |.:.:..||:.:..:...:|:.:...:.....:.|:|||.:..   |:.:.:
  Fly   420 DSTFSFDPSVLNVKKLNKNNKKKIDSRKGVLLASYSKKKTRRKKTKGGKEGGTNGNGNGSNGDDN 484

Human   482 KLSS----------KSAKERRNRRKKRKQKELSEGEEKGDPEKVFKSESEDGMRRKAFRLPDNRI 536
            |..|          .||.||.:....:.||:..:.|::   .|:.||.| .|........|..||
  Fly   485 KSHSATPSPGPSPRHSATERPSALTMQAQKQYQQMEQQ---HKLAKSGS-GGSNNPMAPTPKGRI 545

Human   537 GRKFSIMNQSLLSIPGSPFLSRHNSKSSIFSFRGPGRFRDPGSENEFADDEHSTVEESE------ 595
            .     ...|.:.:.....|...:.|..:.:..|.......|...|.:.|:...|::.|      
  Fly   546 S-----FQDSGMGVKNPNMLYPSDYKGQLIANSGQPSSNSSGVNRESSQDDSGVVDDHEEQDTTN 605

Human   596 --GRRDSLFIPIRARERRSSYSGYSGYSQGSRSSRIFPSLRRSVKRNSTVDCNGVVSLIGGPGSH 658
              |...::.:.:..||.|                              .:.|||.::.|   .:|
  Fly   606 DMGHVSTVELALSPREVR------------------------------LIKCNGNIARI---KNH 637

Human   659 IGGRLLPEATTEVEIKKKGPGSLLVSMDQLASYGRKDRINSIMSVVTNTLVEELEESQRKCPPCW 723
            ....|..|.::||                                   .::::|.:  |.|..|.
  Fly   638 NVYALHQEFSSEV-----------------------------------VVIDDLPD--RNCDRCV 665

Human   724 YKFANTFLIWECHPY--WIKLKEIVNLIVMDPFVDLAITICIVLNTLFMAMEHHPMTPQFEHVLA 786
            :        | |..|  |::.:..:..:|.||..:||||:||||||.|:|||||.|:..|.:.|.
  Fly   666 H--------W-CTDYESWLQFQNCLYKVVRDPLFELAITLCIVLNTAFLAMEHHGMSESFRNALD 721

Human   787 VGNLVFTGIFTAEMFLKLIAMDPYYYFQEGWNIFDGFIVSLSLMELSLADVEGLSVLRSFRLLRV 851
            |||.|||.|||.|..:||:|:.. .:|..||||||..||:.||:::....|:||||||..|||||
  Fly   722 VGNKVFTSIFTFECIVKLMALSK-DFFLCGWNIFDLLIVTASLLDIIFELVDGLSVLRGLRLLRV 785

Human   852 FKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKINQDCELPR 916
            .|||:||.|:.:|:.||.:::||||||||:|.|:::||||:|||||.|.|..  .|.:.| .:||
  Fly   786 LKLAQSWTTMKVLLSIIISTIGALGNLTLILVIVIYIFAVIGMQLFSKDYTP--EKFDPD-PVPR 847

Human   917 WHMHDFFHSFLIVFRVLCGEWIETMWDCM---EVAGQAMCLIVFMMVMVIGNLVVLNLFLALLLS 978
            |:.:||||||:::||:|||||||.:||||   |..|.:.|..:|:..:|:||.:||||||||||:
  Fly   848 WNFNDFFHSFMMIFRILCGEWIEPLWDCMRAEEEQGASTCFAIFLPTLVMGNFMVLNLFLALLLN 912

Human   979 SFSADNLAATDDD-GEMNNLQISVIRI-----KKGVAWTKLKVHAF-----------MQAHFKQ- 1025
            ||:::.|.:..:: ||.:.|..|:.|:     ||.......|...|           .|||.:. 
  Fly   913 SFNSEELKSKKEEVGEESKLARSIERVRDLIRKKRQERKDRKERKFAEKFQQIVLDAQQAHAQTL 977

Human  1026 --------READEVKPLDEL------YEKKANCIAN--------------HT---GADIHRNGDF 1059
                    ...|:...|.|.      |::..|...:              ||   |.:....||.
  Fly   978 SHQAAVGLERGDKPGVLAETKFHRLSYQESMNRPVSGSDFGFQIPLHDGLHTIVDGLEYDDTGDL 1042

Human  1060 QK-----------------------------------NGNGT----------------------- 1066
            .:                                   |||||                       
  Fly  1043 PEQIQLQAHPLPPTSDSMPPTYESAMMATTGGSFSSVNGNGTCQNLTPFVQAERRLQHQISSGVS 1107

Human  1067 ----------------------------------TSGIGS----------SVEKYIIDEDHMSFI 1087
                                              .||.||          |..:|..:|...:|:
  Fly  1108 TQQYDSREEATYTESIELLGQYNSTDTDPYANDQRSGCGSFNRGDSLQDNSSRRYGSEEHDEAFL 1172

Human  1088 N-NPNLTVRVP------------------------------------------------------ 1097
            . ..:|..|.|                                                      
  Fly  1173 KYQKSLLTRSPSYRKSLDRLSQSSGQSQRSLLKSEEAEMRRHSSGQSLNSMSIEQDELLSQQGNL 1237

Human  1098 --------------------------------------------------IAVGESDFENL---- 1108
                                                              ..|..|:|:|:    
  Fly  1238 REELLNCDQKELFQFLQEEEELQKGTKLRRISNVMRSRRPSSQMGQPENETMVEHSEFDNIIQSF 1302

Human  1109 --NTEDV-----------SSESDPEGSKD------------------------------------ 1124
              ..|::           |:.|:|..:.|                                    
  Fly  1303 EKELEEIKRSTTSLERKLSNLSEPSPAADEATKAIMEHIAIITGASERSAADEVVLPLNPYDSYD 1367

Human  1125 -------------------------------KLDD-----------------------------T 1129
                                           |:|:                             |
  Fly  1368 LSSVPRRSQSVSAAAQRQSVKLKRRSLEKQRKIDEDFSISNEIRKICDQIHAPFVAMEAMAVAAT 1432

Human  1130 SSSEG----------------------STIDIKPEVEEVP------------------------- 1147
            |:|:.                      ..:.:...|||||                         
  Fly  1433 SASQAQPNQSPFLRRKVDPFTVQFDRFKRLSLIERVEEVPEEEKPISTLRIESEKMPRKFLHGPD 1497

Human  1148 ----------------------------------------------------------------- 1147
                                                                             
  Fly  1498 QLRLDSLSLKSTNSYENLLIQKQKLGMATPPAVPATPPTSLKSSIEPPTLAQISSLKTTPPLAAL 1562

Human  1148 --------------------------------------VEQPEEYLD------------------ 1156
                                                  :|.|:..||                  
  Fly  1563 TEHQQHFHATSIQAAPTPAHTHAHSQAHAHSMAGQRRRMEHPQSTLDKAASFQSARTESHSSGAA 1627

Human  1157 ----------------------------------------------------------------- 1156
                                                                             
  Fly  1628 DASSALALAMAQKTEQSQSTAPDATQKPSAFTRLTEKPWHCLVSYVDDLTVGGRRNSQGAYNDPM 1692

Human  1157 -------------PDACFTEGCVQR--FKC-----CQVNIEEGLGKSWWILRKTCFLIVEHNWFE 1201
                         ||.||.:.|...  |:|     |   ::....|.|..:|.....:|:...||
  Fly  1693 TFPSYGATKAAKVPDDCFPQKCYDHFYFRCPWFMSC---MDTQSAKHWTRVRTAVLTVVDTPAFE 1754

Human  1202 TFIIFMILLSSGALAFEDIYIEQRKTIRTILEYADKVFTYIFILEMLLKWTAYGFVKFFTNAWCW 1266
            .|::.:|..||..|.||||.:::.||::.:|.:.:..|..||::||:|||.|.||.|:||:.|..
  Fly  1755 WFVLVLIFASSITLCFEDINLDKNKTLKRVLYWINFSFCLIFVVEMILKWLALGFSKYFTSFWTI 1819

Human  1267 LDFLIVAVSLVSLIANALGYSELGAIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVL 1331
            |||:||.||:.||:...  ...|..::|||||||||||||:||::|||:|||||:.|||||.|||
  Fly  1820 LDFIIVFVSVFSLLIEE--NENLKVLRSLRTLRALRPLRAISRWQGMRIVVNALMYAIPSIFNVL 1882

Human  1332 LVCLIFWLIFSIMGVNLFAGKYHYCFNETSEIRFEIEDVNNKTECEKLMEGNNTEIRWKNVKINF 1396
            ||||:||||||||||..|.||:..|.||..|: ..|.:||:|.:|   :|.|.|   |.|.||.|
  Fly  1883 LVCLVFWLIFSIMGVQFFGGKFFKCVNEMGEL-LPITEVNDKWDC---IEQNYT---WINSKITF 1940

Human  1397 DNVGAGYLALLQVATFKGWMDIMYAAVDSRKPDEQPKYEDNIYMYIYFVIFIIFGSFFTLNLFIG 1461
            |:||.|||||||||||:|||::|..|||:|..|.||:.|.|:|.||||||||:.|||||||||||
  Fly  1941 DHVGMGYLALLQVATFEGWMEVMADAVDARGVDLQPQREANLYAYIYFVIFIVCGSFFTLNLFIG 2005

Human  1462 VIIDNFNQQKKKFGG--QDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKIQGIVFDFVTQQAF 1524
            |||||||..|||:.|  .::|:||.||.||.||||||.|||||.|.||:|....:.:|....:.|
  Fly  2006 VIIDNFNMLKKKYEGGVLEMFLTESQKHYYTAMKKLGRKKPQKVIKRPINHFLAMFYDLSNSRRF 2070

Human  1525 DIVIMMLICLNMVTMMVETDTQSKQMENILYWINLVFVIFFTCECVLKMFALRHYYFTIGWNIFD 1589
            :|.|.:||.|||:||.:|...|...:..||...|..|...|..|.::|:..||::|||:.||:||
  Fly  2071 EIAIFVLIFLNMLTMGIEHYDQPHAVFFILEVSNAFFTTVFGLEAIVKIVGLRYHYFTVPWNVFD 2135

Human  1590 FVVVILSIVGMFLADIIEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNI 1654
            |::|:.||.|:.:.||:....:||||.||:|:.||||||||||.|||||.|||||::||||||||
  Fly  2136 FLLVLASIFGILMEDIMIDLPISPTLLRVVRVFRIGRILRLIKAAKGIRKLLFALVVSLPALFNI 2200

Human  1655 GLLLFLVMFIFSIFGMSNFAYVKHEAGIDDMFNFETFGNSMICLFQITTSAGWDGLLLPILNRPP 1719
            |.||.|:.||::|.|||.|..||.:..:|||.||:|||.||..||::.|||||:.:|..::.:||
  Fly  2201 GALLGLITFIYAILGMSLFGNVKLQGALDDMVNFQTFGRSMQLLFRLMTSAGWNDVLESLMIQPP 2265

Human  1720 DCSLDKEHPGSGFKGDCGNPSVGIFFFVSYIIISFLIVVNMYIAIILENFSVATEESADPLSEDD 1784
            ||  |....|. ..|:||:|.:.|.:|.|:||||::||:|||||||||||:.|.:|....:.|||
  Fly  2266 DC--DPFIHGH-TNGNCGHPLLAITYFTSFIIISYMIVINMYIAIILENFNQAHQEEEIGIVEDD 2327

Human  1785 FETFYEIWEKFDPDATQFIEYCKLADFADALEHPLRVPKPNTIELIAMDLPMVSGDRIHCLDILF 1849
            .|.||..|.|:||.|||||.:.:|:||..:|:.||.:.|||.:.|::.:||:..|::|||||||.
  Fly  2328 LEMFYIRWSKYDPHATQFIHFSQLSDFIASLDPPLGISKPNNVALVSFNLPISKGNKIHCLDILH 2392

Human  1850 AFTKRVLGDSGELD---ILRQQMEERFVASNPSKVSYEPITTTLRRKQEEVSAVVLQRAYRGHL- 1910
            |..|.|||...|.|   .|::||:.:|....|::...|.:::|...|::|.:|..:|..::.:| 
  Fly  2393 ALVKHVLGHVEETDNFKQLQEQMDVKFKKQFPTRKELEIVSSTRIWKRQEKAAKTIQTGWKEYLR 2457

Human  1911 -------------------------------------ARRGFICKKTTSNKLENGGTHREKKEST 1938
                                                 :|||..|....|:          :|.|.
  Fly  2458 RKREKERSNSGDSATQTSSPGGWQSKLSALNFFHLQVSRRGTACSSRASS----------RKSSR 2512

Human  1939 PSTAS-----------LP-----SYDSVTKPEKEKQQRAEEGRR-------ERAKRQK 1973
            .|.||           ||     ..|.|.|  ..|||..|.|:|       .||.|::
  Fly  2513 ASDASDLSELAGPWLNLPLMLVSGADEVVK--DIKQQNDELGKRGSIFVEAPRASRRR 2568

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SCN8ANP_001317189.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..20
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 28..62 2/8 (25%)
I. /evidence=ECO:0000305 114..442 150/347 (43%)
Ion_trans 131..421 CDD:395416 140/294 (48%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 446..530 20/96 (21%)
Na_trans_cytopl 504..702 CDD:403218 31/205 (15%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 568..602 7/41 (17%)
II. /evidence=ECO:0000305 735..1007 141/282 (50%)
Ion_trans 752..965 CDD:395416 116/215 (54%)
Na_trans_assoc 991..1192 CDD:399489 72/822 (9%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1107..1148 16/303 (5%)
III. /evidence=ECO:0000305 1180..1495 176/316 (56%)
Ion_trans 1197..1473 CDD:395416 159/275 (58%)
Na_channel_gate 1465..1517 CDD:240441 30/53 (57%)
IV. /evidence=ECO:0000305 1504..1801 149/296 (50%)
Ion_trans 1522..1776 CDD:395416 132/253 (52%)
GPHH 1788..1835 CDD:407139 21/46 (46%)
IQ 1894..1915 CDD:197470 6/58 (10%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1922..1980 20/75 (27%)
NaCP60ENP_001261172.1 Ion_trans 152..371 CDD:278921 113/229 (49%)
Ion_trans 705..902 CDD:278921 105/200 (53%)
Ion_trans 1768..2019 CDD:278921 155/259 (60%)
Na_channel_gate 2009..2063 CDD:240441 30/53 (57%)
Ion_trans 2085..2320 CDD:278921 124/237 (52%)
GPHH 2331..2386 CDD:293510 24/54 (44%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG2301
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D37221at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100419
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R175
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
54.750

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