Sequence 1: | NP_001317189.1 | Gene: | SCN8A / 6334 | HGNCID: | 10596 | Length: | 1980 | Species: | Homo sapiens |
---|---|---|---|---|---|---|---|---|---|
Sequence 2: | NP_001261172.1 | Gene: | NaCP60E / 37981 | FlyBaseID: | FBgn0085434 | Length: | 2896 | Species: | Drosophila melanogaster |
Alignment Length: | 2658 | Identity: | 823/2658 - (30%) |
---|---|---|---|
Similarity: | 1177/2658 - (44%) | Gaps: | 871/2658 - (32%) |
- Green bases have known domain annotations that are detailed below.
Human 53 PKPNSDLEAGKSLPFIYGDIPQGLVAVPLEDFDPYYLTQKTFVVLN---RGKTLFRFSATPALYI 114
Human 115 LSPFNLIRRIAIKILIHSVFSMIIMCTILTNCVFMTFSNPPDWSKNVEYTFTGIYTFESLVKIIA 179
Human 180 RGFCIDGFTFLRDPWNWLDFSVIMMAYVTEFVDLGNVSALRTFRVLRALKTISVIPGLKTIVGAL 244
Human 245 IQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCV-----VWPINFNESYLENGTKGFDWEE 304
Human 305 YINNKTNFYTVPGMLEPLLCGNSSDAGQCPEGYQCMKAGRNPNYGYTSFDTFSWAFLALFRLMTQ 369
Human 370 DYWENLYQLTLRAAGKTYMIFFVLVIFVGSFYLVNLILAVVAMAYEEQNQATLEEAE------QK 428
Human 429 EAEF---------KAMLEQLKKQQEEAQAAAMATSAGTVSEDAIEEEGEEGGGSPR---SSSEIS 481
Human 482 KLSS----------KSAKERRNRRKKRKQKELSEGEEKGDPEKVFKSESEDGMRRKAFRLPDNRI 536
Human 537 GRKFSIMNQSLLSIPGSPFLSRHNSKSSIFSFRGPGRFRDPGSENEFADDEHSTVEESE------ 595
Human 596 --GRRDSLFIPIRARERRSSYSGYSGYSQGSRSSRIFPSLRRSVKRNSTVDCNGVVSLIGGPGSH 658
Human 659 IGGRLLPEATTEVEIKKKGPGSLLVSMDQLASYGRKDRINSIMSVVTNTLVEELEESQRKCPPCW 723
Human 724 YKFANTFLIWECHPY--WIKLKEIVNLIVMDPFVDLAITICIVLNTLFMAMEHHPMTPQFEHVLA 786
Human 787 VGNLVFTGIFTAEMFLKLIAMDPYYYFQEGWNIFDGFIVSLSLMELSLADVEGLSVLRSFRLLRV 851
Human 852 FKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKINQDCELPR 916
Human 917 WHMHDFFHSFLIVFRVLCGEWIETMWDCM---EVAGQAMCLIVFMMVMVIGNLVVLNLFLALLLS 978
Human 979 SFSADNLAATDDD-GEMNNLQISVIRI-----KKGVAWTKLKVHAF-----------MQAHFKQ- 1025
Human 1026 --------READEVKPLDEL------YEKKANCIAN--------------HT---GADIHRNGDF 1059
Human 1060 QK-----------------------------------NGNGT----------------------- 1066
Human 1067 ----------------------------------TSGIGS----------SVEKYIIDEDHMSFI 1087
Human 1088 N-NPNLTVRVP------------------------------------------------------ 1097
Human 1098 --------------------------------------------------IAVGESDFENL---- 1108
Human 1109 --NTEDV-----------SSESDPEGSKD------------------------------------ 1124
Human 1125 -------------------------------KLDD-----------------------------T 1129
Human 1130 SSSEG----------------------STIDIKPEVEEVP------------------------- 1147
Human 1148 ----------------------------------------------------------------- 1147
Human 1148 --------------------------------------VEQPEEYLD------------------ 1156
Human 1157 ----------------------------------------------------------------- 1156
Human 1157 -------------PDACFTEGCVQR--FKC-----CQVNIEEGLGKSWWILRKTCFLIVEHNWFE 1201
Human 1202 TFIIFMILLSSGALAFEDIYIEQRKTIRTILEYADKVFTYIFILEMLLKWTAYGFVKFFTNAWCW 1266
Human 1267 LDFLIVAVSLVSLIANALGYSELGAIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVL 1331
Human 1332 LVCLIFWLIFSIMGVNLFAGKYHYCFNETSEIRFEIEDVNNKTECEKLMEGNNTEIRWKNVKINF 1396
Human 1397 DNVGAGYLALLQVATFKGWMDIMYAAVDSRKPDEQPKYEDNIYMYIYFVIFIIFGSFFTLNLFIG 1461
Human 1462 VIIDNFNQQKKKFGG--QDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKIQGIVFDFVTQQAF 1524
Human 1525 DIVIMMLICLNMVTMMVETDTQSKQMENILYWINLVFVIFFTCECVLKMFALRHYYFTIGWNIFD 1589
Human 1590 FVVVILSIVGMFLADIIEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNI 1654
Human 1655 GLLLFLVMFIFSIFGMSNFAYVKHEAGIDDMFNFETFGNSMICLFQITTSAGWDGLLLPILNRPP 1719
Human 1720 DCSLDKEHPGSGFKGDCGNPSVGIFFFVSYIIISFLIVVNMYIAIILENFSVATEESADPLSEDD 1784
Human 1785 FETFYEIWEKFDPDATQFIEYCKLADFADALEHPLRVPKPNTIELIAMDLPMVSGDRIHCLDILF 1849
Human 1850 AFTKRVLGDSGELD---ILRQQMEERFVASNPSKVSYEPITTTLRRKQEEVSAVVLQRAYRGHL- 1910
Human 1911 -------------------------------------ARRGFICKKTTSNKLENGGTHREKKEST 1938
Human 1939 PSTAS-----------LP-----SYDSVTKPEKEKQQRAEEGRR-------ERAKRQK 1973 |
Gene | Sequence | Domain | Region | External ID | Identity |
---|---|---|---|---|---|
SCN8A | NP_001317189.1 | Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 1..20 | ||
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 28..62 | 2/8 (25%) | |||
I. /evidence=ECO:0000305 | 114..442 | 150/347 (43%) | |||
Ion_trans | 131..421 | CDD:395416 | 140/294 (48%) | ||
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 446..530 | 20/96 (21%) | |||
Na_trans_cytopl | 504..702 | CDD:403218 | 31/205 (15%) | ||
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 568..602 | 7/41 (17%) | |||
II. /evidence=ECO:0000305 | 735..1007 | 141/282 (50%) | |||
Ion_trans | 752..965 | CDD:395416 | 116/215 (54%) | ||
Na_trans_assoc | 991..1192 | CDD:399489 | 72/822 (9%) | ||
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 1107..1148 | 16/303 (5%) | |||
III. /evidence=ECO:0000305 | 1180..1495 | 176/316 (56%) | |||
Ion_trans | 1197..1473 | CDD:395416 | 159/275 (58%) | ||
Na_channel_gate | 1465..1517 | CDD:240441 | 30/53 (57%) | ||
IV. /evidence=ECO:0000305 | 1504..1801 | 149/296 (50%) | |||
Ion_trans | 1522..1776 | CDD:395416 | 132/253 (52%) | ||
GPHH | 1788..1835 | CDD:407139 | 21/46 (46%) | ||
IQ | 1894..1915 | CDD:197470 | 6/58 (10%) | ||
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 1922..1980 | 20/75 (27%) | |||
NaCP60E | NP_001261172.1 | Ion_trans | 152..371 | CDD:278921 | 113/229 (49%) |
Ion_trans | 705..902 | CDD:278921 | 105/200 (53%) | ||
Ion_trans | 1768..2019 | CDD:278921 | 155/259 (60%) | ||
Na_channel_gate | 2009..2063 | CDD:240441 | 30/53 (57%) | ||
Ion_trans | 2085..2320 | CDD:278921 | 124/237 (52%) | ||
GPHH | 2331..2386 | CDD:293510 | 24/54 (44%) | ||
Blue background indicates that the domain is not in the aligned region. |
Tool | Simple Score | Weighted Score | Original Tool Information | |||
---|---|---|---|---|---|---|
BLAST Result | Score | Score Type | Cluster ID | |||
Compara | 0 | 0.000 | Not matched by this tool. | |||
Domainoid | 0 | 0.000 | Not matched by this tool. | |||
eggNOG | 1 | 0.900 | - | - | E1_KOG2301 | |
Hieranoid | 0 | 0.000 | Not matched by this tool. | |||
Homologene | 0 | 0.000 | Not matched by this tool. | |||
Inparanoid | 0 | 0.000 | Not matched by this tool. | |||
Isobase | 0 | 0.000 | Not matched by this tool. | |||
OMA | 0 | 0.000 | Not matched by this tool. | |||
OrthoDB | 1 | 1.010 | - | - | D37221at33208 | |
OrthoFinder | 0 | 0.000 | Not matched by this tool. | |||
OrthoInspector | 0 | 0.000 | Not matched by this tool. | |||
orthoMCL | 1 | 0.900 | - | - | OOG6_100419 | |
Panther | 0 | 0.000 | Not matched by this tool. | |||
Phylome | 1 | 0.910 | - | - | ||
RoundUp | 1 | 1.030 | - | avgDist | Average_Evolutionary_Distance | R175 |
SonicParanoid | 0 | 0.000 | Not matched by this tool. | |||
SwiftOrtho | 0 | 0.000 | Not matched by this tool. | |||
TreeFam | 0 | 0.000 | Not matched by this tool. | |||
User_Submission | 0 | 0.000 | Not matched by this tool. | |||
5 | 4.750 |