DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SCN8A and para

DIOPT Version :9

Sequence 1:	NP_001317189.1	Gene:	SCN8A / 6334	HGNCID:	10596	Length:	1980	Species:	Homo sapiens
Sequence 2:	NP_001259619.1	Gene:	para / 32619	FlyBaseID:	FBgn0285944	Length:	2145	Species:	Drosophila melanogaster

Alignment Length:	2095	Identity:	956/2095 - (45%)
Similarity:	1288/2095 - (61%)	Gaps:	233/2095 - (11%)

- Green bases have known domain annotations that are detailed below.

Human    14 FKPFTPESLANIERRIA----ESKLKKPPKADGS--------------HREDDEDSKPKPNSDLE 60
            |:|||.|||..||:|||    :.|..:..:|:|.              :.::|||..|:|:..||
  Fly    16 FRPFTRESLVQIEQRIAAEHEKQKELERKRAEGEVPQYGRKKKQKEIRYDDEDEDEGPQPDPTLE 80

Human    61 AGKSLPF-IYGDIPQGLVAVPLEDFDPYYLTQKTFVVLNRGKTLFRFSATPALYILSPFNLIRRI 124
            .|..:|. :.|..|..|.:.||||.||||....||||:::||.:|||||:.|:::|.|||.|||:
  Fly    81 QGVPIPVRLQGSFPPELASTPLEDIDPYYSNVLTFVVVSKGKDIFRFSASKAMWMLDPFNPIRRV 145

Human   125 AIKILIHSVFSMIIMCTILTNCVFMTFSNPPDWSKNVEYTFTGIYTFESLVKIIARGFCIDGFTF 189
            ||.||:|.:||:.|:.|||.||:.|.....|. .::.|..|||||||||.||::||||.:..||:
  Fly   146 AIYILVHPLFSLFIITTILVNCILMIMPTTPT-VESTEVIFTGIYTFESAVKVMARGFILCPFTY 209

Human   190 LRDPWNWLDFSVIMMAYVTEFVDLGNVSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDV 254
            |||.||||||.||.:||||..:||||::|||||||||||||::::|||||||||:|:|||.|.||
  Fly   210 LRDAWNWLDFVVIALAYVTMGIDLGNLAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDV 274

Human   255 MILTVFCLSVFALIGLQLFMGNLRNKCV-VWPINFNESYL--ENGTKGFDWEEYINNKTNFYTVP 316
            :|||:|.||||||:|||::||.|..||: .:|::.:...|  ||      |:.:..|.:|:|:..
  Fly   275 IILTMFSLSVFALMGLQIYMGVLTQKCIKKFPLDGSWGNLTDEN------WDYHNRNSSNWYSED 333

Human   317 GMLEPLLCGNSSDAGQCPEGYQCMKA-GRNPNYGYTSFDTFSWAFLALFRLMTQDYWENLYQLTL 380
            ..:...||||.|.||||.:.|.|::. |.||||||||||:|.||||:.|||||||:||:||||.|
  Fly   334 EGISFPLCGNISGAGQCDDDYVCLQGFGPNPNYGYTSFDSFGWAFLSAFRLMTQDFWEDLYQLVL 398

Human   381 RAAGKTYMIFFVLVIFVGSFYLVNLILAVVAMAYEE-QNQATLEEAEQKEA---EFKAMLEQLKK 441
            ||||..:|:||:::||:|||||||||||:|||:|:| |.:|..|||.::||   ..:|...:..|
  Fly   399 RAAGPWHMLFFIVIIFLGSFYLVNLILAIVAMSYDELQKKAEEEEAAEEEAIREAEEAAAAKAAK 463

Human   442 QQEEAQAAAMATSAGTVSEDAIEEEGEEGGGSPRSSSEISKLSSKSAKERRNRRKKRKQKELSEG 506
            .:|.|.|.|.|.:....:|:|...  .|...||..|. ||                   .||..|
  Fly   464 LEERANAQAQAAADAAAAEEAALH--PEMAKSPTYSC-IS-------------------YELFVG 506

Human   507 EEKG----DPEKV------FKSESEDGMRRKAFRLPDNRIGRKFSIMNQSLLSIPGSPFLSRHNS 561
            .|||    :.||:      .:|||...::|:......:: ..|...::.:.||:|||||..|..|
  Fly   507 GEKGNDDNNKEKMSIRSVEVESESVSVIQRQPAPTTAHQ-ATKVRKVSTTSLSLPGSPFNIRRGS 570

Human   562 KSS-IFSFR-GPGRFRDPGSENE---------------FADDEHSTVEESEGRRDSLFIPI---R 606
            :|| .::.| |.|||..|||:.:               :|||.::....|| ...::.:|:   .
  Fly   571 RSSHKYTIRNGRGRFGIPGSDRKPLVLSTYQDAQQHLPYADDSNAVTPMSE-ENGAIIVPVYYGN 634

Human   607 ARERRSSYSGYS------------------GYSQGSRSSRIFPSLRRSVKRNSTVDC-NGVVSLI 652
            ...|.|||:.:.                  |.|..::.|:    ||....||.:|.. ||..:.:
  Fly   635 LGSRHSSYTSHQSRISYTSHGDLLGGMAVMGVSTMTKESK----LRNRNTRNQSVGATNGGTTCL 695

Human   653 --------------------GGPGSHIGGRLLPEATTEVEIKKKGPGSLLVSMDQLASYGR---- 693
                                .|...|.....:....|:..:..|....|...::|.|  ||
  Fly   696 DTNHKLDHRDYEIGLECTDEAGKIKHHDNPFIEPVQTQTVVDMKDVMVLNDIIEQAA--GRHSRA 758

Human   694 KDRINSIMSVVTNTLVEELEESQRKCPPCWYKFANTFLIWECHPYWIKLKEIVNLIVMDPFVDLA 758
            .||..|:....|....|:....:.|......|..:.|.:|:|...|:|.:|.|:|||.||||:|.
  Fly   759 SDRGVSVYYFPTEDDDEDGPTFKDKALEVILKGIDVFCVWDCCWVWLKFQEWVSLIVFDPFVELF 823

Human   759 ITICIVLNTLFMAMEHHPMTPQFEHVLAVGNLVFTGIFTAEMFLKLIAMDPYYYFQEGWNIFDGF 823
            ||:|||:||:||||:||.|..:.|.||..||..||..|..|..:||:||.|.|||||||||||..
  Fly   824 ITLCIVVNTMFMAMDHHDMNKEMERVLKSGNYFFTATFAIEATMKLMAMSPKYYFQEGWNIFDFI 888

Human   824 IVSLSLMELSLADVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFI 888
            ||:|||:||.|..|:||||||||||||||||||||||||:||.|:|.::|||||||.||.||:||
  Fly   889 IVALSLLELGLEGVQGLSVLRSFRLLRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFI 953

Human   889 FAVVGMQLFGKSYKECVCKINQDCELPRWHMHDFFHSFLIVFRVLCGEWIETMWDCMEVAGQAMC 953
            |||:|||||||:|.:...:. .|.:||||:..||.|||:||||||||||||:|||||.| |...|
  Fly   954 FAVMGMQLFGKNYHDHKDRF-PDGDLPRWNFTDFMHSFMIVFRVLCGEWIESMWDCMYV-GDVSC 1016

Human   954 LIVFMMVMVIGNLVVLNLFLALLLSSFSADNLAATDDDGEMNNLQISVIRIKKGVAWTKLKV-HA 1017
            :..|:..:|||||||||||||||||:|.:.:|:|...|.:.|.:..:..||.:..:|.|..: ..
  Fly  1017 IPFFLATVVIGNLVVLNLFLALLLSNFGSSSLSAPTADNDTNKIAEAFNRIGRFKSWVKRNIADC 1081

Human  1018 FMQAHFK-------QREADEVKPLDELY-EKKANC---IANHTGADIHRNGDFQKNGNGTTSGIG 1071
            |.....|       |...:....:..:: |.|..|   .|.|...::....|..........||.
  Fly  1082 FKLIRNKLTNQISDQPSGERTNQISWIWSEGKGVCRCISAEHGDNELELGHDEILADGLIKKGIK 1146

Human  1072 SSVEKYIIDEDHMSFINNPNLTVRVPIAVGESDFENLNTEDVSSESDPEGS-KDKLDDTSSSEGS 1135
            ...:..:...|.|.|..:.::....|   .:|.:.|..|:|.::..:..|| |::.....|.:||
  Fly  1147 EQTQLEVAIGDGMEFTIHGDMKNNKP---KKSKYLNNATDDDTASINSYGSHKNRPFKDESHKGS 1208

Human  1136 T---------------------IDIKPEVEEVPVE-------QPEEYLD--PDACFTEGCVQRFK 1170
            .                     :|.:.|.||.|::       ..|:.||  |..|..:...::|.
  Fly  1209 AETMEGEEKRDASKEDLGLDEELDEEGECEEGPLDGDIIIHAHDEDILDEYPADCCPDSYYKKFP 1273

Human  1171 CCQVNIEEGLGKSWWILRKTCFLIVEHNWFETFIIFMILLSSGALAFEDIYIEQRKTIRTILEYA 1235
            ....:.:....:.|..||...|.::|:.:|||.:|.|||:||.|||.||:::.||..::.||.|.
  Fly  1274 ILAGDDDSPFWQGWGNLRLKTFQLIENKYFETAVITMILMSSLALALEDVHLPQRPILQDILYYM 1338

Human  1236 DKVFTYIFILEMLLKWTAYGFVKFFTNAWCWLDFLIVAVSLVSLIANALGYSELGAIKSLRTLRA 1300
            |::||.||.||||:||.|.||..:||||||||||:||.|||::.:|:.:|...:.|.|::|||||
  Fly  1339 DRIFTVIFFLEMLIKWLALGFKVYFTNAWCWLDFVIVMVSLINFVASLVGAGGIQAFKTMRTLRA 1403

Human  1301 LRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKYHYCFNETSEIRF 1365
            ||||||:||.:||||||||||.|||||.|||||||||||||:||||.||||||..| .:.:..:.
  Fly  1404 LRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKC-EDMNGTKL 1467

Human  1366 EIEDVNNKTECEKLMEGNNTEIRWKNVKINFDNVGAGYLALLQVATFKGWMDIMYAAVDSRKPDE 1430
            ..|.:.|:..||      :....|.|..:|||:||..||.|.||||||||:.||..|:|||:.|:
  Fly  1468 SHEIIPNRNACE------SENYTWVNSAMNFDHVGNAYLCLFQVATFKGWIQIMNDAIDSREVDK 1526

Human  1431 QPKYEDNIYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQ-DIFMTEEQKKYYNAMKK 1494
            ||..|.|||||:|||.||||||||||||||||||||||:||||.||. ::||||:||||||||||
  Fly  1527 QPIRETNIYMYLYFVFFIIFGSFFTLNLFIGVIIDNFNEQKKKAGGSLEMFMTEDQKKYYNAMKK 1591

Human  1495 LGSKKPQKPIPRPLNKIQGIVFDFVTQQAFDIVIMMLICLNMVTMMVETDTQSKQMENILYWINL 1559
            :|||||.|.||||..:.|.|||:.||.:.|||:||:.|.|||.||.::....|.....:|.::|.
  Fly  1592 MGSKKPLKAIPRPRWRPQAIVFEIVTDKKFDIIIMLFIGLNMFTMTLDRYDASDTYNAVLDYLNA 1656

Human  1560 VFVIFFTCECVLKMFALRHYYFTIGWNIFDFVVVILSIVGMFLADIIEKYFVSPTLFRVIRLARI 1624
            :||:.|:.||:||:||||::||...||:||.|||||||:|:.|:||||||||||||.||:|:|::
  Fly  1657 IFVVIFSSECLLKIFALRYHYFIEPWNLFDVVVVILSILGLVLSDIIEKYFVSPTLLRVVRVAKV 1721

Human  1625 GRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIFSIFGMSNFAYVKHEAGIDDMFNFE 1689
            ||:|||:|||||||||||||.|||||||||.||||||||||:|||||.|.:||.::||:|::||:
  Fly  1722 GRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFFMHVKEKSGINDVYNFK 1786

Human  1690 TFGNSMICLFQITTSAGWDGLLLPILNR----PPDCSLDKEHPGSGFKGDCGNPSVGIFFFVSYI 1750
            |||.|||.|||::|||||||:|..|:|.    |||  .||     |:.|:||:.:|||.|.:||:
  Fly  1787 TFGQSMILLFQMSTSAGWDGVLDAIINEEACDPPD--NDK-----GYPGNCGSATVGITFLLSYL 1844

Human  1751 IISFLIVVNMYIAIILENFSVATEESADPLSEDDFETFYEIWEKFDPDATQFIEYCKLADFADAL 1815
            :||||||:|||||:||||:|.|||:..:.|::||::.:||||::|||:.||:|.|.:|::|.|.|
  Fly  1845 VISFLIVINMYIAVILENYSQATEDVQEGLTDDDYDMYYEIWQQFDPEGTQYIRYDQLSEFLDVL 1909

Human  1816 EHPLRVPKPNTIELIAMDLPMVSGDRIHCLDILFAFTKRVLGDSGELDILRQQMEERFVASNPSK 1880
            |.||::.|||..::|:||:|:..||.::|:|||.|.||......|  :.:.:..|...:|:.|..
  Fly  1910 EPPLQIHKPNKYKIISMDIPICRGDLMYCVDILDALTKDFFARKG--NPIEETGEIGEIAARPDT 1972

Human  1881 VSYEPITTTLRRKQEEVSAVVLQRAYRGHLARRGFICKKTTSNKLENGGTHREKKESTPST---- 1941
            ..|||:::||.|::||..|.::|.|:|.|.||.            |.||:..      |.|
  Fly  1973 EGYEPVSSTLWRQREEYCARLIQHAWRKHKARG------------EGGGSFE------PDTDHGD 2019

Human  1942 -----ASLPSYDSVT 1951
                 |..|:.|..|
  Fly  2020 GGDPDAGDPAPDEAT 2034

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SCN8A	NP_001317189.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..20		4/5 (80%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	28..62		13/51 (25%)
		I. /evidence=ECO:0000305	114..442		188/335 (56%)
		Ion_trans	131..421	CDD:395416	170/294 (58%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	446..530		24/93 (26%)
		Na_trans_cytopl	504..702	CDD:403218	62/270 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	568..602		13/49 (27%)
		II. /evidence=ECO:0000305	735..1007		168/271 (62%)
		Ion_trans	752..965	CDD:395416	138/212 (65%)
		Na_trans_assoc	991..1192	CDD:399489	45/243 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1107..1148		13/62 (21%)
		III. /evidence=ECO:0000305	1180..1495		190/315 (60%)
		Ion_trans	1197..1473	CDD:395416	168/275 (61%)
		Na_channel_gate	1465..1517	CDD:240441	37/52 (71%)
		IV. /evidence=ECO:0000305	1504..1801		179/300 (60%)
		Ion_trans	1522..1776	CDD:395416	159/257 (62%)
		GPHH	1788..1835	CDD:407139	24/46 (52%)
		IQ	1894..1915	CDD:197470	9/20 (45%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1922..1980		9/39 (23%)
para	NP_001259619.1	Ion_trans	165..436	CDD:278921	162/277 (58%)
		Na_trans_cytopl	515..648	CDD:288761	36/134 (27%)
		Ion_trans	835..1028	CDD:278921	125/194 (64%)
		Na_trans_assoc	1054..1296	CDD:284034	45/244 (18%)
		Ion_trans	1318..1571	CDD:278921	160/259 (62%)
		Na_channel_gate	1561..1613	CDD:240441	36/51 (71%)
		Ion_trans	1636..1871	CDD:278921	149/241 (62%)
		GPHH	1880..1930	CDD:293510	24/49 (49%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	342	1.000	Domainoid score	I1069
eggNOG	1	0.900	-	-		E1_KOG2301
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1621	1.000	Inparanoid score	I82
Isobase	1	0.950	-	0	Normalized mean entropy	S5486
OMA	1	1.010	-	-		QHG52281
OrthoDB	1	1.010	-	-		D37221at33208
OrthoFinder	1	1.000	-	-		FOG0000268
OrthoInspector	1	1.000	-	-		otm41716
orthoMCL	1	0.900	-	-		OOG6_100419
Panther	1	1.100	-	-	O	PTHR10037
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R175
SonicParanoid	1	1.000	-	-		X214
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	14	13.860