| Sequence 1: | NP_001317189.1 | Gene: | SCN8A / 6334 | HGNCID: | 10596 | Length: | 1980 | Species: | Homo sapiens |
|---|---|---|---|---|---|---|---|---|---|
| Sequence 2: | XP_017172001.1 | Gene: | Scn8a / 20273 | MGIID: | 103169 | Length: | 1988 | Species: | Mus musculus |
| Alignment Length: | 1990 | Identity: | 1953/1990 - (98%) |
|---|---|---|---|
| Similarity: | 1969/1990 - (98%) | Gaps: | 12/1990 - (0%) |
- Green bases have known domain annotations that are detailed below.
|
Human 1 MAARLLAPPGPDSFKPFTPESLANIERRIAESKLKKPPKADGSHREDDEDSKPKPNSDLEAGKSL 65
Human 66 PFIYGDIPQGLVAVPLEDFDPYYLTQKTFVVLNRGKTLFRFSATPALYILSPFNLIRRIAIKILI 130
Human 131 HSVFSMIIMCTILTNCVFMTFSNPPDWSKNVEYTFTGIYTFESLVKIIARGFCIDGFTFLRDPWN 195
Human 196 WLDFSVIMMAYVTEFVDLGNVSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVF 260
Human 261 CLSVFALIGLQLFMGNLRNKCVVWPINFNESYLENGTKGFDWEEYINNKTNFYTVPGMLEPLLCG 325
Human 326 NSSDAGQCPEGYQCMKAGRNPNYGYTSFDTFSWAFLALFRLMTQDYWENLYQLTLRAAGKTYMIF 390
Human 391 FVLVIFVGSFYLVNLILAVVAMAYEEQNQATLEEAEQKEAEFKAMLEQLKKQQEEAQAAAMATSA 455
Human 456 GTVSEDAIEEEGEEGGGSPRSSSEISKLSSKSAKERRNRRKKRKQKELSEGEEKGDPEKVFKSES 520
Human 521 EDGMRRKAFRLPDNRIGRKFSIMNQSLLSIPGSPFLSRHNSKSSIFSFRGPGRFRDPGSENEFAD 585
Human 586 DEHSTVEESEGRRDSLFIPIRARERRSSYSGYSGYSQGSRSSRIFPSLRRSVKRNSTVDCNGVVS 650
Human 651 LIGGPGSHIGGRLLPE----------ATTEVEIKKKGPGSLLVSMDQLASYGRKDRINSIMSVVT 705
Human 706 NTLVEELEESQRKCPPCWYKFANTFLIWECHPYWIKLKEIVNLIVMDPFVDLAITICIVLNTLFM 770
Human 771 AMEHHPMTPQFEHVLAVGNLVFTGIFTAEMFLKLIAMDPYYYFQEGWNIFDGFIVSLSLMELSLA 835
Human 836 DVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKS 900
Human 901 YKECVCKINQDCELPRWHMHDFFHSFLIVFRVLCGEWIETMWDCMEVAGQAMCLIVFMMVMVIGN 965
Human 966 LVVLNLFLALLLSSFSADNLAATDDDGEMNNLQISVIRIKKGVAWTKLKVHAFMQAHFKQREADE 1030
Human 1031 VKPLDELYEKKANCIANHTGADIHRNGDFQKNGNGTTSGIGSSVEKYIIDEDHMSFINNPNLTVR 1095
Human 1096 VPIAVGESDFENLNTEDVSSESDPEGSKDKLDDTSSSEGSTIDIKPEVEEVPVEQPEEYLDPDAC 1160
Human 1161 FTEGCVQRFKCCQVNIEEGLGKSWWILRKTCFLIVEHNWFETFIIFMILLSSGALAFEDIYIEQR 1225
Human 1226 KTIRTILEYADKVFTYIFILEMLLKWTAYGFVKFFTNAWCWLDFLIVAVSLVSLIANALGYSELG 1290
Human 1291 AIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKYHY 1355
Human 1356 CFNETSEIRFEIEDVNNKTECEKLMEGNNTEIRWKNVKINFDNVGAGYLALLQVATFKGWMDIMY 1420
Human 1421 AAVDSRKPDEQPKYEDNIYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQ 1485
Human 1486 KKYYNAMKKLGSKKPQKPIPRPLNKIQGIVFDFVTQQAFDIVIMMLICLNMVTMMVETDTQSKQM 1550
Human 1551 ENILYWINLVFVIFFTCECVLKMFALRHYYFTIGWNIFDFVVVILSIVGMFLADIIEKYFVSPTL 1615
Human 1616 FRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIFSIFGMSNFAYVKHEA 1680
Human 1681 GIDDMFNFETFGNSMICLFQITTSAGWDGLLLPILNRPPDCSLDKEHPGSGFKGDCGNPSVGIFF 1745
Human 1746 FVSYIIISFLIVVNMYIAIILENFSVATEESADPLSEDDFETFYEIWEKFDPDATQFIEYCKLAD 1810
Human 1811 FADALEHPLRVPKPNTIELIAMDLPMVSGDRIHCLDILFAFTKRVLGDSGELDILRQQMEERFVA 1875
Human 1876 SNPSKVSYEPITTTLRRKQEEVSAVVLQRAYRGHLARRGFICKKTTSNKLENGGTHREKKESTPS 1940
Human 1941 TASLPSYDSVTKPEKEKQQRAEEGRRERAKRQKEVRESKC 1980 |
| Gene | Sequence | Domain | Region | External ID | Identity |
|---|---|---|---|---|---|
| SCN8A | NP_001317189.1 | Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 1..20 | 18/18 (100%) | |
| Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 28..62 | 33/33 (100%) | |||
| I. /evidence=ECO:0000305 | 114..442 | 323/327 (99%) | |||
| Ion_trans | 131..421 | CDD:395416 | 285/289 (99%) | ||
| Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 446..530 | 80/83 (96%) | |||
| Na_trans_cytopl | 504..702 | CDD:403218 | 193/207 (93%) | ||
| Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 568..602 | 33/33 (100%) | |||
| II. /evidence=ECO:0000305 | 735..1007 | 266/271 (98%) | |||
| Ion_trans | 752..965 | CDD:395416 | 207/212 (98%) | ||
| Na_trans_assoc | 991..1192 | CDD:399489 | 197/200 (99%) | ||
| Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 1107..1148 | 40/40 (100%) | |||
| III. /evidence=ECO:0000305 | 1180..1495 | 309/314 (98%) | |||
| Ion_trans | 1197..1473 | CDD:395416 | 270/275 (98%) | ||
| Na_channel_gate | 1465..1517 | CDD:240441 | 51/51 (100%) | ||
| IV. /evidence=ECO:0000305 | 1504..1801 | 296/296 (100%) | |||
| Ion_trans | 1522..1776 | CDD:395416 | 253/253 (100%) | ||
| GPHH | 1788..1835 | CDD:407139 | 46/46 (100%) | ||
| IQ | 1894..1915 | CDD:197470 | 20/20 (100%) | ||
| Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 1922..1980 | 56/57 (98%) | |||
| Scn8a | XP_017172001.1 | Ion_trans | 131..421 | CDD:366146 | 285/289 (99%) |
| Na_trans_cytopl | 504..710 | CDD:371806 | 193/207 (93%) | ||
| Ion_trans | 760..973 | CDD:366146 | 207/212 (98%) | ||
| Na_trans_assoc | 999..1200 | CDD:368948 | 197/200 (99%) | ||
| Ion_trans | 1205..1481 | CDD:366146 | 270/275 (98%) | ||
| Na_channel_gate | 1473..1525 | CDD:240441 | 51/51 (100%) | ||
| Ion_trans | 1530..1784 | CDD:366146 | 253/253 (100%) | ||
| GPHH | 1796..1843 | CDD:374878 | 46/46 (100%) | ||
| IQ | 1902..1923 | CDD:197470 | 20/20 (100%) |
| Tool | Simple Score | Weighted Score | Original Tool Information | |||
|---|---|---|---|---|---|---|
| BLAST Result | Score | Score Type | Cluster ID | |||
| Compara | 1 | 0.930 | - | - | C83956406 | |
| Domainoid | 1 | 1.000 | 590 | 1.000 | Domainoid score | I5317 |
| eggNOG | 1 | 0.900 | - | - | E1_KOG2301 | |
| HGNC | 1 | 1.500 | - | - | ||
| Hieranoid | 1 | 1.000 | - | - | ||
| Homologene | 1 | 1.000 | - | - | H7927 | |
| Inparanoid | 1 | 1.050 | 3906 | 1.000 | Inparanoid score | I291 |
| Isobase | 1 | 0.950 | - | 0 | Normalized mean entropy | S5486 |
| NCBI | 1 | 1.000 | - | - | ||
| OMA | 1 | 1.010 | - | - | QHG52281 | |
| OrthoDB | 1 | 1.010 | - | - | D13170at7742 | |
| OrthoFinder | 1 | 1.000 | - | - | FOG0000268 | |
| OrthoInspector | 1 | 1.000 | - | - | oto115883 | |
| orthoMCL | 1 | 0.900 | - | - | OOG6_100419 | |
| Panther | 1 | 1.100 | - | - | LDO | PTHR10037 |
| Phylome | 1 | 0.910 | - | - | ||
| RoundUp | 1 | 1.030 | - | avgDist | Average_Evolutionary_Distance | R175 |
| SonicParanoid | 1 | 1.000 | - | - | X214 | |
| SwiftOrtho | 0 | 0.000 | Not matched by this tool. | |||
| TreeFam | 1 | 0.960 | - | - | ||
| 19 | 19.250 | |||||