DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment SCN8A and egl-19

DIOPT Version :9

Sequence 1:NP_001317189.1 Gene:SCN8A / 6334 HGNCID:10596 Length:1980 Species:Homo sapiens
Sequence 2:NP_001023079.1 Gene:egl-19 / 177513 WormBaseID:WBGene00001187 Length:1877 Species:Caenorhabditis elegans


Alignment Length:1852 Identity:454/1852 - (24%)
Similarity:775/1852 - (41%) Gaps:537/1852 - (28%)


- Green bases have known domain annotations that are detailed below.


Human   111 ALYILSPFNLIRRIAIKILIHSVFSMIIMCTILTNCVFMTFSNP-----PDWS----KNVEYTFT 166
            :|..||..|.||::.|.|:....|..:|:..|..||:.:....|     .|:.    :.:||.|.
 Worm    67 SLLCLSLNNPIRKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFI 131

Human   167 GIYTFESLVKIIARGFCIDGFTFLRDPWNWLDFSVIMMAYVTEF-----VDLGNVSALRTFRVLR 226
            .::|.|.::||:|.||......:||:.||.|||.::::..|:..     :...:|.|||.|||||
 Worm   132 VVFTIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQGFDVKALRAFRVLR 196

Human   227 ALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCVVWPINFNES 291
            .|:.:|.:|.|:.::.|:::::..|..:.:|.:|.:.::|:|||:||.|.|.:.|:         
 Worm   197 PLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCI--------- 252

Human   292 YLENGTKGFDWEEYINNKTNFYTVPGML---EPLLCGNSSD--AGQCPEG---------YQCMK- 341
              :..|                   |.|   :|..||..::  |.:|...         ::|.. 
 Worm   253 --DPAT-------------------GQLAQKDPTPCGTDTEGSAFKCQPSDSLTNMGVRWECSSN 296

Human   342 -AGRNPNYGYTSFDTFSWAFLALFRLMTQDYWENLYQLTLRAAGKTY-MIFFVLVIFVGSFYLVN 404
             ....||.|.|:||.|..|.|.:|:.::.:.|.::......|.|:.: .|:||.::.:|||:::|
 Worm   297 TTWPGPNNGITNFDNFGLAMLTVFQCVSLEGWTDVMYWVNDAVGREWPWIYFVTLVILGSFFVLN 361

Human   405 LILAVVAMAYEEQNQATLEEAEQKEAEFKAMLEQLKKQQEEAQAAAMATSAGTVSEDAIEEEGEE 469
            |:|.|::                  .||       .|::|:|:|                     
 Worm   362 LVLGVLS------------------GEF-------SKEREKARA--------------------- 380

Human   470 GGGSPRSSSEISKLSSKSAKERRNRRKKRKQKELSEGEEKGDPEKVFKSESEDGMRRKAFRLPDN 534
                                  |...:|.::|:..|.:.||..:.:  :::||            
 Worm   381 ----------------------RGLFQKFREKQQLEEDLKGYLDWI--TQAED------------ 409

Human   535 RIGRKFSIMNQSLLSIPGSPFLSRHNSKSSIFSFRGPGRFRDPGSENEFADDEHSTVEESEGRRD 599
                                                    .:|.:|:|..|:             
 Worm   410 ----------------------------------------IEPVNEDEQEDE------------- 421

Human   600 SLFIPIRARERRSSYSGYSGYSQGSRSSRIFPSLRRSVKRNSTVDCNGVVSLIGGPGSHIGGRLL 664
                                                                             
 Worm   422 ----------------------------------------------------------------- 421

Human   665 PEATTEV--EIKKKGPGSLLVSMDQLASYGRKDRINSIMSVVTNTLVEELEESQRKCPPCWYKF- 726
            |.|.|.|  |..::|                ::|:..:........::.||:..|:|.....:. 
 Worm   422 PVAQTVVGEEADEEG----------------EERVEDVRPSKWAARMKRLEKLNRRCRRACRRLV 470

Human   727 -ANTFLIWECHPYWIKLKEIVNLIVMDPFVDLAITICIVLNTLFMAMEHHPMTPQFEHVLAVGNL 790
             :.||       ||:                  :.:.::||||.:..||:..:...:|...:.||
 Worm   471 KSQTF-------YWL------------------VILLVLLNTLVLTSEHYGQSEWLDHFQTMANL 510

Human   791 VFTGIFTAEMFLKLIAMDPYYYFQEGWNIFDGFIVSLSLMELSLADVE-----GLSVLRSFRLLR 850
            .|..:|:.||.||:.::....|....:|.||.|:|..|::|..|...:     |:|||||.||||
 Worm   511 FFVILFSMEMLLKMYSLGFTTYTTSQFNRFDCFVVISSILEFVLVYFDLMKPLGVSVLRSARLLR 575

Human   851 VFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKINQDCELP 915
            :||:.|.|.:|..|:..:.||:.::.:|.|:|.:.:.|||::|||:||..:     ..|.....|
 Worm   576 IFKVTKYWTSLRNLVSSLLNSLRSIISLLLLLFLFIVIFALLGMQVFGGKF-----NFNPQQPKP 635

Human   916 RWHMHDFFHSFLIVFRVLCGE-WIETMWDCME------VAGQAMCLIVFMMVMVIGNLVVLNLFL 973
            |.:...|..:.|.||::|.|| |...|:..:|      ..|..:| |.::::.:.||.::||:||
 Worm   636 RANFDTFVQALLTVFQILTGEDWNTVMYHGIESFGGVGTLGVIVC-IYYIVLFICGNYILLNVFL 699

Human   974 ALLLSSFSADNLAATDDDGEMNNLQISVIRIKKGVAWTKLKVHAFMQAHFKQREADEVKPLDELY 1038
            |:     :.||||..|   .:.|.:                         |:.|..|::..||.:
 Worm   700 AI-----AVDNLADAD---SLTNAE-------------------------KEEEQQEIEGEDEEF 731

Human  1039 EKKANCIANHTGADIHRNGDFQKNGNGTTSGIGSSVEKYIIDEDHMSFINNPNLTVRVPIAVGES 1103
            |                                                                
 Worm   732 E---------------------------------------------------------------- 732

Human  1104 DFENLNTEDVSSESDPEGSKDKLDDTSSSEGSTIDIKPEVEEVPVEQPEEYLDPDACFTEGCVQR 1168
                        |.:.||.:..:|:....|..|......:.|||.....:.: |.|         
 Worm   733 ------------EGEDEGEEHGMDEPEGDEEMTSARPRRMSEVPAASTVKPI-PKA--------- 775

Human  1169 FKCCQVNIEEGLGKSWWILRKT------CFLIVEHNWFETFIIFMILLSSGALAFEDIYIEQRKT 1227
                         .|.:||..|      |.::|.|::|...::|.||:||..||.|| .::...|
 Worm   776 -------------SSLFILSHTNSFRVFCNMVVNHSYFTNAVLFCILVSSAMLAAED-PLQANST 826

Human  1228 IRTILEYADKVFTYIFILEMLLKWTAYGFV----KFFTNAWCWLDFLIVAVSLVSLIANALGYSE 1288
            ...||.|.|..||.:|.:|:.||...:|.|    .|..||:..||.|:|||||.|.:   |....
 Worm   827 RNMILNYFDYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVVAVSLTSFV---LRTDA 888

Human  1289 LGAIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKY 1353
            :..:|.||.||.||||||::|.:|::.||..::.|:.:|.|::||..:...:|:|:||.||.|.:
 Worm   889 MSVVKILRVLRVLRPLRAINRAKGLKHVVQCVIVAVKTIGNIMLVTFMLQFMFAIIGVQLFKGTF 953

Human  1354 HYCFNETSEIRFEIEDVNNKTECE------KLMEGNNT-----EIRWKNVKINFDNVGAGYLALL 1407
            ..|           .|::..||.|      ...:|:.|     :..|.|...||||||...::|.
 Worm   954 FLC-----------NDLSKMTEAECRGEYIHYEDGDPTKPVSKKRVWSNNDFNFDNVGDAMISLF 1007

Human  1408 QVATFKGWMDIMYAAVDSRKPDEQPKYEDNIYMYIYFVIFIIFGSFFTLNLFIGVIIDNF-NQQK 1471
            .|:||:||..::|.|:||.:.|:.|.:.....:.::|:.|||..:||.:|:|:|.:|..| |:.:
 Worm  1008 VVSTFEGWPQLLYVAIDSNEEDKGPIHNSRQAVALFFIAFIIVIAFFMMNIFVGFVIVTFQNEGE 1072

Human  1472 KKFGGQDIFMTEEQKKYYN-AMKKLGSKKPQKPIPRPLNKIQGIVFDFVTQQAFDIVIMMLICLN 1535
            :::  ::..:.:.|:|... |:|   :|..::.|||  |::|..|:.|||.:||:.||.::|.:|
 Worm  1073 REY--ENCELDKNQRKCIEFALK---AKPHRRYIPR--NRLQYRVWWFVTSRAFEYVIFLIIVMN 1130

Human  1536 MVTMMVETDTQSKQMENILYWINLVFVIFFTCECVLKMFALR-HYYFTIGWNIFDFVVVILSIVG 1599
            .|::..:....|:..|:.|...||:|...|..|.|||:.||. ..|.:..||:||.:||    ||
 Worm  1131 TVSLACKHYPSSRGFEDFLDVFNLIFTGVFAFEAVLKIVALNPKNYISDRWNVFDLLVV----VG 1191

Human  1600 MFLADIIEKY------FVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLL 1658
            .|:.....|.      .:|...|   ||.|:.|:::|:...:||||||:..|.|..||..:.||:
 Worm  1192 SFIDITYGKLNPGGTNLISINFF---RLFRVMRLVKLLSRGEGIRTLLWTFMKSFQALPYVALLI 1253

Human  1659 FLVMFIFSIFGMSNFAYVKHEAGIDDMF------NFETFGNSMICLFQITTSAGWDGLLLPILNR 1717
            .|:.||:::.||..|..|    .:||..      ||.:|..:::.||:..|...|..::|...:|
 Worm  1254 VLLFFIYAVIGMQFFGKV----ALDDSTSIHRNNNFHSFPAAILVLFRSATGEAWQDIMLSCSDR 1314

Human  1718 PP---DCSLDKEHPGSGFKGDCGNPSVGIFFFVSYIIISFLIVVNMYIAIILENFSVATEESADP 1779
            ..   |...|..|.|...:..||| :....:|:|:.::...:|:|:::|:|::||...|.:.: .
 Worm  1315 EDVRCDPMSDDYHKGGLNESRCGN-NFAYPYFISFFMLCSFLVINLFVAVIMDNFDYLTRDWS-I 1377

Human  1780 LSEDDFETFYEIWEKFDPDATQFIEYCKLADFADALEHPLRVPK--PNTI---ELIAMDLPMVSG 1839
            |.....|.|..:|.::||||...|::..:......:..||...|  |:.:   .|::|::|:.|.
 Worm  1378 LGPHHLEEFVRLWSEYDPDAKGRIKHLDVVTLLRKISPPLGFGKLCPHRLACKRLVSMNMPLNSD 1442

Human  1840 DRIHCLDILFAF--TKRVLGDSGELDILRQQM 1869
            ..:.....|||.  |...:...|.:|...:|:
 Worm  1443 GTVCFNATLFALVRTNLKIYTEGNIDEANEQL 1474

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SCN8ANP_001317189.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..20
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 28..62
I. /evidence=ECO:0000305 114..442 92/358 (26%)
Ion_trans 131..421 CDD:395416 83/320 (26%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 446..530 10/83 (12%)
Na_trans_cytopl 504..702 CDD:403218 16/199 (8%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 568..602 4/33 (12%)
II. /evidence=ECO:0000305 735..1007 84/283 (30%)
Ion_trans 752..965 CDD:395416 69/224 (31%)
Na_trans_assoc 991..1192 CDD:399489 22/206 (11%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1107..1148 8/40 (20%)
III. /evidence=ECO:0000305 1180..1495 113/337 (34%)
Ion_trans 1197..1473 CDD:395416 103/291 (35%)
Na_channel_gate 1465..1517 CDD:240441 13/53 (25%)
IV. /evidence=ECO:0000305 1504..1801 101/312 (32%)
Ion_trans 1522..1776 CDD:395416 84/269 (31%)
GPHH 1788..1835 CDD:407139 13/51 (25%)
IQ 1894..1915 CDD:197470
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1922..1980
egl-19NP_001023079.1 Ion_trans 105..379 CDD:278921 82/328 (25%)
Ion_trans 493..714 CDD:278921 77/234 (33%)
Ion_trans 815..1074 CDD:278921 96/273 (35%)
Ion_trans 1134..1376 CDD:278921 77/253 (30%)
GPHH 1384..1447 CDD:293510 16/62 (26%)
Ca_chan_IQ 1449..1521 CDD:285917 7/26 (27%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D172471at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R175
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
43.950

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