Sequence 1: | NP_001317189.1 | Gene: | SCN8A / 6334 | HGNCID: | 10596 | Length: | 1980 | Species: | Homo sapiens |
---|---|---|---|---|---|---|---|---|---|
Sequence 2: | NP_001023079.1 | Gene: | egl-19 / 177513 | WormBaseID: | WBGene00001187 | Length: | 1877 | Species: | Caenorhabditis elegans |
Alignment Length: | 1852 | Identity: | 454/1852 - (24%) |
---|---|---|---|
Similarity: | 775/1852 - (41%) | Gaps: | 537/1852 - (28%) |
- Green bases have known domain annotations that are detailed below.
Human 111 ALYILSPFNLIRRIAIKILIHSVFSMIIMCTILTNCVFMTFSNP-----PDWS----KNVEYTFT 166
Human 167 GIYTFESLVKIIARGFCIDGFTFLRDPWNWLDFSVIMMAYVTEF-----VDLGNVSALRTFRVLR 226
Human 227 ALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCVVWPINFNES 291
Human 292 YLENGTKGFDWEEYINNKTNFYTVPGML---EPLLCGNSSD--AGQCPEG---------YQCMK- 341
Human 342 -AGRNPNYGYTSFDTFSWAFLALFRLMTQDYWENLYQLTLRAAGKTY-MIFFVLVIFVGSFYLVN 404
Human 405 LILAVVAMAYEEQNQATLEEAEQKEAEFKAMLEQLKKQQEEAQAAAMATSAGTVSEDAIEEEGEE 469
Human 470 GGGSPRSSSEISKLSSKSAKERRNRRKKRKQKELSEGEEKGDPEKVFKSESEDGMRRKAFRLPDN 534
Human 535 RIGRKFSIMNQSLLSIPGSPFLSRHNSKSSIFSFRGPGRFRDPGSENEFADDEHSTVEESEGRRD 599
Human 600 SLFIPIRARERRSSYSGYSGYSQGSRSSRIFPSLRRSVKRNSTVDCNGVVSLIGGPGSHIGGRLL 664
Human 665 PEATTEV--EIKKKGPGSLLVSMDQLASYGRKDRINSIMSVVTNTLVEELEESQRKCPPCWYKF- 726
Human 727 -ANTFLIWECHPYWIKLKEIVNLIVMDPFVDLAITICIVLNTLFMAMEHHPMTPQFEHVLAVGNL 790
Human 791 VFTGIFTAEMFLKLIAMDPYYYFQEGWNIFDGFIVSLSLMELSLADVE-----GLSVLRSFRLLR 850
Human 851 VFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKINQDCELP 915
Human 916 RWHMHDFFHSFLIVFRVLCGE-WIETMWDCME------VAGQAMCLIVFMMVMVIGNLVVLNLFL 973
Human 974 ALLLSSFSADNLAATDDDGEMNNLQISVIRIKKGVAWTKLKVHAFMQAHFKQREADEVKPLDELY 1038
Human 1039 EKKANCIANHTGADIHRNGDFQKNGNGTTSGIGSSVEKYIIDEDHMSFINNPNLTVRVPIAVGES 1103
Human 1104 DFENLNTEDVSSESDPEGSKDKLDDTSSSEGSTIDIKPEVEEVPVEQPEEYLDPDACFTEGCVQR 1168
Human 1169 FKCCQVNIEEGLGKSWWILRKT------CFLIVEHNWFETFIIFMILLSSGALAFEDIYIEQRKT 1227
Human 1228 IRTILEYADKVFTYIFILEMLLKWTAYGFV----KFFTNAWCWLDFLIVAVSLVSLIANALGYSE 1288
Human 1289 LGAIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKY 1353
Human 1354 HYCFNETSEIRFEIEDVNNKTECE------KLMEGNNT-----EIRWKNVKINFDNVGAGYLALL 1407
Human 1408 QVATFKGWMDIMYAAVDSRKPDEQPKYEDNIYMYIYFVIFIIFGSFFTLNLFIGVIIDNF-NQQK 1471
Human 1472 KKFGGQDIFMTEEQKKYYN-AMKKLGSKKPQKPIPRPLNKIQGIVFDFVTQQAFDIVIMMLICLN 1535
Human 1536 MVTMMVETDTQSKQMENILYWINLVFVIFFTCECVLKMFALR-HYYFTIGWNIFDFVVVILSIVG 1599
Human 1600 MFLADIIEKY------FVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLL 1658
Human 1659 FLVMFIFSIFGMSNFAYVKHEAGIDDMF------NFETFGNSMICLFQITTSAGWDGLLLPILNR 1717
Human 1718 PP---DCSLDKEHPGSGFKGDCGNPSVGIFFFVSYIIISFLIVVNMYIAIILENFSVATEESADP 1779
Human 1780 LSEDDFETFYEIWEKFDPDATQFIEYCKLADFADALEHPLRVPK--PNTI---ELIAMDLPMVSG 1839
Human 1840 DRIHCLDILFAF--TKRVLGDSGELDILRQQM 1869 |
Gene | Sequence | Domain | Region | External ID | Identity |
---|---|---|---|---|---|
SCN8A | NP_001317189.1 | Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 1..20 | ||
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 28..62 | ||||
I. /evidence=ECO:0000305 | 114..442 | 92/358 (26%) | |||
Ion_trans | 131..421 | CDD:395416 | 83/320 (26%) | ||
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 446..530 | 10/83 (12%) | |||
Na_trans_cytopl | 504..702 | CDD:403218 | 16/199 (8%) | ||
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 568..602 | 4/33 (12%) | |||
II. /evidence=ECO:0000305 | 735..1007 | 84/283 (30%) | |||
Ion_trans | 752..965 | CDD:395416 | 69/224 (31%) | ||
Na_trans_assoc | 991..1192 | CDD:399489 | 22/206 (11%) | ||
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 1107..1148 | 8/40 (20%) | |||
III. /evidence=ECO:0000305 | 1180..1495 | 113/337 (34%) | |||
Ion_trans | 1197..1473 | CDD:395416 | 103/291 (35%) | ||
Na_channel_gate | 1465..1517 | CDD:240441 | 13/53 (25%) | ||
IV. /evidence=ECO:0000305 | 1504..1801 | 101/312 (32%) | |||
Ion_trans | 1522..1776 | CDD:395416 | 84/269 (31%) | ||
GPHH | 1788..1835 | CDD:407139 | 13/51 (25%) | ||
IQ | 1894..1915 | CDD:197470 | |||
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 1922..1980 | ||||
egl-19 | NP_001023079.1 | Ion_trans | 105..379 | CDD:278921 | 82/328 (25%) |
Ion_trans | 493..714 | CDD:278921 | 77/234 (33%) | ||
Ion_trans | 815..1074 | CDD:278921 | 96/273 (35%) | ||
Ion_trans | 1134..1376 | CDD:278921 | 77/253 (30%) | ||
GPHH | 1384..1447 | CDD:293510 | 16/62 (26%) | ||
Ca_chan_IQ | 1449..1521 | CDD:285917 | 7/26 (27%) | ||
Blue background indicates that the domain is not in the aligned region. |
Tool | Simple Score | Weighted Score | Original Tool Information | |||
---|---|---|---|---|---|---|
BLAST Result | Score | Score Type | Cluster ID | |||
Compara | 0 | 0.000 | Not matched by this tool. | |||
Domainoid | 0 | 0.000 | Not matched by this tool. | |||
eggNOG | 0 | 0.000 | Not matched by this tool. | |||
Hieranoid | 0 | 0.000 | Not matched by this tool. | |||
Homologene | 0 | 0.000 | Not matched by this tool. | |||
Inparanoid | 0 | 0.000 | Not matched by this tool. | |||
Isobase | 0 | 0.000 | Not matched by this tool. | |||
OMA | 0 | 0.000 | Not matched by this tool. | |||
OrthoDB | 1 | 1.010 | - | - | D172471at2759 | |
OrthoFinder | 0 | 0.000 | Not matched by this tool. | |||
OrthoInspector | 0 | 0.000 | Not matched by this tool. | |||
orthoMCL | 0 | 0.000 | Not matched by this tool. | |||
Panther | 0 | 0.000 | Not matched by this tool. | |||
Phylome | 1 | 0.910 | - | - | ||
RoundUp | 1 | 1.030 | - | avgDist | Average_Evolutionary_Distance | R175 |
SonicParanoid | 0 | 0.000 | Not matched by this tool. | |||
SwiftOrtho | 1 | 1.000 | - | - | ||
TreeFam | 0 | 0.000 | Not matched by this tool. | |||
4 | 3.950 |