| Sequence 1: | NP_001317189.1 | Gene: | SCN8A / 6334 | HGNCID: | 10596 | Length: | 1980 | Species: | Homo sapiens |
|---|---|---|---|---|---|---|---|---|---|
| Sequence 2: | NP_001293824.1 | Gene: | unc-77 / 177379 | WormBaseID: | WBGene00006809 | Length: | 1867 | Species: | Caenorhabditis elegans |
| Alignment Length: | 2054 | Identity: | 376/2054 - (18%) |
|---|---|---|---|
| Similarity: | 725/2054 - (35%) | Gaps: | 632/2054 - (30%) |
- Green bases have known domain annotations that are detailed below.
|
Human 134 FSMIIMCTI--LTNCVF----MTFSNPPDW-SKNVEYTFTGIYTFESLVKIIARGFCIDGFTFLR 191
Human 192 DPWNWLDFSVIM--------MAYVTEFVD-------------LGNVSALRTFRVLRALKTISVIP 235
Human 236 GLKTIVGALI-QSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCVVWPINFNESYLENGTKG 299
Human 300 FDWEEYINNKT--NFYTVPGMLEP-LLCGNSSDAG-QCPEGYQCMKAGRNPN----YGYTSFDTF 356
Human 357 SWAFLALFRLMTQDYWEN-LYQLTLRAAGKTYMIFFVLVIFVGSFYLVNLILAVVAMAYEEQNQA 420
Human 421 TLEEAEQKEAEFKAMLEQLKKQQEEAQAAAMATSAGTVSEDAIEEEGEEGGGSPRSSSEISKLSS 485
Human 486 KSAKERRNRRKKRKQKELSEGEEKGDPEKVFKSESEDGMRRKAFRLPDNRIGRKFSIMNQSLLSI 550
Human 551 PGSPFLSRHNSKSSIFSFRGPGRFRDPGSENEFADDEHSTVEESEGRRDSLFIPIRARERRSSYS 615
Human 616 GYSGYSQGSRSSRIFPSLRRSVKRNSTVDCNGVVSLIGGPGSHIGGRLLPEATTEVEIKKKGPGS 680
Human 681 LLVSMDQLASYGRKDRINSIMSVVTNTLVEELEESQRKCPPCWYKFANTFLIWECHPYWIKLKEI 745
Human 746 VNLIVMDPFVDLAITICIVLNTLFMAMEHHPMTPQFEHVLAVG--NLVFTGIFTAEMFLKL-IAM 807
Human 808 DPYYYFQEGWNIFDGFIVSLSLMELSLADVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSV 872
Human 873 GALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKINQDCELPR-WHMHDFFHSFLIVFRVLCGE 936
Human 937 -WIETMWDCMEVAGQAMCLIV---FMMVMVIGNLVVLNLFLALLLSSFSADNLAATDDDGEMNNL 997
Human 998 QI--SVIRIKKGVAW-----TKLKVHAFMQAHFKQREADEVKPLDELYEKKANCIANHTGADIHR 1055
Human 1056 NGDFQKNGN-GTTSGIGSSVE--KYIIDEDHMSFINNPNLTVRVPIAVGESDFE-NLNT------ 1110
Human 1111 ---EDVSSE-------SDPEGS----KDKLDDTSSSEGSTI----------------DIKPEVEE 1145
Human 1146 VPVEQPEE-YLDPDACFTEGCVQRFKCCQV---NIEEGLGKSWWILRKTCFLIVEHNWFETFIIF 1206
Human 1207 MILL--------SSGALAFEDIYIEQRKTIRTI--LEYADKVFTYIFILEMLLK--WTAYGFVKF 1259
Human 1260 FTNAWCWLD--FLIVAVSL---VSLIANALGYS------ELGAIKS------------------- 1294
Human 1295 -------LRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGK 1352
Human 1353 YHYCFNETSEIRFEIEDVNNKTEC-----EKL------MEGNNTEIR---------WKNVK-INF 1396
Human 1397 DNVGAGYLALLQVATFKGW---MDIMYAAVDSRKPDEQPKYEDNIYMYIYFVIFIIFGSFFTLNL 1458
Human 1459 FIGVIIDNFNQQKKKFGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPLN--KIQGIVFDFVTQ 1521
Human 1522 QAFDIVIMMLICLNMVTMMVETDTQSKQ--------MENILYWINLVFVIFFTCECVLKMFALRH 1578
Human 1579 YYFTIGW----NIFDFVVVILSIVGMFLADIIEKYFVSPTLFRV-----IRLAR----------I 1624
Human 1625 GRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIFSIFGMSNFAYVKHEAGIDDMFNFE 1689
Human 1690 TFGNSMICLFQITTSAGWDGLLLPILNRPPDCSLDKEHPGSGF-KGDCGNPSVGIFFFVSYIIIS 1753
Human 1754 FLIVVNMYIAIILENFSV--ATEESADPLSEDDFETFYEIWEKFDPDATQFIEYCKLADFADALE 1816
Human 1817 HPLRV-PKPNTIELIAMDLPMV---SGDRIHCLDILFAFTKRV--LGDSGELDILRQQMEERFVA 1875
Human 1876 SNPSKVSYEPITTTLRRKQEEVSAVVLQRAYRGHLARRGFICKKTTSNKLENGGTHREKKESTPS 1940
Human 1941 TASLPSYDSVTKPEKEKQQRAEEGRRERAKRQKEVRESK 1979 |
| Gene | Sequence | Domain | Region | External ID | Identity |
|---|---|---|---|---|---|
| SCN8A | NP_001317189.1 | Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 1..20 | ||
| Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 28..62 | ||||
| I. /evidence=ECO:0000305 | 114..442 | 62/345 (18%) | |||
| Ion_trans | 131..421 | CDD:395416 | 60/324 (19%) | ||
| Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 446..530 | 10/83 (12%) | |||
| Na_trans_cytopl | 504..702 | CDD:403218 | 22/197 (11%) | ||
| Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 568..602 | 3/33 (9%) | |||
| II. /evidence=ECO:0000305 | 735..1007 | 53/281 (19%) | |||
| Ion_trans | 752..965 | CDD:395416 | 42/220 (19%) | ||
| Na_trans_assoc | 991..1192 | CDD:399489 | 41/251 (16%) | ||
| Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 1107..1148 | 11/76 (14%) | |||
| III. /evidence=ECO:0000305 | 1180..1495 | 77/387 (20%) | |||
| Ion_trans | 1197..1473 | CDD:395416 | 73/348 (21%) | ||
| Na_channel_gate | 1465..1517 | CDD:240441 | 8/53 (15%) | ||
| IV. /evidence=ECO:0000305 | 1504..1801 | 76/328 (23%) | |||
| Ion_trans | 1522..1776 | CDD:395416 | 65/283 (23%) | ||
| GPHH | 1788..1835 | CDD:407139 | 10/47 (21%) | ||
| IQ | 1894..1915 | CDD:197470 | 5/20 (25%) | ||
| Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 1922..1980 | 12/58 (21%) | |||
| unc-77 | NP_001293824.1 | Ion_trans | 107..383 | CDD:278921 | 56/319 (18%) |
| Ion_trans | 455..660 | CDD:278921 | 58/289 (20%) | ||
| Ion_trans | 973..1214 | CDD:278921 | 58/262 (22%) | ||
| Ion_trans | 1310..1534 | CDD:278921 | 59/238 (25%) | ||
| Blue background indicates that the domain is not in the aligned region. | |||||
| Tool | Simple Score | Weighted Score | Original Tool Information | |||
|---|---|---|---|---|---|---|
| BLAST Result | Score | Score Type | Cluster ID | |||
| Compara | 0 | 0.000 | Not matched by this tool. | |||
| Domainoid | 0 | 0.000 | Not matched by this tool. | |||
| eggNOG | 0 | 0.000 | Not matched by this tool. | |||
| Hieranoid | 0 | 0.000 | Not matched by this tool. | |||
| Homologene | 0 | 0.000 | Not matched by this tool. | |||
| Inparanoid | 0 | 0.000 | Not matched by this tool. | |||
| Isobase | 0 | 0.000 | Not matched by this tool. | |||
| OMA | 0 | 0.000 | Not matched by this tool. | |||
| OrthoDB | 1 | 1.010 | - | - | D172471at2759 | |
| OrthoFinder | 0 | 0.000 | Not matched by this tool. | |||
| OrthoInspector | 0 | 0.000 | Not matched by this tool. | |||
| orthoMCL | 0 | 0.000 | Not matched by this tool. | |||
| Panther | 0 | 0.000 | Not matched by this tool. | |||
| Phylome | 1 | 0.910 | - | - | ||
| RoundUp | 1 | 1.030 | - | avgDist | Average_Evolutionary_Distance | R175 |
| SonicParanoid | 0 | 0.000 | Not matched by this tool. | |||
| SwiftOrtho | 1 | 1.000 | - | - | ||
| TreeFam | 0 | 0.000 | Not matched by this tool. | |||
| 4 | 3.950 | |||||