DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SCN8A and scn1a

DIOPT Version :9

Sequence 1:	NP_001317189.1	Gene:	SCN8A / 6334	HGNCID:	10596	Length:	1980	Species:	Homo sapiens
Sequence 2:	XP_012826731.2	Gene:	scn1a / 100488621	XenbaseID:	XB-GENE-978019	Length:	2020	Species:	Xenopus tropicalis

Alignment Length:	2044	Identity:	1520/2044 - (74%)
Similarity:	1708/2044 - (83%)	Gaps:	90/2044 - (4%)

- Green bases have known domain annotations that are detailed below.

Human     1 MAARLLAPPGPDSFKPFTPESLANIERRIAESKLKKPPKADGSHREDDEDSKPKPNSDLEAGKSL 65
            ||...|.|||||||:.|:.|||..||:||||.|.|||.:   .||:||:|:.|||:|||||||||
Frog     1 MAQARLVPPGPDSFRYFSRESLEAIEKRIAEEKAKKPKQ---EHRDDDDDNGPKPSSDLEAGKSL 62

Human    66 PFIYGDIPQGLVAVPLEDFDPYYLTQKTFVVLNRGKTLFRFSATPALYILSPFNLIRRIAIKILI 130
            ||||||||.|:|:.||||.||||:.||||:||||||.:||||||.|||||:|||.:|::|||:|:
Frog    63 PFIYGDIPPGMVSEPLEDLDPYYMNQKTFIVLNRGKAIFRFSATSALYILTPFNPLRKVAIKVLV 127

Human   131 HSVFSMIIMCTILTNCVFMTFSNPPDWSKNVEYTFTGIYTFESLVKIIARGFCIDGFTFLRDPWN 195
            ||:|||:|||||||||||||.||||:|:||||||||||||||||:||:|||||::.|||||||||
Frog   128 HSLFSMLIMCTILTNCVFMTMSNPPEWTKNVEYTFTGIYTFESLIKILARGFCLEKFTFLRDPWN 192

Human   196 WLDFSVIMMAYVTEFVDLGNVSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVF 260
            |||||||:||||||||:||||||||||||||||||||||||||||||||||||||||||||||||
Frog   193 WLDFSVIVMAYVTEFVNLGNVSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVF 257

Human   261 CLSVFALIGLQLFMGNLRNKCVVWP-----------------INFNESYLENGTKGFDWEEYINN 308
            |||||||||||||||:|||||:.||                 :|.::.:.......|||||||.:
Frog   258 CLSVFALIGLQLFMGHLRNKCLQWPPIDYFPLINIPPILNGTMNIHDPFGNTTNSTFDWEEYITD 322

Human   309 KTNFYTVPGMLEPLLCGNSSDAGQCPEGYQCMKAGRNPNYGYTSFDTFSWAFLALFRLMTQDYWE 373
            |.:||.:.|..:.||||||||:||||:||.|:|.|:|||||||||||||||||:|||||||||||
Frog   323 KNHFYKLEGQKDFLLCGNSSDSGQCPKGYICVKTGKNPNYGYTSFDTFSWAFLSLFRLMTQDYWE 387

Human   374 NLYQLTLRAAGKTYMIFFVLVIFVGSFYLVNLILAVVAMAYEEQNQATLEEAEQKEAEFKAMLEQ 438
            |||||||||||||||||||||||:|||||||||||||||||||||||||||||||||||:.||||
Frog   388 NLYQLTLRAAGKTYMIFFVLVIFLGSFYLVNLILAVVAMAYEEQNQATLEEAEQKEAEFQQMLEQ 452

Human   439 LKKQQEEAQAAAMATSAGTVSEDAIEEEGEEGGGSP--RSSSEISKLSSKSAKERRNRRKKRKQK 501
            ||||||||||||:|      :.:...|..|:||..|  .||||.|||||||||:||||:||||||
Frog   453 LKKQQEEAQAAAVA------ALNMSREYSEDGGFGPLSESSSEASKLSSKSAKDRRNRKKKRKQK 511

Human   502 ELSEGEEKGDPEKVFKSESEDGMRRKAFR--LPDNRI--GRKFSIMNQSLLSIPGSPFLSRHNSK 562
            ||.|..||||.||..|||||..::||.||  :..||:  ..|||..:||||||.||.|..|.||:
Frog   512 ELGEEYEKGDDEKFPKSESETSIKRKGFRFSIEGNRLTYENKFSSPHQSLLSIRGSLFSPRRNSR 576

Human   563 SSIFSFRGPGRFRDPGSENEFADDEHSTVEESEGRRDSLFIPIRARERRSSYSGYSGYSQGSRSS 627
            :|:||||  .|.:|.||||:||||||||.|::|.||.|||:|.|..|||:     |..||.|:||
Frog   577 ASLFSFR--NRAKDVGSENDFADDEHSTFEDNESRRGSLFVPNRHGERRN-----SNISQVSKSS 634

Human   628 RIFPSLRRSVKRNSTVDCNGVVSLIGGPGSHIG--GRLLPE------------ATTEVEIKKKGP 678
            :....|..:.|.:|||||||||||:|||.....  |.||||            .|||.||:|:..
Frog   635 KTMTVLPANGKMHSTVDCNGVVSLLGGPSVPTSPVGLLLPEVIVDKPASDDNGTTTETEIRKRKS 699

Human   679 GSLLVSMDQLASYGRKDRINSIMSVVTNTLVEELEESQRKCPPCWYKFANTFLIWECHPYWIKLK 743
            ....|.||.|.....:.|..|:.|::||| |||||||::||||||||||||||||:|...|:.:|
Frog   700 SCYQVPMDLLEDPTARQRALSVASILTNT-VEELEESRQKCPPCWYKFANTFLIWDCCENWLTVK 763

Human   744 EIVNLIVMDPFVDLAITICIVLNTLFMAMEHHPMTPQFEHVLAVGNLVFTGIFTAEMFLKLIAMD 808
            .||.|||||||||||||||||||||||||||:|||.:|..||::|||||||||||||..||||:|
Frog   764 HIVKLIVMDPFVDLAITICIVLNTLFMAMEHYPMTKEFNDVLSIGNLVFTGIFTAEMVFKLIALD 828

Human   809 PYYYFQEGWNIFDGFIVSLSLMELSLADVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVG 873
            ||||||||||||||.|||||||||.||:|||||||||||||||||||||||||||||||||||||
Frog   829 PYYYFQEGWNIFDGIIVSLSLMELGLANVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVG 893

Human   874 ALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKINQDCELPRWHMHDFFHSFLIVFRVLCGEWI 938
            |||||||||||||||||||||||||||||||||||.::||||||||:||||||||||||||||||
Frog   894 ALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKIAENCELPRWHMNDFFHSFLIVFRVLCGEWI 958

Human   939 ETMWDCMEVAGQAMCLIVFMMVMVIGNLVVLNLFLALLLSSFSADNLAATDDDGEMNNLQISVIR 1003
            ||||||||||||:|||:|||:||||||||||||||||||||||:|||.|||||.|||||||:|.|
Frog   959 ETMWDCMEVAGQSMCLLVFMLVMVIGNLVVLNLFLALLLSSFSSDNLTATDDDNEMNNLQIAVGR 1023

Human  1004 IKKGVAWTKLKVHAFMQAHF--KQREADEVKPLDELYEKKANCIANHTGADIHRNGDFQKNGNGT 1066
            |::|:.:.|..:...:|..|  ||:..||:|||:||:.|:.:|:.||...:|::..|:.|..|||
Frog  1024 IQRGIDYVKKTIRECIQKAFVKKQKGLDEIKPLEELHNKRESCLFNHNAVEINKVLDYHKGDNGT 1088

Human  1067 TSGIGSSVEKYIIDE-DHMSFINNPNLTVRVPIAVGESDFENLNTEDVSSESDPEGSKDKLDDTS 1130
            |||:||||||||||| |:||||:||:|||.|||||||||||||||||.|||||.|.||:||:.||
Frog  1089 TSGVGSSVEKYIIDENDYMSFIHNPSLTVTVPIAVGESDFENLNTEDFSSESDLEESKEKLNMTS 1153

Human  1131 SSEGSTIDIKP-----EVEEVPVE-QPEEYLDPDACFTEGCVQRFKCCQVNIEEGLGKSWWILRK 1189
            ||||||:||:|     |.|..|:: :.||.|:||||||||||:||..|.|||||..||.||..||
Frog  1154 SSEGSTVDIRPPGVVAEGEGEPIDIESEEALEPDACFTEGCVKRFPICYVNIEENKGKLWWTFRK 1218

Human  1190 TCFLIVEHNWFETFIIFMILLSSGALAFEDIYIEQRKTIRTILEYADKVFTYIFILEMLLKWTAY 1254
            ||:.|||||||||||||||||||||||||||||||||||:|:||||||||||||||||||||.||
Frog  1219 TCYTIVEHNWFETFIIFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTYIFILEMLLKWVAY 1283

Human  1255 GFVKFFTNAWCWLDFLIVAVSLVSLIANALGYSELGAIKSLRTLRALRPLRALSRFEGMRVVVNA 1319
            ||||:|||||||||||||.||||||:|||||||||||||||||||||||||||||||||||||||
Frog  1284 GFVKYFTNAWCWLDFLIVDVSLVSLVANALGYSELGAIKSLRTLRALRPLRALSRFEGMRVVVNA 1348

Human  1320 LVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKYHYCFNETSEIRFEIEDVNNKTECEKLMEGNN 1384
            |:||||||||||||||||||||||||||||||||::|.|.|:........|||:::|..|    |
Frog  1349 LIGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKYYHCVNTTTGEMLLDTQVNNRSDCLHL----N 1409

Human  1385 TEIRWKNVKINFDNVGAGYLALLQVATFKGWMDIMYAAVDSRKPDEQPKYEDNIYMYIYFVIFII 1449
            ...||||||:|||||||||||||||||||||||||||||||||.:|||:||||:|||:|||||||
Frog  1410 ESARWKNVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVDSRKVEEQPRYEDNLYMYLYFVIFII 1474

Human  1450 FGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKIQGI 1514
            ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||.||.||:
Frog  1475 FGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPPNKYQGL 1539

Human  1515 VFDFVTQQAFDIVIMMLICLNMVTMMVETDTQSKQMENILYWINLVFVIFFTCECVLKMFALRHY 1579
            ||||||:|||||:||:||||||||||:|||.||:.|||.||||||||:|.||.||:||:.:||||
Frog  1540 VFDFVTKQAFDIIIMILICLNMVTMMIETDEQSQDMENNLYWINLVFIILFTGECILKIISLRHY 1604

Human  1580 YFTIGWNIFDFVVVILSIVGMFLADIIEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFAL 1644
            |||||||||||||||||||||||||:|||||||||||||||||||||||||||||||||||||||
Frog  1605 YFTIGWNIFDFVVVILSIVGMFLADMIEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFAL 1669

Human  1645 MMSLPALFNIGLLLFLVMFIFSIFGMSNFAYVKHEAGIDDMFNFETFGNSMICLFQITTSAGWDG 1709
            ||||||||||||||||||||::|||||||||||.|:|||||||||||||||||||||||||||||
Frog  1670 MMSLPALFNIGLLLFLVMFIYAIFGMSNFAYVKKESGIDDMFNFETFGNSMICLFQITTSAGWDG 1734

Human  1710 LLLPILNR-PPDCSLDKEHPGSGFKGDCGNPSVGIFFFVSYIIISFLIVVNMYIAIILENFSVAT 1773
            ||.||||. .|||....|||||..|||||||||||||||||||||||:|||||||:|||||||||
Frog  1735 LLAPILNSGAPDCDPQMEHPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVAT 1799

Human  1774 EESADPLSEDDFETFYEIWEKFDPDATQFIEYCKLADFADALEHPLRVPKPNTIELIAMDLPMVS 1838
            ||||:||.|||||.|||:||||||||||||||.||::|||||:.|||:.|||.::||||||||||
Frog  1800 EESAEPLGEDDFEMFYEVWEKFDPDATQFIEYSKLSNFADALDPPLRIAKPNRVQLIAMDLPMVS 1864

Human  1839 GDRIHCLDILFAFTKRVLGDSGELDILRQQMEERFVASNPSKVSYEPITTTLRRKQEEVSAVVLQ 1903
            |||||||||||||||||||:..|:|.||..|||||:||||||.||||||:||||||||:|.|::|
Frog  1865 GDRIHCLDILFAFTKRVLGEGDEMDALRLPMEERFMASNPSKASYEPITSTLRRKQEELSVVIIQ 1929

Human  1904 RAYRGHLARR-----GFICKK-------------TTSNKLENGGTHREKKESTPSTASLPSYDSV 1950
            |.:|.:|.|:     .::.||             ...:|| ||.:..||.:.||||.|.||||||
Frog  1930 RCFRKYLLRKTIKKASYLYKKEKLGVNSLPIKEDMVIDKL-NGNSTTEKTDMTPSTTSPPSYDSV 1993

Human  1951 TKPEKEKQQRAEEGRRERAKRQKEVRESK 1979
            |||||||.   |:.:.|:..:.|:.||:|
Frog  1994 TKPEKEKH---EKDKAEKENKSKDARENK 2019

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SCN8A	NP_001317189.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..20		11/18 (61%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	28..62		20/33 (61%)
		I. /evidence=ECO:0000305	114..442		271/344 (79%)
		Ion_trans	131..421	CDD:395416	242/306 (79%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	446..530		50/85 (59%)
		Na_trans_cytopl	504..702	CDD:403218	103/215 (48%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	568..602		21/33 (64%)
		II. /evidence=ECO:0000305	735..1007		237/271 (87%)
		Ion_trans	752..965	CDD:395416	192/212 (91%)
		Na_trans_assoc	991..1192	CDD:399489	127/209 (61%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1107..1148		29/45 (64%)
		III. /evidence=ECO:0000305	1180..1495		270/314 (86%)
		Ion_trans	1197..1473	CDD:395416	237/275 (86%)
		Na_channel_gate	1465..1517	CDD:240441	48/51 (94%)
		IV. /evidence=ECO:0000305	1504..1801		258/297 (87%)
		Ion_trans	1522..1776	CDD:395416	223/254 (88%)
		GPHH	1788..1835	CDD:407139	35/46 (76%)
		IQ	1894..1915	CDD:197470	10/25 (40%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1922..1980		30/58 (52%)
scn1a	XP_012826731.2	Ion_trans	128..435	CDD:395416	242/306 (79%)
		Na_trans_cytopl	515..723	CDD:403218	103/214 (48%)
		Ion_trans	772..985	CDD:395416	192/212 (91%)
		Na_trans_assoc	1011..1222	CDD:399489	128/210 (61%)
		Ion_trans	1226..1498	CDD:395416	237/275 (86%)
		Na_channel_gate	1490..1542	CDD:240441	48/51 (94%)
		Ion_trans	1547..1802	CDD:395416	223/254 (88%)
		GPHH	1814..1861	CDD:407139	35/46 (76%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
NCBI	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG52281
OrthoDB	1	1.010	-	-		D37221at33208
OrthoFinder	1	1.000	-	-		FOG0000268
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X214
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.930