| Sequence 1: | NP_001317189.1 | Gene: | SCN8A / 6334 | HGNCID: | 10596 | Length: | 1980 | Species: | Homo sapiens |
|---|---|---|---|---|---|---|---|---|---|
| Sequence 2: | XP_031760488.1 | Gene: | scn5a / 100485924 | XenbaseID: | XB-GENE-6037407 | Length: | 1989 | Species: | Xenopus tropicalis |
| Alignment Length: | 2031 | Identity: | 1327/2031 - (65%) |
|---|---|---|---|
| Similarity: | 1541/2031 - (75%) | Gaps: | 149/2031 - (7%) |
- Green bases have known domain annotations that are detailed below.
|
Human 3 ARLLAPPGPDSFKPFTPESLANIERRIAESKLKKPPKADGSHREDDEDSKPKPNSDLEAGKSLPF 67
Human 68 IYGDIPQGLVAVPLEDFDPYYLTQKTFVVLNRGKTLFRFSATPALYILSPFNLIRRIAIKILIHS 132
Human 133 VFSMIIMCTILTNCVFMTFSNPPDWSKNVEYTFTGIYTFESLVKIIARGFCIDGFTFLRDPWNWL 197
Human 198 DFSVIMMAYVTEFVDLGNVSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCL 262
Human 263 SVFALIGLQLFMGNLRNKCVVWPINFNESYL-----ENGTKGFDWEEYINNKTNFYTVPGMLEPL 322
Human 323 LCGNSSDAGQCPEGYQCMKAGRNPNYGYTSFDTFSWAFLALFRLMTQDYWENLYQLTLRAAGKTY 387
Human 388 MIFFVLVIFVGSFYLVNLILAVVAMAYEEQNQATLEEAEQKEAEFKAMLEQLKKQQEEAQAAAMA 452
Human 453 TSAGTVSEDAIEEEGEEGGGSPRSSSEISKLSSKSAKERRNRRKKRKQKELSEGEEKGDPEKVFK 517
Human 518 SESEDGMRRKAFRLPDNRIGRKFSIMNQSLLSI---PGSPFLSRHNSKSSIFSFRGPGRFRDPGS 579
Human 580 ENEFADDEHSTVEESEGRRDSLFIPIRARERRS--------SYSGYSGYSQGSRSSRIFPSLRRS 636
Human 637 VKRNSTVDCNGVVSLIGGPGSHI-----GGRLLPEATTEVEIKKKG------PGSLLVSMDQL-- 688
Human 689 -----ASY----GRKDRINSIMSVVTNTLVEELEESQRKCPPCWYKFANTFLIWECHPYWIKLKE 744
Human 745 IVNLIVMDPFVDLAITICIVLNTLFMAMEHHPMTPQFEHVLAVGNLVFTGIFTAEMFLKLIAMDP 809
Human 810 YYYFQEGWNIFDGFIVSLSLMELSLADVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGA 874
Human 875 LGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKINQDCELPRWHMHDFFHSFLIVFRVLCGEWIE 939
Human 940 TMWDCMEVAGQAMCLIVFMMVMVIGNLVVLNLFLALLLSSFSADNLAATDDDGEMNNLQISVIRI 1004
Human 1005 KKGVAWTKLKVHAFMQAHFKQREADEVKPLDELYEKKANC----IANHTGADIHRNGDFQKNGNG 1065
Human 1066 TTSGIGSSVEKYIIDEDHMSFINNPNLTVRVPIAVGESDFENLNTEDVSSESDPEGSKDKLDDTS 1130
Human 1131 SSEGSTIDIKPE---VEEVPVEQPEEYLDPDACFTE--------GCVQRFKCCQVNIEEGLGKSW 1184
Human 1185 WILRKTCFLIVEHNWFETFIIFMILLSSGALAFEDIYIEQRKTIRTILEYADKVFTYIFILEMLL 1249
Human 1250 KWTAYGFVKFFTNAWCWLDFLIVAVSLVSLIANALGYSELGAIKSLRTLRALRPLRALSRFEGMR 1314
Human 1315 VVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKYHYCFNETSEIRFEIEDVNNKTECEKL 1379
Human 1380 MEGNNTEIRWKNVKINFDNVGAGYLALLQVATFKGWMDIMYAAVDSRKPDEQPKYEDNIYMYIYF 1444
Human 1445 VIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPLN 1509
Human 1510 KIQGIVFDFVTQQAFDIVIMMLICLNMVTMMVETDTQSKQMENILYWINLVFVIFFTCECVLKMF 1574
Human 1575 ALRHYYFTIGWNIFDFVVVILSIVGMFLADIIEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRT 1639
Human 1640 LLFALMMSLPALFNIGLLLFLVMFIFSIFGMSNFAYVKHEAGIDDMFNFETFGNSMICLFQITTS 1704
Human 1705 AGWDGLLLPILNR-PPDCSLDKEHPGSGFKGDCGNPSVGIFFFVSYIIISFLIVVNMYIAIILEN 1768
Human 1769 FSVATEESADPLSEDDFETFYEIWEKFDPDATQFIEYCKLADFADALEHPLRVPKPNTIELIAMD 1833
Human 1834 LPMVSGDRIHCLDILFAFTKRVLGDSGELDILRQQMEERFVASNPSKVSYEPITTTLRRKQEEVS 1898
Human 1899 AVVLQRAYRGHLARRGF---------------ICKKTTSNK--------LENGGTHREKKESTPS 1940
Human 1941 TASLPSYDSVTKPEKE 1956 |
| Gene | Sequence | Domain | Region | External ID | Identity |
|---|---|---|---|---|---|
| SCN8A | NP_001317189.1 | Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 1..20 | 12/16 (75%) | |
| Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 28..62 | 13/33 (39%) | |||
| I. /evidence=ECO:0000305 | 114..442 | 248/332 (75%) | |||
| Ion_trans | 131..421 | CDD:395416 | 224/294 (76%) | ||
| Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 446..530 | 30/83 (36%) | |||
| Na_trans_cytopl | 504..702 | CDD:403218 | 80/230 (35%) | ||
| Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 568..602 | 18/33 (55%) | |||
| II. /evidence=ECO:0000305 | 735..1007 | 216/271 (80%) | |||
| Ion_trans | 752..965 | CDD:395416 | 175/212 (83%) | ||
| Na_trans_assoc | 991..1192 | CDD:399489 | 82/215 (38%) | ||
| Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 1107..1148 | 15/43 (35%) | |||
| III. /evidence=ECO:0000305 | 1180..1495 | 242/314 (77%) | |||
| Ion_trans | 1197..1473 | CDD:395416 | 208/275 (76%) | ||
| Na_channel_gate | 1465..1517 | CDD:240441 | 48/51 (94%) | ||
| IV. /evidence=ECO:0000305 | 1504..1801 | 248/297 (84%) | |||
| Ion_trans | 1522..1776 | CDD:395416 | 214/254 (84%) | ||
| GPHH | 1788..1835 | CDD:407139 | 32/46 (70%) | ||
| IQ | 1894..1915 | CDD:197470 | 15/20 (75%) | ||
| Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 1922..1980 | 17/43 (40%) | |||
| scn5a | XP_031760488.1 | Ion_trans | 129..424 | CDD:395416 | 224/294 (76%) |
| Na_trans_cytopl | 485..675 | CDD:403218 | 80/230 (35%) | ||
| Ion_trans | 724..937 | CDD:395416 | 175/212 (83%) | ||
| Na_trans_assoc | 963..1176 | CDD:399489 | 83/216 (38%) | ||
| Ion_trans | 1180..1453 | CDD:395416 | 208/275 (76%) | ||
| Na_channel_gate | 1445..1497 | CDD:240441 | 48/51 (94%) | ||
| Ion_trans | 1502..1757 | CDD:395416 | 214/254 (84%) | ||
| GPHH | 1769..1816 | CDD:407139 | 32/46 (70%) |
| Tool | Simple Score | Weighted Score | Original Tool Information | |||
|---|---|---|---|---|---|---|
| BLAST Result | Score | Score Type | Cluster ID | |||
| Compara | 0 | 0.000 | Not matched by this tool. | |||
| Domainoid | 0 | 0.000 | Not matched by this tool. | |||
| eggNOG | 0 | 0.000 | Not matched by this tool. | |||
| Hieranoid | 0 | 0.000 | Not matched by this tool. | |||
| Homologene | 0 | 0.000 | Not matched by this tool. | |||
| Inparanoid | 0 | 0.000 | Not matched by this tool. | |||
| NCBI | 0 | 0.000 | Not matched by this tool. | |||
| OMA | 0 | 0.000 | Not matched by this tool. | |||
| OrthoDB | 1 | 1.010 | - | - | D172471at2759 | |
| OrthoFinder | 1 | 1.000 | - | - | FOG0000268 | |
| OrthoInspector | 0 | 0.000 | Not matched by this tool. | |||
| Panther | 0 | 0.000 | Not matched by this tool. | |||
| Phylome | 0 | 0.000 | Not matched by this tool. | |||
| RoundUp | 0 | 0.000 | Not matched by this tool. | |||
| SonicParanoid | 1 | 1.000 | - | - | X214 | |
| SwiftOrtho | 1 | 1.000 | - | - | ||
| TreeFam | 0 | 0.000 | Not matched by this tool. | |||
| 4 | 4.010 | |||||