DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment SCN7A and scn1lab

DIOPT Version :9

Sequence 1:NP_002967.2 Gene:SCN7A / 6332 HGNCID:10594 Length:1682 Species:Homo sapiens
Sequence 2:NP_001038360.2 Gene:scn1lab / 559447 ZFINID:ZDB-GENE-060906-1 Length:1996 Species:Danio rerio


Alignment Length:1953 Identity:891/1953 - (45%)
Similarity:1193/1953 - (61%) Gaps:285/1953 - (14%)


- Green bases have known domain annotations that are detailed below.


Human     1 MLASPEPKGLVPFTKESFELIKQHIA---------KTHNEDHEEEDLKPTPDLEVGKKLPFIYGN 56
            :|..|.|....||..||...|:|.||         :...:|.:|...||..|||.||.||||||:
Zfish     5 LLVPPGPDSFRPFLPESLAAIEQRIAEEVAQRPKGERRPDDDDENGPKPNRDLEAGKPLPFIYGD 69

Human    57 LSQGMVSEPLEDVDPYYYKKKNTFIVLNKNRTIFRFNAASILCTLSPFNCIRRTTIKVLVHPFFQ 121
            :...|:|.||||:|.||..:| ||||||:.:.||||||...|..|||||.:||.:|:||||..|.
Zfish    70 VPPHMLSVPLEDLDTYYSNQK-TFIVLNRGKAIFRFNATPALYILSPFNPLRRISIRVLVHSLFS 133

Human   122 LFILISVLIDCVFMSLTNLPKWRPVLENTLLGIYTFEILVKLFARGVWAGSFSFLGDPWNWLDFS 186
            ..|:.::|.:|.||:|:|.|:|...:|.|..||||||.|:|:.|||...|.|:||.|||||||||
Zfish   134 FVIMCTILTNCAFMTLSNPPEWAKNVEYTFTGIYTFESLIKILARGFCVGKFTFLRDPWNWLDFS 198

Human   187 VTVFEVIIRYSPLDFIPTLQTARTLRILKIIPLNQGLKSLVGVLIHCLKQLIGVIILTLFFLSIF 251
            |.:...:..:..|..:..|:|.|.||.||.|.:..|||::||.||..:|:|..|:|||:|.||:|
Zfish   199 VILMAYVTEFVNLGNVSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVF 263

Human   252 SLIGMGLFMGNLKHKCFRWPQEN--ENET-----LHNRTGN-PYYIRETENFYYLEGERYALLCG 308
            :|||:.||||||:.||.:.|:.|  :|.|     |||.|.| ..||.::.|:|::.|.|.|||||
Zfish   264 ALIGLQLFMGNLRQKCVKMPEVNVTDNLTDYSTELHNSTFNWTEYISDSNNYYFIPGRRDALLCG 328

Human   309 NRTDAGQCPEGYVCVKAGINPDQGFTNFDSFGWALFALFRLMAQDYPEVLYHQILYASGKVYMIF 373
            |.:||||||||:.|:|||.|||.|:|:||:|.||..:|||||.||:.|.||.|.|.|:||.||||
Zfish   329 NSSDAGQCPEGFTCIKAGRNPDYGYTSFDTFSWAFLSLFRLMTQDFWENLYQQTLRAAGKPYMIF 393

Human   374 FVVVSFLFSFYMASLFLGILAMAYEEEKQRVGEISKKIEPKFQ---------------------Q 417
            ||:|.||.|||:.:|.|.::||||:|:.|...|.:::.|.:||                     :
Zfish   394 FVLVIFLGSFYLVNLILAVVAMAYDEQNQATIEEAQQKEEEFQAMLEQLKRQQEEAQVAAAAATE 458

Human   418 TGKELQEGNETDE------------AKTIQIEMKKR----------------------------- 441
            :|:....|..::|            ||..:...|||                             
Zfish   459 SGEYSGRGGLSEESSSGGSRLSSKSAKERRNRRKKRKQREEEEKADQEKFHKSASEDSIRRPGFR 523

Human   442 ----------------------------------------------------------------- 441
                                                                             
Zfish   524 FSIDANRLSYEKKCSTPNQSLLSIRGSLFSPRRNSRASLFSFRGRARDFGSENDFADDEHSTFED 588

Human   442 -----------------------------------------------------------SPI--- 444
                                                                       |||   
Zfish   589 SDSRRGSLFVPRCVERRSSTVSHCSLTAPRIMLPANGKMHCTVDCNGVVSLVGGTSVPTSPIGRL 653

Human   445 ---STDTSLDV-------------LEDATLRHK------------EELEKSKKICPLYWYKFAKT 481
               .|.|..||             ||:...|.:            ||||:|::.||..|||||.:
Zfish   654 LPEGTTTESDVRKKRSGSHQPSDYLEETVARKRAMSVASILTNTMEELEESRQKCPPCWYKFANS 718

Human   482 FLIWNCSPCWLKLKEFVHRIIMAPFTDLFLIICIILNVCFLTLEHYPMSKQTNTLLNIGNLVFIG 546
            ||||:|||.|||:||.::.|:|.||.||.:.|||:||..|:.:|||||:.|.:.||::|||||.|
Zfish   719 FLIWDCSPAWLKVKEIMNMIVMDPFVDLAITICIVLNTLFMAMEHYPMTTQFSHLLSVGNLVFTG 783

Human   547 IFTAEMIFKIIAMHPYGYFQVGWNIFDSMIVFHGLIELCLANVAGMALLRLFRMLRIFKLGKYWP 611
            ||||||..|:||:.||.|||.||||||.:||...|:||.||||.|:::||.||:||:|||.|.||
Zfish   784 IFTAEMCLKVIALDPYYYFQEGWNIFDGIIVSLSLMELGLANVEGLSVLRSFRLLRVFKLAKSWP 848

Human   612 TFQILMWSLSNSWVALKDLVLLLFTFIFFSAAFGMKLFGKNYEEFVCHIDKDCQLPRWHMHDFFH 676
            |..:|:..:.||..||.:|.|:|...:|..|..||:||||:|.|.||.|.:.|:||||||.||||
Zfish   849 TLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYRECVCKISESCELPRWHMDDFFH 913

Human   677 SFLNVFRILCGEWVETLWDCMEVAGQSWCIPFYLMVILIGNLLVLYLFLA-LVSSFSSCKDVTAE 740
            |||.|||:|||||:||:||||||||||.|:..::||::||||:||.|||| |:||||:......:
Zfish   914 SFLIVFRVLCGEWIETMWDCMEVAGQSMCLIVFMMVMVIGNLVVLNLFLALLLSSFSADNLAATD 978

Human   741 ENNEAKNLQLAVARIKKGINYV------LLKILCKTQNVPKD-----TMDHVNEVYVKEDISDHT 794
            :::|..|||:||.||:|||..|      .|:.|....:.|:.     .:|.::....:..:|:|.
Zfish   979 DDSEMNNLQIAVGRIQKGIALVKSTLRQFLQSLFLAGSKPRSLDEEKPLDDLHSDGKENCLSNHA 1043

Human   795 LSELSNTQDFLKD--KEKSSGTEKNA----TENESQSLIPSPSVSETVPIASGESDIENLDNKEI 853
            ...:..|:|:||:  ....:|.|.:.    .|.:..|.|.:||::.|||||.||||.|||:.::.
Zfish  1044 PVAVDLTKDYLKEGCVSPGNGVESHVKYGIEEGDYMSFIHNPSLTVTVPIAVGESDFENLNTEDF 1108

Human   854 QSKSGD-GGSKEKIKQS---SSSECSTVDIAISEEEEMFYGGERSKHLK------------NGCR 902
            .|:|.| .|||||:...   ||||.|||||....|      |..|..|:            .||.
Zfish  1109 SSESSDVEGSKEKLPVDTVLSSSEGSTVDIRPPGE------GAESVELEPEESLDPEACFTEGCV 1167

Human   903 RGSSLGQISGASKKGKIWQNIRKTCCKIVENNWFKCFIGLVTLLSTGTLAFEDIYMDQRKTIKIL 967
            ......|:.....|.|.|..:||||..|||:|||:.||..:.|||:|.|||||||::||||||.:
Zfish  1168 MRFQCCQVDVEKGKWKSWWILRKTCFIIVEHNWFESFIIFMILLSSGALAFEDIYIEQRKTIKTV 1232

Human   968 LEYADMIFTYIFILEMLLKWMAYGFKAYFSNGWYRLDFVVVIVFCLSLIGKT-----REELKPLI 1027
            |||||.:|||||||||||||:||||..||:|.|..|||::|.|..:||:...     ...:|.|.
Zfish  1233 LEYADKVFTYIFILEMLLKWVAYGFAKYFTNAWCWLDFLIVDVSLVSLVANALGYSELSAIKSLR 1297

Human  1028 SMKFLRPLRVLSQFERMKVVVRALIKTTLPTLNVFLVCLMIWLIFSIMGVDLFAGRFYECIDPTS 1092
            :::.|||||.||:||.|:|||.||:......:||.||||:.|||||||||:||||::|.|::.|:
Zfish  1298 TLRALRPLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKYYYCVNITN 1362

Human  1093 GERFPSSEVMNKSRCESLL-FNESMLWENAKMNFDNVGNGFLSLLQVATFNGWITIMNSAIDSVA 1156
            .|.||.|.|.|||.|.:|: .|::..|:|.|:||||||.|:|:|||||||.||:.||.:|:||..
Zfish  1363 DELFPVSVVNNKSDCYALIQNNDTARWKNVKINFDNVGAGYLALLQVATFKGWMDIMYAAVDSRD 1427

Human  1157 VNIQPHFEVNIYMYCYFINFIIFGVFLPLSMLITVIIDNFNKHKIKLGGSNIFITVKQRKQYRRL 1221
            :..||.:|.|:|||.||:.|||||.|..|::.|.|||||||:.|.||||.:||:|.:|:|.|..:
Zfish  1428 LEQQPVYETNLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNAM 1492

Human  1222 KKLMYEDSQRPVPRPLNKLQGFIFDVVTSQAFNVIVMVLICFQAIAMMIDTDVQSLQMSIALYWI 1286
            |||..:..|:|:|||.||.||.:||::|.|||::|:|:|||...:.||::||.|:..|...||||
Zfish  1493 KKLGSKKPQKPIPRPANKFQGLVFDLITKQAFDIIIMILICLNMVTMMVETDDQTEDMDNILYWI 1557

Human  1287 NSIFVMLYTMECILKLIAFRCFYFTIAWNIFDFMVVIFSITGLCLPMTVGSYLVPPSLVQLILLS 1351
            |.:|::|:|.||:||:|:.|.::|||.||:|||:|||.||.|:.|...:..|.|.|:|.::|.|:
Zfish  1558 NLVFIILFTGECVLKMISLRHYFFTIGWNVFDFVVVILSIVGMFLSEMIEKYFVSPTLFRVIRLA 1622

Human  1352 RIIHMLRLGKGPKVFHNLMLPLMLSLPALLNIILLIFLVMFIYAVFGMYNFAYVKKEAGINDVSN 1416
            ||..:|||.||.|....|:..||:|||||.||.||:||||||||:|||.||||||:||||:|:.|
Zfish  1623 RIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFAYVKREAGIDDMFN 1687

Human  1417 FETFGNSMLCLFQVAIFAGWDGMLDAIFNSKWSDCDPDKINPGTQVRGDCGNPSVGIFYFVSYIL 1481
            |||||||||||||:...|||||:|..|.|.:..|||.:..:||:..||:|||||||||:|||||:
Zfish  1688 FETFGNSMLCLFQITTSAGWDGLLAPILNKQDPDCDSEMEHPGSFYRGNCGNPSVGIFFFVSYII 1752

Human  1482 ISWLIIVNMYIVVVMEFLNIASKKKNKTLSEDDFRKFFQVWKRFDPDRTQYIDSSKLSDFAAALD 1546
            |.:||:|||||.|::|..::|:::..:.||||||..|::||:||||:.||:::.:||||||.|||
Zfish  1753 ICFLIVVNMYIAVILENFSVATEESAEPLSEDDFEMFYEVWERFDPNATQFVEYNKLSDFADALD 1817

Human  1547 PPLFMAKPNKGQLIALDLPMAVGDRIHCLDILLAFTKRVMGQDVRMEKVVSEIESGFLLANPFKI 1611
            |||.:|||||.||||:||||..||||||||||.|||.||:|::..|:.:..::|..|:.:||.|:
Zfish  1818 PPLRIAKPNKIQLIAMDLPMVSGDRIHCLDILFAFTLRVLGEEGEMDALRGQMEDRFMASNPSKV 1882

Human  1612 TCEPITTTLKRKQEAVSATIIQRAYKNYRLRRNDKNTSDIH---MIDGDRDVHATKEGAYFDKAK 1673
            :.|||||||:||||.:||.:||||::.:|:|:..|..|:.:   :.||...: ..||.....|.:
Zfish  1883 SYEPITTTLRRKQEEMSAVVIQRAFRRHRIRQTVKKASEAYRKQLQDGGGHI-PEKEVLVIGKFQ 1946

Human  1674 EKS 1676
            |.|
Zfish  1947 ENS 1949

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SCN7ANP_002967.2 I. /evidence=ECO:0000305 100..401 163/308 (53%)
Ion_trans 146..403 CDD:278921 141/264 (53%)
II. /evidence=ECO:0000305 487..758 158/271 (58%)
Ion_trans 522..717 CDD:278921 116/194 (60%)
Na_trans_assoc 743..927 CDD:284034 70/216 (32%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 801..871 31/79 (39%)
III. /evidence=ECO:0000305 916..1224 176/313 (56%)
Ion_trans 951..1198 CDD:278921 144/252 (57%)
Na_channel_gate 1194..1246 CDD:240441 27/51 (53%)
IV. /evidence=ECO:0000305 1233..1531 168/297 (57%)
Ion_trans 1268..1497 CDD:278921 135/228 (59%)
scn1labNP_001038360.2 None


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
NCBI 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG52281
OrthoDB 1 1.010 - - D37221at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100419
Panther 1 1.100 - - O PTHR10037
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
65.930

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