DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment SCN7A and scn1laa

DIOPT Version :9

Sequence 1:NP_002967.2 Gene:SCN7A / 6332 HGNCID:10594 Length:1682 Species:Homo sapiens
Sequence 2:NP_956426.2 Gene:scn1laa / 393101 ZFINID:ZDB-GENE-040426-751 Length:1955 Species:Danio rerio


Alignment Length:1962 Identity:847/1962 - (43%)
Similarity:1152/1962 - (58%) Gaps:317/1962 - (16%)


- Green bases have known domain annotations that are detailed below.


Human     1 MLASPEPKGLVPFTKESFELIKQHIA-----KTHNEDHEEED----LKPTPDLEVGKKLPFIYGN 56
            |...|.|:.|..||:||.:.|:..||     |:.|.:...:|    .||...||.||.||||||.
Zfish     4 MFTPPGPQSLRKFTRESLKAIESRIAEENAKKSKNTEERNKDNECSRKPNSGLEAGKTLPFIYGE 68

Human    57 LSQGMVSEPLEDVDPYYYKKKNTFIVLNKNRTIFRFNAASILCTLSPFNCIRRTTIKVLVHPFFQ 121
            :.:|:||.||||:| .:|....||||::|.:.|:||||...|...|.||.:||.:|::|||..|.
Zfish    69 VPKGLVSTPLEDLD-QFYSNHTTFIVVSKKKEIYRFNATPALYIFSSFNLLRRISIQILVHFLFN 132

Human   122 LFILISVLIDCVFMSLTNLPKWRPVLENTLLGIYTFEILVKLFARGVWAGSFSFLGDPWNWLDFS 186
            ..|:.::|.:|.||..|..|.|...:|....||||.|.|||:.|||...|.|:||.||||||||.
Zfish   133 FIIICTILANCAFMVYTQTPDWAKNVEYVFTGIYTLEALVKITARGFCVGRFTFLRDPWNWLDFI 197

Human   187 VTVFEVIIRYSPLDFIPTLQTARTLRILKIIPLNQGLKSLVGVLIHCLKQLIGVIILTLFFLSIF 251
            |.|...:..:..|..:..|:..|.||.||.|.:..|||::||.||..:|:|..|:|||||.||:|
Zfish   198 VIVMAYVTEFVDLGSVSALRAFRVLRALKTISVVPGLKTIVGALIQSVKKLSDVMILTLFCLSVF 262

Human   252 SLIGMGLFMGNLKHKCFRWPQ--ENENETLHNRTGNPYYIRETENFYYLEGERYALLCGNRTDAG 314
            :|:|:.||||.||.||.....  ||:.....|:|... ||....|.|:|.|::.||:|||.:|||
Zfish   263 ALVGLQLFMGILKQKCVYSTSFTENKEACYKNKTCRD-YINNPSNQYFLPGKKDALICGNSSDAG 326

Human   315 QCPEGYVCVKAGINPDQGFTNFDSFGWALFALFRLMAQDYPEVLYHQILYASGKVYMIFFVVVSF 379
            ||||||.|:|||.|||.|:|:|||||||..:|||||.||:.|.||.|.|.|:||.||||||:|.|
Zfish   327 QCPEGYTCLKAGKNPDYGYTSFDSFGWAFLSLFRLMTQDFWENLYQQTLRAAGKTYMIFFVLVIF 391

Human   380 LFSFYMASLFLGILAMAYEEEKQRVGEISKKIEPKF----QQTGKELQE--------------GN 426
            |.|||:.:|.|.::||||:|:.|...:.:.|.|.:|    :|..::.||              |.
Zfish   392 LGSFYLVNLILAVVAMAYDEQNQATIDEALKKEEEFNAMLEQITRQEQEAEAAAEQSKCEGLSGE 456

Human   427 ETD-----------EAKTIQIEMKKR--------------------------------------- 441
            :||           .||..:...|||                                       
Zfish   457 KTDSSSDASKLSSKSAKERRNRKKKRQHQGESEKEEDSIKEGNDRKPNFTFAVDGKIRRSRDRSY 521

Human   442 -----SPISTDTSL--------------------------------------------------- 450
                 ||:|...||                                                   
Zfish   522 TSPRQSPLSFQGSLLTPRRDSKASVFSFRGRIHSDNNYADDEQSMFEETGSRRDSLFLPTRPERL 586

Human   451 ------------------------------------------------------------DVLED 455
                                                                        |...|
Zfish   587 FSNVSKSSLTPHLLLPSNGKARYVDDSNGMVMVTSGASAPNSPVIALNTPEVSRKRAMFDDTCAD 651

Human   456 A-------------------TLRHK------------EELEKSKKICPLYWYKFAKTFLIWNCSP 489
            :                   ::|.:            |..|..|:.|..:|::||:.:|||:|||
Zfish   652 SDDERRSRCNSQNFSKAYRQSMRERALSVASGSNNPAECSEIFKQRCEEWWFEFAENYLIWDCSP 716

Human   490 CWLKLKEFVHRIIMAPFTDLFLIICIILNVCFLTLEHYPMSKQTNTLLNIGNLVFIGIFTAEMIF 554
            .||::||.||.|:|.||.|||:.|||::|..|:.:|.|||....:::|:..|:||||||||||||
Zfish   717 TWLRIKEVVHMIVMDPFADLFITICIVINTVFMAMECYPMDGPYSSMLSTANVVFIGIFTAEMIF 781

Human   555 KIIAMHPYGYFQVGWNIFDSMIVFHGLIELCLANV-AGMALLRLFRMLRIFKLGKYWPTFQILMW 618
            |:||:.||.||..|||||||:||...|:||||||| :|:..||.||:||:|||.|.|||..:|:.
Zfish   782 KVIALDPYSYFLEGWNIFDSIIVTLSLMELCLANVLSGIGFLRPFRLLRVFKLAKSWPTLNMLIK 846

Human   619 SLSNSWVALKDLVLLLFTFIFFSAAFGMKLFGKNYEEFVCHIDKDCQLPRWHMHDFFHSFLNVFR 683
            .:.||..||.:|.|:|...:|..|..||:||||:|.|.||.|..||.||||||:|||||||.|||
Zfish   847 IIGNSLGALSNLTLVLAIIVFIFAVVGMQLFGKSYGECVCKISSDCMLPRWHMNDFFHSFLIVFR 911

Human   684 ILCGEWVETLWDCMEVAGQSWCIPFYLMVILIGNLLVLYLFLALVSSFSSCKDVTAEENNEAKNL 748
            :|||||:||:|||||||||..|:..::||::||||:||.|||||:.|..|..::......:..||
Zfish   912 VLCGEWIETMWDCMEVAGQPLCLTVFMMVMVIGNLVVLNLFLALLLSSFSADNLAVSGEEDENNL 976

Human   749 QLAVARIKKGINYV------LLKILC----KTQNVPKDTMDHVNEVYVKEDISDHTLSELSNTQD 803
            |:||.||:||..::      ..:..|    |.::...:.:.:..|   ::|.::||..||     
Zfish   977 QIAVRRIRKGFTFIKTCLQSFFRSGCLRKKKQKSADGNMIVNCKE---RKDSTNHTTIEL----- 1033

Human   804 FLKDKEKSSGTEKNATENESQSLIPSPSVSETVPIASGESDIENLDNKEIQSKSGD-GGSKEKIK 867
                .:.:.||:   .::::::.|.:||::.:||||:.|||.|.|:.::..|.|.| ...|||:.
Zfish  1034 ----VKSTGGTD---LDSDTENFISNPSLTVSVPIAAEESDFECLNTEDFSSLSSDLEEDKEKLS 1091

Human   868 Q--SSSSECSTVD-------------IAISEE---EEMFYGGERSKHLKNGCRRGSSLGQISGAS 914
            .  ||.||.||||             :.:.||   |..|..         ||.|.....|:.  .
Zfish  1092 DVASSFSEGSTVDLRPLGKDGEDALELVLEEEAYPEPCFTA---------GCVRRFRCCQVD--E 1145

Human   915 KKG--KIWQNIRKTCCKIVENNWFKCFIGLVTLLSTGTLAFEDIYMDQRKTIKILLEYADMIFTY 977
            :||  |.|..:|:||..|||::||:.||..:.|||:|.|||||||:|.||::|.:||:||.:|||
Zfish  1146 EKGIWKKWWLLRQTCYNIVEHSWFETFIVFMILLSSGALAFEDIYLDTRKSVKTILEFADKVFTY 1210

Human   978 IFILEMLLKWMAYGFKAYFSNGWYRLDFVVVIVFCLSLIGKT-----REELKPLISMKFLRPLRV 1037
            ||||||||||:||||..||:|.|..||||:|.|..:||:...     ...:|.|.:::..||||.
Zfish  1211 IFILEMLLKWVAYGFAKYFTNLWCWLDFVIVDVSLISLVANALNYSELSAIKSLRTLRAFRPLRA 1275

Human  1038 LSQFERMKVVVRALIKTTLPTLNVFLVCLMIWLIFSIMGVDLFAGRFYECIDPTSGERFPSSEVM 1102
            ||:|:.|:|||.||:......:||.||||:.||||||:||:.|||:|.|||:.|:.:|.|.|||.
Zfish  1276 LSRFDGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIVGVNFFAGKFSECINITTEQRLPVSEVY 1340

Human  1103 NKSRCESLLFNESMLWENAKMNFDNVGNGFLSLLQVATFNGWITIMNSAIDSVAVNIQPHFEVNI 1167
            ||:.||.:  .:.:.|.|..:||||||||:|:|||||||.||:.||.:|:||.....||.:|||:
Zfish  1341 NKTDCERM--GKGVRWRNVIINFDNVGNGYLALLQVATFKGWMPIMYAAVDSRNPEEQPEYEVNL 1403

Human  1168 YMYCYFINFIIFGVFLPLSMLITVIIDNFNKHKIKLGGSNIFITVKQRKQYRRLKKLMYEDSQRP 1232
            |||.||:.|||.|.|..|::.|.|||||||:.|.|.||.:||:|.:|:|.|..:|||..:..|:|
Zfish  1404 YMYLYFVIFIILGAFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKKYYNAMKKLGSKKPQKP 1468

Human  1233 VPRPLNKLQGFIFDVVTSQAFNVIVMVLICFQAIAMMIDTDVQSLQMSIALYWINSIFVMLYTME 1297
            :|||.||:||.|||:||.|||::.:||||....:.||::|:.||::|:.||||||.||::|:|.|
Zfish  1469 IPRPKNKIQGLIFDLVTKQAFDIFIMVLIWLNMVTMMLETEDQSIEMTRALYWINVIFIVLFTTE 1533

Human  1298 CILKLIAFRCFYFTIAWNIFDFMVVIFSITGLCLPMTVGSYLVPPSLVQLILLSRIIHMLRLGKG 1362
            |:||:||.|.::||:.||:|||:|||.||.|:.|...:..|.|.|:|.::|.|:||..:|||.:.
Zfish  1534 CVLKMIALRHYFFTVGWNVFDFIVVILSIVGMSLTEVIKKYFVSPTLFRVIRLARIGRVLRLIRS 1598

Human  1363 PKVFHNLMLPLMLSLPALLNIILLIFLVMFIYAVFGMYNFAYVKKEAGINDVSNFETFGNSMLCL 1427
            .|....|:..||:|||||.||.||:||||||||:|||.|||||||.|||:|:.|||||.||||||
Zfish  1599 AKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFAYVKKTAGIDDMFNFETFPNSMLCL 1663

Human  1428 FQVAIFAGWDGMLDAIFNSKWSDCDPDKINPGTQVRGDCGNPSVGIFYFVSYILISWLIIVNMYI 1492
            ||:....||||:|..:.|||..||||.|...|:.|.|||||||:|||:|||||:|.:||:|||||
Zfish  1664 FQITTSGGWDGLLAPMLNSKPPDCDPTKNFTGSSVVGDCGNPSIGIFFFVSYIIICFLIVVNMYI 1728

Human  1493 VVVMEFLNIASKKKNKTLSEDDFRKFFQVWKRFDPDRTQYIDSSKLSDFAAALDPPLFMAKPNKG 1557
            .|::|..::|:::..:.||||||.:|::||::|||..||:::..||||||.:|||||.:.|||:.
Zfish  1729 AVILENFSVATEESAEPLSEDDFDRFYEVWEKFDPKATQFMEYGKLSDFADSLDPPLRIPKPNRF 1793

Human  1558 QLIALDLPMAVGDRIHCLDILLAFTKRVMGQDVRMEKVVSEIESGFLLANPFKITCEPITTTLKR 1622
            ||:::||||..||||||||||.||||||:|:...|:.:..::|..|:.:||.|.:.|||||||:|
Zfish  1794 QLMSMDLPMVTGDRIHCLDILFAFTKRVLGEGGEMDMLHGQMEDRFMQSNPSKSSYEPITTTLRR 1858

Human  1623 KQEAVSATIIQRAYKNYRLR------RNDK-------------NTSDIHMIDGDRDVHATKE--- 1665
            |.|.:||.:||||::.:.:|      ||.|             .:.|..|.:.|.|..|...   
Zfish  1859 KHEDMSAAVIQRAFRKHLVRDSMKKVRNFKKKNKHQNGKVPSNQSMDKDMCNEDSDATAATSSPP 1923

Human  1666 --GAYFDKAKEK 1675
              .:..:.||.|
Zfish  1924 SYSSITENAKNK 1935

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SCN7ANP_002967.2 I. /evidence=ECO:0000305 100..401 154/302 (51%)
Ion_trans 146..403 CDD:278921 136/258 (53%)
II. /evidence=ECO:0000305 487..758 155/271 (57%)
Ion_trans 522..717 CDD:278921 115/195 (59%)
Na_trans_assoc 743..927 CDD:284034 58/214 (27%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 801..871 21/72 (29%)
III. /evidence=ECO:0000305 916..1224 168/314 (54%)
Ion_trans 951..1198 CDD:278921 138/251 (55%)
Na_channel_gate 1194..1246 CDD:240441 27/51 (53%)
IV. /evidence=ECO:0000305 1233..1531 168/297 (57%)
Ion_trans 1268..1497 CDD:278921 135/228 (59%)
scn1laaNP_956426.2 Ion_trans 150..416 CDD:278921 139/266 (52%)
Na_trans_cytopl 483..594 CDD:288761 5/110 (5%)
Ion_trans 749..945 CDD:278921 115/195 (59%)
Na_trans_assoc 972..1161 CDD:284034 59/214 (28%)
Ion_trans 1184..1438 CDD:278921 140/255 (55%)
Na_channel_gate 1430..1482 CDD:240441 27/51 (53%)
Ion_trans 1504..1742 CDD:278921 137/237 (58%)
GPHH 1752..1801 CDD:293510 25/48 (52%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
NCBI 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG52281
OrthoDB 1 1.010 - - D37221at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100419
Panther 1 1.100 - - O PTHR10037
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
65.930

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