DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment SCN7A and cch1

DIOPT Version :9

Sequence 1:NP_002967.2 Gene:SCN7A / 6332 HGNCID:10594 Length:1682 Species:Homo sapiens
Sequence 2:NP_593894.1 Gene:cch1 / 2542812 PomBaseID:SPAC6F6.01 Length:1854 Species:Schizosaccharomyces pombe


Alignment Length:2000 Identity:400/2000 - (20%)
Similarity:760/2000 - (38%) Gaps:562/2000 - (28%)


- Green bases have known domain annotations that are detailed below.


Human    12 PFTKESFELIKQHIAKTHNEDH-------------EEEDLKPTPDLEVGKKLPFIYGNLSQGMVS 63
            ||..:||:        :|::.:             :|:.:..|.|   |.:    :.||.   ::
pombe    37 PFVNDSFD--------SHDDSYLDNVNPFEYNVADDEDTISMTSD---GVE----FHNLG---IT 83

Human    64 EPLEDVD----------PYYYKKKNTFI--VLNKNRT-------IFRFNAASILCTLSP-----F 104
            |.:::.|          |...:...|..  :||.::|       :.||....:...|||     |
pombe    84 ETVDEQDKILSELQLAYPTVSRYSETLDKGLLNGDKTTKGDYTSLRRFRKPFLFDKLSPYFTHFF 148

Human   105 NCIRRTTIKVL-----------------------VHPFFQLFILISVLIDCVFMSL-TNLPKWRP 145
            :.|....::|:                       .||.:.:||.:.:::..|.:.: ::.|..:.
pombe   149 SEIYAAVLRVVGPPRANETPGRNLPFSPILRQIYNHPLYNIFIFVVIVLHAVLLMIRSDDPHDKS 213

Human   146 VLENTL---LGI-YTFEILVKLFARG-VWAGSFSF-----------------LGDPWNWLDF--S 186
            ...:.|   :|| ||.|:|:|::..| ::.||.||                 |...||.:||  .
pombe   214 QTIDYLIIVIGILYTLEMLLKIYLFGFLYDGSSSFYDFINSYTKKTPRTMSYLRHSWNRVDFVAI 278

Human   187 VTVFEVIIRYSPLDFIPTLQTARTLRILKIIPLNQGLKSLVGVLIHCLKQLIGVIILTLFFLSIF 251
            |.::..:|................||:.:::.:.:..::::..|......|:.|:....||..:.
pombe   279 VALWISVIGKKQQGIFRLFSMIACLRLTRLLNITRKTETILKSLKESSTPLVQVVSFNAFFGVMI 343

Human   252 SLIGMGLFMGNLKHKCFRWPQENENETLHNRTGNPYYIRETENF---YYLEGERYALLCGNRTDA 313
            :::|:..|..:|..:|. |..:..::.|           .|..|   ::..|.:.|.|..|...:
pombe   344 AILGVQFFKASLNRQCV-WLGDYGDQYL-----------PTGQFCGGHWENGIKRAYLDKNGFPS 396

Human   314 GQCPEGYVCVKAGI-----NPDQGFTNFDSFGWALFALFRLMAQD-YPEVLYHQILYASGKVYMI 372
            ...|.|::|.:..:     ||.....:||:|..:|..:|.:|:.: :.:::| .|:.|...|..:
pombe   397 NVNPRGFICAEKSVCRVVENPYSNTVSFDNFFNSLELIFVIMSSNGFTDIMY-DIMDAEYFVSCL 460

Human   373 FFVVVSFLFSFYMASLFLGILAMAYEEEKQRVGEISKKIEPKFQQTGKELQEGNETDEAKTIQIE 437
            .|::.::..:.::.||.:.::..::.:               .|.:||..:|....|:       
pombe   461 LFIISAYFLTLWLMSLVIAVVTSSFID---------------LQHSGKNQKEQKSVDK------- 503

Human   438 MKKRSPISTDTSLDVLEDATLRHKEELEKSKKICPLYWYKFAKTFLIWNCSPCWLKLKEFVHRII 502
                              ..:|:        |:|..  |.|...|:       |:.       .|
pombe   504 ------------------HLIRN--------KLCEK--YLFYSNFI-------WIS-------FI 526

Human   503 MAPFTDLFLIICIILNVCFLTLEHYPMSKQTNTLLNIGNLVFIG----IFTAEMIFKIIAMHP-Y 562
            :|.|..|          |..|.:      ||::..| ..|:|..    :..||:|.:..|..| |
pombe   527 VAQFVTL----------CTQTYD------QTSSTAN-RYLIFYACVDFLLAAEVILRFFAYLPDY 574

Human   563 G-YFQVGWNIFDSMIVFHGLIELCLA---NVAGMALLRLFRMLRIFKLGKYWPTFQILMWSLSNS 623
            . :|:...|:.|.::....|:.|..:   |......|.:|.:.||::.....|..:.:...|.::
pombe   575 RLFFRRYTNLVDIVLAVLNLVTLLPSIRKNPVAFGWLSIFAIARIYRCILLIPYTRKIAKLLFSN 639

Human   624 WVALKDLVLLLFTFIFFSAAFGMKLF------GKNYEEFVCHIDKDCQLPRWHMHDFFHSFLNVF 682
            :..|.:|:|.|...:|.::...::||      |.:.::.:.....            :.|||.::
pombe   640 FKQLLNLMLFLVIVLFIASLCAVRLFQDLPNDGDSDDDAISFATT------------YESFLYMY 692

Human   683 RILCGE-WVETLWDCMEVAGQ---SWCIP--FYLMVILIGNLLVLYLFLALVS-SFSSCKDVTAE 740
            :||..| |.:.::........   || ||  |:.:..|..|.:||.:|:|::. :|:     .:|
pombe   693 QILTSENWTDVMFAIQARLAHLHLSW-IPGAFFTLWFLFSNNVVLSMFIAVIQVNFA-----PSE 751

Human   741 ENNEAKNLQLAVARIKKGIN----YVLLKILCKTQNVPK-DTMDHVNEVYVKEDISDHTLSELSN 800
            .:.:.:.|::.:||:.:..|    .:.|..|.|.....| .|:|..:..::.||         :.
pombe   752 SDLKMEQLKMYLARLLRNYNPFQASLTLNALIKRNGSRKGKTVDESHYEWLYED---------NI 807

Human   801 TQDFLKDKEKSSGTEKNATENESQSLIPSPSVSETVPIASGESDIENLDNKEIQSKSGDGGSKEK 865
            .:.||:      .|.....|....||..||.:|: ..:|...::.:....::      |..|:..
pombe   808 IKGFLR------VTNIPPKEPLKPSLDTSPELSK-YSLAKLSNNFKRFVMRD------DPFSQAY 859

Human   866 IKQSSSSECSTVDIAISEEEEM--------------FYGGERSKHLKNGCRRGSSLGQISGASKK 916
            .|:.         |.|..|::|              |...::::.|||..:.......|..::: 
pombe   860 FKRV---------IGIRWEKDMNLKTAAKDMQAAKAFVRIKQTEFLKNHPKYNDVFWVIKPSNR- 914

Human   917 GKIWQNIRKTCCKIV------------ENNW---------FKCFIGLVTLLSTGTLAFE-DIYMD 959
                  ||:.|.::|            ...|         :.|.:..|.:....|..:| |..::
pombe   915 ------IRRFCQRLVMPGVNERYGGVEPYQWVYRVIQVFIYACILTAVIIECIATPIYERDHLLN 973

Human   960 QRKTIKILLEYADMIFTYIFILEMLLKWMAYGF----KAYFSNGWYRLDFVVVIVFCLSLIG-KT 1019
            .::....:  :.::.|..||.:|..:|.:|.||    .||..:.|..:||.|::...::|.. .|
pombe   974 DKQHAWFV--WTEVAFATIFTIEAAIKIIADGFCITPNAYLRSTWNCIDFFVLVTLWINLYAVLT 1036

Human  1020 REEL--KPLISMKFLRPLRVLSQFE-RMKVVVRALIKTTLPTLNVFLVCLMIWLIFSIMGVDLFA 1081
            ...|  :...:.|.||.||:::..: ..::...|||.......:..:|...:.:.|::...::|.
pombe  1037 SHALLSRAFRAFKALRVLRLINLTQTSQRMFHDALISGFFKIFSAAVVSATLLIPFALWAKNVFG 1101

Human  1082 GRFYECIDPTSGERFPSSEVMNKSRCESLLFNES----------MLWEN-AKMNFDNVGNGFLSL 1135
            |..|.|.|         ..|::.|:|  :|...|          .:|.| ...:||...:..|:|
pombe  1102 GLLYSCND---------DNVLSASQC--VLEYASTPNNWEVWAPRVWSNPPDYDFDRFPHALLAL 1155

Human  1136 LQVATFNGWITIMNSAIDSVAVNIQPHFEVNIYMYCYFINFIIFGVFLPLSMLITVIIDNFNKHK 1200
            .::|:..||:.||.|.:|....|.||....:.....:|:.|.:..:...|::.|.:||.|:.:..
pombe  1156 FEIASIEGWVDIMRSVMDITGFNNQPQTNASSGNAMFFVLFNLVSMIYILTLFIAIIISNYAERT 1220

Human  1201 IKLGGSNIFITVKQRK--QYRRLKKLMYEDSQRPVPRPLNKLQGFIFDV------VTSQAFNVIV 1257
                 .:.|.|.:||.  :.||..|.| ..|:||..|||. |:|..:|.      :..:.|..:.
pombe  1221 -----GSAFFTAEQRAWLELRRKIKSM-RPSKRPAIRPLG-LRGLCYDFAVQKHGIWRRTFTGLY 1278

Human  1258 MVLICFQAIAMMIDTDVQSLQMSIALYWI-NSIFVML---YTMECILKLIAFRCFYFTIA-WNIF 1317
            :|.:.|.....        ....||..:: ||||::|   ||:...:|:.....:||..: ||:|
pombe  1279 IVHLLFLLTIF--------YPCPIAYTYVRNSIFLILSICYTINICVKVYGLSFYYFFHSFWNMF 1335

Human  1318 DFMVVIFSITGLCLPMTVGSY------LVPPSLVQLILLSRIIHMLRLGKGPKV--FHNLMLPLM 1374
            |.:|.:.|:|  |....:..:      |:..:|:.|:    .:|::     ||.  |..|...::
pombe  1336 DVVVTLGSLT--CNIAILAKFENRSLTLLQTTLLVLV----TVHLI-----PKFDNFDQLSKTVV 1389

Human  1375 LSLPALLNIILLIFLVMFIYAVFGMYNFAYVKKEAGIN--DVSNFETFGNSMLCLFQVAIFAGW- 1436
            .|||::.::|....::...:|:  .:|..:...:.|:|  ...||.:..|:::.||.:....|| 
pombe  1390 ASLPSIFSLIATWIVLYITFAI--AFNQIFGLTKLGLNGGPNKNFRSIRNALVLLFTMTFGEGWN 1452

Human  1437 DGMLDAIFNSKWSDCDPDKINPGTQVRGDCGNPSVGIFYFVSYILISWLIIVNMYIVVVME-FLN 1500
            |.|.|  :...:.:|    :|.......||||.......|:::.:||..|.|||:|.||.: |..
pombe  1453 DVMHD--YTISYPNC----VNGDDFYNSDCGNKPWAYGLFIAWNIISMYIFVNMFITVVFDNFSY 1511

Human  1501 IASKKKNKT-LSEDDFRKFFQVWKRFDPDRTQYIDSSKLSDFAAA-------------------- 1544
            |.:|..:.| |..:|||:|...|..|||..|.||.......|..:                    
pombe  1512 IHTKSSSFTNLQRNDFRQFKDSWAPFDPMVTGYIPKRNAVKFVLSLRGVYDFRIYRDEHTLRSII 1576

Human  1545 --------------LDPPLFMAKPNKGQLIALD---------------------------LPMAV 1568
                          |:.||..::.|   |.|||                           ||   
pombe  1577 SKVQSKTGQQSVPMLENPLMGSEIN---LEALDQIIDTIDVNVVKERRNVLNSLCTEIMTLP--- 1635

Human  1569 GDRIHCLDILL----------------------AFTKRVMGQDVRMEKVVSEIESGFL------- 1604
            |:.|...:||:                      |:....:.:.:||||::..:|:..:       
pombe  1636 GNVISFSNILMLVVLHKIVDHREAFPISDYIRRAYVLSELEKSIRMEKLLGLVETSIIRKTFLQH 1700

Human  1605 -------LANPFKITCE--------PITTTLKR------------KQEAV---SATIIQRAYKNY 1639
                   |.|||.:..|        ||...|::            :..:|   |.:|::......
pombe  1701 MEEKKKALENPFILLSEVSEILPETPIQEVLRQHNADPEQLLMSTRTPSVSDRSFSIVESTVPTI 1765

Human  1640 RLRRNDKNTS-DIH------------------MIDGDRDVHATKEGAYFD 1670
            .....|.|.| :.|                  ::.|...:|:..:...||
pombe  1766 ASGEGDDNHSVEDHLKVPTDNEPRRSPSLKEVLLRGSHSLHSNNDRTSFD 1815

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SCN7ANP_002967.2 I. /evidence=ECO:0000305 100..401 69/362 (19%)
Ion_trans 146..403 CDD:278921 57/289 (20%)
II. /evidence=ECO:0000305 487..758 61/292 (21%)
Ion_trans 522..717 CDD:278921 45/215 (21%)
Na_trans_assoc 743..927 CDD:284034 36/202 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 801..871 13/69 (19%)
III. /evidence=ECO:0000305 916..1224 76/350 (22%)
Ion_trans 951..1198 CDD:278921 62/266 (23%)
Na_channel_gate 1194..1246 CDD:240441 17/53 (32%)
IV. /evidence=ECO:0000305 1233..1531 84/321 (26%)
Ion_trans 1268..1497 CDD:278921 62/244 (25%)
cch1NP_593894.1 Ion_trans 201..485 CDD:278921 58/296 (20%)
Ion_trans 533..748 CDD:278921 52/244 (21%)
Ion_trans 968..1220 CDD:278921 61/264 (23%)
Ion_trans 1289..1517 CDD:278921 65/254 (26%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Domainoid 1 1.000 83 1.000 Domainoid score I2557
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
43.910

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