DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SCN7A and Scn7a

DIOPT Version :9

Sequence 1:	NP_002967.2	Gene:	SCN7A / 6332	HGNCID:	10594	Length:	1682	Species:	Homo sapiens
Sequence 2:	NP_033161.2	Gene:	Scn7a / 20272	MGIID:	102965	Length:	1681	Species:	Mus musculus

Alignment Length:	1684	Identity:	1247/1684 - (74%)
Similarity:	1436/1684 - (85%)	Gaps:	5/1684 - (0%)

- Green bases have known domain annotations that are detailed below.

Human     1 MLASPEPKGLVPFTKESFELIKQHIAKTHNEDHEEED-LKPTPDLEVGKKLPFIYGNLSQGMVSE 64
            ||.|||||||||||.||.|||:.||||..|||.|||: |||:.:||.||:||..||.|.:|.|||
Mouse     1 MLTSPEPKGLVPFTTESLELIENHIAKKCNEDPEEEEGLKPSRNLEAGKRLPIPYGTLPRGTVSE 65

Human    65 PLEDVDPYYYKKKNTFIVLNKNRTIFRFNAASILCTLSPFNCIRRTTIKVLVHPFFQLFILISVL 129
            ||||||||||.|:|||:|||::|.||||||.||.|||||.|.:||..||.||||.|:|.||||||
Mouse    66 PLEDVDPYYYVKRNTFMVLNRSRVIFRFNAVSIFCTLSPLNSLRRAAIKALVHPLFRLLILISVL 130

Human   130 IDCVFMSLTNLPKWRPVLENTLLGIYTFEILVKLFARGVWAGSFSFLGDPWNWLDFSVTVFEVII 194
            .|.:.|.::|||:|...:||||||||.||||||:.|||:||||||||||.|||||||||:||:|.
Mouse   131 TDSILMCMSNLPEWILAIENTLLGIYAFEILVKVIARGIWAGSFSFLGDLWNWLDFSVTLFELIT 195

Human   195 RYSPLDFIPTLQTARTLRILKIIPLNQGLKSLVGVLIHCLKQLIGVIILTLFFLSIFSLIGMGLF 259
            |:|||.....|:|.||.|||||||||.||:|:|..|..|||:|.|.|.|.||||::|||:|||||
Mouse   196 RFSPLSSFLMLKTIRTFRILKIIPLNHGLQSIVMTLAQCLKKLFGAIALALFFLAVFSLLGMGLF 260

Human   260 MGNLKHKCFRWPQENENETLHNRTGNPYYIRETENFYYLEGERYALLCGNRTDAGQCPEGYVCVK 324
            ||||||||.|||:||||||||||||:..|..|..||||:||.:||||||||||||||||||||||
Mouse   261 MGNLKHKCLRWPEENENETLHNRTGSLNYSPERINFYYMEGAKYALLCGNRTDAGQCPEGYVCVK 325

Human   325 AGINPDQGFTNFDSFGWALFALFRLMAQDYPEVLYHQILYASGKVYMIFFVVVSFLFSFYMASLF 389
            .|.|||.|||:||:|||:|.|:||||.|||||:||||||||||||||||||::||.|:||:.|||
Mouse   326 EGTNPDNGFTSFDNFGWSLLAMFRLMTQDYPELLYHQILYASGKVYMIFFVMISFWFAFYLTSLF 390

Human   390 LGILAMAYEEEKQRVGEISKKIEPKFQQTGKELQEGNETDEAKTIQIEMKKRSPISTDTSLDVLE 454
            ||||.|.||:||||..|.|..::||.|||.|||.|.|:..|.:|.|||||||||.|.:|:||:||
Mouse   391 LGILTMTYEKEKQRACEESGGLDPKCQQTVKELDEENDAAEMETTQIEMKKRSPTSINTTLDILE 455

Human   455 DATLRHKEELEKSKKICPLYWYKFAKTFLIWNCSPCWLKLKEFVHRIIMAPFTDLFLIICIILNV 519
            |.||.|:||.|.|:|.||:.|:||.||..||.|||||:||.||..|:|..|..||||:|||:||:
Mouse   456 DTTLGHREEPETSRKKCPICWHKFIKTCFIWKCSPCWVKLNEFADRVITHPLADLFLVICIVLNI 520

Human   520 CFLTLEHYPMSKQTNTLLNIGNLVFIGIFTAEMIFKIIAMHPYGYFQVGWNIFDSMIVFHGLIEL 584
            |||.|||:|||::..:||::||||||||:|.|||.||||||||||||:.||||||::|...|.|:
Mouse   521 CFLALEHFPMSEELRSLLHVGNLVFIGIYTIEMILKIIAMHPYGYFQISWNIFDSILVVLELTEI 585

Human   585 CLANVAGMALLRLFRMLRIFKLGKYWPTFQILMWSLSNSWVALKDLVLLLFTFIFFSAAFGMKLF 649
            .||:|.|:|:|....::.| |||||.|.|:.||..|.:|.:|||||||||..|::|||.||||||
Mouse   586 LLADVEGLAVLITVPLIFI-KLGKYGPPFKSLMRILGSSLMALKDLVLLLCIFVYFSAVFGMKLF 649

Human   650 GKNYEEFVCHIDKDCQLPRWHMHDFFHSFLNVFRILCGEWVETLWDCMEVAGQSWCIPFYLMVIL 714
            |::|::.||||.:|||..||||.||.|:::.|||||||||:||||:|||||||:||||||:||||
Mouse   650 GRSYKDCVCHIKEDCQPQRWHMSDFLHAYMTVFRILCGEWIETLWECMEVAGQAWCIPFYMMVIL 714

Human   715 IGNLLVLYLFLALVSSFSSCKDVTAEENNEAKNLQLAVARIKKGINYVLLKILCKTQNVPKDTMD 779
            |||||:||||:.||||| |..|.|:|.|.||||||||:||||.|||.:|||::|..::||.:..|
Mouse   715 IGNLLILYLFVTLVSSF-SYYDATSEVNKEAKNLQLAMARIKSGINSMLLKLMCTERSVPTEATD 778

Human   780 HVNEVYVKEDISDHTLSELSNTQDFLKDKEKSSGTEKN-ATENESQSLIPSPSVSETVPIASGES 843
            .:.:..|||:||.||||||||||.||:.|::||.|||. .||:||||||.|||.|||||||||||
Mouse   779 QICDPSVKENISGHTLSELSNTQTFLRYKDQSSSTEKTPVTESESQSLIASPSASETVPIASGES 843

Human   844 DIENLDNKEIQSKSGDGGSKEKIKQSSSSECSTVDIAISEEEEMFYGGERSKHLKNGCRRGSSLG 908
            |||||||||.:||||:||||||:|||||||||||||||||||||.|..|:||..|||..|.||.|
Mouse   844 DIENLDNKETRSKSGNGGSKEKMKQSSSSECSTVDIAISEEEEMVYEHEKSKLHKNGYERKSSTG 908

Human   909 QISGASKKGKIWQNIRKTCCKIVENNWFKCFIGLVTLLSTGTLAFEDIYMDQRKTIKILLEYADM 973
            |||..|:.||||:||||||||||||:||:|||||||||.|||||.||||:|||||.|||||||||
Mouse   909 QISRESRNGKIWKNIRKTCCKIVENSWFECFIGLVTLLCTGTLALEDIYIDQRKTTKILLEYADM 973

Human   974 IFTYIFILEMLLKWMAYGFKAYFSNGWYRLDFVVVIVFCLSLIGKTREELKPLISMKFLRPLRVL 1038
            ||.|||||||||||:||||||:|||.||:|||:|||||||||||||||:|.||.|:||||.||||
Mouse   974 IFAYIFILEMLLKWVAYGFKAFFSNNWYKLDFMVVIVFCLSLIGKTREDLNPLTSIKFLRALRVL 1038

Human  1039 SQFERMKVVVRALIKTTLPTLNVFLVCLMIWLIFSIMGVDLFAGRFYECIDPTSGERFPSSEVMN 1103
            |||||||||:||||||||||::||||||||||:||::||.||||:||||||||.|||||..||||
Mouse  1039 SQFERMKVVLRALIKTTLPTVSVFLVCLMIWLLFSVIGVQLFAGKFYECIDPTKGERFPVFEVMN 1103

Human  1104 KSRCESLLFNESMLWENAKMNFDNVGNGFLSLLQVATFNGWITIMNSAIDSVAVNIQPHFEVNIY 1168
            ||:||.|||||||.|||||:||||||||||||||||||||||:|||||||||.||:||.||.|:|
Mouse  1104 KSQCEKLLFNESMPWENAKLNFDNVGNGFLSLLQVATFNGWISIMNSAIDSVGVNMQPSFEYNLY 1168

Human  1169 MYCYFINFIIFGVFLPLSMLITVIIDNFNKHKIKLGGSNIFITVKQRKQYRRLKKLMYEDSQRPV 1233
            ||.|||.|:|||:||||.|||.|||.||||.|||.|||||||||||:||||.||||:|.|.|:|.
Mouse  1169 MYSYFIIFVIFGLFLPLCMLIGVIIRNFNKQKIKQGGSNIFITVKQKKQYRALKKLLYADVQKPT 1233

Human  1234 PRPLNKLQGFIFDVVTSQAFNVIVMVLICFQAIAMMIDTDVQSLQMSIALYWINSIFVMLYTMEC 1298
            |||.||.|||:||:||.:.||||:::||||||..:||..|.||.||..|::|:|||||||:|:||
Mouse  1234 PRPRNKFQGFLFDLVTHRVFNVIIILLICFQATTIMIQKDEQSPQMETAIFWMNSIFVMLFTLEC 1298

Human  1299 ILKLIAFRCFYFTIAWNIFDFMVVIFSITGLCLPMTVGSYLVPPSLVQLILLSRIIHMLRLGKGP 1363
            ||||.||||.|||.|||:.||||||||||||.||:|:|.|.|||||||||||||:||:||.||||
Mouse  1299 ILKLTAFRCHYFTSAWNVHDFMVVIFSITGLLLPLTIGQYFVPPSLVQLILLSRVIHILRPGKGP 1363

Human  1364 KVFHNLMLPLMLSLPALLNIILLIFLVMFIYAVFGMYNFAYVKKEAGINDVSNFETFGNSMLCLF 1428
            ||||:|||||:|:|||||||.|||||||||||:|||||||||||||||||||||||||:||||||
Mouse  1364 KVFHDLMLPLILALPALLNISLLIFLVMFIYAIFGMYNFAYVKKEAGINDVSNFETFGSSMLCLF 1428

Human  1429 QVAIFAGWDGMLDAIFNSKWSDCDPDKINPGTQVRGDCGNPSVGIFYFVSYILISWLIIVNMYIV 1493
            ||..|:||||||||||||:|||||||||||||||:||||:|||||.|||||||||||||||||||
Mouse  1429 QVTTFSGWDGMLDAIFNSQWSDCDPDKINPGTQVKGDCGSPSVGISYFVSYILISWLIIVNMYIV 1493

Human  1494 VVMEFLNIASKKKNKTLSEDDFRKFFQVWKRFDPDRTQYIDSSKLSDFAAALDPPLFMAKPNKGQ 1558
            ::||||:|.|:||::||||||||:||:||.|||||||||||||||||||||||||||||||||||
Mouse  1494 LIMEFLSIPSQKKSRTLSEDDFRRFFRVWNRFDPDRTQYIDSSKLSDFAAALDPPLFMAKPNKGQ 1558

Human  1559 LIALDLPMAVGDRIHCLDILLAFTKRVMGQDVRMEKVVSEIESGFLLANPFKITCEPITTTLKRK 1623
            |:|:|||||.|||||||||||||||||||:|.|:||::|||||||:||||||||.||||||||||
Mouse  1559 LVAMDLPMAAGDRIHCLDILLAFTKRVMGKDERVEKILSEIESGFMLANPFKITYEPITTTLKRK 1623

Human  1624 QEAVSATIIQRAYKNYRLRRNDKNTSDIHMIDGDRDVHATKEGAYFDKAKEKSPIQSQI 1682
            ||||||||||||||:||||:||||.||...||..|| ..|.:||:..|.:||:.||:||
Mouse  1624 QEAVSATIIQRAYKSYRLRQNDKNVSDTPAIDDRRD-DLTSKGAHSGKIEEKASIQTQI 1681

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SCN7A	NP_002967.2	I. /evidence=ECO:0000305	100..401		216/300 (72%)
		Ion_trans	146..403	CDD:278921	191/256 (75%)
		II. /evidence=ECO:0000305	487..758		179/270 (66%)
		Ion_trans	522..717	CDD:278921	126/194 (65%)
		Na_trans_assoc	743..927	CDD:284034	130/184 (71%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	801..871		54/70 (77%)
		III. /evidence=ECO:0000305	916..1224		256/307 (83%)
		Ion_trans	951..1198	CDD:278921	204/246 (83%)
		Na_channel_gate	1194..1246	CDD:240441	38/51 (75%)
		IV. /evidence=ECO:0000305	1233..1531		236/297 (79%)
		Ion_trans	1268..1497	CDD:278921	188/228 (82%)
Scn7a	NP_033161.2	Ion_trans	140..405	CDD:278921	196/264 (74%)
		Ion_trans	523..739	CDD:278921	142/217 (65%)
		Na_trans_assoc	743..927	CDD:284034	130/183 (71%)
		Ion_trans	951..1204	CDD:278921	209/252 (83%)
		Na_channel_gate	1195..1246	CDD:240441	38/50 (76%)
		Ion_trans	1275..1497	CDD:278921	185/221 (84%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C83973746
Domainoid	1	1.000	455	1.000	Domainoid score	I9306
eggNOG	0	0.000	Not matched by this tool.
HGNC	1	1.500	-	-
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H55706
Inparanoid	1	1.050	2540	1.000	Inparanoid score	I892
Isobase	0	0.000	Not matched by this tool.
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG52281
OrthoDB	1	1.010	-	-		D37221at33208
OrthoFinder	1	1.000	-	-		FOG0015394
OrthoInspector	1	1.000	-	-		oto112402
orthoMCL	1	0.900	-	-		OOG6_100419
Panther	1	1.100	-	-	LDO	PTHR10037
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R14107
SonicParanoid	1	1.000	-	-		X12246
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	17	17.440