DRSC/TRiP Functional Genomics Resources

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Protein Alignment SCN7A and cca-1

DIOPT Version :9

Sequence 1:NP_002967.2 Gene:SCN7A / 6332 HGNCID:10594 Length:1682 Species:Homo sapiens
Sequence 2:NP_001367691.1 Gene:cca-1 / 181045 WormBaseID:WBGene00000367 Length:1885 Species:Caenorhabditis elegans


Alignment Length:1766 Identity:412/1766 - (23%)
Similarity:752/1766 - (42%) Gaps:431/1766 - (24%)


- Green bases have known domain annotations that are detailed below.


Human   108 RRTTIKVLVHPFFQLFILISVLIDCVFMSLTNLPKWRP----------------VLENTLLGIYT 156
            |:..:::::.|:|....:..::|:||.:.:     :||                :::|.:...:.
 Worm   120 RKWALQMVMSPWFDRITMAVIMINCVTLGM-----YRPCEDGPDCDTYRCQILDIIDNCIFVYFA 179

Human   157 FEILVKLFARGVWAGSFSFLGDPWNWLDFSVTVFEVIIRYSPLDF------IPTLQTARTLRILK 215
            ||:::|:.|.|.: |..:::.|.||.|||.: |...|..:...::      :..::|.|.||.|:
 Worm   180 FEMVIKIMALGFY-GPAAYMSDTWNRLDFFI-VMAGIAEFVLHEYLGGNINLTAIRTVRVLRPLR 242

Human   216 IIPLNQGLKSLVGVLIHCLKQLIGVIILTLFFLSIFSLIGMGLFMGNLKHKC-FRWPQ---ENEN 276
            .:.....::.||.:|:..|..|..|::|..|...||.::|:.|:.|.|:::| ...|:   ||::
 Worm   243 AVNRIPSMRILVNLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCVINLPKTISENQS 307

Human   277 ETLHNRTGNPYYIRETENFYYLEGERYA---LLCGN----RTDAGQCP---EGY------VCVKA 325
            ...:|.....:||.|..:..|:..:..|   ..|.|    ..|..:|.   :.|      .|:..
 Worm   308 ALFNNVKLTRFYIPEDTSLEYICSQPDANGLHTCSNLPPYTVDGVKCNLTLDEYDKVTNDSCINW 372

Human   326 GI----------NPDQGFTNFDSFGWALFALFRLMA-QDYPEVLYHQILYASGKVYMIFFVVVSF 379
            .|          ||.||..:||:.|:|..|:|.::: :.:.:::|: :..|......|:||::..
 Worm   373 NIYYNECQVMQRNPFQGSVSFDNIGFAWVAIFLVISLEGWTDIMYY-VQDAHSFWNWIYFVLLIV 436

Human   380 LFSFYMASLFLGILAMAYEEEKQRVGEISKKIEPK--------FQQTGKEL------QEGN---- 426
            :.:|:|.:|.|.::|..:.|.|:|  |..:.::.:        ...||.|:      :||:    
 Worm   437 IGAFFMINLCLVVIATQFAETKRR--ETERMLQERKMLLNRDSISCTGSEIGGASSKEEGDTVYA 499

Human   427 --------------------------ETDEAKTIQIEMKKRSPISTDTSLDVLEDATLRHKEEL- 464
                                      |..|.|:.:.:.:::|.:....:|..:|:.....::|. 
 Worm   500 AFVRFIGHTFRRTKRAAKKKYTAYMEERAERKSSERQQRRKSKLDDMATLSRIEEKAEDEEDETT 564

Human   465 ----------------------------------------------------------------E 465
                                                                            |
 Worm   565 ITRENGDDQIEQNGDGVRIKRVKIEEEPKIKIGNGNSNGPHYKHSSSDEESDEDGEEDQVYDGEE 629

Human   466 KSKKICP--LYWYKFAKTFLIWNCSPCWLKLKEFVHRIIMAPFTDLFLIICIILNVCFLTLEHYP 528
            ..||..|  |:|::              .|:::||   |...|| ..:::.|::|...:.:|::.
 Worm   630 AKKKSTPSKLWWFR--------------EKIQKFV---ICDHFT-RGILVAILVNTLSMGVEYHQ 676

Human   529 MSKQTNTLLNIGNLVFIGIFTAEMIFKIIAMHPYGYFQVGWNIFDSMIVFHGLIELCLANVAGMA 593
            ..:....:|...||.|..:|..||:.||||...:||...|:|:||..||...::||......|::
 Worm   677 QPEILTVILEYSNLFFTALFALEMLLKIIASGLFGYLADGFNLFDGGIVALSVLELFQEGKGGLS 741

Human   594 LLRLFRMLRIFKLGKYWPTFQ----ILMWSLSNSWVALKDLVLLLFTFIFFSAAFGMKLFG---- 650
            :||.||:|||.||.::.|..:    :::.::.|..|....|||    |||..:..||.|||    
 Worm   742 VLRTFRLLRILKLVRFMPALRYQLVVMLRTMDNVTVFFGLLVL----FIFIFSILGMNLFGCKFC 802

Human   651 ----------------KNYE------------------EFVCH------------IDKDCQLPRW 669
                            ||::                  :|..|            |...|:..|.
 Worm   803 KVEEKFLGGLAKKCERKNFDTLLWALITVTLGMVLFGCKFCNHPDTGLQCTSAQVISSICECDRM 867

Human   670 HMHDFFHSFLNVFRILCGE-WVETLWDCMEVAGQSWCIPFYLMVILIGNLLVLYLFLA-LVSSFS 732
            :..:|..:.:.||:||..| |...|::.| .....|...:::.::..||.::..|.:| ||..|.
 Worm   868 NFDNFLFATVTVFQILTQEDWNMVLFNGM-AQTNPWAALYFVALMTFGNYVLFNLLVAILVEGFQ 931

Human   733 SCKD-------------VTAEENNEAKNLQLAVAR-----IKKGINYVLLKILCKTQNVPKDTMD 779
            ..|:             ...||:...:.|:|.:|:     ...|:  ...:..|:..:.|:::..
 Worm   932 ESKEEEKRQLEEDARKQAVEEEDERKRELELIIAKTTSPAFNNGV--APAECTCQRPSSPEESPS 994

Human   780 H--VNEVYVKEDISDHTLS---------ELSNTQDFLKDKEKSSGTEKNATENESQSLIPSPSVS 833
            .  ::..|.......|:.:         .|.|:..|  |:...|....::..|...||:      
 Worm   995 PRLLSANYHPSPERKHSANLDAIIDKRLVLRNSAPF--DRSPVSEGRDDSRLNRHASLV------ 1051

Human   834 ETVPIASGESDIENLDNKEIQSKSG------------------DGGSKEKIKQSSSSECSTVDIA 880
              :|:|:|..    ...:.:.|.||                  :..::||..::|..    :..|
 Worm  1052 --LPVANGVP----YRRQRVHSWSGLCHHFNPNCPVHGRRALIETYAREKFLEASQE----LKQA 1106

Human   881 ISEEEEMFYGGERS---KHLKNGCRRGSSLGQISGASKKGKIWQNIRKTCCKIVENNWFK----C 938
            ::|||:.....:.:   |.||..|....:...:.....|..    :|..|.:..:..||.    .
 Worm  1107 LAEEEKRNEAKQNTFVRKLLKKTCLHNRTEFSLFLMGPKNP----LRIKCLQTTQKKWFDYTVLF 1167

Human   939 FIGLVTLLSTGTLAFEDIYMDQRKTIKILLEYADMIFTYIFILEMLLKWMA----YGFKAYFSNG 999
            |||:..:    |||.|...:......:..|..:..|||.||..||::|.:|    .|..|||.:|
 Worm  1168 FIGINCI----TLAMERPSIPPDSFERQFLHISGYIFTVIFTGEMMMKVIANGCFIGQAAYFKDG 1228

Human  1000 WYRLDFVVVIVFCLSLIGKTREEL------------KPLISMKFLRPLRVLSQFERMKVVVRALI 1052
            |..||.::|::   |||....|.|            :.|..::.||||||:::...:|:||..||
 Worm  1229 WNILDGILVVI---SLINIAFELLATGDSPKIFGVIRVLRLLRALRPLRVINRAPGVKLVVMTLI 1290

Human  1053 KTTLPTLNVFLVCLMIWLIFSIMGVDLFAGRFYECIDPTSGERFPSSEVMNKSRCESLLFNESML 1117
            .:..|..|:.|:|...::||.|:||.||.|..|.||.|..|      .|..|:.|.....|:   
 Worm  1291 SSLKPIGNIVLICCTFFIIFGILGVQLFKGMMYHCIGPEVG------NVTTKADCIEDYRNK--- 1346

Human  1118 WENAKMNFDNVGNGFLSLLQVATFNGWITIMNSAIDSVAVNIQPHFEVNIYMYCYFINFIIFGVF 1182
            |.|.:.||||:|...:||..:::.:||::||...||:|.|::||....|.:...|||:|::...|
 Worm  1347 WVNHRYNFDNLGQALMSLFVLSSKDGWVSIMYQGIDAVGVDVQPIENYNEWRMIYFISFLLLVGF 1411

Human  1183 LPLSMLITVIIDNFNKHKIKLGGSNIFITVKQRKQYRRLKKLMYEDSQR----------PVPRPL 1237
            ..|:|.:.|:::||:|.|..| ...:....|:::..|:||:..:|:|..          |.....
 Worm  1412 FVLNMFVGVVVENFHKCKEAL-EKEMREKEKEKRLKRKLKRQKFEESMAGKRKKMERNYPYYHDY 1475

Human  1238 NKLQGFIFDVVTSQAFNVIVMVLICFQAIAMMIDTDVQSLQMSIALYWINSIFVMLYTMECILKL 1302
            ...:.|:..:|||:.|::.:..:|....|:|.::..:..:.:...|..:|..|..::|:|..:||
 Worm  1476 GHTRLFLHGIVTSKYFDLAIAAVIGINVISMAMEFYMMPMGLKYVLKALNYFFTAVFTLEAAMKL 1540

Human  1303 IA--FRCFYFTIAWNIFDFMVVIFSITGLC--------LPMTVGSYLVPPSLVQLILLSRIIHML 1357
            ||  |:.| |...||..|..:||.||.|:.        ||       :.|::::::.:.||..:|
 Worm  1541 IALGFKRF-FIEKWNRLDMFIVILSIAGIIFEEFEALELP-------INPTIIRVMRVLRIARVL 1597

Human  1358 RLGKGPKVFHNLMLPLMLSLPALLNIILLIFLVMFIYAVFGMYNFAYVKKEA-------GINDVS 1415
            :|.|..|...:|:..:..:||.:.|:..|.||:.||:|..|:..|.  |.|.       |:.:.:
 Worm  1598 KLLKMAKGIRSLLDTVGEALPQVGNLGSLFFLLFFIFAALGVELFG--KLECSEDHPCDGLGEHA 1660

Human  1416 NFETFGNSMLCLFQVAIFAGWDG-MLDAIFNSKWSDCD-PDKINPGTQVRGDCGNPSVGIFYFVS 1478
            :|:.||.:.|.||::|....|:| |.||:.:    ||| .|......     |.:|.:...:||.
 Worm  1661 HFKNFGMAFLTLFRIATGDNWNGIMKDALRD----DCDSSDHCETNC-----CVDPILAPCFFVI 1716

Human  1479 YILISWLIIVNMYIVVVMEFLNIASKK-------------KNK-TLSEDDFRKFFQVWKRFDPDR 1529
            ::|||..::||:.:.|:|:.|..::|:             :|: |.|:||     ::.:..:|..
 Worm  1717 FVLISQFVLVNVVVAVLMKHLEESNKRDAEGPAEPTGENIENEITKSDDD-----EIVEEHEPLA 1776

Human  1530 TQYIDSSKLSD 1540
            .:::...:|.:
 Worm  1777 IEHVKEGELDE 1787

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SCN7ANP_002967.2 I. /evidence=ECO:0000305 100..401 80/345 (23%)
Ion_trans 146..403 CDD:278921 73/293 (25%)
II. /evidence=ECO:0000305 487..758 84/344 (24%)
Ion_trans 522..717 CDD:278921 63/249 (25%)
Na_trans_assoc 743..927 CDD:284034 35/220 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 801..871 14/87 (16%)
III. /evidence=ECO:0000305 916..1224 106/327 (32%)
Ion_trans 951..1198 CDD:278921 90/262 (34%)
Na_channel_gate 1194..1246 CDD:240441 13/61 (21%)
IV. /evidence=ECO:0000305 1233..1531 87/330 (26%)
Ion_trans 1268..1497 CDD:278921 71/247 (29%)
cca-1NP_001367691.1 Ion_trans 129..461 CDD:395416 81/341 (24%)
Ion_trans 659..938 CDD:395416 73/283 (26%)
Ion_trans 1159..1430 CDD:395416 97/286 (34%)
Ion_trans 1488..1721 CDD:395416 70/251 (28%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
21.910

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