DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment SCN7A and nca-2

DIOPT Version :9

Sequence 1:NP_002967.2 Gene:SCN7A / 6332 HGNCID:10594 Length:1682 Species:Homo sapiens
Sequence 2:NP_498054.2 Gene:nca-2 / 175674 WormBaseID:WBGene00003558 Length:1785 Species:Caenorhabditis elegans


Alignment Length:1827 Identity:361/1827 - (19%)
Similarity:709/1827 - (38%) Gaps:434/1827 - (23%)


- Green bases have known domain annotations that are detailed below.


Human    57 LSQGMVSEPLEDVDPYYYKKKNTFIVLNKNRTIFRFNAASILCTLSPFNCIRRTTIKVLVHPFFQ 121
            ||..|::.....:|       .|....|:.|......|.:.:..:.|.:.|.::| ::|...|.:
 Worm    19 LSTTMLTRRKSSID-------GTKTERNRRRGESIGGAFTDMINIEPTSIINKST-ELLHERFLR 75

Human   122 LFILISVLIDCVFMSL---TNLPKWRP----VLENTLLG--IYTFEILVKLFARGVWAGSFSFLG 177
            ..:.::.|:..:.:.|   ..:..|.|    :|.|.::.  |:..|..|.:...|::....|:|.
 Worm    76 DMVRVACLLSMISLCLHTPETIKMWPPLNYIILANDVIVTLIFIGEAAVTINQNGLFDNQNSYLR 140

Human   178 DPWNWLDFSVTVFEVI-----------IRYSPLDFI-----PTLQTART---LRILKIIPLNQGL 223
            |.|...:|.:.:..::           |.:..|:|:     ..|::||.   ||.::.|...:..
 Worm   141 DRWYQFEFFLLINHILSCVIHIYELCSIWFPALNFVYYPWLGALRSARPFIFLRFIRSIVRFKLP 205

Human   224 KSLVGVLI-HCLKQLIGVIILTLFFLSIFSLIGMGLFMGNLKHKCFRWPQENENETLHNRTGNPY 287
            |:.:.::| ...:|:..|.|..:||:..::::|:.|| |.|.:.|.....:..|.|:.:..    
 Worm   206 KNRIKLIIKRSSQQIQNVTIFFMFFVFSYAIMGVQLF-GRLNYHCVVNGTDPNNVTIADLA---- 265

Human   288 YIRETENFYYLEGERYALLCGNRTDAG-QCPEGYVCVKAGINP-DQGF-TNFDSFGWALFALFRL 349
             |.:|             :|..:...| :||...||::..:.| ::|| ..|..|..:||.::..
 Worm   266 -IPDT-------------MCSQKGAGGYECPGNMVCMRLQLKPQEEGFYGQFSDFASSLFTVYLA 316

Human   350 MAQD-YPEVLYHQILYASGKVYMIFFVVVSFLFSFYMASLFLGILAMAYEEEKQRVGEISKKIEP 413
            .:|: :..|||..:......:...:||.:.|..::.:.::|:.::...:.|.:.:..|:.:..|.
 Worm   317 ASQEGWVYVLYDCLDSLPSFLAFFYFVTLIFFLAWLVKNVFIAVITETFAEIRVQFSEMWQTREA 381

Human   414 KFQQTGKELQEGNETDEAKTIQIEMKKRSPISTDTSLDVLEDATLRHKEELEKSKKICPLYWYKF 478
            .......:..|.:| |..|.::::...|:  .::.||                            
 Worm   382 TTDHVYTQKLEKDE-DGWKLVEVDKYNRA--HSNNSL---------------------------- 415

Human   479 AKTFLIWNCSPCWLKLKEFVHRIIMAPFTDLFLIICIILNVCF--LTLEHYPMSKQTNTL----L 537
                              |:|.|:.:......:.:.|:.|..|  ..:.::..|.|...:    :
 Worm   416 ------------------FLHTIVTSTAFQTVMQLLILANAIFHATFVFYHDESDQIRKIWYYYV 462

Human   538 NIGNLVFIGIFTAEMIFKIIAMHPYGYFQVGWNIFDSMIVFHGLIELCLANVAGMA-------LL 595
            .:|   |..:|..|:|.||.|.....|...|.:.||.:        ||:.:.....       :.
 Worm   463 EVG---FTILFNTEVIIKIYAFGWKAYIARGQHKFDCI--------LCVGSSLNAIWVLYETNIF 516

Human   596 RLFRMLRIFKLGKYWPTFQILMWSLSNSWVALKDLVLLLFTFIFFSAAFGMKLFGKNYEEFVCHI 660
            ..|::.||.:|.|..|..:..::.:......|..||:.....:..::|..::||           
 Worm   517 TYFQVFRIARLIKASPMLEDFVYKIFGPGKKLGGLVIFTGILLIVTSAISLQLF----------- 570

Human   661 DKDCQLPRWH-MHDFFHSFLNVFRILCGE-W----VETLWDCMEVAGQSWCIPF----YLMVILI 715
               |.:|:.: ..:|..:|:::|:|:..| |    :|.|..|.|.|     :||    ::...|:
 Worm   571 ---CYVPKLNKFTNFAVAFMSMFQIITQEGWTDVVIEILRACNEQA-----VPFVAIYFVAYHLL 627

Human   716 GNLLVLYLFLALV-------SSFSSCKDVTAEENNEAKN---LQLAV-ARIKKGINYVLLKILCK 769
            ..|.||.||:|::       ......|.:.|.|.:..|.   ::|.: .|.......|.:|.:..
 Worm   628 VTLFVLSLFVAVILDNLEMDEELKKVKQLKAREQDTIKTTLPMRLRIFNRFPTAPTMVTMKKVSS 692

Human   770 TQNVPKDTMDHVNEVYVKE--DISDHTLSELS-NTQDFLKDKEKSSGTEKNATENE----SQSLI 827
            ...:|| ..|.....:..|  :.||.|:.|:. ..:..|..:..|..|....|...    |...|
 Worm   693 EFPLPK-IRDSFTRQFADEFVETSDDTIQEIGFKVRSMLSGRGPSKETRITTTIRHVGQLSNKTI 756

Human   828 PSPSVSET----VPIASGESDIENLDNKEIQSKSGDGGSKEKIKQSSSSECSTVDIAISEEEEMF 888
            .:..::|:    ...:.....:.:|......||.|..|:     .|::|...|..:|..:.:.|.
 Worm   757 LTSMLTESNRNRALFSESNQHLASLTRSNTSSKHGKSGA-----LSTNSRSRTRGLASLKGKHMV 816

Human   889 YGGERSKHLK--NGCRRGSSLGQIS----------GASKKGKIWQNIR----------------- 924
            .|.:.:..|:  :..|:....|:|.          ....:.:|.:.:|                 
 Worm   817 EGFKENGDLRPEDTARKVEKHGEIDFKALQMKRAHAEITRNRIEEEMRENHPMFDRPLFLVGRES 881

Human   925 --KTCCKIV----------------ENNWFKCF-------------IGLVTLLSTGTLAFEDIYM 958
              :..|:::                .:|.:|.|             :.|||.||..::.:|..:.
 Worm   882 SLRRMCQLIAHSRHSYDQNDGQHRKHSNKYKQFHDFLAIMTYMDWTMVLVTTLSCCSMLWESPWP 946

Human   959 DQRKTI---KILLEYADMIFTYIFILEMLLKWMAYGF----KAYFSN-GWYRLDFVVVIVFCLSL 1015
            ...:.:   ...|:.|:.||..:...|:::|.:|.|.    ||..:: |    |.:.:.::..||
 Worm   947 TTGENLIFNNFYLQIAEYIFVLVMSFELIVKCIANGLFFTPKALVTDVG----DILTIFIYITSL 1007

Human  1016 IG--------KTREELKPLISMKFLRPLRVLSQFERMKVVVRALIKTTLPTLNVFLVCLMIWLIF 1072
            :.        :.....:.|:..:.:|||||.:....::.||..|.:.....|.|.::.:::..||
 Worm  1008 MFLIWMPNHIEINSWAQLLMVCRAMRPLRVYALIPHIRRVVVELCRGFREILLVTILLVVLMFIF 1072

Human  1073 SIMGVDLFAGRFYECIDPTSGERFPSSEVMNKSRCESL----LF---------NESML------- 1117
            :..||.|..|:...|.||.         :.::..|..|    ||         |::::       
 Worm  1073 ASFGVQLVGGKLASCNDPM---------ITSRENCTGLYDVKLFVTRMEVYGKNDNLMHPSIIVP 1128

Human  1118 --WENAK-MNFDNVGNGFLSLLQVATFNGWITIMNSAIDSVAVNIQPHFEVNIYM-----YCYFI 1174
              |.|.: .|||::||..|:|.:..::.||..:.:.                :|:     ...||
 Worm  1129 RVWTNPRNFNFDHIGNAMLALFETLSYKGWNVVRDV----------------LYLRHGAWAVLFI 1177

Human  1175 NFIIF-GVFLPLSMLITVIIDNFNKHKIKLGGSNIFITVKQRKQYRRLKKLMYEDSQRPVPRPLN 1238
            :..:| |..:.|::.:.|::.|:.:::     ....:||.||:.:....:|.........|:|..
 Worm  1178 HIYVFIGCMIGLTLFVGVVVANYTENR-----GTALLTVDQRRWHDLKARLKMAQPLHVPPKPPE 1237

Human  1239 --KLQGFIFDVVTSQAFNVIVMVLICFQAIAMMIDTDVQSLQ----MSIALYWINSIFVMLYTME 1297
              ||:.:::|:.||:.|..:..||:...:..::|..:|...|    ..:.|..|::|..:|:|:|
 Worm  1238 SAKLRCYLYDLTTSRWFKQLFAVLVVVNSFTLVIPWNVSEEQDRKTFLLCLTVISAICNILFTLE 1302

Human  1298 CILKLIAFRCFYFTIAW----NIFDFMVVIFSITGLC--------------------LPMTVGSY 1338
            |:||:|||....|   |    |..||::.|..|..:.                    |..|.| |
 Worm  1303 CLLKMIAFTLSGF---WQSRRNRIDFIITILGINWIVFHFLFQLPAYFAGGITEWKRLTYTYG-Y 1363

Human  1339 LVPPSLVQLILLSRIIHMLRLGKGPKVFHNLMLPLMLSLPALLNIILLIFLVMFIYAVFGMYNFA 1403
            ||.           |:....:.........|||.:::|:.....||..:||::..||..|:..|.
 Worm  1364 LVV-----------ILRFFTIAGRKSTLKMLMLTVVMSMVRSSFIIAAMFLLVLFYANAGVVLFG 1417

Human  1404 YVKKEAGINDVSNFETFGNSMLCLFQVAIFAGWDGMLDAIFNSKWSDC--DPDKIN--PGTQV-R 1463
            .||....:....||.....:::.||:......|:.::        .||  .|...|  ||... :
 Worm  1418 MVKYGQAVGKHVNFRNGREALVVLFRSVTGEDWNDIM--------HDCMRAPPFCNWHPGLSYWQ 1474

Human  1464 GDCGNPSVGIFYFVSYILISWLIIVNMYIVVVME-FLNIASKKKNKTLSEDDFRKFFQVWKRFDP 1527
            .||||....|.||.|:.||...|::|:.:.::|| |....|.:::..||..|.|.|..||...|.
 Worm  1475 TDCGNYVGAIVYFCSFYLIITYIVLNLLVAIIMENFSLFYSSEEDALLSYADIRNFQLVWNMVDI 1539

Human  1528 DRTQYIDSSKLSDFAAALDPPLFMAKPNKGQLIALDLPMAV--------------GDRIHCLDIL 1578
            ::.:.|...::.          |:.:..||:|...|....:              ||.:...|:|
 Worm  1540 EQKRSIPVRRVK----------FLLRLLKGRLEVNDESDGLLFKHMCHEMERLHNGDDVSFHDVL 1594

Human  1579 --LAFTKRVMGQDVRMEKVVSEIESGFLLANPFKITCEPITTTLKRKQEAVSATI---IQRAYKN 1638
              |::....:.:.:::|:::...|..:::                 ::|....||   ::...||
 Worm  1595 NMLSYRSVDIRKSLQLEELLQREELEYII-----------------EEEVAKHTIRAWLENCLKN 1642

Human  1639 YRLRRND 1645
            .:.::|:
 Worm  1643 IKAKQNN 1649

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SCN7ANP_002967.2 I. /evidence=ECO:0000305 100..401 68/333 (20%)
Ion_trans 146..403 CDD:278921 59/282 (21%)
II. /evidence=ECO:0000305 487..758 62/304 (20%)
Ion_trans 522..717 CDD:278921 44/215 (20%)
Na_trans_assoc 743..927 CDD:284034 37/229 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 801..871 13/77 (17%)
III. /evidence=ECO:0000305 916..1224 74/400 (19%)
Ion_trans 951..1198 CDD:278921 59/291 (20%)
Na_channel_gate 1194..1246 CDD:240441 10/53 (19%)
IV. /evidence=ECO:0000305 1233..1531 88/333 (26%)
Ion_trans 1268..1497 CDD:278921 66/261 (25%)
nca-2NP_498054.2 Ion_trans 95..371 CDD:278921 61/294 (21%)
Ion_trans 444..649 CDD:278921 50/234 (21%)
Ion_trans 959..1202 CDD:278921 58/271 (21%)
Ion_trans 1288..1518 CDD:278921 67/252 (27%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
21.910

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