DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment SCN7A and scn3a

DIOPT Version :9

Sequence 1:NP_002967.2 Gene:SCN7A / 6332 HGNCID:10594 Length:1682 Species:Homo sapiens
Sequence 2:XP_012826714.1 Gene:scn3a / 100125099 XenbaseID:XB-GENE-5812330 Length:2019 Species:Xenopus tropicalis


Alignment Length:1953 Identity:892/1953 - (45%)
Similarity:1184/1953 - (60%) Gaps:298/1953 - (15%)


- Green bases have known domain annotations that are detailed below.


Human     1 MLASPEPKGLVPFTKESFELIKQHIA---------KTHNEDHEEEDLKPTPDLEVGKKLPFIYGN 56
            :|..|.|..|...|:||..::::..|         |...:|.:|...||..|||.||.||||||:
 Frog     5 LLPPPGPDSLRLLTRESLAVLEKRFAEEKARKASQKDRRDDDDENGPKPNSDLEAGKNLPFIYGD 69

Human    57 LSQGMVSEPLEDVDPYYYKKKNTFIVLNKNRTIFRFNAASILCTLSPFNCIRRTTIKVLVHPFFQ 121
            :.||||:.|:||:||||..:| ||||||:.:.||||:|.|.|..|:|||.:||.:||:|||..|.
 Frog    70 IPQGMVAVPMEDLDPYYSNQK-TFIVLNRGKAIFRFSATSALYILTPFNPLRRISIKILVHSLFS 133

Human   122 LFILISVLIDCVFMSLTNLPKWRPVLENTLLGIYTFEILVKLFARGVWAGSFSFLGDPWNWLDFS 186
            :.|:.::|.:|.||:::|.|:|...:|.|..||||||.|||:.|||....||:||.|||||||||
 Frog   134 MLIMCTILTNCFFMTMSNPPEWTKNVEYTFTGIYTFESLVKILARGFCLESFTFLRDPWNWLDFS 198

Human   187 VTVFEVIIRYSPLDFIPTLQTARTLRILKIIPLNQGLKSLVGVLIHCLKQLIGVIILTLFFLSIF 251
            |.|...:..:..|..:..|:|.|.||.||.|.:..|||::||.||..:|:|..|:|||:|.||:|
 Frog   199 VIVMAYVTEFVDLGNVSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVF 263

Human   252 SLIGMGLFMGNLKHKCFRWPQENE-------NETLH---NRTGNPY----YIRETENFYYLEGER 302
            :|||:.||||:|::||.|||.|.|       |||..   |.|.||:    ||.|..|||:|.|.|
 Frog   264 ALIGLQLFMGHLRNKCVRWPPEYEPNITSYFNETAGLYINVTLNPFNREEYILEETNFYFLPGTR 328

Human   303 YALLCGNRTDAGQCPEGYVCVKAGINPDQGFTNFDSFGWALFALFRLMAQDYPEVLYHQILYASG 367
            .||||||.:||||||:||||:|.|.||:.|:|:||:|.||..:|||||.||:.|.||...|.|:|
 Frog   329 DALLCGNSSDAGQCPKGYVCLKTGRNPNYGYTSFDTFSWAFLSLFRLMTQDFWENLYQLTLRAAG 393

Human   368 KVYMIFFVVVSFLFSFYMASLFLGILAMAYEEEKQRV---------------------------- 404
            |.||||||:|.||.|||:.:|.|.::||||||:.|..                            
 Frog   394 KTYMIFFVLVIFLGSFYLINLILAVVAMAYEEQNQATLEEAEQKEAEFQLMMEQLKKHQEEIQAA 458

Human   405 ----------------------------------------------------GEISKKIEPKFQQ 417
                                                                ||..|..:.||.:
 Frog   459 ALAAETMDGSREFSGGTGYGGLSESSSEASKPSSKSAKERRNRRKKRKQKEQGEDEKADDEKFHK 523

Human   418 TGKELQ----------EGN---------------------------------------------- 426
            :..|..          |||                                              
 Frog   524 SASETSIKRKGFRFSIEGNRLTYEKKYSSPHQSRLSFRGSLFFPRRDSRASLCSFRGRGKDVGSE 588

Human   427 ------------------------------------ETDEA-KTIQI------------------ 436
                                                :|.:| :|:.:                  
 Frog   589 NDFADDEHSTFEDNESRRGSLFVPHRHGERRNSNISQTSKASRTLPVLPVNGKMHSTVDCNGVVS 653

Human   437 -----------------------------------EMKKRSPISTDTSLDVLEDATLRHK----- 461
                                               |::||...|...|:|.|||..||.:     
 Frog   654 LLGGPSGPTSPAGLLLPEVIIDKPASDDNGTNTENELRKRRLSSYHVSMDFLEDPILRQRALSIA 718

Human   462 -------EELEKSKKICPLYWYKFAKTFLIWNCSPCWLKLKEFVHRIIMAPFTDLFLIICIILNV 519
                   ||||:|::.||..|.|||.|:|||:||..|||:|..|:.|:|.||.||.:.|||:||.
 Frog   719 SNLTNTMEELEESREKCPPCWNKFANTYLIWDCSDSWLKIKHVVNLIVMDPFVDLAITICIVLNT 783

Human   520 CFLTLEHYPMSKQTNTLLNIGNLVFIGIFTAEMIFKIIAMHPYGYFQVGWNIFDSMIVFHGLIEL 584
            .|:.:||||::.:....||:|||||.|||||||:||:||:.||.||||||||||.:||...|:||
 Frog   784 LFMAMEHYPITDEFAGALNVGNLVFTGIFTAEMVFKLIALDPYYYFQVGWNIFDGVIVSLSLMEL 848

Human   585 CLANVAGMALLRLFRMLRIFKLGKYWPTFQILMWSLSNSWVALKDLVLLLFTFIFFSAAFGMKLF 649
            .|::|.|:::||.||:||:|||.|.|||..:|:..:.||..||.:|.|:|...:|..|..||:||
 Frog   849 GLSDVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF 913

Human   650 GKNYEEFVCHI-DKDCQLPRWHMHDFFHSFLNVFRILCGEWVETLWDCMEVAGQSWCIPFYLMVI 713
            ||:|:|.||.| ..||:||||||:|||||||.|||:|||||:||:|||||||||:.|:..::||:
 Frog   914 GKSYKECVCKIAPDDCELPRWHMNDFFHSFLIVFRVLCGEWIETMWDCMEVAGQAMCLTVFMMVM 978

Human   714 LIGNLLVLYLFLA-LVSSFSSCKDVTAEENNEAKNLQLAVARIKKGINYVLLKILCKTQNVPKDT 777
            :||||:||.|||| |:|||||......|::||..|||:||||:.:||.||..|:....||.....
 Frog   979 VIGNLVVLNLFLALLLSSFSSDNLAATEDDNEMNNLQIAVARMHEGIAYVKRKMREFIQNAFVKK 1043

Human   778 MDHVNEVYVKED--------ISDHTLSELSNTQDFLKDKEKSSGT-------EKN-ATENESQSL 826
            ...:.|....||        ||:||..|:|...|:|||...::.|       ||. ..|::..|.
 Frog  1044 QKALEETKPLEDMQNQKDSCISNHTTVEISKEYDYLKDGNVTTATSGIGSSVEKYIIDESDYMSF 1108

Human   827 IPSPSVSETVPIASGESDIENLDNKEIQSKSGDGGSKEKIKQSSSSECSTVDIAIS--------- 882
            |.:||::.|||||.||||.|||:.:|..|:|....||||:..|||||.|||||..:         
 Frog  1109 IHNPSLTVTVPIAVGESDFENLNTEEFSSESDLEESKEKLNSSSSSEGSTVDIRPAGEGEPVPQV 1173

Human   883 EEEEMFYGGERSKHLKNGCRRGSSLGQISGASKKGKIWQNIRKTCCKIVENNWFKCFIGLVTLLS 947
            |.||.   .|......:||.|......:..:..|.|.|.|:||||..|||:|||:.||..:.|:|
 Frog  1174 EVEEF---QEPDACFTDGCIRRFPCCVVDVSHGKWKQWWNLRKTCFLIVEHNWFETFIIFMILMS 1235

Human   948 TGTLAFEDIYMDQRKTIKILLEYADMIFTYIFILEMLLKWMAYGFKAYFSNGWYRLDFVVVIVFC 1012
            :|.|||||||::|||||||:|||||.:|||||||||||||:||||:.||:|.|..|||::|.|..
 Frog  1236 SGALAFEDIYIEQRKTIKIILEYADKVFTYIFILEMLLKWVAYGFQKYFTNAWCWLDFLIVDVSL 1300

Human  1013 LSLIGKT--REEL---KPLISMKFLRPLRVLSQFERMKVVVRALIKTTLPTLNVFLVCLMIWLIF 1072
            :|||...  ..||   |.|.:::.|||||.||:||.|:|||.||:......:||.||||:.||||
 Frog  1301 VSLIANALGYSELGAIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIF 1365

Human  1073 SIMGVDLFAGRFYECIDPTSGERFPSSEVMNKSRCESLLF-NESMLWENAKMNFDNVGNGFLSLL 1136
            |||||::|:|::..|::.|....|..:.|.|:|:|..|:. |::..|:|.|:||||||.|:|:||
 Frog  1366 SIMGVNMFSGKYGYCVNYTDDVVFDYTIVNNRSQCMDLISENKTARWKNVKVNFDNVGFGYLALL 1430

Human  1137 QVATFNGWITIMNSAIDSVAVNIQPHFEVNIYMYCYFINFIIFGVFLPLSMLITVIIDNFNKHKI 1201
            |||||.||:.||.:|:||.....||.:|.|:|||.||:.|||||.|..|::.|.|||||||:.|.
 Frog  1431 QVATFKGWMEIMYAAVDSRKQEEQPKYEDNLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKK 1495

Human  1202 KLGGSNIFITVKQRKQYRRLKKLMYEDSQRPVPRPLNKLQGFIFDVVTSQAFNVIVMVLICFQAI 1266
            |.||.:||:|.:|:|.|..:|||..:..|:|||||.||.||.:||.|:.|.|::.:|:|||...:
 Frog  1496 KFGGQDIFMTEEQKKYYNAMKKLGSKKPQKPVPRPDNKFQGAVFDFVSKQPFDIAIMILICLNMV 1560

Human  1267 AMMIDTDVQSLQMSIALYWINSIFVMLYTMECILKLIAFRCFYFTIAWNIFDFMVVIFSITGLCL 1331
            .|||:||.||::....|||||::|::|:|.||:||||:.|.:||||.||||||:|||.||.|:.|
 Frog  1561 TMMIETDDQSIETENNLYWINAVFIVLFTGECVLKLISLRHYYFTIGWNIFDFVVVILSIVGMFL 1625

Human  1332 PMTVGSYLVPPSLVQLILLSRIIHMLRLGKGPKVFHNLMLPLMLSLPALLNIILLIFLVMFIYAV 1396
            ...:..|.|.|:|.::|.|:||..:|||.||.|....|:..||:|||||.||.||:||||||||:
 Frog  1626 ADLIEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAI 1690

Human  1397 FGMYNFAYVKKEAGINDVSNFETFGNSMLCLFQVAIFAGWDGMLDAIFNSKWSDCDPDKINPGTQ 1461
            |||.|||||||||||:|:.|||||||||:||||:...|||||:|..|.||...||||...:.|:.
 Frog  1691 FGMSNFAYVKKEAGIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSGAPDCDPKAEHSGSS 1755

Human  1462 VRGDCGNPSVGIFYFVSYILISWLIIVNMYIVVVMEFLNIASKKKNKTLSEDDFRKFFQVWKRFD 1526
            |:|||||||||||:|||||:||:|::|||||.|::|..::|:::..:.|.||||..|::||::||
 Frog  1756 VKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVATEESAEPLGEDDFEMFYEVWEKFD 1820

Human  1527 PDRTQYIDSSKLSDFAAALDPPLFMAKPNKGQLIALDLPMAVGDRIHCLDILLAFTKRVMGQDVR 1591
            .:.||:|...||:|||.||||||.|.|||..||||:||||..||||||||:|.||||||:|:...
 Frog  1821 SNATQFIQYVKLTDFADALDPPLRMPKPNNAQLIAMDLPMVSGDRIHCLDVLFAFTKRVLGEGDE 1885

Human  1592 MEKVVSEIESGFLLANPFKITCEPITTTLKRKQEAVSATIIQRAYKNYRLRRNDKNTSDIHMIDG 1656
            |:.:...:|..|:.:||.|.:.||||:||:||||.::|.:|||.|:.|.||:..|:.|.::..:.
 Frog  1886 MDNLRQPMEERFMASNPSKASYEPITSTLRRKQEELAAIVIQRCYRCYALRKGIKHASFMYNQEK 1950

Human  1657 DRD 1659
            .:|
 Frog  1951 GKD 1953

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SCN7ANP_002967.2 I. /evidence=ECO:0000305 100..401 167/314 (53%)
Ion_trans 146..403 CDD:278921 147/270 (54%)
II. /evidence=ECO:0000305 487..758 158/272 (58%)
Ion_trans 522..717 CDD:278921 114/195 (58%)
Na_trans_assoc 743..927 CDD:284034 79/208 (38%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 801..871 32/77 (42%)
III. /evidence=ECO:0000305 916..1224 172/313 (55%)
Ion_trans 951..1198 CDD:278921 141/252 (56%)
Na_channel_gate 1194..1246 CDD:240441 27/51 (53%)
IV. /evidence=ECO:0000305 1233..1531 170/297 (57%)
Ion_trans 1268..1497 CDD:278921 141/228 (62%)
scn3aXP_012826714.1 Ion_trans 151..430 CDD:278921 151/278 (54%)
Na_trans_cytopl 512..627 CDD:288761 8/114 (7%)
Ion_trans 786..982 CDD:278921 114/195 (58%)
Na_trans_assoc 1008..1216 CDD:284034 80/210 (38%)
Ion_trans 1239..1496 CDD:278921 143/256 (56%)
Na_channel_gate 1488..1540 CDD:240441 27/51 (53%)
Ion_trans 1562..1800 CDD:278921 143/237 (60%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
NCBI 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG52281
OrthoDB 1 1.010 - - D37221at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR10037
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
55.030

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