Protein Alignment SCN5A and na

DIOPT Version :10

• Sequence 1: NP_932173.1
• Gene: SCN5A / 6331
• HGNCID: 10593
• Length: 2016
• Species: Homo sapiens
• Sequence 2: NP_001096981.2
• Gene: na / 45338
• FlyBaseID: FBgn0002917
• Length: 2233
• Species: Drosophila melanogaster
• Alignment Length: 2157
• Identity: 436/2157 - (20%)
• Similarity: 746/2157 - (34%)
• Gaps: 715/2157 - (33%)

Human    77 GEP-LEDLDPFYSTQKTFIVLNKGKTIFRFSATNALYVLSPFHPIRRAAVKILVHSLFNMLIMCT 140
            ||| |.|..|..|       ||:...|   ...|.|:|       ||            ::.:|.
  Fly   331 GEPFLADYGPEES-------LNESADI---EWVNKLWV-------RR------------LMRLCA 366

Human   141 ILTNCVFMAQHDPPPWTKYVEYTF---------TAIYTFESLVKILARGFCLHAFTFLRDPWNWL 196
             |.:...::.:.|..:.:|....|         |.::|.|.:.|:..||.......:|:|.|...
  Fly   367 -LVSLTSVSLNTPKTFERYPSLQFITFASDTAVTLLFTAEMIAKMHIRGVLHGEVPYLKDHWCQF 430

Human   197 DFSVI-------------IMAYTTEFVDLGNVSALRTFRVLRALKTISVISGLKTIVGALI-QSV 247
            |.|::             ::....:|..|..:.|.|...::|.|:.....|..|:.:..:. :|.
  Fly   431 DASMVSFLWISIILQIFEVLEIVPKFSYLSIMRAPRPLIMIRFLRVFLKFSMPKSRINQIFKRSS 495

Human   248 KKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTALNGTNGSVEADGLVWESLDLY----- 307
            :::.:|.:..:|.:|::.|:|:| |.|.|::.||.|.|                 ..|||
  Fly   496 QQIYNVTLFFLFFMSLYGLLGVQ-FFGELKNHCVMNNT-----------------EYDLYKRPIL 542

Human   308 ----LSDPENYLLKNGTSDVLLCGNSSDAG-TCPEGYRCLKAGENPDH--GYTSFDSFAWAFLAL 365
                |:.|:.:           |....|:| .|..|..|:|......:  |:..|:..|.:...:
  Fly   543 TINSLAIPDTF-----------CSMDPDSGYQCSPGMVCMKMDFLSSYVIGFNGFEDIATSIFTV 596

Human   366 FRLMTQDCWERLYQQTL------RSAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYEEQNQATI 424
            ::..:|:.|..:..:.:      |:|     .:|..:||..::.:.|:.:||:...:
  Fly   597 YQAASQEGWVFIMYRAIDSLPAWRAA-----FYFSTMIFFLAWLVKNVFIAVITETF-------- 648

Human   425 AETEEKEKRFQE---AMEMLKKEHEALTIRGVDTVSRSSLEMSPLAPVNSHERRSKRRKRMSSGT 486
               .|...:||:   |...::|...:..:.|.||..|
  Fly   649 ---NEIRVQFQQMWGARGHIQKTAASQILSGNDTGWR---------------------------- 682

Human   487 EECGEDRLPKSDSEDGPRAMNHLSLTRGLSRTSMKPRSSRGSIFTFRRRDLGSEADFADDENSTA 551
                                                      :.|.             |:|...
  Fly   683 ------------------------------------------LVTI-------------DDNKHG 692

Human   552 G-ESESHHTSLLVPWPLRRTSAQGQPSPGTSAPGHALHGKKNSTVDCNGVVSLLGAGDPEATSPG 615
            | ..|:.|..|..|:                     ......|.:..||:|:        ||...
  Fly   693 GLAPETCHAILRSPY---------------------FRMLVMSVILANGIVT--------ATMTF 728

Human   616 SHLLRPVMLEHPPDTTTPSEEPGGPQMLTSQAPCVDGFEEPGARQRALSAVSVLTSALEELEESR 680
            .|                   .|.|:         |.|.|
  Fly   729 KH-------------------DGRPR---------DVFYE------------------------- 740

Human   681 HKCPPCWNRLAQRYLIWECCPLWMSIKQGVKLVVMDPFTDLTITMCIVLNTLFMALEHYNMTSEF 745
                        ||...|
  Fly   741 ------------RYYYIE----------------------------------------------- 746

Human   746 EEMLQVGNLVFTGIFTAEMTFKIIALDPYYYFQQGWNIFDSIIVILSLMELGLSRMSNLSVLRSF 810
                    ||||.:...|..|||..|....|::...:.|:  :::.:...|.:..|...|.|..|
  Fly   747 --------LVFTCLLDLETLFKIYCLGWRGYYKHSIHKFE--LLLAAGTTLHIVPMFYPSGLTYF 801

Human   811 RLLRVFKLAKSWPTLNTLI-KIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKNYSELRDSDSG 874
            ::|||.:|.|:.|.|...: ||.|.. ..||:|.:....::.|.:.:.||||
  Fly   802 QVLRVVRLIKASPMLEGFVYKIFGPG-KKLGSLIIFTMCLLIISSSISMQLF------------- 852

Human   875 LLPRWHMMDFF------HAFLIIFRILCGE-WIETMWDCMEVSGQSLCLLV---FLLVMVIGNLV 929
                ..:.||.      .||:.:|:||..| |:|.|.:.|..:.::|..||   |:|..:...|:
  Fly   853 ----CFLCDFTKFESFPEAFMSMFQILTQEAWVEVMDETMIRTSKTLTPLVAVYFILYHLFVTLI 913

Human   930 VLNLFLALLLSSFSADNLTAPDEDREMNNLQL--ALARIQRGLRF----------------VKRT 976
            ||:||:|::|     |||...::.:::..|:.  ..|.|:..|.|                :.|.
  Fly   914 VLSLFVAVIL-----DNLELDEDIKKLKQLKFREQSAEIKETLPFRLRIFEKFPDSPQMTILHRI 973

Human   977 TWDFCCGLLRQ----------------------------------RPQKP-------AALAAQGQ 1000
            ..||....:|:                                  |.|||       |.:.|.|.
  Fly   974 PNDFMLPKVRESFMKHFVIELETEDSLVENCKRPMSECWESNVVFRKQKPVRIMNKTAKVRAAGS 1038

Human  1001 LPSCIATPYSPPPPETEKVPPTRKETRFEEGEQPG-----QGTPGDPEPVCVPIAVAESDTDDQE 1060
            ....:|..:.......:::...........|.:.|     |||....:|..|          ||:
  Fly  1039 SLRKLAITHIINDSNNQRLMLGDSAMLPVVGTKGGGGLKSQGTITHSKPWRV----------DQK 1093

Human  1061 EDEENSLGTEEESS----KQ-----QESQPVSGGPEA------PPDSRTWSQVSATASSEAEASA 1110
            :....|:.....|.    ||     .|:..::..|.|      |.|         ......:|..
  Fly  1094 KFGSRSIRRSVRSGSIKLKQTYEHLMENGDIAAAPRANSGRARPHD---------LDIKLLQAKR 1149

Human  1111 SQADWRQQWKAEP--------QAPGCGETPEDSCSEGSTADMTNTAELLEQIPDLGQD--VKDPE 1165
            .||:.|:..:.|.        ..| ....|.:|          ...::.::|.....|  :|||
  Fly  1150 QQAEMRRNQREEDLRENHPFFDTP-LFLVPRES----------RFRKICQKIVHARYDARLKDP- 1202

Human  1166 DCFTEGCVRRCPCCAVDTTQAPGKVWWRLRKTCYHIVEH-----SWFETFIIFMILLSSGALAFE 1225
                                ..||.    ||..|..:.:     ::.:..:||...||..::.||
  Fly  1203 --------------------LTGKE----RKVQYKSLHNFLGLVTYLDWVMIFATTLSCISMMFE 1243

Human  1226 --DIYLEERKTIKVLLEYADKMFTYVFVLEMLLKWVAYGF----KKYFTNAWCWLDFLIVDVSLV 1284
              :..:.:..|::: .||.   |.....||:.||.:|.|.    |.|..:....||..|..||..
  Fly  1244 TPNYRVMDHPTLQI-AEYG---FVIFMSLELALKILADGLFFTPKAYIKDVAAALDVFIYVVSTS 1304

Human  1285 SLVANTLGFAEMGPIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFS 1349
            .|....|........:.|..||.:||||..:....||.||..|......|:.|..:.::...||:
  Fly  1305 FLCWMPLNIPTNSAAQLLMILRCVRPLRIFTLVPHMRKVVYELCRGFKEILLVSTLLILLMFIFA 1369

Human  1350 IMGVNLFAGKFGRCINQTEGDLPLNYTIVNNKSQCESLNLTGELYWTKVKV-------------- 1400
            ..||.|:.|:..||.:.|          ::.:..|..:.:. .::.||:|:
  Fly  1370 SYGVQLYGGRLARCNDPT----------ISRREDCVGVFMR-RVFVTKMKLTPGPDESYPAMLVP 1423

Human  1401 ---------NFDNVGAGYLALLQVATFKGWMDIMYAAVDSRGYEEQPQWEYNLYMYIYFVIFIIF 1456
                     ||||:|...|.|.:|.:||||:|:....:.:.|....          :|..|:|..
  Fly  1424 RVWANPRRFNFDNIGDAMLTLFEVLSFKGWLDVRDVLIKAVGPVHA----------VYIHIYIFL 1478

Human  1457 GSFFTLNLFIGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRP-LNKYQGF 1520
            |....|.||:||:|.|:::.|     ....:|.:|:::.:..|:|...:|....||| ..|.:.|
  Fly  1479 GCMIGLTLFVGVVIANYSENK-----GTALLTVDQRRWCDLKKRLKIAQPLHLPPRPDGRKIRAF 1538

Human  1521 IFDIVTKQAFDVTIMFLICLNMVTMMVE--TDDQSPEKINILAKINLLFVAIFTGECIVK-LAAL 1582
            .:||.....|...|..::.:|.:.:.:.  ..:...|::.|::.: |.||  |..|.::| :|..
  Fly  1539 TYDITQHIIFKRVIAVVVLINSMLLSITWIKGEVHTERLVIVSAV-LTFV--FVVEVVMKNIAFT 1600

Human  1583 RHYYFTNSWNIFDFVVVILSIVGTVLSDIIQ---KYFFSPTLFRVIRLARIGRILRLIRGAKGIR 1644
            ...|:.:..|.:|.:|.:..::..:|..|::   .|||.   |.|:.|    |...:......::
  Fly  1601 PRGYWQSRRNRYDLLVTVAGVIWIILQTILRNDLSYFFG---FMVVIL----RFFTITGKHTTLK 1658

Human  1645 TLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANFAYVKWEAGIDDMFNFQTFANSMLCLFQITT 1709
            .|:..:.:|:...|.|...:||::|.|::.|...|..||:..||....||.:....:..||:|.|
  Fly  1659 MLMLTVGVSVCKSFFIIFGMFLLVFFYALAGTILFGTVKYGEGIGRRANFGSPVTGVAMLFRIVT 1723

Human  1710 SAGWDGLLSPILNTGPPYCDPTLPNSNGSRGDCGSPAVGILFFTTYIIISFLIVVNMYIAIILEN 1774
            ...|:.::...: ..||||  ||.| |....|||:....:::|.|:.:|...||:|:.:|||:||
  Fly  1724 GEDWNKIMHDCM-VQPPYC--TLGN-NYWETDCGNFTASLIYFCTFYVIITYIVLNLLVAIIMEN 1784

Human  1775 FSV-ATEESTEPLSEDDFDMFYEIWEKFDPEATQFIEYSVLSDFADALSEPLRIAKPNQISLINM 1838
            ||: .:.|....||..|...|...|...|......|              |:|..|
  Fly  1785 FSLFYSNEEDALLSYADIRNFQNTWNIVDIHQRGVI--------------PVRRVK--------- 1826

Human  1839 DLPMVSGDRIHCMDILFAFTKRVLGESGEMDALKIQMEEKFMAANPSKI-SYEPITTTLRRKHEE 1902
                              |..|:|....|.|..|.::..|:|.....|: :.|.:|.     |:.
  Fly  1827 ------------------FILRLLKGRLECDPQKDRLLFKYMCYELDKLHNGEDVTF-----HDV 1868

Human  1903 VSAMVIQRAFRRHLLQRSLKHASFLFRQQAGSGLSEEDAPER-----EGLIAYVMSENFSR---- 1958
            ::.:    ::|...::::|:....|.|::....:.||.|...     ||.:..:.::|.|:
  Fly  1869 INML----SYRSVDIRKALQLEELLAREEFEYLVEEEVAKMTIRTWLEGCLKKIRAQNASKQQNS 1929

Human  1959 -----------------------PLGPPSSSSISSTS------FPPSYD--SVTRATSDNLQVRG 1992
                                   |||....|:||:.|      .||:.|  |.|.::::|.:..|
  Fly  1930 LIAGLRATNEQPVMRPNIQEDKAPLGAVDKSAISTISGAVAGACPPTSDAFSPTFSSTENEEKDG 1994

Human  1993 SDYS-----HSE 1999
            |..:     |||
  Fly  1995 SSSAVVQLPHSE 2006

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SCN5A	NP_932173.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	28..56
		I. /evidence=ECO:0000305	113..420		66/347 (19%)
		Ion_trans	130..423	CDD:459842	63/333 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	461..591		8/130 (6%)
		Na_trans_cytopl	507..667	CDD:463401	20/160 (13%)
		II. /evidence=ECO:0000305	699..969		64/282 (23%)
		Ion_trans	716..927	CDD:459842	51/221 (23%)
		Na_trans_assoc	953..1200	CDD:461936	52/335 (16%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1005..1141		27/163 (17%)
		III. /evidence=ECO:0000305	1187..1501		86/347 (25%)
		Ion_trans	1204..1479	CDD:459842	78/308 (25%)
		Na_channel_gate	1471..1523	CDD:240441	12/52 (23%)
		IV. /evidence=ECO:0000305	1510..1807		84/304 (28%)
		Ion_trans	1528..1782	CDD:459842	70/260 (27%)
		Interaction with FGF13. /evidence=ECO:0000269|PubMed:22705208	1839..1901		11/62 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1959..2016		18/54 (33%)
		Interaction with NEDD4, NEDD4L and WWP2. /evidence=ECO:0000269|PubMed:15548568	1974..1977		2/2 (100%)
na	NP_001096981.2	Ion_trans	361..654	CDD:459842	64/338 (19%)
		Ion_trans	705..927	CDD:459842	76/395 (19%)
		Ion_trans	1224..1497	CDD:459842	77/297 (26%)
		Ion_trans	1545..1793	CDD:459842	70/261 (27%)