DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment SCN5A and NaCP60E

DIOPT Version :9

Sequence 1:NP_001092874.1 Gene:SCN5A / 6331 HGNCID:10593 Length:2016 Species:Homo sapiens
Sequence 2:NP_001261172.1 Gene:NaCP60E / 37981 FlyBaseID:FBgn0085434 Length:2896 Species:Drosophila melanogaster


Alignment Length:2633 Identity:865/2633 - (32%)
Similarity:1192/2633 - (45%) Gaps:775/2633 - (29%)


- Green bases have known domain annotations that are detailed below.


Human    25 EKRMAEKQ----ARGSTTLQESRE-GLPEEEA--PRPQLDLQASKKLPDLYGNPPQELIGEPLED 82
            ||.:|:.|    .:.|....|:|. .|..|..  ||.:..::....||..:...|:.:.|:|||:
  Fly    11 EKAVAKHQVVAYTQRSQVKHENRHIQLVREYGFHPRTKASVEDGDVLPRKFEPFPEHMYGKPLEE 75

Human    83 LDPFYSTQKTFIVLNK---GKTIFRFSATNALYVLSPFHPIRRAAVKILVHSLFNMLIMCTILTN 144
            :|.|. .::||.|::|   ...|.||:.|.:|::..|:.|.||..|.|..:..|:..:|.|||.|
  Fly    76 IDTFI-YEETFCVVSKRFRKNYIHRFTGTKSLFLFYPWSPARRVCVYIATNQFFDYCVMATILFN 139

Human   145 CVFMAQHDPPPWTKYVEYTFTAIYTFESLVKILARGFCLHAFTFLRDPWNWLDFSVIIMAYVSEN 209
            |:|:|..:.   .:..||.|.|||:.|.::||:|:||.|:.:|:||:|||||||.||...|.:..
  Fly   140 CIFLAMTET---VEEAEYIFLAIYSIEMVIKIIAKGFLLNKYTYLRNPWNWLDFVVITSGYATIG 201

Human   210 IKLGNLSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMG 274
            :::|||:.||||||||||||:|::||||||:.||:.|.::||:||.||:|||.||||..||::||
  Fly   202 MEVGNLAGLRTFRVLRALKTVSIMPGLKTIINALLHSFRQLAEVMTLTIFCLMVFALFALQVYMG 266

Human   275 NLRHKCVRNFTALNGTNGSVEADGLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGY 339
            .||:||||. ...:.||.| ..|..:|      ::|.:|:|.......| ||||.:.|..||..|
  Fly   267 ELRNKCVRQ-VPTDWTNVS-HTDWQIW------VNDTDNWLYDEDELPV-LCGNLTGARHCPFEY 322

Human   340 RCLKAGENPDHGYTSFDSFAWAFLALFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYL 404
            .||..||||:||||:||:|.|:.|..|:|:|.|.||.:|...|.:.|.:.:.||.:|:|.|||||
  Fly   323 VCLCVGENPNHGYTNFDNFMWSMLTTFQLITLDYWENVYNMVLATCGPMSVSFFTVVVFFGSFYL 387

Human   405 VNLILAVVAMAYEEQNQATIAETEEKEKRFQEAMEMLKKEHEALTIRGVDTVSRSSLEMSPLAPV 469
            :||:|||||::|||:.:.|   .||::|..                  :|....|:....|  .|
  Fly   388 INLMLAVVALSYEEEAEIT---NEERKKDL------------------LDHRDDSTFSFDP--SV 429

Human   470 NSHERRSKRRKRMSSGTEECGEDRLPKSDSEDGPRAMNHLSLTRGLSRTSMKPRSSRGSIFTFRR 534
            .:.::.:|..|:              |.||..|       .|....|:...:.:.::|       
  Fly   430 LNVKKLNKNNKK--------------KIDSRKG-------VLLASYSKKKTRRKKTKG------- 466

Human   535 RDLGSEADFADDENSTAGESESHHTSLLVPWPLRRTSAQGQPSPGTSAPGHALHGKKNSTVDCNG 599
               |.|.....:.|.:.|:....|::...|.|..|.||..:||..|...     .|:...::...
  Fly   467 ---GKEGGTNGNGNGSNGDDNKSHSATPSPGPSPRHSATERPSALTMQA-----QKQYQQMEQQH 523

Human   600 VVSLLGAG---DPEATSP---------GSHLLRPVMLEHPPD--------TTTPSEEPGGPQMLT 644
            .::..|:|   :|.|.:|         |..:..|.|| :|.|        :..||....|....:
  Fly   524 KLAKSGSGGSNNPMAPTPKGRISFQDSGMGVKNPNML-YPSDYKGQLIANSGQPSSNSSGVNRES 587

Human   645 SQ--APCVDGFEEPGARQRALSAVSVLTSALEELEESRHKC------------------------ 683
            ||  :..||..||... ...:..||.:..||...|....||                        
  Fly   588 SQDDSGVVDDHEEQDT-TNDMGHVSTVELALSPREVRLIKCNGNIARIKNHNVYALHQEFSSEVV 651

Human   684 -----PPCWNRLAQRYLIWECCPL--WMSIKQGVKLVVMDPFTDLTITMCIVLNTLFMALEHYNM 741
                 |   :|...|.:.| |...  |:..:..:..||.||..:|.||:||||||.|:|:||:.|
  Fly   652 VIDDLP---DRNCDRCVHW-CTDYESWLQFQNCLYKVVRDPLFELAITLCIVLNTAFLAMEHHGM 712

Human   742 TSEFEEMLQVGNLVFTGIFTAEMTFKIIALDPYYYFQQGWNIFDSIIVILSLMELGLSRMSNLSV 806
            :..|...|.|||.|||.|||.|...|::||.. .:|..||||||.:||..||:::....:..|||
  Fly   713 SESFRNALDVGNKVFTSIFTFECIVKLMALSK-DFFLCGWNIFDLLIVTASLLDIIFELVDGLSV 776

Human   807 LRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKNYS-ELRD 870
            ||..|||||.|||:||.|:..|:.||.:::||||||||:|.|:::||||:|||||.|:|: |..|
  Fly   777 LRGLRLLRVLKLAQSWTTMKVLLSIIISTIGALGNLTLILVIVIYIFAVIGMQLFSKDYTPEKFD 841

Human   871 SDSGLLPRWHMMDFFHAFLIIFRILCGEWIETMWDCM---EVSGQSLCLLVFLLVMVIGNLVVLN 932
            .|.  :|||:..||||:|::|||||||||||.:||||   |..|.|.|..:||..:|:||.:|||
  Fly   842 PDP--VPRWNFNDFFHSFMMIFRILCGEWIEPLWDCMRAEEEQGASTCFAIFLPTLVMGNFMVLN 904

Human   933 LFLALLLSSFSADNLTAPDED-REMNNLQLALARIQRGLRFVKRTTWD----------------- 979
            |||||||:||:::.|.:..|: .|.:.|..::.|::..:|..::...|                 
  Fly   905 LFLALLLNSFNSEELKSKKEEVGEESKLARSIERVRDLIRKKRQERKDRKERKFAEKFQQIVLDA 969

Human   980 -----------FCCGLLRQRPQKPAALAA------------------------------------ 997
                       ...||  :|..||..||.                                    
  Fly   970 QQAHAQTLSHQAAVGL--ERGDKPGVLAETKFHRLSYQESMNRPVSGSDFGFQIPLHDGLHTIVD 1032

Human   998 ------QGQLPSCIATPYSPPPPETEKVPPT---------------------------------- 1022
                  .|.||..|.....|.||.::.:|||                                  
  Fly  1033 GLEYDDTGDLPEQIQLQAHPLPPTSDSMPPTYESAMMATTGGSFSSVNGNGTCQNLTPFVQAERR 1097

Human  1023 ----------------RKETRFEEG-EQPGQGTPGDPEPV-------CVPIAVAESDTDD----- 1058
                            |:|..:.|. |..||....|.:|.       |......:|..|:     
  Fly  1098 LQHQISSGVSTQQYDSREEATYTESIELLGQYNSTDTDPYANDQRSGCGSFNRGDSLQDNSSRRY 1162

Human  1059 --QEEDEE--------------------------------------------------NSLGTEE 1071
              :|.||.                                                  ||:..|:
  Fly  1163 GSEEHDEAFLKYQKSLLTRSPSYRKSLDRLSQSSGQSQRSLLKSEEAEMRRHSSGQSLNSMSIEQ 1227

Human  1072 ESSKQQE---------------------------------------------------------- 1078
            :....|:                                                          
  Fly  1228 DELLSQQGNLREELLNCDQKELFQFLQEEEELQKGTKLRRISNVMRSRRPSSQMGQPENETMVEH 1292

Human  1079 -------------------------------SQPVSGGPEA------------------------ 1088
                                           |:|.....||                        
  Fly  1293 SEFDNIIQSFEKELEEIKRSTTSLERKLSNLSEPSPAADEATKAIMEHIAIITGASERSAADEVV 1357

Human  1089 ----PPDS-------RTWSQVSATASSE------------------------------------- 1105
                |.||       |....|||.|..:                                     
  Fly  1358 LPLNPYDSYDLSSVPRRSQSVSAAAQRQSVKLKRRSLEKQRKIDEDFSISNEIRKICDQIHAPFV 1422

Human  1106 -------AEASASQADWRQ----QWKAEP------------------------------------ 1123
                   |..|||||...|    :.|.:|                                    
  Fly  1423 AMEAMAVAATSASQAQPNQSPFLRRKVDPFTVQFDRFKRLSLIERVEEVPEEEKPISTLRIESEK 1487

Human  1124 --------------------------------------QAPGCGETPEDS--------------- 1135
                                                  ..|....||..|               
  Fly  1488 MPRKFLHGPDQLRLDSLSLKSTNSYENLLIQKQKLGMATPPAVPATPPTSLKSSIEPPTLAQISS 1552

Human  1136 ----------------------------------------------------------------- 1135
                                                                             
  Fly  1553 LKTTPPLAALTEHQQHFHATSIQAAPTPAHTHAHSQAHAHSMAGQRRRMEHPQSTLDKAASFQSA 1617

Human  1136 --------CSEGSTADMTNTAELLEQ----IPDLGQD---------------------------- 1160
                    .::.|:|.....|:..||    .||..|.                            
  Fly  1618 RTESHSSGAADASSALALAMAQKTEQSQSTAPDATQKPSAFTRLTEKPWHCLVSYVDDLTVGGRR 1682

Human  1161 --------------------VKDPEDCFTEGCVR----RCP--CCAVDTTQAPGKVWWRLRKTCY 1199
                                .|.|:|||.:.|..    |||  ...:||..|  |.|.|:|....
  Fly  1683 NSQGAYNDPMTFPSYGATKAAKVPDDCFPQKCYDHFYFRCPWFMSCMDTQSA--KHWTRVRTAVL 1745

Human  1200 HIVEHSWFETFIIFMILLSSGALAFEDIYLEERKTIKVLLEYADKMFTYVFVLEMLLKWVAYGFK 1264
            .:|:...||.|::.:|..||..|.||||.|::.||:|.:|.:.:..|..:||:||:|||:|.||.
  Fly  1746 TVVDTPAFEWFVLVLIFASSITLCFEDINLDKNKTLKRVLYWINFSFCLIFVVEMILKWLALGFS 1810

Human  1265 KYFTNAWCWLDFLIVDVSLVSLVANTLGFAEMGPIKSLRTLRALRPLRALSRFEGMRVVVNALVG 1329
            ||||:.|..|||:||.||:.||:...  ...:..::|||||||||||||:||::|||:|||||:.
  Fly  1811 KYFTSFWTILDFIIVFVSVFSLLIEE--NENLKVLRSLRTLRALRPLRAISRWQGMRIVVNALMY 1873

Human  1330 AIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFGRCINQTEGDLPLNYTIVNNKSQCESLNLTGELY 1394
            |||||.|||||||:||||||||||..|.|||.:|:|:....||:  |.||:|..|...|.|    
  Fly  1874 AIPSIFNVLLVCLVFWLIFSIMGVQFFGGKFFKCVNEMGELLPI--TEVNDKWDCIEQNYT---- 1932

Human  1395 WTKVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVDSRGYEEQPQWEYNLYMYIYFVIFIIFGSF 1459
            |...|:.||:||.|||||||||||:|||::|..|||:||.:.|||.|.|||.||||||||:.|||
  Fly  1933 WINSKITFDHVGMGYLALLQVATFEGWMEVMADAVDARGVDLQPQREANLYAYIYFVIFIVCGSF 1997

Human  1460 FTLNLFIGVIIDNFNQQKKKLGG--QDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKYQGFIF 1522
            |||||||||||||||..|||..|  .::|:||.||.||.||||||.|||||.|.||:|.:....:
  Fly  1998 FTLNLFIGVIIDNFNMLKKKYEGGVLEMFLTESQKHYYTAMKKLGRKKPQKVIKRPINHFLAMFY 2062

Human  1523 DIVTKQAFDVTIMFLICLNMVTMMVETDDQSPEKINILAKINLLFVAIFTGECIVKLAALRHYYF 1587
            |:...:.|::.|..||.|||:||.:|..||......||...|..|..:|..|.|||:..||::||
  Fly  2063 DLSNSRRFEIAIFVLIFLNMLTMGIEHYDQPHAVFFILEVSNAFFTTVFGLEAIVKIVGLRYHYF 2127

Human  1588 TNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPTLFRVIRLARIGRILRLIRGAKGIRTLLFALMM 1652
            |..||:|||::|:.||.|.::.||:.....||||.||:|:.|||||||||:.|||||.|||||::
  Fly  2128 TVPWNVFDFLLVLASIFGILMEDIMIDLPISPTLLRVVRVFRIGRILRLIKAAKGIRKLLFALVV 2192

Human  1653 SLPALFNIGLLLFLVMFIYSIFGMANFAYVKWEAGIDDMFNFQTFANSMLCLFQITTSAGWDGLL 1717
            |||||||||.||.|:.|||:|.||:.|..||.:..:|||.|||||..||..||::.|||||:.:|
  Fly  2193 SLPALFNIGALLGLITFIYAILGMSLFGNVKLQGALDDMVNFQTFGRSMQLLFRLMTSAGWNDVL 2257

Human  1718 SPILNTGPPYCDPTLPNSNGSRGDCGSPAVGILFFTTYIIISFLIVVNMYIAIILENFSVATEES 1782
            ..:: ..||.|||.:  ...:.|:||.|.:.|.:||::||||::||:|||||||||||:.|.:|.
  Fly  2258 ESLM-IQPPDCDPFI--HGHTNGNCGHPLLAITYFTSFIIISYMIVINMYIAIILENFNQAHQEE 2319

Human  1783 TEPLSEDDFDMFYEIWEKFDPEATQFIEYSVLSDFADALSEPLRIAKPNQISLINMDLPMVSGDR 1847
            ...:.|||.:|||..|.|:||.|||||.:|.||||..:|..||.|:|||.::|::.:||:..|::
  Fly  2320 EIGIVEDDLEMFYIRWSKYDPHATQFIHFSQLSDFIASLDPPLGISKPNNVALVSFNLPISKGNK 2384

Human  1848 IHCMDILFAFTKRVLGESGEMD---ALKIQMEEKFMAANPSKISYEPITTTLRRKHEEVSAMVIQ 1909
            |||:|||.|..|.|||...|.|   .|:.||:.||....|::...|.:::|...|.:|.:|..||
  Fly  2385 IHCLDILHALVKHVLGHVEETDNFKQLQEQMDVKFKKQFPTRKELEIVSSTRIWKRQEKAAKTIQ 2449

Human  1910 RAFRRHLLQRSLKHASFLFRQQAGSGLSEEDAPEREGLIAYVMSENF-----SRPLGPPSSSSIS 1969
            ..::.:|.::..|.     |..:|...::..:|  .|..:.:.:.||     || .|...||..|
  Fly  2450 TGWKEYLRRKREKE-----RSNSGDSATQTSSP--GGWQSKLSALNFFHLQVSR-RGTACSSRAS 2506

Human  1970 STSFPPSYDSVTRATSDNLQVRGSDYSHSEDLA 2002
            |           |.:|     |.||.|...:||
  Fly  2507 S-----------RKSS-----RASDASDLSELA 2523

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SCN5ANP_001092874.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 28..56 9/34 (26%)
I. /evidence=ECO:0000305 113..420 149/306 (49%)
Ion_trans 151..423 CDD:278921 134/271 (49%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 461..591 24/129 (19%)
Na_trans_cytopl 485..578 CDD:288761 18/92 (20%)
II. /evidence=ECO:0000305 699..969 138/276 (50%)
Ion_trans 734..927 CDD:278921 103/196 (53%)
Na_trans_assoc 953..1200 CDD:284034 89/824 (11%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1005..1141 50/584 (9%)
III. /evidence=ECO:0000305 1187..1501 179/315 (57%)
Ion_trans 1222..1479 CDD:278921 155/256 (61%)
Na_channel_gate 1471..1523 CDD:240441 30/53 (57%)
IV. /evidence=ECO:0000305 1510..1807 149/296 (50%)
Ion_trans 1545..1782 CDD:278921 124/236 (53%)
GPHH 1792..1849 CDD:293510 28/56 (50%)
Interaction with FGF13. /evidence=ECO:0000269|PubMed:22705208 1839..1901 25/64 (39%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1959..2016 13/44 (30%)
Interaction with NEDD4, NEDD4L and WWP2. /evidence=ECO:0000269|PubMed:15548568 1974..1977 0/2 (0%)
NaCP60ENP_001261172.1 Ion_trans 152..371 CDD:278921 115/227 (51%)
Ion_trans 705..902 CDD:278921 105/199 (53%)
Ion_trans 1768..2019 CDD:278921 157/258 (61%)
Na_channel_gate 2009..2063 CDD:240441 30/53 (57%)
Ion_trans 2085..2320 CDD:278921 125/237 (53%)
GPHH 2331..2386 CDD:293510 27/54 (50%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG2301
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D37221at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100419
Panther 1 1.100 - - O PTHR10037
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
54.820

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