Protein Alignment SCN5A and cac

DIOPT Version :10

• Sequence 1: NP_932173.1
• Gene: SCN5A / 6331
• HGNCID: 10593
• Length: 2016
• Species: Homo sapiens
• Sequence 2: NP_001356945.1
• Gene: cac / 32158
• FlyBaseID: FBgn0263111
• Length: 2110
• Species: Drosophila melanogaster
• Alignment Length: 1984
• Identity: 468/1984 - (23%)
• Similarity: 810/1984 - (40%)
• Gaps: 526/1984 - (26%)

Human   110 ALYVLSPFHPIRRAAVKILVHSLFNMLIMCTILTNCVFMAQHDPPPW---------TKYVEYTFT 165
            :|::|:..:|||:....|:....|...::.||:.|||.:|..:..|.         .:..|..|.
  Fly    17 SLFILTEDNPIRKYTRFIIEWPPFEYAVLLTIIANCVVLALEEHLPGGDKTVLAQKLEKTEAYFL 81

Human   166 AIYTFESLVKILARGFCLHAFTFLRDPWNWLDFSVIIMAYTTEFVDLG---NVSALRTFRVLRAL 227
            .|:..|:.:||||.|..||..::||:.||.:||.|::..:.|::..:|   ::..||..||||.|
  Fly    82 CIFCVEASLKILALGLVLHKHSYLRNIWNIMDFFVVVTGFMTQYPQIGPEVDLRTLRAIRVLRPL 146

Human   228 KTISVISGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTALNGTNG 292
            |.:|.|..|:.::.::|:::..|..:.:|.:|.:.:||:|||:.:.|.|...|..
  Fly   147 KLVSGIPSLQVVLKSIIKAMAPLLQIGLLVLFAIVIFAIIGLEFYSGALHKTCYS---------- 201

Human   293 SVEADGLVWESLDLYLSDPENYLLKNGTSDV--------------LLCGNSSDAGTCPEGYRCLK 343
                           |.|| |.|:|.|.|:.              .:|.|::.        .||:
  Fly   202 ---------------LEDP-NKLVKEGESETPCNTDNILEKATGSFVCNNTTS--------MCLE 242

Human   344 AGENPDHGYTSFDSFAWAFLALFRLMTQDCWERLYQQTLRSAGKIY-MIFFMLVIFLGSFYLVNL 407
            ..|.|:.|.||||:..:|.|.:|:.:|.:.|..:...|..:.|..: .|:|:.:|.:|||:::||
  Fly   243 KWEGPNSGITSFDNIGFAMLTVFQCITMEGWTAILYWTNDALGSAFNWIYFVPLIVIGSFFMLNL 307

Human   408 ILAVVAMAYEEQNQATIAETEEKEKRFQEAMEMLKKEHEALTIRG-VDTVSRS---------SLE 462
            :|.|::        ...|:..||.:..||.:::.:::.....:.| |:.:.::         :.|
  Fly   308 VLGVLS--------GEFAKEREKVENRQEFLKLRRQQQLERELNGYVEWICKAEEVILAEERTTE 364

Human   463 MSPLAPVNSHERRSKRRKRMSSGTEECGEDRLPKSDSEDGPRAMNHLSLTRGLSRTSMKPRSSRG 527
            ...:..:.:..|.:.:||::.|         |.||.|.|
  Fly   365 EEKMHIMEARRRNAAKRKKLKS---------LGKSKSTD-------------------------- 394

Human   528 SIFTFRRRDLGSEADFADDENSTAGESESHHTSLLVPWPLRRTSAQGQPSPGTSAPGHALHGKKN 592
                  ..:..:|.|:.||     |..::            |:..||
  Fly   395 ------TEEEEAEEDYGDD-----GYLKT------------RSKPQG------------------ 418

Human   593 STVDCNGVVSLLGAGDPEATSPGSHLLRPVMLEHPPDTTTPSEEPGGPQMLTSQAPCVDGFEEPG 657
               .|.|.
  Fly   419 ---SCTGF--------------------------------------------------------- 423

Human   658 ARQRALSAVSVLTSALEELEESRHKCPPCWNRLAQRYLIWECCPLWMSIKQGVKLVVMDPFTDLT 722
                                         | |..:|:..|        |:..||......|
  Fly   424 -----------------------------W-RAEKRFRFW--------IRHTVKTQWFYWF---- 446

Human   723 ITMCIVLNTLFMALEHYNMTSEFEEMLQVGNLVFTGIFTAEMTFKIIALDPYYYFQQGWNIFDSI 787
            :.:.:.|||:.:|:|||...|...|.|.....:|.|:|.:||..|:.||.|..||:..:|.||.:
  Fly   447 VIVLVFLNTVCVAVEHYGQPSFLTEFLYYAEFIFLGLFMSEMFIKMYALGPRIYFESSFNRFDCV 511

Human   788 IVILSLMELGLSRMS----NLSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNLTLVLAI 848
            ::..|:.|:..|.:.    .|||||:.||||:||:.|.|.:|..|:..:.||:.::.:|..:|.:
  Fly   512 VISGSIFEVIWSEVKGGSFGLSVLRALRLLRIFKVTKYWSSLRNLVISLLNSMRSIISLLFLLFL 576

Human   849 IVFIFAVVGMQLFGKNYSELRDSDSGLLPRWHMMDFFHAFLIIFRILCGE-WIETMWDCMEVSGQ 912
            .:.|||::||||||..::.     .|..|..:...|..|.|.:|:||.|| |.|.|:..:...|.
  Fly   577 FILIFALLGMQLFGGQFNL-----PGGTPETNFNTFPIALLTVFQILTGEDWNEVMYQGIISQGG 636

Human   913 S----LCLLVFLLVMVIGNLVVLNLFLALLLSSF-SADNLTAPDEDREMNNLQLALARIQRGLRF 972
            :    :..:.|:::::.||..:||:|||:.:.:. :|..|||.:|::...:.:..|..:::.:.
  Fly   637 AQKGMIYSIYFIVLVLFGNYTLLNVFLAIAVDNLANAQELTAAEEEQVEEDKEKQLQELEKEME- 700

Human   973 VKRTTWDFCCGLLRQRPQKPAALAAQGQLPSCIATPYSPPPPETEKVPPTRKETRFEEGEQPGQG 1037
                                 ||.|.|                          ...|.|:.
  Fly   701 ---------------------ALQADG--------------------------VHVENGDG---- 714

Human  1038 TPGDPEPVCVPIAVAESDTDDQEEDEENSLGTEEESSKQQESQPVSGGPEAPPDSRTWSQVSATA 1102
                        |||.|.:..::::||           ::|.:.|:.||
  Fly   715 ------------AVAPSKSKGKKKEEE-----------KKEEEEVTEGP---------------- 740

Human  1103 SSEAEASASQADWRQQWKAEPQAPGCGETPEDSCSEGSTADMTNTAELLEQIPDLGQDVKDPEDC 1167
                               :|..|         .|.......||.
  Fly   741 -------------------KPMLP---------YSSMFILSPTNP-------------------- 757

Human  1168 FTEGCVRRCPCCAVDTTQAPGKVWWRLRKTCYHIVEHSWFETFIIFMILLSSGALAFEDIYLEER 1232
                                      :|:..:.:|...:|:.||:.:|.:||.|||.||...|..
  Fly   758 --------------------------IRRGAHWVVNLPYFDFFIMVVISMSSIALAAEDPVRENS 796

Human  1233 KTIKVLLEYADKMFTYVFVLEMLLKWVAYGF----KKYFTNAWCWLDFLIVDVSLVSLVANTLGF 1293
            :..|: |.|.|..||.||.:|||||.|..|.    ..|....|..:|.::|..:.||...:..|.
  Fly   797 RRNKI-LNYFDYAFTGVFTIEMLLKIVDLGVILHPGSYLREFWNIMDAVVVICAAVSFGFDMSGS 860

Human  1294 A---EMGPIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNL 1355
            :   .:..|||||.||.||||:.:.|...::.|.:.:|.::.:::|:|:|.::|..|||::||.|
  Fly   861 SAGQNLSTIKSLRVLRVLRPLKTIKRVPKLKAVFDCVVNSLKNVVNILIVYILFQFIFSVIGVQL 925

Human  1356 FAGKFGRCINQTEGDLPLNYTIVNNKSQCESLNLTGE----------LYWTKVKVNFDNVGAGYL 1410
            |.|||..|.::::          :..::|:......|          ..|.....::|||.|..|
  Fly   926 FNGKFFYCTDESK----------HTSAECQGSYFKYEEDELLPKQELRVWKPRAFHYDNVAAAML 980

Human  1411 ALLQVATFKGWMDI----MYAAVDSRGYEEQPQWEYNLYMYIYFVIFIIFGSFFTLNLFIGVIID 1471
            .|..|.|.:||..:    |.|..:.||    |...:.:.|.|:::::.|...||.:|:|:.:||.
  Fly   981 TLFAVQTGEGWPQVLQHSMAATYEDRG----PIQNFRIEMSIFYIVYFIVFPFFFVNIFVALIII 1041

Human  1472 NFNQQ-KKKLGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKYQGFIFDIVTKQAFDVTIM 1535
            .|.:| :.:|  ||..:.:.||...:.  .:|::..::.:|:..|.::..::.||....|:..||
  Fly  1042 TFQEQGEAEL--QDGEIDKNQKSCIDF--TIGARPLERYMPKNRNTFKYKVWRIVVSTPFEYFIM 1102

Human  1536 FLICLNMVTMMVETDDQSPEKINILAKINLLFVAIFTGECIVKLAALR-HYYFTNSWNIFDFVVV 1599
            .||..|.:.:|::..:|.......|..||:.|..:|:.|.::|:.... ..:|.:.|||||.:.|
  Fly  1103 MLIVFNTLLLMMKYHNQGDMYEKSLKYINMGFTGMFSVETVLKIIGFGVKNFFKDPWNIFDLITV 1167

Human  1600 ILSIVGTVLSDIIQKYFFSPTL-FRVIRLARIGRILRLIRGAKGIRTLLFALMMSLPALFNIGLL 1663
            :.|||     |.:...|.|.:: ...:||.|..|:::|:|....||.||:..:.|..||..:.||
  Fly  1168 LGSIV-----DALWMEFGSNSINVGFLRLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLL 1227

Human  1664 LFLVMFIYSIFGMANFAYVKW---EAGIDDMFNFQTFANSMLCLFQITTSAGWDGLLSPILNTGP 1725
            :.::.|||:|.||..|..:|.   |..|....|||:|...::.||:..|...|..::...|.  .
  Fly  1228 IAMLFFIYAIIGMQVFGNIKLGTVENSITRHNNFQSFIQGVMLLFRCATGEAWPNIMLACLK--G 1290

Human  1726 PYCDPTLPNSNGSRGDCGSPAVGILFFTTYIIISFLIVVNMYIAIILENFSVATEESTEPLSEDD 1790
            ..||.....:.|..  ||| .:...:|.::|.....:::|:::|:|::||...|.:|: .|....
  Fly  1291 KACDDDAEKAPGEY--CGS-TLAYAYFVSFIFFCSFLMLNLFVAVIMDNFDYLTRDSS-ILGAHH 1351

Human  1791 FDMFYEIWEKFDPEATQFIEYSVLSDFADALSEPLRIAK--PNQIS---LINMDLPMVSGDRIHC 1850
            .|.|..||.::||.||..|.|:.:.|....:..||....  ||:::   ||.|::|:....|:..
  Fly  1352 LDEFVRIWAEYDPNATGKIHYTEMYDMLKNMDPPLGFGNKCPNRLAYKKLIRMNMPLDDELRVQF 1416

Human  1851 MDILFAFTKRVLG----ESGEMDALKIQMEEKFMAANPSKISYEPITTTLRRKHEEVS--AMVIQ 1909
            ...|||..:..|.    ...|||...:::.|..  .|...:..:.:...|....::::  .:.:.
  Fly  1417 TTTLFALIRENLSIKMRAPEEMDQADMELRETI--TNIWPLQAKKMLNLLVPPSDQLNKGKLSVG 1479

Human  1910 RAFRRHLLQRSLKHASFLFRQQAGSG---LSEEDA---PEREGLI---AYVMSENFSRPLGPPSS 1965
            :.:...|:..|.:...|   .|..||   |..:||   |.:|.|.   |..:....|...|...|
  Fly  1480 KIYAGFLILESWRSTRF---GQLDSGMPMLELQDASRHPSQESLTGADAGHLHPGHSYMNGHRRS 1541

Human  1966 SSISSTSFPPSYDSVTRATSDNLQVRGSDYSHSE 1999
            .|:.....|       .|.|.:.:.||..|.|.:
  Fly  1542 PSLRHNGSP-------LARSPSPRRRGHQYIHHD 1568

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SCN5A	NP_932173.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	28..56
		I. /evidence=ECO:0000305	113..420		92/333 (28%)
		Ion_trans	130..423	CDD:459842	87/319 (27%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	461..591		18/129 (14%)
		Na_trans_cytopl	507..667	CDD:463401	10/159 (6%)
		II. /evidence=ECO:0000305	699..969		87/279 (31%)
		Ion_trans	716..927	CDD:459842	71/219 (32%)
		Na_trans_assoc	953..1200	CDD:461936	23/246 (9%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1005..1141		15/135 (11%)
		III. /evidence=ECO:0000305	1187..1501		99/335 (30%)
		Ion_trans	1204..1479	CDD:459842	92/296 (31%)
		Na_channel_gate	1471..1523	CDD:240441	10/52 (19%)
		IV. /evidence=ECO:0000305	1510..1807		89/301 (30%)
		Ion_trans	1528..1782	CDD:459842	76/258 (29%)
		Interaction with FGF13. /evidence=ECO:0000269|PubMed:22705208	1839..1901		12/65 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1959..2016		10/41 (24%)
		Interaction with NEDD4, NEDD4L and WWP2. /evidence=ECO:0000269|PubMed:15548568	1974..1977		1/2 (50%)
cac	NP_001356945.1	Ion_trans	37..324	CDD:459842	90/328 (27%)
		Ion_trans	441..677	CDD:459842	79/244 (32%)
		Ion_trans	769..1050	CDD:459842	92/295 (31%)
		Ion_trans	1094..1345	CDD:459842	76/260 (29%)
		GPHH	1354..1407	CDD:465306	17/52 (33%)
		Ca_chan_IQ	1417..1496	CDD:462591	12/80 (15%)
		AF-4	<1512..>1704	CDD:461550	15/64 (23%)