|
Human 110 ALYVLSPFHPIRRAAVKILVHSLFNMLIMCTILTNCVFMAQHDP-------PPWTKYVEYTFTAI 167
::..|:.:...|...:.::.:..|..:.:..||.||:.:..:.| ....|.::.....|
Fly 280 SIRALTQYTRPRNWCLMLITNPWFERVSILVILLNCITLGMYQPCVDDACVTNRCKILQIFDDII 344
Human 168 YTF---ESLVKILARGFCLHAFTFLRDPWNWLDFSVI---IMAYTTEFVDLGNVSALRTFRVLRA 226
:.| |..:|::|.|.| ...|:|.|.||.|||.:: ::.|.....:| |::|:||.||||.
Fly 345 FAFFALEMTIKMVAMGIC-GKNTYLADSWNRLDFFIVLAGLLEYVMHVENL-NLTAIRTIRVLRP 407
Human 227 LKTISVISGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTALNGTN 291
|:.|:.|..::.:|..|:.::..|.:|::|..|...:|.:||:||:.|.||.:|
Fly 408 LRAINRIPSMRILVMLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWEGILRQRC----------- 461
Human 292 GSVEADGLVW--------------ESLDLY--LSDPENYLLKN-GTSDVLLCGN----SSDAGTC 335
..:..:|:|: .||..| .|..::|:... ..|.:.|||| ...:..|
Fly 462 SLMRTEGMVYPLTVPEVYRVRVRVNSLSQYYEFSKDQDYICSTPNDSGMHLCGNFPPYRIGSLVC 526
Human 336 PEGYR---------------------CLKAGENPDHGYTSFDSFAWAFLALFRLMTQDCWERL-- 377
.|..: |.::||||..|..|||:...|::|:|.:::.:.|..:
Fly 527 NEEAKLFDFNEPTNTSCVNWNQYYTTCKQSGENPFQGTISFDNIGMAWVAIFLVISLEGWTDIMY 591
Human 378 YQQTLRSAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYEEQNQ----------------ATIA- 425
|.|...|... .|:|:|:|.:|||:::||.|.|:|..:.|..: :|:|
Fly 592 YVQDAHSFWD--WIYFVLLIVIGSFFMINLCLVVIATQFSETKKREMERMRQERARYTSTSTLAS 654
Human 426 ETEEKE----------------KRFQEAMEMLKK----------EHEALTIRGVDTV----SR-- 458
.|...| :||:. .|||| ..|.| :...|.: ||
Fly 655 STNNSEPATCYAEIVKYIAHLWRRFKR--RMLKKYRLYKYQRQQRKEGL-LPNADNLTFSPSRIK 716
Human 459 --------------SSLE---MSPLAPVNS----------------------------------- 471
||:: ::.:.|:||
Fly 717 CHHPKCPKYSNRKPSSIQDQMITVMVPLNSASNNINNNNNNNSNSSNHNGSGNHTAAGGGNNNNN 781
Human 472 --------------------------------------------HERRSKRRKRM----SSGTEE 488
|:.:.:::::. |..||:
Fly 782 NNNNNAASCTTVALVNGINGSAASVTMSSAHHQQHQLLQHQQQQHQNQQQQQQQQQHSSSDNTEQ 846
Human 489 -CGEDRLPKS---------------------------------DSED------------------ 501
...|.||:| |||.
Fly 847 SLAPDGLPRSSSLKKSTAHHQLKPEGSAAEQKTILLKFPQQMIDSEQLILQLGNLGKSHPCTSGF 911
Human 502 ----------------------GPRAMNHLSLTRGLSRTSMKP---------------------- 522
.|.|:|....|.| :.|::.|
Fly 912 LSPPTSASRRPSVMFNEYVLLHTPPALNADPATAG-TTTTVAPTVATVAGTAAAAAAAAATGSGS 975
Human 523 ------------------RSSRGSIFTFRR---------------RDLGSEAD-FADDEN----- 548
.:.:.:||:..: :.:|:.|: :||...
Fly 976 GNNNHQNGGASGGAGTGGTTEKSNIFSTEKMTQAGDGSIWQVNLPQTIGTIANPYADCSELGIHD 1040
Human 549 --------------STA---GES--ESHHTSLLVPWPLRRTSAQGQPSPGTSAPGHALH------ 588
|.| |:| ||.:||| .:..|.|:....|.|
Fly 1041 AMTCQELLAFSVAFSAALPTGQSTLESFYTSL------------ARCDPHTAEALRAHHKPRSVP 1093
Human 589 -GKKNSTVDCNGVVSLLG--AGD------PEATSP------GSHLLRPVMLEHPP---------D 629
|:..:|....|...::. ||| |...|. .||.......||.. :
Fly 1094 TGQNQTTPGAEGATVMVASTAGDTGQTLQPSTVSAVVGGTIDSHAANHRRKEHHQQSHHHHNNNN 1158
Human 630 TTTPS------EEPGGPQMLTSQAPCVDGFEEPGARQRALSAVSVLTSALEELEESRHKCPPCWN 688
||:.| :..|..:|...:||..:..|:... ...:..:||..|:|...:..|...
Fly 1159 TTSHSRNYRSRQGQGNSRMREPRAPTGNYMEDYAC------CYDLYQNALSPLDERPRQRSPTTR 1217
Human 689 RLAQRYLIWECCPLWMSIKQGVKLVVMDPFTDLTITMCIVLNTLFMALEHYNMTSEFEEMLQVGN 753
.|...|........| |::.::.:|...:....|.:.|::|||.|.:|::|...|...:::..|
Fly 1218 CLISVYRCMSRVCSW--IRRYIRRLVEHKYFQQGILLAILINTLSMGIEYHNQPPELTAIVETSN 1280
Human 754 LVFTGIFTAEMTFKIIALDPYYYFQQGWNIFDSIIVILSLMELGLSRMSN--------LSVLRSF 810
:||:|||..||..|::|..|:.|...|:|:||.||||||.:|:..:.|.| |||||:|
Fly 1281 VVFSGIFAVEMLLKVVAEGPFRYIANGFNVFDGIIVILSAIEICQTFMGNGTGGGGSGLSVLRTF 1345
Human 811 RLLRVFKLAKSWPTLNTLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKNYSELRDSDSGL 875
||||:.||.:..|.|...:.::..::..:.....:|.:.:|||:::||.|||..:.:..| :|||
Fly 1346 RLLRILKLVRFMPNLRRQLFVMLRTMDNVAVFFSLLVLFIFIFSILGMYLFGGKFCKFLD-ESGL 1409
Human 876 -----------------LPRWHMMDFFHAFLIIFRILCGE-WIETMWDCMEVSGQSLCLLVFLLV 922
..|.|..:...|.:.:|:||..| |...:::.||.:.. ...|.|:.:
Fly 1410 ERECTCPEIISRHPQCECDRKHFNNILWATVTVFQILTQEDWNVVLFNGMEKTSH-WAALYFVAL 1473
Human 923 MVIGNLVVLNLFLALLLSSFS--------------------------------------ADNLTA 949
|..||.|:.||.:|:|:..|| ||:.|.
Fly 1474 MTFGNYVLFNLLVAILVEGFSSERNERREREQRELVKKLREETLAENYSDGMYDESRSEADSSTT 1538
Human 950 PDEDREMNN----------LQLALARI---------QRGLRFVKRTTWDFCCGLLRQRPQKPAAL 995
.|...|:.| ||.::..| ||.| :.|.|: .:.:.|...||.
Fly 1539 NDSYYEVRNRWRSAEDVRKLQDSVELIIEAKSNMHRQRLL----QPTHDY---QINELPASSAAP 1596
Human 996 AAQG------------------------------------------------------------- 999
:|.|
Fly 1597 SASGTSGASAPGDRERDRDRDRDRERDRDRDRERDREAGGGGKEEGAQHAKPRGGLKKTYSIKER 1661
Human 1000 -------------QLPSCIAT--------------------------PYSPPP------------ 1013
:.|..|.| |.|||.
Fly 1662 RSEAPRLSKIRLARDPPIITTTAATPQDSPSTTLEPGMSFRQWGDMEPPSPPSPSLLRPPNIFTG 1726
Human 1014 ---------PETEKVPP----TRKETRFEEGEQPGQGTPGD------------------------ 1041
|..:.:|| :.|........|.|.|..|.
Fly 1727 GQRSLDEGIPSIDLIPPSPVLSHKPLNILNASQLGVGMGGGVPSTAGSSSSMHSVIIDDISKSSS 1791
Human 1042 ----PEPVCVPIAVAESDTDDQEE--------------------DEENSLGTEEESSKQQESQPV 1082
..|:.||...:.:|...|.. ....:.|.....|...|..|:
Fly 1792 STAAATPIYVPTISSTADAQSQSHSLNDVSVGSSPGGEIPATGMSRNANTGASTSGSSSSERLPL 1856
Human 1083 SGGPEAPPDSRTWSQ-----------VSATA---------------------------------- 1102
: .||...::.| .||.|
Fly 1857 A----PPPQQGSFKQRLRRGSSKKRRASALALATDDNPARRTLDNQARRTQDEEEEQQQLNNGGD 1917
Human 1103 ------SSEAEASASQADWRQQWKAEPQ------------------------------------- 1124
:|.|..|.|.:..::..:..||
Fly 1918 NSCLLRNSNAVVSGSSSGTKETNRLSPQNSIRRLSNTLSIGSGPVGSRRASACIFNSQVYQNLNQ 1982
Human 1125 ----APGCGETPEDSC------------------------------------SEGSTADMTNTAE 1149
.||.|:....|. |.|:..:..|..:
Fly 1983 PPKLRPGSGQRRMSSIELAFSKTSHLNLHNLEANRKSLSYTNSKMDLDKWNKSYGNLNEPDNMLQ 2047
Human 1150 L-------------------------LEQIPDLGQD--VKDPEDCFTEGCVRRCPCCAVDTTQ-- 1185
. |:|:..|.|. ::..:|.|: .|||
Fly 2048 QYMEARDKRKNSISHYNLKKRLEEKELQQLQQLHQQQLLQQRQDSFS------------STTQQQ 2100
Human 1186 -----------------------APG------KVWW--------------------------RLR 1195
.|| |:.. |.|
Fly 2101 QQQLQQHRLSKDQQQLAMQPHSMVPGGGERYSKLKMLIEQLTPKHFTTEREDYSLYIFPEDNRFR 2165
Human 1196 KTCYHIVEHSWFETFIIFMILLSSGALAFEDIYLEERKTIKVLLEYADKMFTYVFVLEMLLKWVA 1260
:.|...|...||:..::..|.|:...||.|...:....|.::.|..|:.:||.||.:||.:|.||
Fly 2166 QICTWFVNQKWFDNVVLLFIALNCITLAMERPNIPPSSTERLFLATANYVFTVVFTVEMFIKVVA 2230
Human 1261 ----YGFKKYFTNAWCWLDFLIVDVSLVSLVANTLGFAE---MGPIKSLRTLRALRPLRALSRFE 1318
||...|||:.|..:|..:|.:|::.|:.:.:..:. .|.::..|.||:|||||.::|..
Fly 2231 TGMFYGHDAYFTSGWNIMDGSLVTISIIDLLMSLISESSPRIFGILRVFRLLRSLRPLRVINRAP 2295
Human 1319 GMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFGRCINQTEGDLPLNYTIVNNKSQ 1383
|:::||..|:.::..|.|::|:|..|::||.|:||.||.|.|..| ||: |...|.|..:
Fly 2296 GLKLVVQTLLSSLRPIGNIVLICCTFFIIFGILGVQLFKGTFYYC----EGE---NIKGVRNADE 2353
Human 1384 CESLNLTGELYWTKVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVDSRGYEEQPQWEYNLYMYI 1448
|. .:.|.: ||..|.|||::|...::|..:::..||::|||..:|:.|.::||...||.:..:
Fly 2354 CR--RIPGNV-WTNRKYNFDDLGKALMSLFVLSSRDGWVNIMYTGLDAVGVDQQPIVNYNEWRLL 2415
Human 1449 YFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNAMKK-LGSKKPQKPIPR 1512
||:.||:...||.||:|:||:::||::.::: .|:::|...|.|: |..:|.::.:..
Fly 2416 YFIAFILLVGFFVLNMFVGVVVENFHRCREE--------QEKEEKIRRAAKRALQMEKKRRRMHE 2472
Human 1513 P-----LNKYQGFIFDIVTKQAFDVTIMFLICLNMVTMMVETDDQSPEKINILAKI-NLLFVAIF 1571
| .:..:.|:.::||.:.||:.|..:|.||:|||.:|. .:.|..:....|| |..|.|:|
Fly 2473 PPYYTNYSPTRMFVHNVVTSKYFDLAIAAVIGLNVVTMAMEY-YKMPSGLKYALKIFNYFFTAVF 2536
Human 1572 TGECIVKLAALR-HYYFTNSWNIFDFVVVILSIVGTVLSDI----IQKYFFSPTLFRVIRLARIG 1631
..|..:||.||. ..|..:.||..|..:|:|||||.||.:: .|....:||:.||:|:.||.
Fly 2537 ILEANMKLVALGWKLYLKDRWNQLDVGIVLLSIVGIVLEELETNTHQIIPINPTIIRVMRVLRIA 2601
Human 1632 RILRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANFAYVKWE-----AGIDDM 1691
|:|:|::.|.|||.||..:|.:||.:.|:|||.||:.||::..|:..|..::.. .|:.:.
Fly 2602 RVLKLLKMANGIRALLDTVMQALPQVGNLGLLFFLLFFIFAALGVELFGRLECSDEIPCQGLGEH 2666
Human 1692 FNFQTFANSMLCLFQITTSAGWDGLLSPILNTGPPYCDPTLPNSNGSRGDCGSPAVGILFFTTYI 1756
.:|..|..:.|.||::.|...|:|::...|... ||.. ::..|..|.|..:..:||..::
Fly 2667 AHFANFGMAFLTLFRVATGDNWNGIMKDTLRDN---CDDA---ADCVRNCCVSSVIAPIFFVIFV 2725
Human 1757 IISFLIVVNMYIAIILENFSVATEESTEPLSEDDFDMFYEIWEKFDPEATQFIEYSVLSDFADAL 1821
:::..::||:.:|:::::. |||.:.: ||:.||..|:..:...|.....|..:....|:|.
Fly 2726 LMAQFVLVNVVVAVLMKHL----EESHKQM-EDELDMEVELERELVREQEFAQEQKLCQQLAEAQ 2785
Human 1822 SE----PLRIAKPNQI------SLINMD--LPMVSG 1845
|: |..:||...: |..::| .|.|||
Fly 2786 SKAAAPPRPLAKVKSLPKNFIYSTPSLDKKFPAVSG 2821
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