DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment SCN4A and NaCP60E

DIOPT Version :9

Sequence 1:NP_000325.4 Gene:SCN4A / 6329 HGNCID:10591 Length:1836 Species:Homo sapiens
Sequence 2:NP_001261172.1 Gene:NaCP60E / 37981 FlyBaseID:FBgn0085434 Length:2896 Species:Drosophila melanogaster


Alignment Length:2613 Identity:822/2613 - (31%)
Similarity:1142/2613 - (43%) Gaps:911/2613 - (34%)


- Green bases have known domain annotations that are detailed below.


Human    29 EQRAVEEEARLQRNKQMEIEEPER------------KPRSDLEAGKNLPMIYGDPPPEVIGIPLE 81
            :::||.:...:...::.:::...|            :.::.:|.|..||..:...|..:.|.|||
  Fly    10 DEKAVAKHQVVAYTQRSQVKHENRHIQLVREYGFHPRTKASVEDGDVLPRKFEPFPEHMYGKPLE 74

Human    82 DLDPYYSNKKTFIVLNK---GKAIFRFSATPALYLLSPFSVVRRGAIKVLIHALFSMFIMITILT 143
            ::|.:. .::||.|::|   ...|.||:.|.:|:|..|:|..||..:.:..:..|...:|.|||.
  Fly    75 EIDTFI-YEETFCVVSKRFRKNYIHRFTGTKSLFLFYPWSPARRVCVYIATNQFFDYCVMATILF 138

Human   144 NCVFMTMSDPPPWSKNVEYTFTGIYTFESLIKILARGFCVDDFTFLRDPWNWLDFSVIMMAYLTE 208
            ||:|:.|::.   .:..||.|..||:.|.:|||:|:||.::.:|:||:|||||||.||...|.|.
  Fly   139 NCIFLAMTET---VEEAEYIFLAIYSIEMVIKIIAKGFLLNKYTYLRNPWNWLDFVVITSGYATI 200

Human   209 FVDLGNISALRTFRVLRALKTITVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALVGLQLFM 273
            .:::||::.||||||||||||::::||||||:.||:.|.::|::||.||:|||.||||..||::|
  Fly   201 GMEVGNLAGLRTFRVLRALKTVSIMPGLKTIINALLHSFRQLAEVMTLTIFCLMVFALFALQVYM 265

Human   274 GNLRQKCVRWPPPFNDTNTTWYSNDTWYGNDTWYGNEMWYGNDSWYANDTWNSHASWA--TNDTF 336
            |.||.||||..|      |.|                            |..||..|.  .|||.
  Fly   266 GELRNKCVRQVP------TDW----------------------------TNVSHTDWQIWVNDTD 296

Human   337 DWDAYISDEGNFYFLEGSNDALLCGNSSDAGHCPEGYECIKTGRNPNYGYTSYDTFSWAFLALFR 401
            :| .|..||          ..:||||.:.|.|||..|.|:..|.|||:|||::|.|.|:.|..|:
  Fly   297 NW-LYDEDE----------LPVLCGNLTGARHCPFEYVCLCVGENPNHGYTNFDNFMWSMLTTFQ 350

Human   402 LMTQDYWENLFQLTLRAAGKTYMIFFVVIIFLGSFYLINLILAVVAMAYAEQNEATLAE------ 460
            |:|.|||||::.:.|...|...:.||.|::|.||||||||:|||||::|.|:.|.|..|      
  Fly   351 LITLDYWENVYNMVLATCGPMSVSFFTVVVFFGSFYLINLMLAVVALSYEEEAEITNEERKKDLL 415

Human   461 DKEKEEEFQ------------------------QMLEKFKKHQEELEKAKAAQALEGGE------ 495
            |...:..|.                        .:|..:.|.:...:|.|..:  |||.      
  Fly   416 DHRDDSTFSFDPSVLNVKKLNKNNKKKIDSRKGVLLASYSKKKTRRKKTKGGK--EGGTNGNGNG 478

Human   496 ADGD--------------PAHG------------------------------------------- 503
            ::||              |.|.                                           
  Fly   479 SNGDDNKSHSATPSPGPSPRHSATERPSALTMQAQKQYQQMEQQHKLAKSGSGGSNNPMAPTPKG 543

Human   504 -------------------KDCNGSLDTSQGE-----KGAPRQSSSGDSGISDAMEELEEA---- 540
                               .|..|.|..:.|:     .|..|:||..|||:.|..||.:..    
  Fly   544 RISFQDSGMGVKNPNMLYPSDYKGQLIANSGQPSSNSSGVNRESSQDDSGVVDDHEEQDTTNDMG 608

Human   541 ----------------------------------HQK---------------CPPWWYKCAHKVL 556
                                              ||:               |.    :|.|   
  Fly   609 HVSTVELALSPREVRLIKCNGNIARIKNHNVYALHQEFSSEVVVIDDLPDRNCD----RCVH--- 666

Human   557 IWNCCA---PWLKFKNIIHLIVMDPFVDLGITICIVLNTLFMAMEHYPMTEHFDNVLTVGNLVFT 618
             |  |.   .||:|:|.::.:|.||..:|.||:||||||.|:||||:.|:|.|.|.|.|||.|||
  Fly   667 -W--CTDYESWLQFQNCLYKVVRDPLFELAITLCIVLNTAFLAMEHHGMSESFRNALDVGNKVFT 728

Human   619 GIFTAEMVLKLIAMDPYEYFQQGWNIFDSIIVTLSLVELGLANVQGLSVLRSFRLLRVFKLAKSW 683
            .|||.|.::||:|:.. ::|..||||||.:|||.||:::....|.||||||..|||||.|||:||
  Fly   729 SIFTFECIVKLMALSK-DFFLCGWNIFDLLIVTASLLDIIFELVDGLSVLRGLRLLRVLKLAQSW 792

Human   684 PTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKIALDCNLPRWHMHDFF 748
            .|:.:|:.||.:::||||||||:|.|:::||||:|||||.|.|..  .|...| .:|||:.:|||
  Fly   793 TTMKVLLSIIISTIGALGNLTLILVIVIYIFAVIGMQLFSKDYTP--EKFDPD-PVPRWNFNDFF 854

Human   749 HSFLIVFRILCGEWIETMWDCM---EVAGQAMCLTVFLMVMVIGNLVVLNLFLALLLSSFSADSL 810
            |||:::||||||||||.:||||   |..|.:.|..:||..:|:||.:||||||||||:||:::.|
  Fly   855 HSFMMIFRILCGEWIEPLWDCMRAEEEQGASTCFAIFLPTLVMGNFMVLNLFLALLLNSFNSEEL 919

Human   811 AASDED-GEMNNLQIAIGRIKLGI-------------GFAKAFLLGLL-----HGKILS------ 850
            .:..|: ||.:.|..:|.|::..|             .||:.|...:|     |.:.||      
  Fly   920 KSKKEEVGEESKLARSIERVRDLIRKKRQERKDRKERKFAEKFQQIVLDAQQAHAQTLSHQAAVG 984

Human   851 ----------------------------------------------------------PKDIML- 856
                                                                      |:.|.| 
  Fly   985 LERGDKPGVLAETKFHRLSYQESMNRPVSGSDFGFQIPLHDGLHTIVDGLEYDDTGDLPEQIQLQ 1049

Human   857 -------------------------SLGEADGAG------------------------------- 865
                                     |....:|.|                               
  Fly  1050 AHPLPPTSDSMPPTYESAMMATTGGSFSSVNGNGTCQNLTPFVQAERRLQHQISSGVSTQQYDSR 1114

Human   866 ----------------------------------------------------------------- 865
                                                                             
  Fly  1115 EEATYTESIELLGQYNSTDTDPYANDQRSGCGSFNRGDSLQDNSSRRYGSEEHDEAFLKYQKSLL 1179

Human   866 ---------------EAGEAGETAPEDEKKE---------------------------------- 881
                           .:|::..:..:.|:.|                                  
  Fly  1180 TRSPSYRKSLDRLSQSSGQSQRSLLKSEEAEMRRHSSGQSLNSMSIEQDELLSQQGNLREELLNC 1244

Human   882 ---------PPEEDLKK----------------------------------DN------------ 891
                     ..||:|:|                                  ||            
  Fly  1245 DQKELFQFLQEEEELQKGTKLRRISNVMRSRRPSSQMGQPENETMVEHSEFDNIIQSFEKELEEI 1309

Human   892 --------------------------HILNHMGLADG---------------PPSSLELD----- 910
                                      .|:.|:.:..|               |..|.:|.     
  Fly  1310 KRSTTSLERKLSNLSEPSPAADEATKAIMEHIAIITGASERSAADEVVLPLNPYDSYDLSSVPRR 1374

Human   911 -------------------------------------------HLNFI----------------- 915
                                                       |..|:                 
  Fly  1375 SQSVSAAAQRQSVKLKRRSLEKQRKIDEDFSISNEIRKICDQIHAPFVAMEAMAVAATSASQAQP 1439

Human   916 -NNPYLTIQVPIASEESDL-----------EMPTEEETDTFSEPEDSKKP------PQPLYDGNS 962
             .:|:|..:|...:.:.|.           |:|.||:..:....|..|.|      |..|...:.
  Fly  1440 NQSPFLRRKVDPFTVQFDRFKRLSLIERVEEVPEEEKPISTLRIESEKMPRKFLHGPDQLRLDSL 1504

Human   963 SVCSTADY------------------------------KPPE----------------------- 974
            |:.||..|                              :||.                       
  Fly  1505 SLKSTNSYENLLIQKQKLGMATPPAVPATPPTSLKSSIEPPTLAQISSLKTTPPLAALTEHQQHF 1569

Human   975 --------------------------------EDPE----------------------------- 978
                                            |.|:                             
  Fly  1570 HATSIQAAPTPAHTHAHSQAHAHSMAGQRRRMEHPQSTLDKAASFQSARTESHSSGAADASSALA 1634

Human   979 -------EQAEEN-PEGEQPEECFTEACVQRWPCL--YVD--------ISQG------------- 1012
                   ||::.. |:..|....||....:.|.||  |||        .|||             
  Fly  1635 LAMAQKTEQSQSTAPDATQKPSAFTRLTEKPWHCLVSYVDDLTVGGRRNSQGAYNDPMTFPSYGA 1699

Human  1013 ---------------------------------RGKKWWTLRRACFKIVEHNWFETFIVFMILLS 1044
                                             ..|.|..:|.|...:|:...||.|::.:|..|
  Fly  1700 TKAAKVPDDCFPQKCYDHFYFRCPWFMSCMDTQSAKHWTRVRTAVLTVVDTPAFEWFVLVLIFAS 1764

Human  1045 SGALAFEDIYIEQRRVIRTILEYADKVFTYIFIMEMLLKWVAYGFKVYFTNAWCWLDFLIVDVSI 1109
            |..|.||||.:::.:.::.:|.:.:..|..||::||:|||:|.||..|||:.|..|||:||.||:
  Fly  1765 SITLCFEDINLDKNKTLKRVLYWINFSFCLIFVVEMILKWLALGFSKYFTSFWTILDFIIVFVSV 1829

Human  1110 ISLVANWLGYSELGPIKSLRTLRALRPLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIF 1174
            .||:..  ....|..::|||||||||||||:||::|||:|||||:.|||||.|||||||:|||||
  Fly  1830 FSLLIE--ENENLKVLRSLRTLRALRPLRAISRWQGMRIVVNALMYAIPSIFNVLLVCLVFWLIF 1892

Human  1175 SIMGVNLFAGKFYYCINTTTSERFDISEVNNKSECESLMHTGQVRWLNVKVNYDNVGLGYLSLLQ 1239
            |||||..|.|||:.|:| ...|...|:|||:|.:|....:|    |:|.|:.:|:||:|||:|||
  Fly  1893 SIMGVQFFGGKFFKCVN-EMGELLPITEVNDKWDCIEQNYT----WINSKITFDHVGMGYLALLQ 1952

Human  1240 VATFKGWMDIMYAAVDSREKEEQPQYEVNLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKK 1304
            ||||:|||::|..|||:|..:.|||.|.|||.|:||||||:.||||||||||||||||||..|||
  Fly  1953 VATFEGWMEVMADAVDARGVDLQPQREANLYAYIYFVIFIVCGSFFTLNLFIGVIIDNFNMLKKK 2017

Human  1305 LGG--KDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPQNKIQGMVYDLVTKQAFDITIMILICLNM 1367
            ..|  .::|:||.||.||.||||||.|||||.|.||.|....|.|||...:.|:|.|.:||.|||
  Fly  2018 YEGGVLEMFLTESQKHYYTAMKKLGRKKPQKVIKRPINHFLAMFYDLSNSRRFEIAIFVLIFLNM 2082

Human  1368 VTMMVETDNQSQLKVDILYNINMIFIIIFTGECVLKMLALRQYYFTVGWNIFDFVVVILSIVGLA 1432
            :||.:|..:|......||...|..|..:|..|.::|::.||.:||||.||:|||::|:.||.|:.
  Fly  2083 LTMGIEHYDQPHAVFFILEVSNAFFTTVFGLEAIVKIVGLRYHYFTVPWNVFDFLLVLASIFGIL 2147

Human  1433 LSDLIQKYFVSPTLFRVIRLARIGRVLRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYS 1497
            :.|::....:||||.||:|:.||||:||||:.|||||.|||||::|||||||||.||.|:.|||:
  Fly  2148 MEDIMIDLPISPTLLRVVRVFRIGRILRLIKAAKGIRKLLFALVVSLPALFNIGALLGLITFIYA 2212

Human  1498 IFGMSNFAYVKKESGIDDMFNFETFGNSIICLFEITTSAGWDGLLNPILNSGPPDCDPNLENPGT 1562
            |.|||.|..||.:..:|||.||:|||.|:..||.:.|||||:.:|..::.. ||||||.:..   
  Fly  2213 ILGMSLFGNVKLQGALDDMVNFQTFGRSMQLLFRLMTSAGWNDVLESLMIQ-PPDCDPFIHG--- 2273

Human  1563 SVKGDCGNPSIGICFFCSYIIISFLIVVNMYIAIILENFNVATEESSEPLGEDDFEMFYETWEKF 1627
            ...|:||:|.:.|.:|.|:||||::||:||||||||||||.|.:|....:.|||.||||..|.|:
  Fly  2274 HTNGNCGHPLLAITYFTSFIIISYMIVINMYIAIILENFNQAHQEEEIGIVEDDLEMFYIRWSKY 2338

Human  1628 DPDATQFIAYSRLSDFVDTLQEPLRIAKPNKIKLITLDLPMVPGDKIHCLDILFALTKEVLGDSG 1692
            ||.|||||.:|:||||:.:|..||.|:|||.:.|::.:||:..|:||||||||.||.|.|||...
  Fly  2339 DPHATQFIHFSQLSDFIASLDPPLGISKPNNVALVSFNLPISKGNKIHCLDILHALVKHVLGHVE 2403

Human  1693 EMDALKQTMEE---KFMAANPSKVSYEPITTTLKRKHEEVCAIKIQRAYRRHLLQRSMKQASYMY 1754
            |.|..||..|:   ||....|::...|.:::|...|.:|..|..||..::.:|.::..|:.|   
  Fly  2404 ETDNFKQLQEQMDVKFKKQFPTRKELEIVSSTRIWKRQEKAAKTIQTGWKEYLRRKREKERS--- 2465

Human  1755 RHSHDGSGDDAPE-------KEGLLANTMSKMYGHENGN--SSSPSPEEKGEAGD-------AGP 1803
                 .|||.|.:       :..|.|.....:.....|.  ||..|..:...|.|       |||
  Fly  2466 -----NSGDSATQTSSPGGWQSKLSALNFFHLQVSRRGTACSSRASSRKSSRASDASDLSELAGP 2525

Human  1804 --TMGLMPISPSD 1814
              .:.||.:|.:|
  Fly  2526 WLNLPLMLVSGAD 2538

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SCN4ANP_000325.4 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 39..63 3/35 (9%)
I. /evidence=ECO:0000305 113..454 149/342 (44%)
Ion_trans 152..457 CDD:278921 136/306 (44%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 493..530 16/123 (13%)
II. /evidence=ECO:0000305 560..832 146/278 (53%)
Ion_trans 595..790 CDD:278921 107/197 (54%)
Na_trans_assoc 816..1026 CDD:284034 76/820 (9%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 863..886 6/176 (3%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 930..992 22/200 (11%)
III. /evidence=ECO:0000305 1013..1326 171/314 (54%)
Ion_trans 1048..1304 CDD:278921 147/255 (58%)
Na_channel_gate 1296..1348 CDD:240441 31/53 (58%)
Important for rapid channel inactivation. /evidence=ECO:0000250|UniProtKB:P15390 1310..1312 0/1 (0%)
IV. /evidence=ECO:0000305 1335..1633 152/297 (51%)
Ion_trans 1370..1609 CDD:278921 123/238 (52%)
GPHH 1620..1675 CDD:293510 28/54 (52%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1778..1836 13/48 (27%)
NaCP60ENP_001261172.1 Ion_trans 152..371 CDD:278921 116/263 (44%)
Ion_trans 705..902 CDD:278921 109/200 (55%)
Ion_trans 1768..2019 CDD:278921 149/257 (58%)
Na_channel_gate 2009..2063 CDD:240441 31/53 (58%)
Ion_trans 2085..2320 CDD:278921 123/238 (52%)
GPHH 2331..2386 CDD:293510 28/54 (52%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG2301
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D37221at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100419
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
43.720

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