DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SCN4A and Scn4a

DIOPT Version :9

Sequence 1:	NP_000325.4	Gene:	SCN4A / 6329	HGNCID:	10591	Length:	1836	Species:	Homo sapiens
Sequence 2:	NP_037310.2	Gene:	Scn4a / 25722	RGDID:	3636	Length:	1840	Species:	Rattus norvegicus

Alignment Length:	1849	Identity:	1705/1849 - (92%)
Similarity:	1747/1849 - (94%)	Gaps:	22/1849 - (1%)

- Green bases have known domain annotations that are detailed below.

Human     1 MARPSLCTLVPLGPECLRPFTRESLAAIEQRAVEEEARLQRNKQMEIEEPERKPRSDLEAGKNLP 65
            ||..||..|||.||.||||||.|||||||||||||||||||||||||||||||||||||||||||
  Rat     1 MASSSLPNLVPPGPHCLRPFTPESLAAIEQRAVEEEARLQRNKQMEIEEPERKPRSDLEAGKNLP 65

Human    66 MIYGDPPPEVIGIPLEDLDPYYSNKKTFIVLNKGKAIFRFSATPALYLLSPFSVVRRGAIKVLIH 130
            :||||||||||||||||||||||:|||||||||||||||||||||||||||||:|||.|||||||
  Rat    66 LIYGDPPPEVIGIPLEDLDPYYSDKKTFIVLNKGKAIFRFSATPALYLLSPFSIVRRVAIKVLIH 130

Human   131 ALFSMFIMITILTNCVFMTMSDPPPWSKNVEYTFTGIYTFESLIKILARGFCVDDFTFLRDPWNW 195
            |||||||||||||||||||||:||.|||:||||||||||||||||:||||||:||||||||||||
  Rat   131 ALFSMFIMITILTNCVFMTMSNPPSWSKHVEYTFTGIYTFESLIKMLARGFCIDDFTFLRDPWNW 195

Human   196 LDFSVIMMAYLTEFVDLGNISALRTFRVLRALKTITVIPGLKTIVGALIQSVKKLSDVMILTVFC 260
            ||||||.|||:||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   196 LDFSVITMAYVTEFVDLGNISALRTFRVLRALKTITVIPGLKTIVGALIQSVKKLSDVMILTVFC 260

Human   261 LSVFALVGLQLFMGNLRQKCVRWPPPFNDTNTTWYSNDTWYGNDTWYGNEMWYGNDSWYANDTWN 325
            ||||||||||||||||||||||||||.||||||||.|||||.|||      |||||:||.|||||
  Rat   261 LSVFALVGLQLFMGNLRQKCVRWPPPMNDTNTTWYGNDTWYSNDT------WYGNDTWYINDTWN 319

Human   326 SHASWATNDTFDWDAYISDEGNFYFLEGSNDALLCGNSSDAGHCPEGYECIKTGRNPNYGYTSYD 390
            |..|||.|.||||:|||:||||||||||||||||||||||||||||||||||.||||||||||||
  Rat   320 SQESWAGNSTFDWEAYINDEGNFYFLEGSNDALLCGNSSDAGHCPEGYECIKAGRNPNYGYTSYD 384

Human   391 TFSWAFLALFRLMTQDYWENLFQLTLRAAGKTYMIFFVVIIFLGSFYLINLILAVVAMAYAEQNE 455
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   385 TFSWAFLALFRLMTQDYWENLFQLTLRAAGKTYMIFFVVIIFLGSFYLINLILAVVAMAYAEQNE 449

Human   456 ATLAEDKEKEEEFQQMLEKFKKHQEELEKAKAAQALEGG-EADGDPAHGKDCNGSLDTSQGEKGA 519
            ||||||:||||||||||||:||||||:||||||||||.| ||||||.|.||||||||.| ||||.
  Rat   450 ATLAEDQEKEEEFQQMLEKYKKHQEEVEKAKAAQALESGEEADGDPTHNKDCNGSLDAS-GEKGP 513

Human   520 PRQSSSGDSGISDAMEELEEAHQKCPPWWYKCAHKVLIWNCCAPWLKFKNIIHLIVMDPFVDLGI 584
            ||.|.|.||.|||||||||||||||||||||||||||||||||||:|||:||:||||||||||||
  Rat   514 PRPSCSADSAISDAMEELEEAHQKCPPWWYKCAHKVLIWNCCAPWVKFKHIIYLIVMDPFVDLGI 578

Human   585 TICIVLNTLFMAMEHYPMTEHFDNVLTVGNLVFTGIFTAEMVLKLIAMDPYEYFQQGWNIFDSII 649
            ||||||||||||||||||||||||||:||||||||||||||||||||||||||||||||||||.|
  Rat   579 TICIVLNTLFMAMEHYPMTEHFDNVLSVGNLVFTGIFTAEMVLKLIAMDPYEYFQQGWNIFDSFI 643

Human   650 VTLSLVELGLANVQGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIF 714
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   644 VTLSLVELGLANVQGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIF 708

Human   715 AVVGMQLFGKSYKECVCKIALDCNLPRWHMHDFFHSFLIVFRILCGEWIETMWDCMEVAGQAMCL 779
            ||||||||||||||||||||.|||||||||:||||||||||||||||||||||||||||||||||
  Rat   709 AVVGMQLFGKSYKECVCKIASDCNLPRWHMNDFFHSFLIVFRILCGEWIETMWDCMEVAGQAMCL 773

Human   780 TVFLMVMVIGNLVVLNLFLALLLSSFSADSLAASDEDGEMNNLQIAIGRIKLGIGFAKAFLLGLL 844
            |||||||||||||||||||||||||||||||||||||||||||||||||||.||||||.||||||
  Rat   774 TVFLMVMVIGNLVVLNLFLALLLSSFSADSLAASDEDGEMNNLQIAIGRIKWGIGFAKTFLLGLL 838

Human   845 HGKILSPKDIMLSLGEADGAGEAGEAGETAPEDEKKEPPEEDLK-KDNHILNHMGLADGPPSSLE 908
            .|||||||:|:|||||..||||..|  |:.|||||||||.||.: ||||||||:||.|||.||:|
  Rat   839 RGKILSPKEIILSLGEPGGAGENAE--ESTPEDEKKEPPPEDKELKDNHILNHVGLTDGPRSSIE 901

Human   909 LDHLNFINNPYLTIQVPIASEESDLEMPTEEETDTFSEPEDSKKPPQPLYDGNSSVCSTADYKPP 973
            ||||||||||||||.|||||||||||||||||||.||||||.|||.|||||||||||||||||||
  Rat   902 LDHLNFINNPYLTIHVPIASEESDLEMPTEEETDAFSEPEDIKKPLQPLYDGNSSVCSTADYKPP 966

Human   974 EEDPEEQAEENPEGEQPEECFTEACVQRWPCLYVDISQGRGKKWWTLRRACFKIVEHNWFETFIV 1038
            ||||||||||||||||||||||||||:|.|||||||||||||.||||||||||||||||||||||
  Rat   967 EEDPEEQAEENPEGEQPEECFTEACVKRCPCLYVDISQGRGKMWWTLRRACFKIVEHNWFETFIV 1031

Human  1039 FMILLSSGALAFEDIYIEQRRVIRTILEYADKVFTYIFIMEMLLKWVAYGFKVYFTNAWCWLDFL 1103
            |||||||||||||||||||||||||||||||||||||||:|||||||||||||||||||||||||
  Rat  1032 FMILLSSGALAFEDIYIEQRRVIRTILEYADKVFTYIFILEMLLKWVAYGFKVYFTNAWCWLDFL 1096

Human  1104 IVDVSIISLVANWLGYSELGPIKSLRTLRALRPLRALSRFEGMRVVVNALLGAIPSIMNVLLVCL 1168
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat  1097 IVDVSIISLVANWLGYSELGPIKSLRTLRALRPLRALSRFEGMRVVVNALLGAIPSIMNVLLVCL 1161

Human  1169 IFWLIFSIMGVNLFAGKFYYCINTTTSERFDISEVNNKSECESLMHTGQVRWLNVKVNYDNVGLG 1233
            |||||||||||||||||||||:|||||||||||.|||||||||||:||||||:||||||||||||
  Rat  1162 IFWLIFSIMGVNLFAGKFYYCVNTTTSERFDISVVNNKSECESLMYTGQVRWMNVKVNYDNVGLG 1226

Human  1234 YLSLLQVATFKGWMDIMYAAVDSREKEEQPQYEVNLYMYLYFVIFIIFGSFFTLNLFIGVIIDNF 1298
            ||||||||||||||||||||||||||||||.||||||||||||||||||||||||||||||||||
  Rat  1227 YLSLLQVATFKGWMDIMYAAVDSREKEEQPDYEVNLYMYLYFVIFIIFGSFFTLNLFIGVIIDNF 1291

Human  1299 NQQKKKLGGKDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPQNKIQGMVYDLVTKQAFDITIMILI 1363
            ||||||.|||||||||||||||||||||||||||||||||||||||||||.||||.|||:|||||
  Rat  1292 NQQKKKFGGKDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPQNKIQGMVYDFVTKQVFDISIMILI 1356

Human  1364 CLNMVTMMVETDNQSQLKVDILYNINMIFIIIFTGECVLKMLALRQYYFTVGWNIFDFVVVILSI 1428
            ||||||||||||:||||||||||||||:|||||||||||||.|||.||||:||||||||||||||
  Rat  1357 CLNMVTMMVETDDQSQLKVDILYNINMVFIIIFTGECVLKMFALRHYYFTIGWNIFDFVVVILSI 1421

Human  1429 VGLALSDLIQKYFVSPTLFRVIRLARIGRVLRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVM 1493
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat  1422 VGLALSDLIQKYFVSPTLFRVIRLARIGRVLRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVM 1486

Human  1494 FIYSIFGMSNFAYVKKESGIDDMFNFETFGNSIICLFEITTSAGWDGLLNPILNSGPPDCDPNLE 1558
            ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||.||
  Rat  1487 FIYSIFGMSNFAYVKKESGIDDMFNFETFGNSIICLFEITTSAGWDGLLNPILNSGPPDCDPTLE 1551

Human  1559 NPGTSVKGDCGNPSIGICFFCSYIIISFLIVVNMYIAIILENFNVATEESSEPLGEDDFEMFYET 1623
            ||||:|:|||||||||||||||||||||||||||||||||||||||||||||||.||||||||||
  Rat  1552 NPGTNVRGDCGNPSIGICFFCSYIIISFLIVVNMYIAIILENFNVATEESSEPLSEDDFEMFYET 1616

Human  1624 WEKFDPDATQFIAYSRLSDFVDTLQEPLRIAKPNKIKLITLDLPMVPGDKIHCLDILFALTKEVL 1688
            ||||||||||||.|||||||||||||||:||||||||||||||||||||||||||||||||||||
  Rat  1617 WEKFDPDATQFIDYSRLSDFVDTLQEPLKIAKPNKIKLITLDLPMVPGDKIHCLDILFALTKEVL 1681

Human  1689 GDSGEMDALKQTMEEKFMAANPSKVSYEPITTTLKRKHEEVCAIKIQRAYRRHLLQRSMKQASYM 1753
            |||||||||||||||||||||||||||||||||||||.||||||||||||||||||||:||||||
  Rat  1682 GDSGEMDALKQTMEEKFMAANPSKVSYEPITTTLKRKQEEVCAIKIQRAYRRHLLQRSVKQASYM 1746

Human  1754 YRHSHDGSGDDAPEKEGLLANTMSKMYGHENGNS--SSPSPEEKGEAGDAGPTMGLMPISPSDTA 1816
            ||||.||:||.||||||||||||:||||||....  .|...|||....|||||:...|.|.||||
  Rat  1747 YRHSQDGNGDGAPEKEGLLANTMNKMYGHEKEGDGVQSQGEEEKASTEDAGPTVEPKPTSSSDTA 1811

Human  1817 WPPAPPP---------GQTVRPGVKESLV 1836
            ..|:|||         |||||||||||||
  Rat  1812 LTPSPPPLPPSSSPPQGQTVRPGVKESLV 1840

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SCN4A	NP_000325.4	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	39..63		23/23 (100%)
		I. /evidence=ECO:0000305	113..454		313/340 (92%)
		Ion_trans	152..457	CDD:278921	279/304 (92%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	493..530		27/37 (73%)
		II. /evidence=ECO:0000305	560..832		264/271 (97%)
		Ion_trans	595..790	CDD:278921	190/194 (98%)
		Na_trans_assoc	816..1026	CDD:284034	182/210 (87%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	863..886		15/22 (68%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	930..992		58/61 (95%)
		III. /evidence=ECO:0000305	1013..1326		304/312 (97%)
		Ion_trans	1048..1304	CDD:278921	249/255 (98%)
		Na_channel_gate	1296..1348	CDD:240441	50/51 (98%)
		Important for rapid channel inactivation. /evidence=ECO:0000250\|UniProtKB:P15390	1310..1312		1/1 (100%)
		IV. /evidence=ECO:0000305	1335..1633		285/297 (96%)
		Ion_trans	1370..1609	CDD:278921	230/238 (97%)
		GPHH	1620..1675	CDD:293510	52/54 (96%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1778..1836		36/68 (53%)
Scn4a	NP_037310.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	36..63		26/26 (100%)
		I. /evidence=ECO:0000305	113..448		313/340 (92%)
		Ion_trans	130..451	CDD:395416	301/326 (92%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	481..522		31/41 (76%)
		II. /evidence=ECO:0000305	554..826		264/271 (97%)
		Ion_trans	571..784	CDD:395416	208/212 (98%)
		Na_trans_assoc	810..1019	CDD:399489	182/210 (87%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	854..884		19/31 (61%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	925..983		54/57 (95%)
		III. /evidence=ECO:0000305	1006..1319		304/312 (97%)
		Ion_trans	1023..1297	CDD:395416	267/273 (98%)
		Na_channel_gate	1289..1341	CDD:240441	50/51 (98%)
		Important for rapid channel inactivation. /evidence=ECO:0000269\|PubMed:28012039	1303..1305		1/1 (100%)
		IV. /evidence=ECO:0000305	1328..1626		285/297 (96%)
		Ion_trans	1346..1602	CDD:395416	245/255 (96%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1775..1840		32/64 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C83689672
Domainoid	1	1.000	635	1.000	Domainoid score	I4330
eggNOG	1	0.900	-	-		E1_KOG2301
HGNC	1	1.500	-	-
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H283
Inparanoid	1	1.050	3422	1.000	Inparanoid score	I366
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG52281
OrthoDB	1	1.010	-	-		D12413at7742
OrthoFinder	1	1.000	-	-		FOG0000268
OrthoInspector	1	1.000	-	-		oto143059
orthoMCL	1	0.900	-	-		OOG6_100419
Panther	1	1.100	-	-	LDO	PTHR10037
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X214
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	17	17.310