DRSC/TRiP Functional Genomics Resources

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Protein Alignment SCN4A and cch1

DIOPT Version :10

Sequence 1:NP_000325.4 Gene:SCN4A / 6329 HGNCID:10591 Length:1836 Species:Homo sapiens
Sequence 2:NP_593894.1 Gene:cch1 / 2542812 PomBaseID:SPAC6F6.01 Length:1854 Species:Schizosaccharomyces pombe


Alignment Length:1857 Identity:406/1857 - (21%)
Similarity:717/1857 - (38%) Gaps:503/1857 - (27%)


- Green bases have known domain annotations that are detailed below.


Human    81 EDLDPYYSN--KKTFIVLNKGKAIFRFSATPALYLLSPFSVVRRGAIKVLIHALFSMFIMITILT 143
            :.|.||:::  .:.:..:.:.....|.:.||...|  |||.:.|   ::..|.|:::||.:.|:.
pombe   138 DKLSPYFTHFFSEIYAAVLRVVGPPRANETPGRNL--PFSPILR---QIYNHPLYNIFIFVVIVL 197

Human   144 NCVFMTM--SDPPPWSKNVEYTFTGI---YTFESLIKILARGFCVD------DF----------- 186
            :.|.:.:  .||...|:.::|....|   ||.|.|:||...||..|      ||           
pombe   198 HAVLLMIRSDDPHDKSQTIDYLIIVIGILYTLEMLLKIYLFGFLYDGSSSFYDFINSYTKKTPRT 262

Human   187 -TFLRDPWNWLDFSVIMMAYLTE--------FVDLGNISALRTFRVLR-ALKTITVIPGLKTIVG 241
             ::||..||.:||..|:..:::.        |.....|:.||..|:|. ..||.|::..||    
pombe   263 MSYLRHSWNRVDFVAIVALWISVIGKKQQGIFRLFSMIACLRLTRLLNITRKTETILKSLK---- 323

Human   242 ALIQSVKKLSDVMILTVFCLSVFALVGLQLFMGNLRQKCVRWPPPFNDTNTTWYSNDTWYGNDTW 306
               :|...|..|:....|...:.|::|:|.|..:|.::||                  |.|:   
pombe   324 ---ESSTPLVQVVSFNAFFGVMIAILGVQFFKASLNRQCV------------------WLGD--- 364

Human   307 YGNEMWYGNDSWYANDTWNSHASWATNDTFDWDAYISDEGNFYFLEGSNDALLCGNSSDAGHCPE 371
            ||::  |.....:....|.:                          |...|.|..|...:...|.
pombe   365 YGDQ--YLPTGQFCGGHWEN--------------------------GIKRAYLDKNGFPSNVNPR 401

Human   372 GYECIKTG-----RNPNYGYTSYDTFSWAFLALFRLMTQDYWENLFQLTLRAAGKTYMIFFVVII 431
            |:.|.:..     .||.....|:|.|..:...:|.:|:.:.:.::....:.|......:.|::..
pombe   402 GFICAEKSVCRVVENPYSNTVSFDNFFNSLELIFVIMSSNGFTDIMYDIMDAEYFVSCLLFIISA 466

Human   432 FLGSFYLINLILAVVAMAYAEQNEATLAEDKEKEEEFQQMLEKFKKHQEELEKAKAAQALEGGEA 496
            :..:.:|::|::|||..::.:                   |:...|:|:|               
pombe   467 YFLTLWLMSLVIAVVTSSFID-------------------LQHSGKNQKE--------------- 497

Human   497 DGDPAHGKDCNGSLDTSQGEKGAPRQSSSGDSGISDAMEELEEAHQKCPPWWYKCAHKVLIWN-C 560
                                                                .|...|.||.| .
pombe   498 ----------------------------------------------------QKSVDKHLIRNKL 510

Human   561 CAPWLKFKNIIHL-IVMDPFVDLGITICIVLNTLFMAMEHYPMTEHFDNVLTVGN--LVFTG--- 619
            |..:|.:.|.|.: .::..||    |:|               |:.:|...:..|  |:|..   
pombe   511 CEKYLFYSNFIWISFIVAQFV----TLC---------------TQTYDQTSSTANRYLIFYACVD 556

Human   620 -IFTAEMVLKLIAMDP-YE-YFQQGWNIFDSIIVTLSLVELGLANVQGLSV----LRSFRLLRVF 677
             :..||::|:..|..| |. :|::..|:.|.::..|:||.| |.:::...|    |..|.:.|::
pombe   557 FLLAAEVILRFFAYLPDYRLFFRRYTNLVDIVLAVLNLVTL-LPSIRKNPVAFGWLSIFAIARIY 620

Human   678 KLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF------GKSYKECVCKIALD 736
            :.....|....:.|::.::...|.||.|.|.|::||.::..::||      |.|..:.:      
pombe   621 RCILLIPYTRKIAKLLFSNFKQLLNLMLFLVIVLFIASLCAVRLFQDLPNDGDSDDDAI------ 679

Human   737 CNLPRWHMHDFFHSFLIVFRILCGE-WIETMWDCMEVAGQAMCL---------TVFLMVMVIGNL 791
                  .....:.|||.:::||..| |.:.|:     |.||...         ..|.:..:..|.
pombe   680 ------SFATTYESFLYMYQILTSENWTDVMF-----AIQARLAHLHLSWIPGAFFTLWFLFSNN 733

Human   792 VVLNLFLALLLSSFSADSLAASDEDGEMNNLQIAIGRIKLGIGFAKAFLLGLLHGKILSPKDIML 856
            |||::|:|::..:|     |.|:.|.:|..|              |.:|..||..  .:|....|
pombe   734 VVLSMFIAVIQVNF-----APSESDLKMEQL--------------KMYLARLLRN--YNPFQASL 777

Human   857 SLG---EADGAGEAGEAGETAPEDEKKEPPEEDLKKDNHILNHMGLADGPPSSLELDHLNFINNP 918
            :|.   :.:|:    ..|:|..|..     .|.|.:||.|...:.:.:.||..            
pombe   778 TLNALIKRNGS----RKGKTVDESH-----YEWLYEDNIIKGFLRVTNIPPKE------------ 821

Human   919 YLTIQVPIASEESDLEMPTEEETDTFSEPEDSKKPPQPLYDGNSSVCSTADYK--PPEEDPEEQA 981
                             |.:...||  .||.||.....|         :.::|  ...:||..||
pombe   822 -----------------PLKPSLDT--SPELSKYSLAKL---------SNNFKRFVMRDDPFSQA 858

Human   982 EENPEGEQPEECFTEACVQRW---------------PCLYVDISQGRGKK--------WWT---- 1019
                       .|......||               ...:|.|.|....|        :|.    
pombe   859 -----------YFKRVIGIRWEKDMNLKTAAKDMQAAKAFVRIKQTEFLKNHPKYNDVFWVIKPS 912

Human  1020 --LRRACFKIV------------EHNW----FETFIVFMILLSSGALAFEDIY--IEQRRVIRTI 1064
              :||.|.::|            .:.|    .:.||...||.   |:..|.|.  |.:|..:...
pombe   913 NRIRRFCQRLVMPGVNERYGGVEPYQWVYRVIQVFIYACILT---AVIIECIATPIYERDHLLND 974

Human  1065 LEYA-----DKVFTYIFIMEMLLKWVAYGF----KVYFTNAWCWLDFLIVDVSIISLVANWLGYS 1120
            .::|     :..|..||.:|..:|.:|.||    ..|..:.|..:||.::....|:|.|....::
pombe   975 KQHAWFVWTEVAFATIFTIEAAIKIIADGFCITPNAYLRSTWNCIDFFVLVTLWINLYAVLTSHA 1039

Human  1121 ELGPIKSLRTLRALRPLRALSRFE-GMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAG 1184
            .|.  ::.|..:|||.||.::..: ..|:..:||:.....|.:..:|.....:.|::...|:|.|
pombe  1040 LLS--RAFRAFKALRVLRLINLTQTSQRMFHDALISGFFKIFSAAVVSATLLIPFALWAKNVFGG 1102

Human  1185 KFYYCINTTTSERFDISEVNNKSEC----ESLMHTGQV----RWLN-VKVNYDNVGLGYLSLLQV 1240
            ..|.|         :...|.:.|:|    .|..:..:|    .|.| ...::|......|:|.::
pombe  1103 LLYSC---------NDDNVLSASQCVLEYASTPNNWEVWAPRVWSNPPDYDFDRFPHALLALFEI 1158

Human  1241 ATFKGWMDIMYAAVDSREKEEQPQYEVNLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKL 1305
            |:.:||:|||.:.:|......|||...:....::||:|.:....:.|.|||.:||.|:.::.   
pombe  1159 ASIEGWVDIMRSVMDITGFNNQPQTNASSGNAMFFVLFNLVSMIYILTLFIAIIISNYAERT--- 1220

Human  1306 GGKDIFMTEEQKKYYNAMKKLGSKKPQK-PIPRPQNKIQGMVYDL------VTKQAFDITIMILI 1363
              ...|.|.||:.:....:|:.|.:|.| |..||.. ::|:.||.      :.::.| ..:.|:.
pombe  1221 --GSAFFTAEQRAWLELRRKIKSMRPSKRPAIRPLG-LRGLCYDFAVQKHGIWRRTF-TGLYIVH 1281

Human  1364 CLNMVTMMVETDNQSQLKVDILYNINMIFIII---FTGECVLKMLALRQYYFTVG-WNIFDFVVV 1424
            .|.::|:..      ...:...|..|.||:|:   :|....:|:..|..|||... ||:||.||.
pombe  1282 LLFLLTIFY------PCPIAYTYVRNSIFLILSICYTINICVKVYGLSFYYFFHSFWNMFDVVVT 1340

Human  1425 ILSIV-GLALSDLIQKYFVSPTLFRVIRLARIGRVLRLIRGAKGIRTLLFALMMSLPALFNIGLL 1488
            :.|:. .:|:....:..  |.||.:...|..:  .:.||........|...::.|||::|:: :.
pombe  1341 LGSLTCNIAILAKFENR--SLTLLQTTLLVLV--TVHLIPKFDNFDQLSKTVVASLPSIFSL-IA 1400

Human  1489 LFLVMFI------YSIFGMSNFAYVKKESGIDDMFNFETFGNSIICLFEITTSAGWDGLLNPILN 1547
            .::|::|      ..|||::....   ..|.:.  ||.:..|:::.||.:|...||:.:::....
pombe  1401 TWIVLYITFAIAFNQIFGLTKLGL---NGGPNK--NFRSIRNALVLLFTMTFGEGWNDVMHDYTI 1460

Human  1548 SGPPDCDPNLENPGTSVKGDCGNPSIGICFFCSYIIISFLIVVNMYIAIILENFN-VATEESS-E 1610
            |     .||..|.......||||.......|.::.|||..|.|||:|.::.:||: :.|:.|| .
pombe  1461 S-----YPNCVNGDDFYNSDCGNKPWAYGLFIAWNIISMYIFVNMFITVVFDNFSYIHTKSSSFT 1520

Human  1611 PLGEDDFEMFYETWEKFDPDATQFIAYSRLSDFVDTL-----------QEPLRI------AKPNK 1658
            .|..:||..|.::|..|||..|.:|.......||.:|           :..||.      :|..:
pombe  1521 NLQRNDFRQFKDSWAPFDPMVTGYIPKRNAVKFVLSLRGVYDFRIYRDEHTLRSIISKVQSKTGQ 1585

Human  1659 IKLITLDLPMVPGDKIHCLDILFALTKEVLGDSGEMDALKQ------TMEEKFMAANPSKVSYEP 1717
            ..:..|:.|:: |.:|:    |.||.:.:  |:.:::.:|:      ::..:.|....:.:|:..
pombe  1586 QSVPMLENPLM-GSEIN----LEALDQII--DTIDVNVVKERRNVLNSLCTEIMTLPGNVISFSN 1643

Human  1718 I--TTTLKR--KHEEVCAIK--IQRAYRRHLLQRSMK 1748
            |  ...|.:  .|.|...|.  |:|||....|::|::
pombe  1644 ILMLVVLHKIVDHREAFPISDYIRRAYVLSELEKSIR 1680

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SCN4ANP_000325.4 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 39..63
I. /evidence=ECO:0000305 113..454 83/377 (22%)
Ion_trans 130..457 CDD:459842 78/363 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 493..530 0/36 (0%)
II. /evidence=ECO:0000305 560..832 69/300 (23%)
Ion_trans 577..790 CDD:459842 53/240 (22%)
Na_trans_assoc 816..1026 CDD:461936 45/243 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 863..885 4/21 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 930..992 13/63 (21%)
III. /evidence=ECO:0000305 1013..1326 84/363 (23%)
Ion_trans 1030..1304 CDD:459842 74/298 (25%)
Na_channel_gate 1296..1348 CDD:240441 13/52 (25%)
Important for rapid channel inactivation. /evidence=ECO:0000250|UniProtKB:P15390 1310..1312 0/1 (0%)
IV. /evidence=ECO:0000305 1335..1633 83/316 (26%)
Ion_trans 1353..1609 CDD:459842 68/267 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1778..1836
cch1NP_593894.1 Ion_trans 184..485 CDD:459842 78/356 (22%)
Ion_trans 514..748 CDD:459842 63/275 (23%)
Ion_trans 941..1220 CDD:459842 73/292 (25%)
Ion_trans 1267..1517 CDD:459842 68/271 (25%)
Blue background indicates that the domain is not in the aligned region.

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