DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SCN4A and cch1

DIOPT Version :9

Sequence 1:	NP_000325.4	Gene:	SCN4A / 6329	HGNCID:	10591	Length:	1836	Species:	Homo sapiens
Sequence 2:	NP_593894.1	Gene:	cch1 / 2542812	PomBaseID:	SPAC6F6.01	Length:	1854	Species:	Schizosaccharomyces pombe

Alignment Length:	1857	Identity:	406/1857 - (21%)
Similarity:	717/1857 - (38%)	Gaps:	503/1857 - (27%)

- Green bases have known domain annotations that are detailed below.

Human    81 EDLDPYYSN--KKTFIVLNKGKAIFRFSATPALYLLSPFSVVRRGAIKVLIHALFSMFIMITILT 143
            :.|.||:::  .:.:..:.:.....|.:.||...|  |||.:.|   ::..|.|:::||.:.|:.
pombe   138 DKLSPYFTHFFSEIYAAVLRVVGPPRANETPGRNL--PFSPILR---QIYNHPLYNIFIFVVIVL 197

Human   144 NCVFMTM--SDPPPWSKNVEYTFTGI---YTFESLIKILARGFCVD------DF----------- 186
            :.|.:.:  .||...|:.::|....|   ||.|.|:||...||..|      ||
pombe   198 HAVLLMIRSDDPHDKSQTIDYLIIVIGILYTLEMLLKIYLFGFLYDGSSSFYDFINSYTKKTPRT 262

Human   187 -TFLRDPWNWLDFSVIMMAYLTE--------FVDLGNISALRTFRVLR-ALKTITVIPGLKTIVG 241
             ::||..||.:||..|:..:::.        |.....|:.||..|:|. ..||.|::..||
pombe   263 MSYLRHSWNRVDFVAIVALWISVIGKKQQGIFRLFSMIACLRLTRLLNITRKTETILKSLK---- 323

Human   242 ALIQSVKKLSDVMILTVFCLSVFALVGLQLFMGNLRQKCVRWPPPFNDTNTTWYSNDTWYGNDTW 306
               :|...|..|:....|...:.|::|:|.|..:|.::||                  |.|:
pombe   324 ---ESSTPLVQVVSFNAFFGVMIAILGVQFFKASLNRQCV------------------WLGD--- 364

Human   307 YGNEMWYGNDSWYANDTWNSHASWATNDTFDWDAYISDEGNFYFLEGSNDALLCGNSSDAGHCPE 371
            ||::  |.....:....|.:                          |...|.|..|...:...|.
pombe   365 YGDQ--YLPTGQFCGGHWEN--------------------------GIKRAYLDKNGFPSNVNPR 401

Human   372 GYECIKTG-----RNPNYGYTSYDTFSWAFLALFRLMTQDYWENLFQLTLRAAGKTYMIFFVVII 431
            |:.|.:..     .||.....|:|.|..:...:|.:|:.:.:.::....:.|......:.|::..
pombe   402 GFICAEKSVCRVVENPYSNTVSFDNFFNSLELIFVIMSSNGFTDIMYDIMDAEYFVSCLLFIISA 466

Human   432 FLGSFYLINLILAVVAMAYAEQNEATLAEDKEKEEEFQQMLEKFKKHQEELEKAKAAQALEGGEA 496
            :..:.:|::|::|||..::.:                   |:...|:|:|
pombe   467 YFLTLWLMSLVIAVVTSSFID-------------------LQHSGKNQKE--------------- 497

Human   497 DGDPAHGKDCNGSLDTSQGEKGAPRQSSSGDSGISDAMEELEEAHQKCPPWWYKCAHKVLIWN-C 560
                                                                .|...|.||.| .
pombe   498 ----------------------------------------------------QKSVDKHLIRNKL 510

Human   561 CAPWLKFKNIIHL-IVMDPFVDLGITICIVLNTLFMAMEHYPMTEHFDNVLTVGN--LVFTG--- 619
            |..:|.:.|.|.: .::..||    |:|               |:.:|...:..|  |:|..
pombe   511 CEKYLFYSNFIWISFIVAQFV----TLC---------------TQTYDQTSSTANRYLIFYACVD 556

Human   620 -IFTAEMVLKLIAMDP-YE-YFQQGWNIFDSIIVTLSLVELGLANVQGLSV----LRSFRLLRVF 677
             :..||::|:..|..| |. :|::..|:.|.::..|:||.| |.:::...|    |..|.:.|::
pombe   557 FLLAAEVILRFFAYLPDYRLFFRRYTNLVDIVLAVLNLVTL-LPSIRKNPVAFGWLSIFAIARIY 620

Human   678 KLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF------GKSYKECVCKIALD 736
            :.....|....:.|::.::...|.||.|.|.|::||.::..::||      |.|..:.:
pombe   621 RCILLIPYTRKIAKLLFSNFKQLLNLMLFLVIVLFIASLCAVRLFQDLPNDGDSDDDAI------ 679

Human   737 CNLPRWHMHDFFHSFLIVFRILCGE-WIETMWDCMEVAGQAMCL---------TVFLMVMVIGNL 791
                  .....:.|||.:::||..| |.:.|:     |.||...         ..|.:..:..|.
pombe   680 ------SFATTYESFLYMYQILTSENWTDVMF-----AIQARLAHLHLSWIPGAFFTLWFLFSNN 733

Human   792 VVLNLFLALLLSSFSADSLAASDEDGEMNNLQIAIGRIKLGIGFAKAFLLGLLHGKILSPKDIML 856
            |||::|:|::..:|     |.|:.|.:|..|              |.:|..||..  .:|....|
pombe   734 VVLSMFIAVIQVNF-----APSESDLKMEQL--------------KMYLARLLRN--YNPFQASL 777

Human   857 SLG---EADGAGEAGEAGETAPEDEKKEPPEEDLKKDNHILNHMGLADGPPSSLELDHLNFINNP 918
            :|.   :.:|:    ..|:|..|..     .|.|.:||.|...:.:.:.||..
pombe   778 TLNALIKRNGS----RKGKTVDESH-----YEWLYEDNIIKGFLRVTNIPPKE------------ 821

Human   919 YLTIQVPIASEESDLEMPTEEETDTFSEPEDSKKPPQPLYDGNSSVCSTADYK--PPEEDPEEQA 981
                             |.:...||  .||.||.....|         :.::|  ...:||..||
pombe   822 -----------------PLKPSLDT--SPELSKYSLAKL---------SNNFKRFVMRDDPFSQA 858

Human   982 EENPEGEQPEECFTEACVQRW---------------PCLYVDISQGRGKK--------WWT---- 1019
                       .|......||               ...:|.|.|....|        :|.
pombe   859 -----------YFKRVIGIRWEKDMNLKTAAKDMQAAKAFVRIKQTEFLKNHPKYNDVFWVIKPS 912

Human  1020 --LRRACFKIV------------EHNW----FETFIVFMILLSSGALAFEDIY--IEQRRVIRTI 1064
              :||.|.::|            .:.|    .:.||...||.   |:..|.|.  |.:|..:...
pombe   913 NRIRRFCQRLVMPGVNERYGGVEPYQWVYRVIQVFIYACILT---AVIIECIATPIYERDHLLND 974

Human  1065 LEYA-----DKVFTYIFIMEMLLKWVAYGF----KVYFTNAWCWLDFLIVDVSIISLVANWLGYS 1120
            .::|     :..|..||.:|..:|.:|.||    ..|..:.|..:||.::....|:|.|....::
pombe   975 KQHAWFVWTEVAFATIFTIEAAIKIIADGFCITPNAYLRSTWNCIDFFVLVTLWINLYAVLTSHA 1039

Human  1121 ELGPIKSLRTLRALRPLRALSRFE-GMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAG 1184
            .|.  ::.|..:|||.||.::..: ..|:..:||:.....|.:..:|.....:.|::...|:|.|
pombe  1040 LLS--RAFRAFKALRVLRLINLTQTSQRMFHDALISGFFKIFSAAVVSATLLIPFALWAKNVFGG 1102

Human  1185 KFYYCINTTTSERFDISEVNNKSEC----ESLMHTGQV----RWLN-VKVNYDNVGLGYLSLLQV 1240
            ..|.|         :...|.:.|:|    .|..:..:|    .|.| ...::|......|:|.::
pombe  1103 LLYSC---------NDDNVLSASQCVLEYASTPNNWEVWAPRVWSNPPDYDFDRFPHALLALFEI 1158

Human  1241 ATFKGWMDIMYAAVDSREKEEQPQYEVNLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKL 1305
            |:.:||:|||.:.:|......|||...:....::||:|.:....:.|.|||.:||.|:.::.
pombe  1159 ASIEGWVDIMRSVMDITGFNNQPQTNASSGNAMFFVLFNLVSMIYILTLFIAIIISNYAERT--- 1220

Human  1306 GGKDIFMTEEQKKYYNAMKKLGSKKPQK-PIPRPQNKIQGMVYDL------VTKQAFDITIMILI 1363
              ...|.|.||:.:....:|:.|.:|.| |..||.. ::|:.||.      :.::.| ..:.|:.
pombe  1221 --GSAFFTAEQRAWLELRRKIKSMRPSKRPAIRPLG-LRGLCYDFAVQKHGIWRRTF-TGLYIVH 1281

Human  1364 CLNMVTMMVETDNQSQLKVDILYNINMIFIII---FTGECVLKMLALRQYYFTVG-WNIFDFVVV 1424
            .|.::|:..      ...:...|..|.||:|:   :|....:|:..|..|||... ||:||.||.
pombe  1282 LLFLLTIFY------PCPIAYTYVRNSIFLILSICYTINICVKVYGLSFYYFFHSFWNMFDVVVT 1340

Human  1425 ILSIV-GLALSDLIQKYFVSPTLFRVIRLARIGRVLRLIRGAKGIRTLLFALMMSLPALFNIGLL 1488
            :.|:. .:|:....:..  |.||.:...|..:  .:.||........|...::.|||::|:: :.
pombe  1341 LGSLTCNIAILAKFENR--SLTLLQTTLLVLV--TVHLIPKFDNFDQLSKTVVASLPSIFSL-IA 1400

Human  1489 LFLVMFI------YSIFGMSNFAYVKKESGIDDMFNFETFGNSIICLFEITTSAGWDGLLNPILN 1547
            .::|::|      ..|||::....   ..|.:.  ||.:..|:::.||.:|...||:.:::....
pombe  1401 TWIVLYITFAIAFNQIFGLTKLGL---NGGPNK--NFRSIRNALVLLFTMTFGEGWNDVMHDYTI 1460

Human  1548 SGPPDCDPNLENPGTSVKGDCGNPSIGICFFCSYIIISFLIVVNMYIAIILENFN-VATEESS-E 1610
            |     .||..|.......||||.......|.::.|||..|.|||:|.::.:||: :.|:.|| .
pombe  1461 S-----YPNCVNGDDFYNSDCGNKPWAYGLFIAWNIISMYIFVNMFITVVFDNFSYIHTKSSSFT 1520

Human  1611 PLGEDDFEMFYETWEKFDPDATQFIAYSRLSDFVDTL-----------QEPLRI------AKPNK 1658
            .|..:||..|.::|..|||..|.:|.......||.:|           :..||.      :|..:
pombe  1521 NLQRNDFRQFKDSWAPFDPMVTGYIPKRNAVKFVLSLRGVYDFRIYRDEHTLRSIISKVQSKTGQ 1585

Human  1659 IKLITLDLPMVPGDKIHCLDILFALTKEVLGDSGEMDALKQ------TMEEKFMAANPSKVSYEP 1717
            ..:..|:.|:: |.:|:    |.||.:.:  |:.:::.:|:      ::..:.|....:.:|:..
pombe  1586 QSVPMLENPLM-GSEIN----LEALDQII--DTIDVNVVKERRNVLNSLCTEIMTLPGNVISFSN 1643

Human  1718 I--TTTLKR--KHEEVCAIK--IQRAYRRHLLQRSMK 1748
            |  ...|.:  .|.|...|.  |:|||....|::|::
pombe  1644 ILMLVVLHKIVDHREAFPISDYIRRAYVLSELEKSIR 1680

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SCN4A	NP_000325.4	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	39..63
		I. /evidence=ECO:0000305	113..454		83/377 (22%)
		Ion_trans	152..457	CDD:278921	72/339 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	493..530		0/36 (0%)
		II. /evidence=ECO:0000305	560..832		69/300 (23%)
		Ion_trans	595..790	CDD:278921	49/222 (22%)
		Na_trans_assoc	816..1026	CDD:284034	45/243 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	863..886		4/22 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	930..992		13/63 (21%)
		III. /evidence=ECO:0000305	1013..1326		84/363 (23%)
		Ion_trans	1048..1304	CDD:278921	68/276 (25%)
		Na_channel_gate	1296..1348	CDD:240441	13/52 (25%)
		Important for rapid channel inactivation. /evidence=ECO:0000250\|UniProtKB:P15390	1310..1312		0/1 (0%)
		IV. /evidence=ECO:0000305	1335..1633		83/316 (26%)
		Ion_trans	1370..1609	CDD:278921	64/250 (26%)
		GPHH	1620..1675	CDD:293510	16/71 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1778..1836
cch1	NP_593894.1	Ion_trans	201..485	CDD:278921	72/339 (21%)
		Ion_trans	533..748	CDD:278921	57/252 (23%)
		Ion_trans	968..1220	CDD:278921	65/262 (25%)
		Ion_trans	1289..1517	CDD:278921	64/248 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	83	1.000	Domainoid score	I2557
eggNOG	1	0.900	-	-		E1_KOG2301
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.810