DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SCN4A and Scn4a

DIOPT Version :9

Sequence 1:	NP_000325.4	Gene:	SCN4A / 6329	HGNCID:	10591	Length:	1836	Species:	Homo sapiens
Sequence 2:	NP_573462.2	Gene:	Scn4a / 110880	MGIID:	98250	Length:	1841	Species:	Mus musculus

Alignment Length:	1851	Identity:	1701/1851 - (91%)
Similarity:	1749/1851 - (94%)	Gaps:	25/1851 - (1%)

- Green bases have known domain annotations that are detailed below.

Human     1 MARPSLCTLVPLGPECLRPFTRESLAAIEQRAVEEEARLQRNKQMEIEEPERKPRSDLEAGKNLP 65
            ||..||.||||.||.||||||.||||||||||:||||||||||||||||||||||||||||||||
Mouse     1 MASSSLPTLVPPGPHCLRPFTPESLAAIEQRAMEEEARLQRNKQMEIEEPERKPRSDLEAGKNLP 65

Human    66 MIYGDPPPEVIGIPLEDLDPYYSNKKTFIVLNKGKAIFRFSATPALYLLSPFSVVRRGAIKVLIH 130
            :|||||||||||:||||||||||:|||||||||||||||||||||||:|||||:|||.|||||||
Mouse    66 LIYGDPPPEVIGVPLEDLDPYYSDKKTFIVLNKGKAIFRFSATPALYMLSPFSIVRRVAIKVLIH 130

Human   131 ALFSMFIMITILTNCVFMTMSDPPPWSKNVEYTFTGIYTFESLIKILARGFCVDDFTFLRDPWNW 195
            |||||||||||||||||||||:||.|||:||||||||||||||||:||||||:||||||||||||
Mouse   131 ALFSMFIMITILTNCVFMTMSNPPSWSKDVEYTFTGIYTFESLIKMLARGFCIDDFTFLRDPWNW 195

Human   196 LDFSVIMMAYLTEFVDLGNISALRTFRVLRALKTITVIPGLKTIVGALIQSVKKLSDVMILTVFC 260
            ||||||.|||:||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   196 LDFSVITMAYVTEFVDLGNISALRTFRVLRALKTITVIPGLKTIVGALIQSVKKLSDVMILTVFC 260

Human   261 LSVFALVGLQLFMGNLRQKCVRWPPPFNDTNTTWYSNDTWYGNDTWYGNEMWYGNDSWYANDTWN 325
            ||||||||||||||||||||||||||.||||||||.|||||||||      |||||:||.|||||
Mouse   261 LSVFALVGLQLFMGNLRQKCVRWPPPMNDTNTTWYGNDTWYGNDT------WYGNDTWYGNDTWN 319

Human   326 SHASWATNDTFDWDAYISDEGNFYFLEGSNDALLCGNSSDAGHCPEGYECIKTGRNPNYGYTSYD 390
            |..||.:|.||||:|||:||||||||||||||||||||||||||||||||:|.||||||||||||
Mouse   320 SQESWVSNSTFDWEAYINDEGNFYFLEGSNDALLCGNSSDAGHCPEGYECMKAGRNPNYGYTSYD 384

Human   391 TFSWAFLALFRLMTQDYWENLFQLTLRAAGKTYMIFFVVIIFLGSFYLINLILAVVAMAYAEQNE 455
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   385 TFSWAFLALFRLMTQDYWENLFQLTLRAAGKTYMIFFVVIIFLGSFYLINLILAVVAMAYAEQNE 449

Human   456 ATLAEDKEKEEEFQQMLEKFKKHQEELEKAKAAQALEGG-EADGDPAHGKDCNGSLDTSQGEKGA 519
            ||||||:|||||||||||||||||||||||||||||||| ||||||.|.|||||||||| ||||.
Mouse   450 ATLAEDQEKEEEFQQMLEKFKKHQEELEKAKAAQALEGGEEADGDPTHSKDCNGSLDTS-GEKGP 513

Human   520 PRQSSSGDSGISDAMEELEEAHQKCPPWWYKCAHKVLIWNCCAPWLKFKNIIHLIVMDPFVDLGI 584
            ||.|.|.:|.|||||||||||||||||||||||||||||||||||:|||:||.||||||||||||
Mouse   514 PRPSCSAESAISDAMEELEEAHQKCPPWWYKCAHKVLIWNCCAPWVKFKHIILLIVMDPFVDLGI 578

Human   585 TICIVLNTLFMAMEHYPMTEHFDNVLTVGNLVFTGIFTAEMVLKLIAMDPYEYFQQGWNIFDSII 649
            ||||||||||||||||||||||||||:||||||||||||||||||||||||||||||||||||.|
Mouse   579 TICIVLNTLFMAMEHYPMTEHFDNVLSVGNLVFTGIFTAEMVLKLIAMDPYEYFQQGWNIFDSFI 643

Human   650 VTLSLVELGLANVQGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIF 714
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   644 VTLSLVELGLANVQGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIF 708

Human   715 AVVGMQLFGKSYKECVCKIALDCNLPRWHMHDFFHSFLIVFRILCGEWIETMWDCMEVAGQAMCL 779
            ||||||||||||||||||||.||:|||||||||||||||||||||||||||||||||||||||||
Mouse   709 AVVGMQLFGKSYKECVCKIASDCSLPRWHMHDFFHSFLIVFRILCGEWIETMWDCMEVAGQAMCL 773

Human   780 TVFLMVMVIGNLVVLNLFLALLLSSFSADSLAASDEDGEMNNLQIAIGRIKLGIGFAKAFLLGLL 844
            |||||||||||||||||||||||||||||||||||||||||||||||||||.||.|||.||||||
Mouse   774 TVFLMVMVIGNLVVLNLFLALLLSSFSADSLAASDEDGEMNNLQIAIGRIKWGIAFAKTFLLGLL 838

Human   845 HGKILSPKDIMLSLGEADGAGEAGEAGETAPEDEKKEPPEEDLK---KDNHILNHMGLADGPPSS 906
            ||||||.|||||||||..|   |||.||:.|||||||||.||..   ||||||||:||.|||.||
Mouse   839 HGKILSLKDIMLSLGEPGG---AGENGESPPEDEKKEPPPEDGNKELKDNHILNHVGLTDGPRSS 900

Human   907 LELDHLNFINNPYLTIQVPIASEESDLEMPTEEETDTFSEPEDSKKPPQPLYDGNSSVCSTADYK 971
            :|:|||||||||||||.||||||||||||||||||||||||||.|||.|||||||||||||||||
Mouse   901 IEMDHLNFINNPYLTIHVPIASEESDLEMPTEEETDTFSEPEDIKKPLQPLYDGNSSVCSTADYK 965

Human   972 PPEEDPEEQAEENPEGEQPEECFTEACVQRWPCLYVDISQGRGKKWWTLRRACFKIVEHNWFETF 1036
            |||||||||||||||||.||||||||||:|.|||||||||||||.||||||||||||||||||||
Mouse   966 PPEEDPEEQAEENPEGELPEECFTEACVKRCPCLYVDISQGRGKMWWTLRRACFKIVEHNWFETF 1030

Human  1037 IVFMILLSSGALAFEDIYIEQRRVIRTILEYADKVFTYIFIMEMLLKWVAYGFKVYFTNAWCWLD 1101
            |||||||||||||||||||||||||:|||||||||||||||:|||||||||||||||||||||||
Mouse  1031 IVFMILLSSGALAFEDIYIEQRRVIQTILEYADKVFTYIFILEMLLKWVAYGFKVYFTNAWCWLD 1095

Human  1102 FLIVDVSIISLVANWLGYSELGPIKSLRTLRALRPLRALSRFEGMRVVVNALLGAIPSIMNVLLV 1166
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse  1096 FLIVDVSIISLVANWLGYSELGPIKSLRTLRALRPLRALSRFEGMRVVVNALLGAIPSIMNVLLV 1160

Human  1167 CLIFWLIFSIMGVNLFAGKFYYCINTTTSERFDISEVNNKSECESLMHTGQVRWLNVKVNYDNVG 1231
            |||||||||||||||||||||||||||||||||||.|||||||||||:||||||:||||||||||
Mouse  1161 CLIFWLIFSIMGVNLFAGKFYYCINTTTSERFDISVVNNKSECESLMYTGQVRWMNVKVNYDNVG 1225

Human  1232 LGYLSLLQVATFKGWMDIMYAAVDSREKEEQPQYEVNLYMYLYFVIFIIFGSFFTLNLFIGVIID 1296
            ||||||||||||||||||||||||||||||||.||||||||||||||||||||||||||||||||
Mouse  1226 LGYLSLLQVATFKGWMDIMYAAVDSREKEEQPDYEVNLYMYLYFVIFIIFGSFFTLNLFIGVIID 1290

Human  1297 NFNQQKKKLGGKDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPQNKIQGMVYDLVTKQAFDITIMI 1361
            ||||||||.|||||||||||||||||||||||||||||||||||||||||||.||||.|||:|||
Mouse  1291 NFNQQKKKFGGKDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPQNKIQGMVYDFVTKQVFDISIMI 1355

Human  1362 LICLNMVTMMVETDNQSQLKVDILYNINMIFIIIFTGECVLKMLALRQYYFTVGWNIFDFVVVIL 1426
            ||||||||||||||:||||||||||||||:|||:|||||||||.|||.||||:||||||||||||
Mouse  1356 LICLNMVTMMVETDDQSQLKVDILYNINMVFIIVFTGECVLKMFALRHYYFTIGWNIFDFVVVIL 1420

Human  1427 SIVGLALSDLIQKYFVSPTLFRVIRLARIGRVLRLIRGAKGIRTLLFALMMSLPALFNIGLLLFL 1491
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse  1421 SIVGLALSDLIQKYFVSPTLFRVIRLARIGRVLRLIRGAKGIRTLLFALMMSLPALFNIGLLLFL 1485

Human  1492 VMFIYSIFGMSNFAYVKKESGIDDMFNFETFGNSIICLFEITTSAGWDGLLNPILNSGPPDCDPN 1556
            ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||.
Mouse  1486 VMFIYSIFGMSNFAYVKKESGIDDMFNFETFGNSIICLFEITTSAGWDGLLNPILNSGPPDCDPT 1550

Human  1557 LENPGTSVKGDCGNPSIGICFFCSYIIISFLIVVNMYIAIILENFNVATEESSEPLGEDDFEMFY 1621
            ||||||::||||||||||||||||||||||||||||||||||||||||||||||||.||||||||
Mouse  1551 LENPGTNIKGDCGNPSIGICFFCSYIIISFLIVVNMYIAIILENFNVATEESSEPLCEDDFEMFY 1615

Human  1622 ETWEKFDPDATQFIAYSRLSDFVDTLQEPLRIAKPNKIKLITLDLPMVPGDKIHCLDILFALTKE 1686
            ||||||||||||||.|||||||||||||||:||||||||||||||||||||||||||||||||||
Mouse  1616 ETWEKFDPDATQFIDYSRLSDFVDTLQEPLKIAKPNKIKLITLDLPMVPGDKIHCLDILFALTKE 1680

Human  1687 VLGDSGEMDALKQTMEEKFMAANPSKVSYEPITTTLKRKHEEVCAIKIQRAYRRHLLQRSMKQAS 1751
            |||||||||||||||||||||||||||||||||||||||.||||||||||||||||||||:||||
Mouse  1681 VLGDSGEMDALKQTMEEKFMAANPSKVSYEPITTTLKRKQEEVCAIKIQRAYRRHLLQRSVKQAS 1745

Human  1752 YMYRHSHDGSGDDAPEKEGLLANTMSKMYGHENGNS--SSPSPEEKGEAGDAGPTMGLMPISPSD 1814
            ||||||.:|:||.||||||||||||:||||.|..::  .|...:||....|||||..:...|.||
Mouse  1746 YMYRHSQEGNGDGAPEKEGLLANTMNKMYGSEKEDNGVQSQGEKEKDSTEDAGPTTEVTAPSSSD 1810

Human  1815 TAW---PPAPPP------GQTVRPGVKESLV 1836
            ||.   ||:|||      |||||||||||||
Mouse  1811 TALTPPPPSPPPPSSPPQGQTVRPGVKESLV 1841

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SCN4A	NP_000325.4	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	39..63		23/23 (100%)
		I. /evidence=ECO:0000305	113..454		311/340 (91%)
		Ion_trans	152..457	CDD:278921	278/304 (91%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	493..530		28/37 (76%)
		II. /evidence=ECO:0000305	560..832		264/271 (97%)
		Ion_trans	595..790	CDD:278921	190/194 (98%)
		Na_trans_assoc	816..1026	CDD:284034	182/212 (86%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	863..886		15/22 (68%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	930..992		58/61 (95%)
		III. /evidence=ECO:0000305	1013..1326		304/312 (97%)
		Ion_trans	1048..1304	CDD:278921	249/255 (98%)
		Na_channel_gate	1296..1348	CDD:240441	50/51 (98%)
		Important for rapid channel inactivation. /evidence=ECO:0000250\|UniProtKB:P15390	1310..1312		1/1 (100%)
		IV. /evidence=ECO:0000305	1335..1633		284/297 (96%)
		Ion_trans	1370..1609	CDD:278921	229/238 (96%)
		GPHH	1620..1675	CDD:293510	52/54 (96%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1778..1836		34/68 (50%)
Scn4a	NP_573462.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	32..63		29/30 (97%)
		I. /evidence=ECO:0000305	113..448		311/340 (91%)
		Ion_trans	130..451	CDD:395416	300/326 (92%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	484..522		30/38 (79%)
		II. /evidence=ECO:0000305	554..826		264/271 (97%)
		Ion_trans	571..784	CDD:395416	208/212 (98%)
		Na_trans_assoc	810..1020	CDD:399489	182/212 (86%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	854..896		28/44 (64%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	925..983		55/57 (96%)
		III. /evidence=ECO:0000305	1007..1320		304/312 (97%)
		Ion_trans	1024..1298	CDD:395416	267/273 (98%)
		Na_channel_gate	1290..1342	CDD:240441	50/51 (98%)
		Important for rapid channel inactivation. /evidence=ECO:0000250\|UniProtKB:P15390	1304..1306		1/1 (100%)
		IV. /evidence=ECO:0000305	1329..1627		284/297 (96%)
		Ion_trans	1347..1603	CDD:395416	244/255 (96%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1776..1841		30/64 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C83966127
Domainoid	1	1.000	636	1.000	Domainoid score	I4626
eggNOG	1	0.900	-	-		E1_KOG2301
HGNC	1	1.500	-	-
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H283
Inparanoid	1	1.050	3413	1.000	Inparanoid score	I439
Isobase	0	0.000	Not matched by this tool.
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG52281
OrthoDB	1	1.010	-	-		D37221at33208
OrthoFinder	1	1.000	-	-		FOG0000268
OrthoInspector	1	1.000	-	-		oto127007
orthoMCL	1	0.900	-	-		OOG6_100419
Panther	1	1.100	-	-	LDO	PTHR10037
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R6276
SonicParanoid	1	1.000	-	-		X214
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	19	19.300