| Sequence 1: | NP_008853.3 | Gene: | SCN3A / 6328 | HGNCID: | 10590 | Length: | 2000 | Species: | Homo sapiens |
|---|---|---|---|---|---|---|---|---|---|
| Sequence 2: | XP_008760136.1 | Gene: | Scn3a / 497770 | RGDID: | 3635 | Length: | 1983 | Species: | Rattus norvegicus |
| Alignment Length: | 2000 | Identity: | 1930/2000 - (96%) |
|---|---|---|---|
| Similarity: | 1956/2000 - (97%) | Gaps: | 17/2000 - (0%) |
- Green bases have known domain annotations that are detailed below.
|
Human 1 MAQALLVPPGPESFRLFTRESLAAIEKRAAEEKAKKPKKEQDNDDENKPKPNSDLEAGKNLPFIY 65
Human 66 GDIPPEMVSEPLEDLDPYYINKKTFIVMNKGKAIFRFSATSALYILTPLNPVRKIAIKILVHSLF 130
Human 131 SMLIMCTILTNCVFMTLSNPPDWTKNVEYTFTGIYTFESLIKILARGFCLEDFTFLRDPWNWLDF 195
Human 196 SVIVMAYVTEFVDLGNVSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSV 260
Human 261 FALIGLQLFMGNLRNKCLQWPPSDSAFETNTTSYFNGTMDSNGTFVNVTMSTFNWKDYIGDDSHF 325
Human 326 YVLDGQKDPLLCGNGSDAGQCPEGYICVKAGRNPNYGYTSFDTFSWAFLSLFRLMTQDYWENLYQ 390
Human 391 LTLRAAGKTYMIFFVLVIFLGSFYLVNLILAVVAMAYEEQNQATLEEAEQKEAEFQQMLEQLKKQ 455
Human 456 QEEAQAVAAASAASRDFSGIGGLGELLESSSEASKLSSKSAKEWRNRRKKRRQREHLEGNNKGER 520
Human 521 DSFPKSESEDSVKRSSFLFSMDGNRLTSDKKFCSPHQSLLSIRGSLFSPRRNSKTSIFSFRGRAK 585
Human 586 DVGSENDFADDEHSTFEDSESRRDSLFVPHRHGERRNSNVSQASMSSRMVPGLPANGKMHSTVDC 650
Human 651 NGVVSLVGGPSALTSPTGQLPPEGTTTETEVRKRRLSSYQISMEMLEDSSGRQRAVSIASILTNT 715
Human 716 MEELEESRQKCPPCWYRFANVFLIWDCCDAWLKVKHLVNLIVMDPFVDLAITICIVLNTLFMAME 780
Human 781 HYPMTEQFSSVLTVGNLVFTGIFTAEMVLKIIAMDPYYYFQEGWNIFDGIIVSLSLMELGLSNVE 845
Human 846 GLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKE 910
Human 911 CVCKINDDCTLPRWHMNDFFHSFLIVFRVLCGEWIETMWDCMEVAGQTMCLIVFMLVMVIGNLVV 975
Human 976 LNLFLALLLSSFSSDNLAATDDDNEMNNLQIAVGRMQKGIDYVKNKMRECFQKAFFRKPKVIEIH 1040
Human 1041 EGNKIDSCMSNNTGIEISKELNYLRDGNGTTSGVGTGSSVEKYVIDENDYMSFINNPSLTVTVPI 1105
Human 1106 AVGESDFENLNTEEFSSESELEESKEKLNATSSSEGSTVDVVLPREGEQAETEPEEDLKPEACFT 1170
Human 1171 EGCIKKFPFCQVSTEEGKGKIWWNLRKTCYSIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKT 1235
Human 1236 IKTMLEYADKVFTYIFILEMLLKWVAYGFQTYFTNAWCWLDFLIVDVSLVSLVANALGYSELGAI 1300
Human 1301 KSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCV 1365
Human 1366 NMTTGNMFDISDVNNLSDCQALGKQARWKNVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVDSR 1430
Human 1431 DVKLQPVYEENLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKKYYNA 1495
Human 1496 MKKLGSKKPQKPIPRPANKFQGMVFDFVTRQVFDISIMILICLNMVTMMVETDDQGKYMTLVLSR 1560
Human 1561 INLVFIVLFTGEFVLKLVSLRHYYFTIGWNIFDFVVVILSIVGMFLAEMIEKYFVSPTLFRVIRL 1625
Human 1626 ARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFAYVKKEAGIDDMF 1690
Human 1691 NFETFGNSMICLFQITTSAGWDGLLAPILNSAPPDCDPDTIHPGSSVKGDCGNPSVGIFFFVSYI 1755
Human 1756 IISFLVVVNMYIAVILENFSVATEESAEPLSEDDFEMFYEVWEKFDPDATQFIEFSKLSDFAAAL 1820
Human 1821 DPPLLIAKPNKVQLIAMDLPMVSGDRIHCLDILFAFTKRVLGESGEMDALRIQMEDRFMASNPSK 1885
Human 1886 VSYEPITTTLKRKQEEVSAAIIQRNFRCYLLKQRLKNISSNYNKEAIKGRIDLPIKQDMIIDKLN 1950
Human 1951 GNSTPEKTDGSSSTTSPPSYDSVTKPDKEKFEKDKPEKESKGKEVRENQK 2000 |
| Gene | Sequence | Domain | Region | External ID | Identity |
|---|---|---|---|---|---|
| SCN3A | NP_008853.3 | Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 28..60 | 30/31 (97%) | |
| I. /evidence=ECO:0000305 | 110..455 | 343/344 (100%) | |||
| Ion_trans | 149..434 | CDD:278921 | 283/284 (100%) | ||
| Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 493..528 | 28/34 (82%) | |||
| Na_trans_cytopl | 510..629 | CDD:288761 | 105/118 (89%) | ||
| Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 587..631 | 42/43 (98%) | |||
| Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 662..681 | 6/18 (33%) | |||
| II. /evidence=ECO:0000305 | 742..1014 | 267/271 (99%) | |||
| Ion_trans | 777..972 | CDD:278921 | 190/194 (98%) | ||
| Na_trans_assoc | 998..1200 | CDD:284034 | 193/201 (96%) | ||
| Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 1118..1162 | 40/43 (93%) | |||
| III. /evidence=ECO:0000305 | 1188..1499 | 304/310 (98%) | |||
| Ion_trans | 1223..1477 | CDD:278921 | 247/253 (98%) | ||
| Na_channel_gate | 1469..1521 | CDD:240441 | 51/51 (100%) | ||
| IV. /evidence=ECO:0000305 | 1508..1806 | 291/297 (98%) | |||
| Ion_trans | 1543..1781 | CDD:278921 | 231/237 (97%) | ||
| ChtBD1 | 1708..>1743 | CDD:302575 | 33/34 (97%) | ||
| GPHH | 1793..1848 | CDD:293510 | 53/54 (98%) | ||
| Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 1949..2000 | 49/50 (98%) | |||
| Scn3a | XP_008760136.1 | Ion_trans | 149..434 | CDD:278921 | 283/284 (100%) |
| Na_trans_cytopl | 510..629 | CDD:288761 | 105/118 (89%) | ||
| Ion_trans | 760..955 | CDD:278921 | 190/194 (98%) | ||
| Na_trans_assoc | 981..1183 | CDD:284034 | 193/201 (96%) | ||
| Ion_trans | 1206..1460 | CDD:278921 | 247/253 (98%) | ||
| Na_channel_gate | 1452..1504 | CDD:240441 | 51/51 (100%) | ||
| Ion_trans | 1526..1764 | CDD:278921 | 231/237 (97%) | ||
| ChtBD1 | 1691..>1726 | CDD:302575 | 33/34 (97%) | ||
| GPHH | 1776..1831 | CDD:293510 | 53/54 (98%) |
| Tool | Simple Score | Weighted Score | Original Tool Information | |||
|---|---|---|---|---|---|---|
| BLAST Result | Score | Score Type | Cluster ID | |||
| Compara | 1 | 0.930 | - | - | C83684388 | |
| Domainoid | 1 | 1.000 | 625 | 1.000 | Domainoid score | I4483 |
| eggNOG | 1 | 0.900 | - | - | E1_KOG2301 | |
| HGNC | 1 | 1.500 | - | - | ||
| Hieranoid | 1 | 1.000 | - | - | ||
| Homologene | 1 | 1.000 | - | - | H56005 | |
| Inparanoid | 1 | 1.050 | 3767 | 1.000 | Inparanoid score | I270 |
| NCBI | 1 | 1.000 | - | - | ||
| OMA | 1 | 1.010 | - | - | QHG52281 | |
| OrthoDB | 1 | 1.010 | - | - | D10241at32523 | |
| OrthoFinder | 1 | 1.000 | - | - | FOG0000268 | |
| OrthoInspector | 1 | 1.000 | - | - | oto142933 | |
| orthoMCL | 1 | 0.900 | - | - | OOG6_100419 | |
| Panther | 1 | 1.100 | - | - | LDO | PTHR10037 |
| Phylome | 1 | 0.910 | - | - | ||
| SonicParanoid | 1 | 1.000 | - | - | X214 | |
| SwiftOrtho | 1 | 1.000 | - | - | ||
| TreeFam | 1 | 0.960 | - | - | ||
| 18 | 18.270 | |||||