back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SCN2A and CCH1

DIOPT Version :9

Sequence 1:	NP_001035232.1	Gene:	SCN2A / 6326	HGNCID:	10588	Length:	2005	Species:	Homo sapiens
Sequence 2:	NP_011733.3	Gene:	CCH1 / 853131	SGDID:	S000003449	Length:	2039	Species:	Saccharomyces cerevisiae

Alignment Length:	2331	Identity:	423/2331 - (18%)
Similarity:	771/2331 - (33%)	Gaps:	804/2331 - (34%)

- Green bases have known domain annotations that are detailed below.

Human     4 SVLVPPGPDSFRFFTRESLAAIEQ-------RIAEEKAKRP----KQERKDEDDEN--------- 48
            |::.....|.|....:...:||::       ::..||: ||    .::|.:.:.|:
Yeast   176 SLIAADDMDDFEDLQKGFKSAIDEEGLTWLPQLKSEKS-RPVSDVGEDRGEGEQESIPDVHTPNV 239

Human    49 -----------GPKP--NSDLEAG----------KSLPFIYGDIPPEMVSVPLEDLDPYYINKKT 90
                       .|:|  |..:..|          |..|..:..:.|:.     ||.|...:.:..
Yeast   240 GASATPGSIHLTPEPAQNGSVSEGLEGSINNSRKKPSPKFFHHLSPQK-----EDKDQTEVIEYA 299

Human    91 FIVLNKGKAISRFSATP------ALYILTPFNPIRKLAIKILVHSLFNML---------IMCTIL 140
            ..:|:......:..:.|      :|.:.:|.||:|....:.|:|..:::|         |:..|.
Yeast   300 EDILDFETLQRKLESRPFVLYGHSLGVFSPTNPLRIKIARFLLHRRYSLLYNTLLTFYAILLAIR 364

Human   141 T----NCVFM-TMSNPPDWTKNVEYTFTGIYTFESLIKILARGFC-------------------- 180
            |    |.||: ..||   ||....:..:..:|...:.||:|.||.
Yeast   365 TYNPHNVVFLYRFSN---WTDYFIFILSACFTGNDIAKIIAFGFWDDSEMFKAYGREYKSILQRS 426

Human   181 ----------------LEDF-----------------------------------------TFLR 188
                            |.||                                         .|.|
Yeast   427 GIMKLYIYLREKYGRKLIDFIIPFRIISPGEETKYQRSSLSTSLTKPYGAKENQRPFGTPRAFAR 491

Human   189 DPWNWLDFTVITFAYVTEFVDLGNV---SALRTFR---VLRALKTISVIPGLKTIVGALIQSVKK 247
            ..||.:|.......::..|:.:.:.   :.:|.|:   :||.|:.::|..|:.:|:..|...:.:
Yeast   492 SSWNRIDLVSSVSFWLGMFLSIKSYDTKTGIRIFKPLAILRILRLVNVDTGMPSILRGLKYGIPQ 556

Human   248 LSDVMILTVFCLSVFALIGLQLFMGNLRNKCLQW-----PPDNSSFEINITSFFNNSLDGNGTTF 307
            |.:|..:.|:....|.::|:|:|.|:.|.:|: |     |.|...:::.....:
Yeast   557 LVNVSSMLVYFWIFFGILGVQIFQGSFRRQCV-WFNPEDPTDTYQYDMQFCGGY----------- 609

Human   308 NRTVSIFNWDEYIEDKSHFYFLEGQNDALLCGNSSDAGQCPEGYICVKAGRNPNYGYTSFDTFSW 372
                    .|...:.|.::.:.:|..     |:.|....||:...|| :..||..|..|||....
Yeast   610 --------LDPVTKRKQNYIYEDGSE-----GSVSKGFLCPQYSKCV-SNANPYNGRISFDNIVN 660

Human   373 AFLSLFRLMTQDFWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLINLILAVVAMAYEEQNQATLE 437
            :...:|.:|:.:.:.:|...|:.:......:||::.||:.:.:|:||::||:..::|..|:
Yeast   661 SMELVFVIMSANTFTDLMYYTMDSDEMAACLFFIVCIFVLTIWLLNLLIAVLVSSFEIANE---- 721

Human   438 EAEQKEAEFQQMLEQLKKQQEEAQAAAAAASAESRDFSGAGGIGVFSESSSVASKLSSKSEKELK 502
                   |:
Yeast   722 -------EY-------------------------------------------------------- 723

Human   503 NRRKKKKQKEQSGEEEKNDRVRKSESEDSIRRKGFRFSLEGSRLT-YEKRFSSPHQSLLSIRGSL 566
               ||||                              .:.|||.| |..|..:.:.....::.:
Yeast   724 ---KKKK------------------------------FIYGSRKTGYVARIVTGYWKYFKLKAN- 754

Human   567 FSPRRNSRASLFSFRGRAKDIGSENDFADDEHSTFEDNDSRRDSLFVPHRHGERRHSNVSQASRA 631
                                                                :.:..|.||...|
Yeast   755 ----------------------------------------------------QTKFPNWSQKGLA 767

Human   632 SRVLPILPMNGKMHSAVDCNGVVSLVGGPSTLTSAGQLLPEGTTTETEIRKRRSSSYHVSMDLLE 696
                        ::|.|:...|:.::                    .:|..|
Yeast   768 ------------IYSHVEFIFVILII--------------------CDIGMR------------- 787

Human   697 DPTSRQRAMSIASILTNTMEELEESRQKCPPCWYKFANMCLIWDCCKPWLKVKHLVNLVVMDPFV 761
                       ||:..:|.                 ||      |....||....:::|:   |:
Yeast   788 -----------ASVKVSTS-----------------AN------CNNILLKTDRGISIVL---FI 815

Human   762 DLAITICIVLNTLFMAMEHYPMTEQFSSVLSVGNLVFTGIFTAEMFLKIIAMDPYYYFQEGWNIF 826
            :                             |:..||   ::...|: |.:....|.|
Yeast   816 E-----------------------------SLARLV---LYLPNMW-KFLTKPSYVY-------- 839

Human   827 DGFIVSLSLMELGLANVEG--------LSVL---RSFRLLRVFKLAKS-WPTLNMLIKIIGNSVG 879
             .||:|:..:.:....|||        ||:.   |.:|::..|.|.|. |.      :|:.|.|
Yeast   840 -DFIISIITLVISCLAVEGVLGHMYAWLSIFHISRFYRVIISFNLTKKLWK------QILSNGV- 896

Human   880 ALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKISNDCELPRWHMHDFFHSFLIVFRVLCGE-W 943
            .:.||:.......|:.|:: |.:    |.|.|.......:.| :.|:...:|||.:|.:...| |
Yeast   897 MIWNLSSFYFFFTFLVAII-MAV----YFEGVIPPEEMADQP-FGMYSLPNSFLSLFIIGSTENW 955

Human   944 IETMWDCME----VAGQTMCLTVFMMVMVIGNLVVLNLFLALLLSSFSSDNLAATDDDNEMNNLQ 1004
            .:.::...:    ::....|...|::..::.|.|:||:|:||:     |:::...:::....
Yeast   956 TDILYALQKHSPNISSTFFCSVFFIIWFLLSNSVILNIFIALI-----SESMEVKEEEKRPQ--- 1012

Human  1005 IAVGRMQKGIDFV-KRKIREFIQKAFV-RKQKALDEIKPLEDLNNKKDSCISNHTTIEIGKDLNY 1067
                :::..:.|| .:||:|:...:.| |.:|........||..:.|...:.....:.|.:::..
Yeast  1013 ----QIKHYLKFVYPQKIQEYTHASLVARIRKKFFGGHRNEDTRDFKQFLMRGTAIMNIAQNMGE 1073

Human  1068 LKDGNGTTSGIGSSVEKYVVDESDYMSFINNPS----------LTVTVPIAVGESDFENLNTEEF 1122
            |.|                       .|...||          ||:.||.......|.|   ..|
Yeast  1074 LAD-----------------------EFKEPPSENLFKKGLSKLTIGVPSLKRLRMFAN---NPF 1112

Human  1123 SSESDMEESKEKLNATSSSEGSTVDIGAPAEGEQPEVEPEE---------------SLEPEACFT 1172
            ...||:     ....|:...|.|..:      |..|.|.|:               ...|:..|
Yeast  1113 YKNSDV-----VFTETNDINGRTYIL------ELNEYEDEKLDYLKKYPLFNYSYYFFSPQHRF- 1165

Human  1173 EDCVRKFKCCQISIEEGKGKL------------WWNLRKTCYKIVEHNWFETFIVFMILLSSGAL 1225
                |:|  ||..:....||.            .:| :::.:..:|.:.|    ||:..|::..|
Yeast  1166 ----RRF--CQRLVPPSTGKRTDGSRFFEDSTDLYN-KRSYFHHIERDVF----VFIFALATILL 1219

Human  1226 AFEDIYI------EQRKTIKTMLEYADKVFTYIFILEMLLKWVAYGF----QVYFTNAWCWLDFL 1280
            .....|:      ..:..........|..|...|.:|.::|.||.||    ..|..|.|.::||.
Yeast  1220 IVCSCYVTPLYRMHHKMGTWNWSSALDCAFIGAFSIEFIVKTVADGFIYSPNAYLRNPWNFIDFC 1284

Human  1281 IVDVSLVSLTANALGY----SELGAIKSLRTLRALRPLRALSRFEGMRVVVN-ALLGAIPSIMNV 1340
            :    |:|:..|.:.|    ..|..|  .:.|.|||.||.|:.....|...| .:...:..|...
Yeast  1285 V----LISMWINLIAYLKNNGNLSRI--FKGLTALRALRCLTISNTARQTFNLVMFDGLNKIFEA 1343

Human  1341 LLVCLIFWLIFSIMGVNLFAGKFYHCINYTTGEMFDVSVVNNYSECKALIESNQTARW------- 1398
            .|:.|.....|::.|:::|.|:...|   ..|.:......|.|        ||...:|
Yeast  1344 GLISLSLLFPFTVWGLSIFKGRLGTC---NDGSLGRADCYNEY--------SNSVFQWDIMSPRV 1397

Human  1399 -KNVKVNFDNVGLGYLSLLQVATFKGWMDIMYAAVDSRNVELQPKYEDNLYMYLYFVIFIIFGSF 1462
             :...::.|:....:.||.|:.:.:||:|::...::|..:........:....|:.|:|......
Yeast  1398 YQQPYLHLDSFASAFSSLYQIISLEGWVDLLENMMNSSGIGTPATVMGSAGNALFLVLFNFLSMV 1462

Human  1463 FTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPANKFQGMVFDF 1527
            |.||||:..|::|   |.:..|  ..:.|.|:|.:..:.|.|...|| |.||......:...|.:
Yeast  1463 FILNLFVSFIVNN---QARTTG--SAYFTIEEKAWLESQKLLSQAKP-KAIPNLIELSRVRQFFY 1521

Human  1528 ---VTKQVFDIS--IMILICLNMVTMMVETDDQSQEMTNILYWINLVFIVLFTGECVLKLISLRY 1587
               |.|:.|..:  :.:::.|:::.::    .:|....|::.:..:.|  :|:....|...:|..
Yeast  1522 QLAVEKKNFYYASFLQVVLYLHIIMLL----SRSYNPGNLIGYQGVYF--MFSTSVFLIQEALHM 1580

Human  1588 ------YYFTIGWNIFDFVVVILSIV-------------------GMFLAELIEKYFVSP---TL 1624
                  .||...||.....::|::.:                   |.||  |:...|:.|   ||
Yeast  1581 CGEGPRLYFRQKWNSIRLSIIIIAFIMNAVAFHVPASHYWFHNIKGFFL--LVIFLFIIPQNDTL 1643

Human  1625 FRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFAYVKREV 1689
            ..::..|                      |.|||.:.::.....::..:|||.....|...:...
Yeast  1644 TELLETA----------------------MASLPPILSLTYTWGVLFLVYAIALNQIFGLTRLGS 1686

Human  1690 GIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSGPPDCDPDKDHPGSSVKGDCGNPSVGIF 1754
            ...|..||.|...|||.||:.:...||:.::|. |....|.|..|    .:|...|||:.:....
Yeast  1687 NTTDNINFRTVIKSMIVLFRCSFGEGWNYIMAD-LTVSEPYCSSD----DNSTYTDCGSETYAYL 1746

Human  1755 FFVSYIIISFLVVVNMYIAVILENFSVATEE--SAEPLSEDDFEMFYEVWEKFDPDATQFIEFAK 1817
            ..:|:.|||..:.|||::::|:.|||.....  |...::..:.:.:.|.|.|||.|.|..:|.:.
Yeast  1747 LLMSWNIISMYIFVNMFVSLIIGNFSYVYRSGGSRSGINRSEIKKYIEAWSKFDTDGTGELELSY 1811

Human  1818 LSDFADALDPPL------------------LIAKPN-----KVQLIAMDLPMVSGDRIHCLDILF 1859
            |.....:.|.||                  :...|:     |:.||.::..:.:.|:...:.
Yeast  1812 LPRIMHSFDGPLSFKIWEGRLTIKSLVENYMEVNPDDPYDVKIDLIGLNKELNTIDKAKIIQ--- 1873

Human  1860 AFTKRVLGESGEMDALRIQMEERFMASNPSKVSYE------------PITTTLKRKQ-----EEV 1907
                            |.....||:.|.....:|.            |:.|....::     :.|
Yeast  1874 ----------------RKLQYRRFVQSIHYTNAYNGCIRFSDLLLQIPLYTAYSARECLGIDQYV 1922

Human  1908 SAIIIQRAYRRYLLKQKVKKVSSI----------YKKDKGKECDGTPIKEDTL---IDKLNENST 1959
            ..:.|.....:||..|:...|..:          .|:....|.|   :|:.|:   |..:|.|..
Yeast  1923 HHLYILGKVDKYLENQRNFDVLEMVVTRWKFHCRMKRTIEPEWD---VKDPTVSSHISNINVNLE 1984

Human  1960 PEK--TDMTPSTTSPPSY-------------DSVTKPEKEKFEKDKSEKEDKGKDI 2000
            |..  .:..|..|....|             ||..:|.:|..:.:    :|...|:
Yeast  1985 PAPGILEREPIATPRMDYGVNNFMWSPRMNQDSTMEPPEEPIDNN----DDSANDL 2036

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.