back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SCN2A and NaCP60E

DIOPT Version :9

Sequence 1:	NP_001035232.1	Gene:	SCN2A / 6326	HGNCID:	10588	Length:	2005	Species:	Homo sapiens
Sequence 2:	NP_001261172.1	Gene:	NaCP60E / 37981	FlyBaseID:	FBgn0085434	Length:	2896	Species:	Drosophila melanogaster

Alignment Length:	2594	Identity:	824/2594 - (31%)
Similarity:	1181/2594 - (45%)	Gaps:	815/2594 - (31%)

- Green bases have known domain annotations that are detailed below.

Human    17 FTRESLAAIEQRIAEEKAKRPKQERKDED--DENG--PKPNSDLEAGKSLPFIYGDIPPEMVSVP 77
            |..|...|..|.:|..:..:.|.|.:...  .|.|  |:..:.:|.|..||..:...|..|...|
  Fly     8 FNDEKAVAKHQVVAYTQRSQVKHENRHIQLVREYGFHPRTKASVEDGDVLPRKFEPFPEHMYGKP 72

Human    78 LEDLDPYYINKKTFIVLNK---GKAISRFSATPALYILTPFNPIRKLAIKILVHSLFNMLIMCTI 139
            ||::|. :|.::||.|::|   ...|.||:.|.:|::..|::|.|::.:.|..:..|:..:|.||
  Fly    73 LEEIDT-FIYEETFCVVSKRFRKNYIHRFTGTKSLFLFYPWSPARRVCVYIATNQFFDYCVMATI 136

Human   140 LTNCVFMTMSNPPDWTKNVEYTFTGIYTFESLIKILARGFCLEDFTFLRDPWNWLDFTVITFAYV 204
            |.||:|:.|:   :..:..||.|..||:.|.:|||:|:||.|..:|:||:|||||||.|||..|.
  Fly   137 LFNCIFLAMT---ETVEEAEYIFLAIYSIEMVIKIIAKGFLLNKYTYLRNPWNWLDFVVITSGYA 198

Human   205 TEFVDLGNVSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQL 269
            |..:::||::.||||||||||||:|::||||||:.||:.|.::|::||.||:|||.||||..||:
  Fly   199 TIGMEVGNLAGLRTFRVLRALKTVSIMPGLKTIINALLHSFRQLAEVMTLTIFCLMVFALFALQV 263

Human   270 FMGNLRNKCLQWPPDNSSFEINITSFFNNSLDGNGTTFNRTVSIFNWDEYIEDKSHFYFLEGQND 334
            :||.|||||::..|         |.:.|             ||..:|..::.|..::.:.|.:.
  Fly   264 YMGELRNKCVRQVP---------TDWTN-------------VSHTDWQIWVNDTDNWLYDEDEL- 305

Human   335 ALLCGNSSDAGQCPEGYICVKAGRNPNYGYTSFDTFSWAFLSLFRLMTQDFWENLYQLTLRAAGK 399
            .:||||.:.|..||..|:|:..|.|||:|||:||.|.|:.|:.|:|:|.|:|||:|.:.|...|.
  Fly   306 PVLCGNLTGARHCPFEYVCLCVGENPNHGYTNFDNFMWSMLTTFQLITLDYWENVYNMVLATCGP 370

Human   400 TYMIFFVLVIFLGSFYLINLILAVVAMAYEEQNQATLEEAEQKEAEFQQMLEQLKKQQEEAQAAA 464
            ..:.||.:|:|.||||||||:|||||::|||:.:.|.||.:      :.:|:.
  Fly   371 MSVSFFTVVVFFGSFYLINLMLAVVALSYEEEAEITNEERK------KDLLDH------------ 417

Human   465 AAASAESRDFSGAGGIGVFSESSSV--ASKLSSKSEKELKNR---------RKKKKQKEQSGEEE 518
                   ||.|      .||...||  ..||:..::|::.:|         :||.::|:..|.:|
  Fly   418 -------RDDS------TFSFDPSVLNVKKLNKNNKKKIDSRKGVLLASYSKKKTRRKKTKGGKE 469

Human   519 ---------KNDRVRKSESEDSIRRKGFRFSL--EGSRLTYE-----KRFSSPHQSLLSIRGSLF 567
                     .|....||.|.........|.|.  ..|.||.:     ::....|:...|..|...
  Fly   470 GGTNGNGNGSNGDDNKSHSATPSPGPSPRHSATERPSALTMQAQKQYQQMEQQHKLAKSGSGGSN 534

Human   568 SPRRNSRASLFSFRGRAKDIGSEN-----DF---------ADDEHSTFEDNDSRRDSLFVPHRHG 618
            :|...:.....||:.....:.:.|     |:         ....:|:..:.:|.:|...|...|.
  Fly   535 NPMAPTPKGRISFQDSGMGVKNPNMLYPSDYKGQLIANSGQPSSNSSGVNRESSQDDSGVVDDHE 599

Human   619 ERRHSNVSQASRASRV-LPILPMNGKMHSAVDCNGVVSLVGGPSTLTSAGQLLPEGTTTETEIRK 682
            |:..:|  .....|.| |.:.|...::   :.|||.::.:...:...                ..
  Fly   600 EQDTTN--DMGHVSTVELALSPREVRL---IKCNGNIARIKNHNVYA----------------LH 643

Human   683 RRSSSYHVSMDLLEDPTSRQRAMSIASILTNTMEELEESRQKCPPCWYKFANMCLIWDCC--KPW 745
            :..||..|.:|.|.|                         :.|        :.|:.| |.  :.|
  Fly   644 QEFSSEVVVIDDLPD-------------------------RNC--------DRCVHW-CTDYESW 674

Human   746 LKVKHLVNLVVMDPFVDLAITICIVLNTLFMAMEHYPMTEQFSSVLSVGNLVFTGIFTAEMFLKI 810
            |:.::.:..||.||..:||||:||||||.|:||||:.|:|.|.:.|.|||.|||.|||.|..:|:
  Fly   675 LQFQNCLYKVVRDPLFELAITLCIVLNTAFLAMEHHGMSESFRNALDVGNKVFTSIFTFECIVKL 739

Human   811 IAMDPYYYFQEGWNIFDGFIVSLSLMELGLANVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIG 875
            :|:.. .:|..||||||..||:.||:::....|:||||||..|||||.|||:||.|:.:|:.||.
  Fly   740 MALSK-DFFLCGWNIFDLLIVTASLLDIIFELVDGLSVLRGLRLLRVLKLAQSWTTMKVLLSIII 803

Human   876 NSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKISNDCELPRWHMHDFFHSFLIVFRVLC 940
            :::||||||||:|.|:::||||:|||||.|.|..  .|...| .:|||:.:||||||:::||:||
  Fly   804 STIGALGNLTLILVIVIYIFAVIGMQLFSKDYTP--EKFDPD-PVPRWNFNDFFHSFMMIFRILC 865

Human   941 GEWIETMWDCM---EVAGQTMCLTVFMMVMVIGNLVVLNLFLALLLSSFSSDNLAATDDD-NEMN 1001
            |||||.:||||   |..|.:.|..:|:..:|:||.:||||||||||:||:|:.|.:..:: .|.:
  Fly   866 GEWIEPLWDCMRAEEEQGASTCFAIFLPTLVMGNFMVLNLFLALLLNSFNSEELKSKKEEVGEES 930

Human  1002 NLQIAVGRM--------QKGIDFVKRKIREFIQKAFVRKQKA---------------------LD 1037
            .|..::.|:        |:..|..:||..|..|:..:..|:|                     |.
  Fly   931 KLARSIERVRDLIRKKRQERKDRKERKFAEKFQQIVLDAQQAHAQTLSHQAAVGLERGDKPGVLA 995

Human  1038 EIK-----------------------PLED----------------------------------- 1044
            |.|                       ||.|
  Fly   996 ETKFHRLSYQESMNRPVSGSDFGFQIPLHDGLHTIVDGLEYDDTGDLPEQIQLQAHPLPPTSDSM 1060

Human  1045 ----------------------------------------------------------------- 1044

  Fly  1061 PPTYESAMMATTGGSFSSVNGNGTCQNLTPFVQAERRLQHQISSGVSTQQYDSREEATYTESIEL 1125

Human  1045 ------------LNNKKDSC--------ISNHTTIEIG-----------------------KDLN 1066
                        .|:::..|        :.::::...|                       |.|:
  Fly  1126 LGQYNSTDTDPYANDQRSGCGSFNRGDSLQDNSSRRYGSEEHDEAFLKYQKSLLTRSPSYRKSLD 1190

Human  1067 YLKDGNGTTS--------------GIGSSVEKYVVDESDYMSFINN------------------- 1098
            .|...:|.:.              ..|.|:....:::.:.:|...|
  Fly  1191 RLSQSSGQSQRSLLKSEEAEMRRHSSGQSLNSMSIEQDELLSQQGNLREELLNCDQKELFQFLQE 1255

Human  1099 ---------------------PSLTVTVP---IAVGESDFENLNTEEFSSESDMEESKEKLNA-- 1137
                                 ||..:..|   ..|..|:|:|:..   |.|.::||.|....:
  Fly  1256 EEELQKGTKLRRISNVMRSRRPSSQMGQPENETMVEHSEFDNIIQ---SFEKELEEIKRSTTSLE 1317

Human  1138 ---------------------------TSSSEGSTVD---------------------------- 1147
                                       |.:||.|..|
  Fly  1318 RKLSNLSEPSPAADEATKAIMEHIAIITGASERSAADEVVLPLNPYDSYDLSSVPRRSQSVSAAA 1382

Human  1148 ----------------------------------IGAP-------------AEGEQP-------- 1157
                                              |.||             |...||
  Fly  1383 QRQSVKLKRRSLEKQRKIDEDFSISNEIRKICDQIHAPFVAMEAMAVAATSASQAQPNQSPFLRR 1447

Human  1158 ---------------------EVEPEE-------------------------------------- 1163
                                 |..|||
  Fly  1448 KVDPFTVQFDRFKRLSLIERVEEVPEEEKPISTLRIESEKMPRKFLHGPDQLRLDSLSLKSTNSY 1512

Human  1164 ----------------------------SLE---------------------------------- 1166
                                        |:|
  Fly  1513 ENLLIQKQKLGMATPPAVPATPPTSLKSSIEPPTLAQISSLKTTPPLAALTEHQQHFHATSIQAA 1577

Human  1167 ----------------------------------------------------------------- 1166

  Fly  1578 PTPAHTHAHSQAHAHSMAGQRRRMEHPQSTLDKAASFQSARTESHSSGAADASSALALAMAQKTE 1642

Human  1167 ---------------------------------------------------------------PE 1168
                                                                           |:
  Fly  1643 QSQSTAPDATQKPSAFTRLTEKPWHCLVSYVDDLTVGGRRNSQGAYNDPMTFPSYGATKAAKVPD 1707

Human  1169 ACFTEDCVRK--FKC-----CQISIEEGKGKLWWNLRKTCYKIVEHNWFETFIVFMILLSSGALA 1226
            .||.:.|...  |:|     |   ::....|.|..:|.....:|:...||.|::.:|..||..|.
  Fly  1708 DCFPQKCYDHFYFRCPWFMSC---MDTQSAKHWTRVRTAVLTVVDTPAFEWFVLVLIFASSITLC 1769

Human  1227 FEDIYIEQRKTIKTMLEYADKVFTYIFILEMLLKWVAYGFQVYFTNAWCWLDFLIVDVSLVSLTA 1291
            ||||.:::.||:|.:|.:.:..|..||::||:|||:|.||..|||:.|..|||:||.||:.||..
  Fly  1770 FEDINLDKNKTLKRVLYWINFSFCLIFVVEMILKWLALGFSKYFTSFWTILDFIIVFVSVFSLLI 1834

Human  1292 NALGYSELGAIKSLRTLRALRPLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGV 1356
            ..  ...|..::|||||||||||||:||::|||:|||||:.|||||.|||||||:||||||||||
  Fly  1835 EE--NENLKVLRSLRTLRALRPLRAISRWQGMRIVVNALMYAIPSIFNVLLVCLVFWLIFSIMGV 1897

Human  1357 NLFAGKFYHCINYTTGEMFDVSVVNNYSECKALIESNQTARWKNVKVNFDNVGLGYLSLLQVATF 1421
            ..|.|||:.|:| ..||:..::.||:..:|   ||.|.|  |.|.|:.||:||:|||:|||||||
  Fly  1898 QFFGGKFFKCVN-EMGELLPITEVNDKWDC---IEQNYT--WINSKITFDHVGMGYLALLQVATF 1956

Human  1422 KGWMDIMYAAVDSRNVELQPKYEDNLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGG- 1485
            :|||::|..|||:|.|:|||:.|.|||.|:||||||:.||||||||||||||||||..|||:.|
  Fly  1957 EGWMEVMADAVDARGVDLQPQREANLYAYIYFVIFIVCGSFFTLNLFIGVIIDNFNMLKKKYEGG 2021

Human  1486 -QDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPANKFQGMVFDFVTKQVFDISIMILICLNMVTMM 1549
             .::|:||.||.||.||||||.|||||.|.||.|.|..|.:|....:.|:|:|.:||.|||:||.
  Fly  2022 VLEMFLTESQKHYYTAMKKLGRKKPQKVIKRPINHFLAMFYDLSNSRRFEIAIFVLIFLNMLTMG 2086

Human  1550 VETDDQSQEMTNILYWINLVFIVLFTGECVLKLISLRYYYFTIGWNIFDFVVVILSIVGMFLAEL 1614
            :|..||...:..||...|..|..:|..|.::|::.|||:|||:.||:|||::|:.||.|:.:.::
  Fly  2087 IEHYDQPHAVFFILEVSNAFFTTVFGLEAIVKIVGLRYHYFTVPWNVFDFLLVLASIFGILMEDI 2151

Human  1615 IEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGM 1679
            :....:||||.||:|:.||||||||||.|||||.|||||::|||||||||.||.|:.|||||.||
  Fly  2152 MIDLPISPTLLRVVRVFRIGRILRLIKAAKGIRKLLFALVVSLPALFNIGALLGLITFIYAILGM 2216

Human  1680 SNFAYVKREVGIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSGPPDCDPDKDHPGSSVKG 1744
            |.|..||.:..:|||.||:|||.||..||::.|||||:.:|..::.. ||||||   .......|
  Fly  2217 SLFGNVKLQGALDDMVNFQTFGRSMQLLFRLMTSAGWNDVLESLMIQ-PPDCDP---FIHGHTNG 2277

Human  1745 DCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVATEESAEPLSEDDFEMFYEVWEKFDPDA 1809
            :||:|.:.|.:|.|:||||:::|:|||||:|||||:.|.:|....:.|||.||||..|.|:||.|
  Fly  2278 NCGHPLLAITYFTSFIIISYMIVINMYIAIILENFNQAHQEEEIGIVEDDLEMFYIRWSKYDPHA 2342

Human  1810 TQFIEFAKLSDFADALDPPLLIAKPNKVQLIAMDLPMVSGDRIHCLDILFAFTKRVLGESGEMD- 1873
            ||||.|::||||..:|||||.|:|||.|.|::.:||:..|::|||||||.|..|.|||...|.|
  Fly  2343 TQFIHFSQLSDFIASLDPPLGISKPNNVALVSFNLPISKGNKIHCLDILHALVKHVLGHVEETDN 2407

Human  1874 --ALRIQMEERFMASNPSKVSYEPITTTLKRKQEEVSAIIIQRAYRRYLLKQKVKKVSS 1930
              .|:.||:.:|....|::...|.:::|...|::|.:|..||..::.||.:::.|:.|:
  Fly  2408 FKQLQEQMDVKFKKQFPTRKELEIVSSTRIWKRQEKAAKTIQTGWKEYLRRKREKERSN 2466

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.