back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SCN2A and cch1

DIOPT Version :9

Sequence 1:	NP_001035232.1	Gene:	SCN2A / 6326	HGNCID:	10588	Length:	2005	Species:	Homo sapiens
Sequence 2:	NP_593894.1	Gene:	cch1 / 2542812	PomBaseID:	SPAC6F6.01	Length:	1854	Species:	Schizosaccharomyces pombe

Alignment Length:	2110	Identity:	404/2110 - (19%)
Similarity:	750/2110 - (35%)	Gaps:	695/2110 - (32%)

- Green bases have known domain annotations that are detailed below.

Human    63 PFIYGDIPPEMVSVPLEDLDPYYIN--KKTFIVLNKGKAISRFSATPALYILTPFNPIRKLAIKI 125
            ||::            :.|.||:.:  .:.:..:.:.....|.:.||...:  ||:||.:   :|
pombe   134 PFLF------------DKLSPYFTHFFSEIYAAVLRVVGPPRANETPGRNL--PFSPILR---QI 181

Human   126 LVHSLFNMLIMCTILTNCVFMTM--SNPPDWTKNVEYTFTGI---YTFESLIKILARGFCLE--- 182
            ..|.|:|:.|...|:.:.|.:.:  .:|.|.::.::|....|   ||.|.|:||...||..:
pombe   182 YNHPLYNIFIFVVIVLHAVLLMIRSDDPHDKSQTIDYLIIVIGILYTLEMLLKIYLFGFLYDGSS 246

Human   183 ---DF------------TFLRDPWNWLDFTVITFAYVTEFVDLGNVSALRTFRV---LRALKTIS 229
               ||            ::||..||.:||..|...::: .:........|.|.:   ||..:.::
pombe   247 SFYDFINSYTKKTPRTMSYLRHSWNRVDFVAIVALWIS-VIGKKQQGIFRLFSMIACLRLTRLLN 310

Human   230 VIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCLQWPPDNSSFEINITS 294
            :....:||:.:|.:|...|..|:....|...:.|::|:|.|..:|..:|: |..|.....:....
pombe   311 ITRKTETILKSLKESSTPLVQVVSFNAFFGVMIAILGVQFFKASLNRQCV-WLGDYGDQYLPTGQ 374

Human   295 FFNNSLDGNGTTFNRTVSIFNWDEYIEDKSHFYFLEGQNDALLCGNSSDAGQCPEGYICVKAG-- 357
            |...                :|:            .|...|.|..|...:...|.|:||.:..
pombe   375 FCGG----------------HWE------------NGIKRAYLDKNGFPSNVNPRGFICAEKSVC 411

Human   358 ---RNPNYGYTSFDTFSWAFLSLFRLMTQD-FWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLIN 418
               .||.....|||.|..:...:|.:|:.: |.:.:|.:.......:.::|.:...|| :.:|::
pombe   412 RVVENPYSNTVSFDNFFNSLELIFVIMSSNGFTDIMYDIMDAEYFVSCLLFIISAYFL-TLWLMS 475

Human   419 LILAVVAMAYEEQNQATLEEAEQKEAEFQQMLEQLKKQQEEAQAAAAAASAESRDFSGAGGIGVF 483
            |::|||..::                                           .|...:|
pombe   476 LVIAVVTSSF-------------------------------------------IDLQHSG----- 492

Human   484 SESSSVASKLSSKSEKELKNRRKKKKQKEQSGEEEKNDRVRKSESEDSIRRKGFRFSLEGSRLTY 548
                                    |.||||           ||..:..||.|           ..
pombe   493 ------------------------KNQKEQ-----------KSVDKHLIRNK-----------LC 511

Human   549 EKRFSSPHQSLLSIRGSLFSPRRNSRASLFSFRGRAKDIGSENDFADDEHSTFEDNDSRRDSLFV 613
            ||                                                           .||
pombe   512 EK-----------------------------------------------------------YLF- 516

Human   614 PHRHGERRHSNVSQASRASRVLPILPMNGKMHSAVDCNGVVSLVGGPSTLTSAGQLLPEGTTTET 678
                    :||
pombe   517 --------YSN------------------------------------------------------ 519

Human   679 EIRKRRSSSYHVSMDLLEDPTSRQRAMSIASILTNTMEELEESRQKCPPCWYKFANMCLIWDCCK 743
                                                                      .||
pombe   520 ----------------------------------------------------------FIW---- 522

Human   744 PWLKVKHLVNLVVMDPFVDLAITICIVLNTLFMAMEHYPMTEQFSSVLSVGN--LVFTG----IF 802
                    ::.:|..     .:|:|               |:.:....|..|  |:|..    :.
pombe   523 --------ISFIVAQ-----FVTLC---------------TQTYDQTSSTANRYLIFYACVDFLL 559

Human   803 TAEMFLKIIAMDPYY--YFQEGWNIFDGFIVSLSLMELGLANVEGLSV----LRSFRLLRVFKLA 861
            .||:.|:..|..|.|  :|:...|:.|..:..|:|:.| |.::....|    |..|.:.|:::..
pombe   560 AAEVILRFFAYLPDYRLFFRRYTNLVDIVLAVLNLVTL-LPSIRKNPVAFGWLSIFAIARIYRCI 623

Human   862 KSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF------GKSYKECVCKISNDCEL 920
            ...|....:.|::.::...|.||.|.|.|::||.::..::||      |.|..:.:...:.
pombe   624 LLIPYTRKIAKLLFSNFKQLLNLMLFLVIVLFIASLCAVRLFQDLPNDGDSDDDAISFATT---- 684

Human   921 PRWHMHDFFHSFLIVFRVLCGE-WIETM-------------WDCMEVAGQTMCLTVFMMVMVIGN 971
                    :.|||.::::|..| |.:.|             |    :.|     ..|.:..:..|
pombe   685 --------YESFLYMYQILTSENWTDVMFAIQARLAHLHLSW----IPG-----AFFTLWFLFSN 732

Human   972 LVVLNLFLALLLSSFSSDNLAATDDDNEMNNLQIAVGRMQKGIDFVKRK--IREFIQKAFVRKQK 1034
            .|||::|:|::     ..|.|.::.|.:|..|::.:.|:.:..:..:..  :...|::...||.|
pombe   733 NVVLSMFIAVI-----QVNFAPSESDLKMEQLKMYLARLLRNYNPFQASLTLNALIKRNGSRKGK 792

Human  1035 ALDE--------------------IKPLEDLNNKKDSCISNHTTIEIGKDLNYLKDGNGTTSGIG 1079
            .:||                    |.|.|.|....|      |:.|:.|   |      :.:.:.
pombe   793 TVDESHYEWLYEDNIIKGFLRVTNIPPKEPLKPSLD------TSPELSK---Y------SLAKLS 842

Human  1080 SSVEKYVVDESDYMSFINNPSLTVTVPIAVG---ESDFENLNTEEFSSESDMEESKEKLNATSSS 1141
            ::.:::|:.:        :|.........:|   |.|. ||.|    :..||:.:|..:
pombe   843 NNFKRFVMRD--------DPFSQAYFKRVIGIRWEKDM-NLKT----AAKDMQAAKAFV------ 888

Human  1142 EGSTVDIGAPAEGEQPEVEPEESLEPEACFTE--------DCVRKFKCCQISIEEGKGKLWWNLR 1198
                            .::..|.|:....:.:        :.:|:|  ||..:..|..:.:..:.
pombe   889 ----------------RIKQTEFLKNHPKYNDVFWVIKPSNRIRRF--CQRLVMPGVNERYGGVE 935

Human  1199 --KTCYKIVEHNWFETFIVFMILLSSGALAFEDIY--IEQRKTIKTMLEYA-----DKVFTYIFI 1254
              :..|:::     :.||...||.   |:..|.|.  |.:|..:....::|     :..|..||.
pombe   936 PYQWVYRVI-----QVFIYACILT---AVIIECIATPIYERDHLLNDKQHAWFVWTEVAFATIFT 992

Human  1255 LEMLLKWVAYGF----QVYFTNAWCWLDFLIVDVSLVSLTANALGYSELGAIKSLRTLRALRPLR 1315
            :|..:|.:|.||    ..|..:.|..:||.::....::|.|....::.|.  ::.|..:|||.||
pombe   993 IEAAIKIIADGFCITPNAYLRSTWNCIDFFVLVTLWINLYAVLTSHALLS--RAFRAFKALRVLR 1055

Human  1316 ALSRFE-GMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCINYTTGEMFDVSV 1379
            .::..: ..|:..:||:.....|.:..:|.....:.|::...|:|.|..|.|        .|.:|
pombe  1056 LINLTQTSQRMFHDALISGFFKIFSAAVVSATLLIPFALWAKNVFGGLLYSC--------NDDNV 1112

Human  1380 VNNYSECKALIESNQTAR---------WKN-VKVNFDNVGLGYLSLLQVATFKGWMDIMYAAVDS 1434
            : :.|:|  ::|...|..         |.| ...:||......|:|.::|:.:||:|||.:.:|.
pombe  1113 L-SASQC--VLEYASTPNNWEVWAPRVWSNPPDYDFDRFPHALLALFEIASIEGWVDIMRSVMDI 1174

Human  1435 RNVELQPKYEDNLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKKYYN 1499
            .....||:...:....::||:|.:....:.|.|||.:||.|:.::.     ...|.|.||:.:..
pombe  1175 TGFNNQPQTNASSGNAMFFVLFNLVSMIYILTLFIAIIISNYAERT-----GSAFFTAEQRAWLE 1234

Human  1500 AMKKLGSKKPQK-PIPRPANKFQGMVFDFVTKQ----------VFDISIMILICLNMVTMMVETD 1553
            ..:|:.|.:|.| |..||.. .:|:.:||..::          ::.:.::.|:.:.....:..|
pombe  1235 LRRKIKSMRPSKRPAIRPLG-LRGLCYDFAVQKHGIWRRTFTGLYIVHLLFLLTIFYPCPIAYT- 1297

Human  1554 DQSQEMTNILYWINLVFIVL---FTGECVLKLISLRYYYFTIG-WNIFDFVVVILSIVGMFLAEL 1614
                      |..|.:|::|   :|....:|:..|.:|||... ||:|| |||.|..:...:|.|
pombe  1298 ----------YVRNSIFLILSICYTINICVKVYGLSFYYFFHSFWNMFD-VVVTLGSLTCNIAIL 1351

Human  1615 IEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFI-YAIFG 1678
            .:....|.||.:...|..:  .:.||........|...::.|||::|:: :..::|::| :||..
pombe  1352 AKFENRSLTLLQTTLLVLV--TVHLIPKFDNFDQLSKTVVASLPSIFSL-IATWIVLYITFAIAF 1413

Human  1679 MSNFAYVKREVGIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSGPPDCDPDKDHPGSSVK 1743
            ...|...|..:......||.:..|:::.||.:|...||:.::.....| .|:|....|...|
pombe  1414 NQIFGLTKLGLNGGPNKNFRSIRNALVLLFTMTFGEGWNDVMHDYTIS-YPNCVNGDDFYNS--- 1474

Human  1744 GDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFS-VATEESA-EPLSEDDFEMFYEVWEKFD 1806
             ||||.......|:::.|||..:.|||:|.|:.:||| :.|:.|: ..|..:||..|.:.|..||
pombe  1475 -DCGNKPWAYGLFIAWNIISMYIFVNMFITVVFDNFSYIHTKSSSFTNLQRNDFRQFKDSWAPFD 1538

Human  1807 PDATQFI----------EFAKLSDFADALDPPLLIAKPNKVQ-------LIAMDLPMVSGD-RIH 1853
            |..|.:|          ....:.||....|...|.:..:|||       :..::.|::..: .:.
pombe  1539 PMVTGYIPKRNAVKFVLSLRGVYDFRIYRDEHTLRSIISKVQSKTGQQSVPMLENPLMGSEINLE 1603

Human  1854 CLD----------------ILFAFTKRVLGESGEMDALR-----------IQMEERFMASNPSKV 1891
            .||                :|.:....::...|.:.:..           :...|.|..|:..:.
pombe  1604 ALDQIIDTIDVNVVKERRNVLNSLCTEIMTLPGNVISFSNILMLVVLHKIVDHREAFPISDYIRR 1668

Human  1892 SYEPITTTLKR--KQEE----VSAIIIQRAYRRYLLKQK---------VKKVSSIYKKDKGKECD 1941
            :|  :.:.|::  :.|:    |...||::.:.:::.::|         :.:||.|..:
pombe  1669 AY--VLSELEKSIRMEKLLGLVETSIIRKTFLQHMEEKKKALENPFILLSEVSEILPE------- 1724

Human  1942 GTPIKEDTLIDKLNENSTPEKTDMTPSTTS 1971
             |||:|..    ...|:.||:..|:..|.|
pombe  1725 -TPIQEVL----RQHNADPEQLLMSTRTPS 1749

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.