back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SCN2A and unc-2

DIOPT Version :9

Sequence 1:	NP_001035232.1	Gene:	SCN2A / 6326	HGNCID:	10588	Length:	2005	Species:	Homo sapiens
Sequence 2:	NP_001355464.1	Gene:	unc-2 / 180570	WormBaseID:	WBGene00006742	Length:	2171	Species:	Caenorhabditis elegans

Alignment Length:	2074	Identity:	490/2074 - (23%)
Similarity:	813/2074 - (39%)	Gaps:	604/2074 - (29%)

- Green bases have known domain annotations that are detailed below.

Human     9 PGPDSFRFFTRESLAAIEQRIAEEKAKRPKQERKDEDDENGPKPNSDLEAGKSLPFIYGDIPPEM 73
            |.|        ..|||.|.| .|:||:.....||.....|.|
Worm   191 PSP--------SQLAAEEAR-REQKAESGTFVRKTTLSSNAP----------------------- 223

Human    74 VSVPLEDLDPYYINKKTFIVLNKGKAISRFSATPALYILTPFNPIRKLAIKILVHSLFNMLIMCT 138
                               |..||.:        :|:|....|.||:.|..|:....|...|:.|
Worm   224 -------------------VKEKGPS--------SLFIFAEDNIIRRNAKAIIEWGPFEYFILLT 261

Human   139 ILTNCVFMTMSNP---------PDWTKNVEYTFTGIYTFESLIKILARGFCLEDFTFLRDPWNWL 194
            |:.|||.::|...         .:|.:..|..|.||:..|.::|::|.||.|...::||..||.:
Worm   262 IIGNCVVLSMEQHLPKNDKKALSEWLERTEPYFMGIFCLECVLKVIAFGFALHKGSYLRSGWNIM 326

Human   195 DFTVITFAYVT------------EFVDLGNVSALRTFRVLRALKTISVIPGLKTIVGALIQSVKK 247
            ||.|:....||            :.||..::..||..||||.||.:|.||.|:.::.:::.::..
Worm   327 DFIVVVSGVVTMLPFSPATQTANQPVDSVDLRTLRAVRVLRPLKLVSGIPSLQVVLKSILCAMAP 391

Human   248 LSDVMILTVFCLSVFALIGLQLFMGNLRNKCLQWPPDNSSFEINITSFFNNSLDGNGTTFNRT-- 310
            |..:.:|.:|.:.:||:|||:.:.|...:.|.     |...||      .|..:......|:|
Worm   392 LLQIGLLVLFAIIIFAIIGLEFYSGAFHSACY-----NERGEI------ENVSERPMPCTNKTSP 445

Human   311 VSIFNWDEYIEDKSHFYFLEGQNDALLCGNSSDAGQCPEGYICVKAGRNPNYGYTSFDTFSWAFL 375
            :.::|.|                              .:|..|::....||||.||||...:|.:
Worm   446 MGVYNCD------------------------------VKGTTCLQKWIGPNYGITSFDNIGFAMI 480

Human   376 SLFRLMTQDFWENLYQLTLRAAGKTY-MIFFVLVIFLGSFYLINLILAVVAMAYEEQNQATLEEA 439
            ::|:.:|.:.|..:...|..:.|.|| ..:|:.:|.||||:::||:|.|::
Worm   481 TVFQCITMEGWTTVMYYTNDSLGSTYNWAYFIPLIVLGSFFMLNLVLGVLS-------------- 531

Human   440 EQKEAEFQQMLEQLKKQQEEAQAAAAAASAESRDFSGAGGIGVFSESSSVASKLSSKSEKELKNR 504
                .||.:..|:::.:               |:|                          ||.|
Worm   532 ----GEFAKERERVENR---------------REF--------------------------LKLR 551

Human   505 RKKKKQKEQSGEEE----------KNDRVRKSESEDSIRRKGFRFSLEGSRLTYEKRFSSPHQSL 559
            |:::.::|.:|..|          |.||..:.|
Worm   552 RQQQIERELNGYLEWILTAEEVILKEDRTTEEE-------------------------------- 584

Human   560 LSIRGSLFSPRRNSRASLFSFRGRAKDIGSENDFADDEHSTFEDNDSRRDSLFVPHRHGERRHSN 624
               :.::...||.:.........:.:...:|.||.:||....|
Worm   585 ---KAAIMEARRRAANKKLKQASKQQSTETEEDFEEDEDEMEE---------------------- 624

Human   625 VSQASRASRVLPILPMNGKMHSAVDCNGVVSLVGGPSTLTSAGQLLPEGTTTETEI--RKRRSSS 687
                                                       :.:.||.|.|.|.  ||:|...
Worm   625 -------------------------------------------EYVDEGGTVEDEFAERKKRGCC 646

Human   688 YHVSMDLLEDPTSRQRAMSIASILTNTMEELEESRQKCPPCWYKFANMCLIWDCCKPWLKVKHLV 752
            :.|.                                       ||...          |:::  :
Worm   647 HSVG---------------------------------------KFIKQ----------LRIQ--I 660

Human   753 NLVVMDPFVDLAITICIVLNTLFMAMEHYPMTEQFSSVLSVGNLVFTGIFTAEMFLKIIAMDPYY 817
            .::|.......::...:.|||..:|.|||...:.|:..|.....||.|||..||.||:.||....
Worm   661 RIMVKTQIFYWSVITLVFLNTCCVASEHYGQPQWFTDFLKYAEFVFLGIFVVEMLLKLFAMGSRT 725

Human   818 YFQEGWNIFDGFIVSLSLMELGLANVE----GLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSV 878
            ||...:|.||..::..|..|:..|.|.    |:||:|:.||||:|||...|.:|..|::.:.||:
Worm   726 YFASKFNRFDCVVIVGSAAEVIWAEVYGGSFGISVMRALRLLRIFKLTSYWVSLRNLVRSLMNSM 790

Human   879 GALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKISNDCELPRWHMHDFFHSF----LIVFRVL 939
            .::.:|..:|.:.:.|||::||||||..:           ..|..|.:..|.:|    :.||::|
Worm   791 RSIISLLFLLFLFILIFALLGMQLFGGRF-----------NFPTMHPYTHFDTFPVALITVFQIL 844

Human   940 CGE-WIETMWDCMEVAGQTMC----LTVFMMVMVI-GNLVVLNLFLALLLSSFSSDNL------- 991
            .|| |.|.|:..:|..|....    .:::.:|:|: ||..:||:|||:.:     |||
Worm   845 TGEDWNEVMYLAIESQGGIYSGGWPYSIYFIVLVLFGNYTLLNVFLAIAV-----DNLANAQELT 904

Human   992 AATDDDNEMNNLQIAVGRMQKGIDFVKRKIREFIQKAFVRKQKALDEIKPLEDLNNKKDSCISNH 1056
            ||.:.|.:.|.::                                :|.:.|::...:.|.|
Worm   905 AAEEADEKANEIE--------------------------------EESEELDEQYQEGDHC---- 933

Human  1057 TTIEIGKDLNYLKDGNGTTSGIGSSVEKYVVDESDYMSFINNPSLTVTVPIAVGESDFENLNTEE 1121
             ||          |..|.|:|...:|.: .:|:.|
Worm   934 -TI----------DMEGKTAGDMCAVAR-AMDDLD------------------------------ 956

Human  1122 FSSESDMEESKEKLNATSSSEGSTVDIGAPAEGEQPEVEPEES---LEPEACFTEDCVRKFKCCQ 1183
              .|.:.|||                   |..|.:|.| |..|   |.|...|
Worm   957 --EECEEEES-------------------PFGGPKPMV-PYSSMFFLSPTNPF------------ 987

Human  1184 ISIEEGKGKLWWNLRKTCYKIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKV 1248
                          |...:.||...:||..::.:|.|||.:||.||...|:....| :|:|.|..
Worm   988 --------------RVLIHSIVCTKYFEMMVMTVICLSSVSLAAEDPVDEENPRNK-VLQYMDYC 1037

Human  1249 FTYIFILEMLLKWVAYGFQV----YFTNAWCWLDFLIVDVSLVSL----TANALGYSELGAIKSL 1305
            ||.:|..|||||.:..|..:    |..:.|..||.::|..:|.:.    |..:.| ..|..||||
Worm  1038 FTGVFACEMLLKLIDQGILLHPGSYCRDFWNILDGIVVTCALFAFGFAGTEGSAG-KNLNTIKSL 1101

Human  1306 RTLRALRPLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHC---- 1366
            |.||.||||:.:.|...::.|.:.::.::.::.|:|:|..:|..||:::.|.||.|||:.|
Worm  1102 RVLRVLRPLKTIKRIPKLKAVFDCVVNSLKNVFNILIVYFLFQFIFAVIAVQLFNGKFFFCTDKN 1166

Human  1367 ---INYTTGEMFDVSVVNNYSECKALIESNQTARWKNVKVNFDNVGLGYLSLLQVATFKGWMDIM 1428
               .|...|:.|   |.:|.:: ...:|..:   |:....|:||.....|:|..|.|.:||..|.
Worm  1167 RKFANTCHGQFF---VYDNQND-PPRVEQRE---WRLRPFNYDNTINAMLTLFVVTTGEGWPGIR 1224

Human  1429 YAAVDSRNVELQPKYEDNLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEE 1493
            ..::|:...:..|.....:.:.|::|:|.|...||.:|:|:.:||..|.:|    |..::...:.
Worm  1225 QNSMDTTFEDQGPSPFFRVEVALFYVMFFIVFPFFFVNIFVALIIITFQEQ----GEAELSEGDL 1285

Human  1494 QKKYYNAMKKLGSKKPQKP-IPRPANKFQGMVFDFVTKQVFDISIMILICLNMVTMMVETDDQSQ 1557
            .|.....:....:.:|:.. :|...|..:..::..||...|:..||.:||.|.:.:|::..:...
Worm  1286 DKNQKQCIDFALNARPRSLFMPEDKNSTKYRIWRLVTSPPFEYFIMTMICCNTLILMMKYYNNPL 1350

Human  1558 EMTNILYWINLVFIVLFTGECVLKLISLRY-YYFTIGWNIFDFVVVILSIVGMFLAELIEKYFVS 1621
            ....||...|.....:||.|.:||:::... .||..|||.||||.|:.||....:.| ...:|||
Worm  1351 FYEEILRLFNTALTAVFTVESILKILAFGVRNYFRDGWNRFDFVTVVGSITDALVTE-FGGHFVS 1414

Human  1622 PTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFA--Y 1684
               ...:||.|..|::||::....||.||:..:.|..||..:.||:.::.|||||.||..|.  :
Worm  1415 ---LGFLRLFRAARLIRLLQQGYTIRILLWTFVQSFKALPYVCLLIGMLFFIYAIVGMQVFGNIW 1476

Human  1685 VKREVGIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSGPPDCDPDKDHPGSS----VKGD 1745
            :.....|:...||::|.|::|.||:..|..||..::...:..  .||    ...||:    .||.
Worm  1477 LNAATEINRHNNFQSFFNAVILLFRCATGEGWQDIMMAAVQG--KDC----ARAGSAEINFEKGQ 1535

Human  1746 -CGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVATEESAEPLSEDDFEMFYEVWEKFDPDA 1809
             ||: :|...:|.|::.:|..:::|:::|||::||...|.:|: .|.....:.|..||..:||.|
Worm  1536 TCGS-NVSYAYFTSFVFLSSFLMLNLFVAVIMDNFDYLTRDSS-ILGPHHLDEFIRVWADYDPAA 1598

Human  1810 TQFIEFAKLSDFADALDPPLLIAK--PNKV---QLIAMDLPMVSGDRIHCLDILFAFTKRVLGES 1869
            |..|.::::.:....:.||:...|  |.::   .||.|::|:.....:|....|||..:
Worm  1599 TGRIHYSEMYEMLRIMAPPVGFGKKCPYRLAYKHLIRMNMPVAEDGTVHFTTTLFALIR------ 1657

Human  1870 GEMDALRIQM---EERFMASNPSKVSYEPITTTLKRKQEEVSAII------------IQRAYRRY 1919
               ::|.|:|   ||...|....:::.:.| ..||.|:..|..::            :.:.|...
Worm  1658 ---ESLSIKMRPVEEMDEADEELRLTLKKI-WPLKAKKNMVDLVVPPNHELCFQKLTVGKIYAGL 1718

Human  1920 LLKQKVKKVSSIYKKDK------GKECDGTPIKEDTLIDKLNENSTPEKTDMTPSTTSP 1972
            |:.:.       |:..|      |:...|..::......|..|:.....|...|..|:|
Worm  1719 LILEN-------YRARKSGTEVGGQGLFGGGLRSLVAAAKAAESQHSSHTPQPPEETTP 1770

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.