DRSC/TRiP Functional Genomics Resources

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Protein Alignment SCN2A and F17C8.6

DIOPT Version :10

Sequence 1:NP_066287.2 Gene:SCN2A / 6326 HGNCID:10588 Length:2005 Species:Homo sapiens
Sequence 2:NP_497974.1 Gene:F17C8.6 / 175626 WormBaseID:WBGene00008911 Length:279 Species:Caenorhabditis elegans


Alignment Length:254 Identity:51/254 - (20%)
Similarity:85/254 - (33%) Gaps:82/254 - (32%)


- Green bases have known domain annotations that are detailed below.


Human  1776 LENFSV--ATEESAEPLSEDDFEMFYEVWEKFDPDATQFIEFAKLSDFADALDPPLLIAKPNKVQ 1838
            :||||:  ::||.| .||..|...|..||...|.:..:.|...::.                   
 Worm     1 MENFSLLYSSEEDA-LLSYADIRNFQLVWNMVDIEQKRSIPVRRVK------------------- 45

Human  1839 LIAMDLPMVSGDRIHCLDILFAFTKRVLGESGEMDAL--RIQMEERFMASNPSKVSYEPITTTLK 1901
                              .|....|..|..:.|.|.|  :....|.....|...||:..:...|.
 Worm    46 ------------------FLLRLLKGRLEVNDESDGLLFKHMCHEMERLHNGDDVSFHDVLNMLS 92

Human  1902 RKQEEVSAI-----IIQRAYRRYLLKQKVKK------VSSIYKKDKGKECDGTPIKEDTLIDKLN 1955
            .:..::...     ::||....|:::::|.|      :.:..|..|.|                 
 Worm    93 YRSVDIRKSLQLEELLQREELEYIIEEEVAKHTIRAWLENCLKNIKAK----------------- 140

Human  1956 ENSTPEKTDMTPSTTS-PPSYDSVTK--------PEKEKFEKDK---SEKEDKGKDIRE 2002
            :|:|..|.....||.: |.|.:.:||        ||::..:.||   .:|..:|..|.|
 Worm   141 QNNTLGKMSSIGSTFAFPQSQEVLTKGVVLTEASPEEDSLQGDKGSGKKKAQRGNSITE 199

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SCN2ANP_066287.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 28..61
I. /evidence=ECO:0000305 111..456
Ion_trans 128..435 CDD:459842
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 494..529
Na_trans_cytopl 558..709 CDD:463401
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 590..610
II. /evidence=ECO:0000305 741..1013
Ion_trans 758..971 CDD:459842
Binds SCN2B. /evidence=ECO:0000305|PubMed:30765605 917..918
Na_trans_assoc 997..1203 CDD:461936
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1120..1165
III. /evidence=ECO:0000305 1190..1504
Ion_trans 1207..1482 CDD:459842
Na_channel_gate 1474..1526 CDD:240441
IV. /evidence=ECO:0000305 1513..1811 14/36 (39%)
Ion_trans 1531..1786 CDD:459842 5/11 (45%)
GPHH 1798..1845 CDD:465306 5/46 (11%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1935..2005 19/80 (24%)
F17C8.6NP_497974.1 None
Blue background indicates that the domain is not in the aligned region.

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