DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment SCN2A and F17C8.6

DIOPT Version :9

Sequence 1:	NP_001035232.1	Gene:	SCN2A / 6326	HGNCID:	10588	Length:	2005	Species:	Homo sapiens
Sequence 2:	NP_497974.1	Gene:	F17C8.6 / 175626	WormBaseID:	WBGene00008911	Length:	279	Species:	Caenorhabditis elegans

Alignment Length:	254	Identity:	51/254 - (20%)
Similarity:	85/254 - (33%)	Gaps:	82/254 - (32%)

- Green bases have known domain annotations that are detailed below.

Human  1776 LENFSV--ATEESAEPLSEDDFEMFYEVWEKFDPDATQFIEFAKLSDFADALDPPLLIAKPNKVQ 1838
            :||||:  ::||.| .||..|...|..||...|.:..:.|...::.
Worm     1 MENFSLLYSSEEDA-LLSYADIRNFQLVWNMVDIEQKRSIPVRRVK------------------- 45

Human  1839 LIAMDLPMVSGDRIHCLDILFAFTKRVLGESGEMDAL--RIQMEERFMASNPSKVSYEPITTTLK 1901
                              .|....|..|..:.|.|.|  :....|.....|...||:..:...|.
Worm    46 ------------------FLLRLLKGRLEVNDESDGLLFKHMCHEMERLHNGDDVSFHDVLNMLS 92

Human  1902 RKQEEVSAI-----IIQRAYRRYLLKQKVKK------VSSIYKKDKGKECDGTPIKEDTLIDKLN 1955
            .:..::...     ::||....|:::::|.|      :.:..|..|.|
Worm    93 YRSVDIRKSLQLEELLQREELEYIIEEEVAKHTIRAWLENCLKNIKAK----------------- 140

Human  1956 ENSTPEKTDMTPSTTS-PPSYDSVTK--------PEKEKFEKDK---SEKEDKGKDIRE 2002
            :|:|..|.....||.: |.|.:.:||        ||::..:.||   .:|..:|..|.|
Worm   141 QNNTLGKMSSIGSTFAFPQSQEVLTKGVVLTEASPEEDSLQGDKGSGKKKAQRGNSITE 199

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SCN2A	NP_001035232.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	28..61
		I. /evidence=ECO:0000305	111..456
		Ion_trans	128..435	CDD:366146
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	494..529
		Na_trans_cytopl	514..709	CDD:371806
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	590..610
		II. /evidence=ECO:0000305	741..1013
		Ion_trans	758..971	CDD:366146
		Binds SCN2B. /evidence=ECO:0000305\|PubMed:30765605	917..918
		Na_trans_assoc	997..1203	CDD:368948
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1120..1165
		III. /evidence=ECO:0000305	1190..1504
		Ion_trans	1207..1482	CDD:366146
		Na_channel_gate	1474..1526	CDD:240441
		IV. /evidence=ECO:0000305	1513..1811		14/36 (39%)
		Ion_trans	1531..1786	CDD:366146	5/11 (45%)
		GPHH	1798..1845	CDD:374878	5/46 (11%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1935..2005		19/80 (24%)
F17C8.6	NP_497974.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2301
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900