DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SCN1A and scn1lab

DIOPT Version :9

Sequence 1:	NP_001159435.1	Gene:	SCN1A / 6323	HGNCID:	10585	Length:	2009	Species:	Homo sapiens
Sequence 2:	NP_001038360.2	Gene:	scn1lab / 559447	ZFINID:	ZDB-GENE-060906-1	Length:	1996	Species:	Danio rerio

Alignment Length:	2023	Identity:	1576/2023 - (77%)
Similarity:	1769/2023 - (87%)	Gaps:	48/2023 - (2%)

- Green bases have known domain annotations that are detailed below.

Human     1 MEQTVLVPPGPDSFNFFTRESLAAIERRIAEEKAKNPKPDKK--DDDENGPKPNSDLEAGKNLPF 63
            |...:|||||||||..|..|||||||:|||||.|:.||.:::  ||||||||||.||||||.|||
Zfish     1 MAAQLLVPPGPDSFRPFLPESLAAIEQRIAEEVAQRPKGERRPDDDDENGPKPNRDLEAGKPLPF 65

Human    64 IYGDIPPEMVSEPLEDLDPYYINKKTFIVLNKGKAIFRFSATSALYILTPFNPLRKIAIKILVHS 128
            ||||:||.|:|.||||||.||.|:|||||||:|||||||:||.|||||:||||||:|:|::||||
Zfish    66 IYGDVPPHMLSVPLEDLDTYYSNQKTFIVLNRGKAIFRFNATPALYILSPFNPLRRISIRVLVHS 130

Human   129 LFSMLIMCTILTNCVFMTMSNPPDWTKNVEYTFTGIYTFESLIKIIARGFCLEDFTFLRDPWNWL 193
            |||.:|||||||||.|||:||||:|.|||||||||||||||||||:|||||:..|||||||||||
Zfish   131 LFSFVIMCTILTNCAFMTLSNPPEWAKNVEYTFTGIYTFESLIKILARGFCVGKFTFLRDPWNWL 195

Human   194 DFTVITFAYVTEFVDLGNVSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCL 258
            ||:||..|||||||:||||||||||||||||||||||||||||||||||||||||||||||||||
Zfish   196 DFSVILMAYVTEFVNLGNVSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCL 260

Human   259 SVFALIGLQLFMGNLRNKCIQWPPTNASLEEHSIEKNITVNYNGTLINETVFEFDWKSYIQDSRY 323
            ||||||||||||||||.||::.|..|       :..|:| :|:..|.|.|   |:|..||.||..
Zfish   261 SVFALIGLQLFMGNLRQKCVKMPEVN-------VTDNLT-DYSTELHNST---FNWTEYISDSNN 314

Human   324 HYFLEGFLDALLCGNSSDAGQCPEGYMCVKAGRNPNYGYTSFDTFSWAFLSLFRLMTQDFWENLY 388
            :||:.|..|||||||||||||||||:.|:||||||:|||||||||||||||||||||||||||||
Zfish   315 YYFIPGRRDALLCGNSSDAGQCPEGFTCIKAGRNPDYGYTSFDTFSWAFLSLFRLMTQDFWENLY 379

Human   389 QLTLRAAGKTYMIFFVLVIFLGSFYLINLILAVVAMAYEEQNQATLEEAEQKEAEFQQMIEQLKK 453
            |.|||||||.||||||||||||||||:|||||||||||:||||||:|||:|||.|||.|:||||:
Zfish   380 QQTLRAAGKPYMIFFVLVIFLGSFYLVNLILAVVAMAYDEQNQATIEEAQQKEEEFQAMLEQLKR 444

Human   454 QQEAAQQAATATASEHSREPSAAGRLS-DSSSEASKLSSKSAKERRNRRKKRKQKEQSGGEEKDE 517
            |||.||.|| |.|:| |.|.|..|.|| :|||..|:||||||||||||||||||:|:.  |:.|:
Zfish   445 QQEEAQVAA-AAATE-SGEYSGRGGLSEESSSGGSRLSSKSAKERRNRRKKRKQREEE--EKADQ 505

Human   518 DEFQKSESEDSIRRKGFRFSIEGNRLTYEKRYSSPHQSLLSIRGSLFSPRRNSRTSLFSFRGRAK 582
            ::|.||.|||||||.||||||:.|||:|||:.|:|:||||||||||||||||||.|||||||||:
Zfish   506 EKFHKSASEDSIRRPGFRFSIDANRLSYEKKCSTPNQSLLSIRGSLFSPRRNSRASLFSFRGRAR 570

Human   583 DVGSENDFADDEHSTFEDNESRRDSLFVPRRHGERRNSNLSQTSRSSRMLAVFPANGKMHSTVDC 647
            |.||||||||||||||||::|||.||||| |..|||:|.:|..|.::..: :.|||||||.||||
Zfish   571 DFGSENDFADDEHSTFEDSDSRRGSLFVP-RCVERRSSTVSHCSLTAPRI-MLPANGKMHCTVDC 633

Human   648 NGVVSLVGGPSVPTSPVGQLLPEVIIDKPATDDNGTTTETEMRKRRSSSFHVSMDFLEDPSQRQR 712
            |||||||||.||||||:|:||||           |||||:::||:||.| |...|:||:...|:|
Zfish   634 NGVVSLVGGTSVPTSPIGRLLPE-----------GTTTESDVRKKRSGS-HQPSDYLEETVARKR 686

Human   713 AMSIASILTNTVEELEESRQKCPPCWYKFSNIFLIWDCSPYWLKVKHVVNLVVMDPFVDLAITIC 777
            |||:|||||||:|||||||||||||||||:|.||||||||.|||||.::|::|||||||||||||
Zfish   687 AMSVASILTNTMEELEESRQKCPPCWYKFANSFLIWDCSPAWLKVKEIMNMIVMDPFVDLAITIC 751

Human   778 IVLNTLFMAMEHYPMTDHFNNVLTVGNLVFTGIFTAEMFLKIIAMDPYYYFQEGWNIFDGFIVTL 842
            ||||||||||||||||..|:::|:||||||||||||||.||:||:|||||||||||||||.||:|
Zfish   752 IVLNTLFMAMEHYPMTTQFSHLLSVGNLVFTGIFTAEMCLKVIALDPYYYFQEGWNIFDGIIVSL 816

Human   843 SLVELGLANVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVV 907
            ||:||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Zfish   817 SLMELGLANVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVV 881

Human   908 GMQLFGKSYKDCVCKIASDCQLPRWHMNDFFHSFLIVFRVLCGEWIETMWDCMEVAGQAMCLTVF 972
            |||||||||::|||||:..|:||||||:||||||||||||||||||||||||||||||:|||.||
Zfish   882 GMQLFGKSYRECVCKISESCELPRWHMDDFFHSFLIVFRVLCGEWIETMWDCMEVAGQSMCLIVF 946

Human   973 MMVMVIGNLVVLNLFLALLLSSFSADNLAATDDDNEMNNLQIAVDRMHKGVAYVKRKIYEFIQQS 1037
            ||||||||||||||||||||||||||||||||||:|||||||||.|:.||:|.||..:.:|:|..
Zfish   947 MMVMVIGNLVVLNLFLALLLSSFSADNLAATDDDSEMNNLQIAVGRIQKGIALVKSTLRQFLQSL 1011

Human  1038 FI--RKQKILDEIKPLDDLNNK-KDSCMSNHTAEIGKDL--DYLKDVNGTTS-GIGTGSSVEKYI 1096
            |:  .|.:.|||.||||||::. |::|:||| |.:..||  ||||:  |..| |.|..|.| ||.
Zfish  1012 FLAGSKPRSLDEEKPLDDLHSDGKENCLSNH-APVAVDLTKDYLKE--GCVSPGNGVESHV-KYG 1072

Human  1097 IDESDYMSFINNPSLTVTVPIAVGESDFENLNTEDFSSE-SDLEESKEKLNESS--SSSEGSTVD 1158
            |:|.||||||:|||||||||||||||||||||||||||| ||:|.|||||...:  |||||||||
Zfish  1073 IEEGDYMSFIHNPSLTVTVPIAVGESDFENLNTEDFSSESSDVEGSKEKLPVDTVLSSSEGSTVD 1137

Human  1159 IGAPVE--EQPVVEPEETLEPEACFTEGCVQRFKCCQINVEEGRGKQWWNLRRTCFRIVEHNWFE 1221
            |..|.|  |...:||||:|:||||||||||.||:|||::||:|:.|.||.||:|||.||||||||
Zfish  1138 IRPPGEGAESVELEPEESLDPEACFTEGCVMRFQCCQVDVEKGKWKSWWILRKTCFIIVEHNWFE 1202

Human  1222 TFIVFMILLSSGALAFEDIYIDQRKTIKTMLEYADKVFTYIFILEMLLKWVAYGYQTYFTNAWCW 1286
            :||:|||||||||||||||||:|||||||:||||||||||||||||||||||||:..||||||||
Zfish  1203 SFIIFMILLSSGALAFEDIYIEQRKTIKTVLEYADKVFTYIFILEMLLKWVAYGFAKYFTNAWCW 1267

Human  1287 LDFLIVDVSLVSLTANALGYSELGAIKSLRTLRALRPLRALSRFEGMRVVVNALLGAIPSIMNVL 1351
            |||||||||||||.|||||||||.|||||||||||||||||||||||||||||||||||||||||
Zfish  1268 LDFLIVDVSLVSLVANALGYSELSAIKSLRTLRALRPLRALSRFEGMRVVVNALLGAIPSIMNVL 1332

Human  1352 LVCLIFWLIFSIMGVNLFAGKFYHCINTTTGDRFDIEDVNNHTDCLKLIERNETARWKNVKVNFD 1416
            |||||||||||||||||||||:|:|:|.|..:.|.:..|||.:||..||:.|:||||||||:|||
Zfish  1333 LVCLIFWLIFSIMGVNLFAGKYYYCVNITNDELFPVSVVNNKSDCYALIQNNDTARWKNVKINFD 1397

Human  1417 NVGFGYLSLLQVATFKGWMDIMYAAVDSRNVELQPKYEESLYMYLYFVIFIIFGSFFTLNLFIGV 1481
            |||.|||:|||||||||||||||||||||::|.||.||.:|||||||||||||||||||||||||
Zfish  1398 NVGAGYLALLQVATFKGWMDIMYAAVDSRDLEQQPVYETNLYMYLYFVIFIIFGSFFTLNLFIGV 1462

Human  1482 IIDNFNQQKKKFGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPGNKFQGMVFDFVTRQVFDIS 1546
            |||||||||||.|||||||||||||||||||||||||||||||||.|||||:|||.:|:|.|||.
Zfish  1463 IIDNFNQQKKKLGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPANKFQGLVFDLITKQAFDII 1527

Human  1547 IMILICLNMVTMMVETDDQSEYVTTILSRINLVFIVLFTGECVLKLISLRHYYFTIGWNIFDFVV 1611
            |||||||||||||||||||:|.:..||..||||||:|||||||||:||||||:||||||:|||||
Zfish  1528 IMILICLNMVTMMVETDDQTEDMDNILYWINLVFIILFTGECVLKMISLRHYFFTIGWNVFDFVV 1592

Human  1612 VILSIVGMFLAELIEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLL 1676
            ||||||||||:|:||||||||||||||||||||||||||||||||||||||||||||||||||||
Zfish  1593 VILSIVGMFLSEMIEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLL 1657

Human  1677 LFLVMFIYAIFGMSNFAYVKREVGIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSKPPDC 1741
            ||||||||||||||||||||||.|||||||||||||||:||||||||||||||||||||.:.|||
Zfish  1658 LFLVMFIYAIFGMSNFAYVKREAGIDDMFNFETFGNSMLCLFQITTSAGWDGLLAPILNKQDPDC 1722

Human  1742 DPNKVNPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVATEESAEPLSEDDFE 1806
            |....:|||..:|:|||||||||||||||||.||:||||||||||||||||||||||||||||||
Zfish  1723 DSEMEHPGSFYRGNCGNPSVGIFFFVSYIIICFLIVVNMYIAVILENFSVATEESAEPLSEDDFE 1787

Human  1807 MFYEVWEKFDPDATQFMEFEKLSQFAAALEPPLNLPQPNKLQLIAMDLPMVSGDRIHCLDILFAF 1871
            |||||||:|||:||||:|:.|||.||.||:|||.:.:|||:||||||||||||||||||||||||
Zfish  1788 MFYEVWERFDPNATQFVEYNKLSDFADALDPPLRIAKPNKIQLIAMDLPMVSGDRIHCLDILFAF 1852

Human  1872 TKRVLGESGEMDALRIQMEERFMASNPSKVSYQPITTTLKRKQEEVSAVIIQRAYRRHLLKRTVK 1936
            |.|||||.|||||||.|||:||||||||||||:||||||:|||||:|||:||||:|||.:::|||
Zfish  1853 TLRVLGEEGEMDALRGQMEDRFMASNPSKVSYEPITTTLRRKQEEMSAVVIQRAFRRHRIRQTVK 1917

Human  1937 QASFTYNKNKIKGGANLLIKEDMIIDRINENSITEKTDLTMSTAACPPSYDRVTKPIVEKHEQEG 2001
            :||..|.|....||.::..||.::|.:..|||.::|||:|.|:|: ||||:.|.|...:|:|:|.
Zfish  1918 KASEAYRKQLQDGGGHIPEKEVLVIGKFQENSASDKTDMTPSSAS-PPSYNSVAKSEKDKYEKER 1981

Human  2002 KDEKAKGK 2009
            ::::.|.|
Zfish  1982 REKEDKAK 1989

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SCN1A	NP_001159435.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	28..60		23/33 (70%)
		I. /evidence=ECO:0000305	110..454		273/343 (80%)
		Ion_trans	127..433	CDD:306908	245/305 (80%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	455..529		46/74 (62%)
		Na_trans_cytopl	510..705	CDD:314757	128/194 (66%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	584..627		30/42 (71%)
		II. /evidence=ECO:0000305	750..1022		240/271 (89%)
		Ion_trans	767..980	CDD:306908	191/212 (90%)
		Na_trans_assoc	1006..1213	CDD:310839	136/217 (63%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1129..1163		25/36 (69%)
		III. /evidence=ECO:0000305	1200..1514		269/313 (86%)
		Ion_trans	1217..1492	CDD:306908	237/274 (86%)
		Na_channel_gate	1484..1536	CDD:240441	48/51 (94%)
		IV. /evidence=ECO:0000305	1523..1821		259/297 (87%)
		Ion_trans	1540..1796	CDD:306908	223/255 (87%)
		S1-S2 loop of repeat IV. /evidence=ECO:0000250\|UniProtKB:A2APX8	1561..1571		6/9 (67%)
		S3b-S4 loop of repeat IV. /evidence=ECO:0000250\|UniProtKB:A2APX8	1619..1636		14/16 (88%)
		GPHH	1800..1863	CDD:318993	49/62 (79%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1986..2009		7/22 (32%)
scn1lab	NP_001038360.2	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	500	1.000	Domainoid score	I2753
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	3174	1.000	Inparanoid score	I136
NCBI	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG52281
OrthoDB	1	1.010	-	-		D13587at7742
OrthoFinder	1	1.000	-	-		FOG0000268
OrthoInspector	1	1.000	-	-		otm28796
orthoMCL	1	0.900	-	-		OOG6_100419
Panther	1	1.100	-	-	O	PTHR10037
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X214
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	11	10.980