DRSC/TRiP Functional Genomics Resources

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Protein Alignment SCN1A and NaCP60E

DIOPT Version :9

Sequence 1:NP_001159435.1 Gene:SCN1A / 6323 HGNCID:10585 Length:2009 Species:Homo sapiens
Sequence 2:NP_001261172.1 Gene:NaCP60E / 37981 FlyBaseID:FBgn0085434 Length:2896 Species:Drosophila melanogaster


Alignment Length:2553 Identity:810/2553 - (31%)
Similarity:1173/2553 - (45%) Gaps:794/2553 - (31%)


- Green bases have known domain annotations that are detailed below.


Human    49 PKPNSDLEAGKNLPFIYGDIPPEMVSEPLEDLDPYYINKKTFIVLNK---GKAIFRFSATSALYI 110
            |:..:.:|.|..||..:...|..|..:|||::|. :|.::||.|::|   ...|.||:.|.:|::
  Fly    45 PRTKASVEDGDVLPRKFEPFPEHMYGKPLEEIDT-FIYEETFCVVSKRFRKNYIHRFTGTKSLFL 108

Human   111 LTPFNPLRKIAIKILVHSLFSMLIMCTILTNCVFMTMSNPPDWTKNVEYTFTGIYTFESLIKIIA 175
            ..|::|.|::.:.|..:..|...:|.|||.||:|:.|:   :..:..||.|..||:.|.:|||||
  Fly   109 FYPWSPARRVCVYIATNQFFDYCVMATILFNCIFLAMT---ETVEEAEYIFLAIYSIEMVIKIIA 170

Human   176 RGFCLEDFTFLRDPWNWLDFTVITFAYVTEFVDLGNVSALRTFRVLRALKTISVIPGLKTIVGAL 240
            :||.|..:|:||:|||||||.|||..|.|..:::||::.||||||||||||:|::||||||:.||
  Fly   171 KGFLLNKYTYLRNPWNWLDFVVITSGYATIGMEVGNLAGLRTFRVLRALKTVSIMPGLKTIINAL 235

Human   241 IQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCIQWPPTNASLEEHSIEKNITVNYNGTLI 305
            :.|.::|::||.||:|||.||||..||::||.|||||::..||:.:...|:              
  Fly   236 LHSFRQLAEVMTLTIFCLMVFALFALQVYMGELRNKCVRQVPTDWTNVSHT-------------- 286

Human   306 NETVFEFDWKSYIQDSRYHYFLEGFLDALLCGNSSDAGQCPEGYMCVKAGRNPNYGYTSFDTFSW 370
                   ||:.::.|:....:.|..| .:||||.:.|..||..|:|:..|.|||:|||:||.|.|
  Fly   287 -------DWQIWVNDTDNWLYDEDEL-PVLCGNLTGARHCPFEYVCLCVGENPNHGYTNFDNFMW 343

Human   371 AFLSLFRLMTQDFWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLINLILAVVAMAYEEQNQATLE 435
            :.|:.|:|:|.|:|||:|.:.|...|...:.||.:|:|.||||||||:|||||::|||:.:.|.|
  Fly   344 SMLTTFQLITLDYWENVYNMVLATCGPMSVSFFTVVVFFGSFYLINLMLAVVALSYEEEAEITNE 408

Human   436 EAEQKEAEFQQMIEQLKKQQEAAQQAATATASEHSREPSAAGRLSDSSSEASKLSSK------SA 494
            |.::         :.|..:.:          |..|.:||.......:.:...|:.|:      |.
  Fly   409 ERKK---------DLLDHRDD----------STFSFDPSVLNVKKLNKNNKKKIDSRKGVLLASY 454

Human   495 KERRNRRKKRKQKEQSG----GEEKDEDEFQKSESEDSIRRKGFRFSIEGNRLTYEKRYSSPHQS 555
            .:::.||||.|..::.|    |...:.|: .||.|..                      .||.. 
  Fly   455 SKKKTRRKKTKGGKEGGTNGNGNGSNGDD-NKSHSAT----------------------PSPGP- 495

Human   556 LLSIRGSLFSPRRNS--RTSLFSFRGRAKDVGSENDFADDEHSTFEDNESRRDSLFVPRRHGERR 618
                     |||.::  |.|..:.:.:     .:....:.:|...:......::...|...|...
  Fly   496 ---------SPRHSATERPSALTMQAQ-----KQYQQMEQQHKLAKSGSGGSNNPMAPTPKGRIS 546

Human   619 NSNLSQTSRSSRMLAVFPANGKMHSTVDCNGVVSLVGGPSVPTSPVGQLLPEVIIDKPATDDNGT 683
            ..:.....::..||  :|::.|       ..:::..|.||..:|.|.:        :.:.||:|.
  Fly   547 FQDSGMGVKNPNML--YPSDYK-------GQLIANSGQPSSNSSGVNR--------ESSQDDSGV 594

Human   684 TTETEMRKRRSSSFHVSMDFLEDPSQRQRAM----SIASILTNTVEELEES------------RQ 732
            ..:.|.:...:...|||...|....:..|.:    :||.|..:.|..|.:.            .:
  Fly   595 VDDHEEQDTTNDMGHVSTVELALSPREVRLIKCNGNIARIKNHNVYALHQEFSSEVVVIDDLPDR 659

Human   733 KCPPCWYKFSNIFLIWDCSPY--WLKVKHVVNLVVMDPFVDLAITICIVLNTLFMAMEHYPMTDH 795
            .|..|.:        | |:.|  ||:.::.:..||.||..:||||:||||||.|:||||:.|::.
  Fly   660 NCDRCVH--------W-CTDYESWLQFQNCLYKVVRDPLFELAITLCIVLNTAFLAMEHHGMSES 715

Human   796 FNNVLTVGNLVFTGIFTAEMFLKIIAMDPYYYFQEGWNIFDGFIVTLSLVELGLANVEGLSVLRS 860
            |.|.|.|||.|||.|||.|..:|::|:.. .:|..||||||..|||.||:::....|:||||||.
  Fly   716 FRNALDVGNKVFTSIFTFECIVKLMALSK-DFFLCGWNIFDLLIVTASLLDIIFELVDGLSVLRG 779

Human   861 FRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKDCVCKIAS 925
            .|||||.|||:||.|:.:|:.||.:::||||||||:|.|:::||||:|||||.|.|..  .|...
  Fly   780 LRLLRVLKLAQSWTTMKVLLSIIISTIGALGNLTLILVIVIYIFAVIGMQLFSKDYTP--EKFDP 842

Human   926 DCQLPRWHMNDFFHSFLIVFRVLCGEWIETMWDCM---EVAGQAMCLTVFMMVMVIGNLVVLNLF 987
            | .:|||:.|||||||:::||:|||||||.:||||   |..|.:.|..:|:..:|:||.:|||||
  Fly   843 D-PVPRWNFNDFFHSFMMIFRILCGEWIEPLWDCMRAEEEQGASTCFAIFLPTLVMGNFMVLNLF 906

Human   988 LALLLSSFSADNLAATDDD-NEMNNLQIAVDRMHKGVAYVK--------RKIYEFIQQSFIRKQK 1043
            |||||:||:::.|.:..:: .|.:.|..:::|:...:...:        ||..|..||..:..|:
  Fly   907 LALLLNSFNSEELKSKKEEVGEESKLARSIERVRDLIRKKRQERKDRKERKFAEKFQQIVLDAQQ 971

Human  1044 ---------------------ILDEIK-----------------------PLDD----------- 1053
                                 :|.|.|                       ||.|           
  Fly   972 AHAQTLSHQAAVGLERGDKPGVLAETKFHRLSYQESMNRPVSGSDFGFQIPLHDGLHTIVDGLEY 1036

Human  1054 ------------------------------------------LN--------------------- 1055
                                                      :|                     
  Fly  1037 DDTGDLPEQIQLQAHPLPPTSDSMPPTYESAMMATTGGSFSSVNGNGTCQNLTPFVQAERRLQHQ 1101

Human  1056 -----------------------------------------------NKKDSCMSNHTAEIG--- 1070
                                                           |:.||...|.:...|   
  Fly  1102 ISSGVSTQQYDSREEATYTESIELLGQYNSTDTDPYANDQRSGCGSFNRGDSLQDNSSRRYGSEE 1166

Human  1071 --------------------KDLDYLKDVNGTTSGI------------GTGSSVEKYIIDESDYM 1103
                                |.||.|...:|.:...            .:|.|:....|::.:.:
  Fly  1167 HDEAFLKYQKSLLTRSPSYRKSLDRLSQSSGQSQRSLLKSEEAEMRRHSSGQSLNSMSIEQDELL 1231

Human  1104 SFINN----------------------------------------PSLTVTVP---IAVGESDFE 1125
            |...|                                        ||..:..|   ..|..|:|:
  Fly  1232 SQQGNLREELLNCDQKELFQFLQEEEELQKGTKLRRISNVMRSRRPSSQMGQPENETMVEHSEFD 1296

Human  1126 NLNTEDFSSE--------SDLEESKEKLNESSSSSEGSTVDI--------GA------------- 1161
            |: .:.|..|        :.||.....|:|.|.:::.:|..|        ||             
  Fly  1297 NI-IQSFEKELEEIKRSTTSLERKLSNLSEPSPAADEATKAIMEHIAIITGASERSAADEVVLPL 1360

Human  1162 ----------------------------------------------------------------- 1161
                                                                             
  Fly  1361 NPYDSYDLSSVPRRSQSVSAAAQRQSVKLKRRSLEKQRKIDEDFSISNEIRKICDQIHAPFVAME 1425

Human  1162 ----------------------------------------------PVEEQPV------------ 1168
                                                          |.||:|:            
  Fly  1426 AMAVAATSASQAQPNQSPFLRRKVDPFTVQFDRFKRLSLIERVEEVPEEEKPISTLRIESEKMPR 1490

Human  1169 ---------------------------------------------------VE------------ 1170
                                                               :|            
  Fly  1491 KFLHGPDQLRLDSLSLKSTNSYENLLIQKQKLGMATPPAVPATPPTSLKSSIEPPTLAQISSLKT 1555

Human  1171 ------------------------------------------------PEETLE----------- 1176
                                                            |:.||:           
  Fly  1556 TPPLAALTEHQQHFHATSIQAAPTPAHTHAHSQAHAHSMAGQRRRMEHPQSTLDKAASFQSARTE 1620

Human  1177 ----------------------------------------------------------------- 1176
                                                                             
  Fly  1621 SHSSGAADASSALALAMAQKTEQSQSTAPDATQKPSAFTRLTEKPWHCLVSYVDDLTVGGRRNSQ 1685

Human  1177 --------------------PEACFTEGCVQR--FKC-----CQINVEEGRGKQWWNLRRTCFRI 1214
                                |:.||.:.|...  |:|     |   ::....|.|..:|.....:
  Fly  1686 GAYNDPMTFPSYGATKAAKVPDDCFPQKCYDHFYFRCPWFMSC---MDTQSAKHWTRVRTAVLTV 1747

Human  1215 VEHNWFETFIVFMILLSSGALAFEDIYIDQRKTIKTMLEYADKVFTYIFILEMLLKWVAYGYQTY 1279
            |:...||.|::.:|..||..|.||||.:|:.||:|.:|.:.:..|..||::||:|||:|.|:..|
  Fly  1748 VDTPAFEWFVLVLIFASSITLCFEDINLDKNKTLKRVLYWINFSFCLIFVVEMILKWLALGFSKY 1812

Human  1280 FTNAWCWLDFLIVDVSLVSLTANALGYSELGAIKSLRTLRALRPLRALSRFEGMRVVVNALLGAI 1344
            ||:.|..|||:||.||:.||....  ...|..::|||||||||||||:||::|||:|||||:.||
  Fly  1813 FTSFWTILDFIIVFVSVFSLLIEE--NENLKVLRSLRTLRALRPLRAISRWQGMRIVVNALMYAI 1875

Human  1345 PSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCINTTTGDRFDIEDVNNHTDCLKLIERNETARWK 1409
            |||.|||||||:||||||||||..|.|||:.|:| ..|:...|.:||:..||   ||:|.|  |.
  Fly  1876 PSIFNVLLVCLVFWLIFSIMGVQFFGGKFFKCVN-EMGELLPITEVNDKWDC---IEQNYT--WI 1934

Human  1410 NVKVNFDNVGFGYLSLLQVATFKGWMDIMYAAVDSRNVELQPKYEESLYMYLYFVIFIIFGSFFT 1474
            |.|:.||:||.|||:|||||||:|||::|..|||:|.|:|||:.|.:||.|:||||||:.|||||
  Fly  1935 NSKITFDHVGMGYLALLQVATFEGWMEVMADAVDARGVDLQPQREANLYAYIYFVIFIVCGSFFT 1999

Human  1475 LNLFIGVIIDNFNQQKKKFGG--QDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPGNKFQGMVFDF 1537
            |||||||||||||..|||:.|  .::|:||.||.||.||||||.|||||.|.||.|.|..|.:|.
  Fly  2000 LNLFIGVIIDNFNMLKKKYEGGVLEMFLTESQKHYYTAMKKLGRKKPQKVIKRPINHFLAMFYDL 2064

Human  1538 VTRQVFDISIMILICLNMVTMMVETDDQSEYVTTILSRINLVFIVLFTGECVLKLISLRHYYFTI 1602
            ...:.|:|:|.:||.|||:||.:|..||...|..||...|..|..:|..|.::|::.||::|||:
  Fly  2065 SNSRRFEIAIFVLIFLNMLTMGIEHYDQPHAVFFILEVSNAFFTTVFGLEAIVKIVGLRYHYFTV 2129

Human  1603 GWNIFDFVVVILSIVGMFLAELIEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSL 1667
            .||:|||::|:.||.|:.:.:::....:||||.||:|:.||||||||||.|||||.|||||::||
  Fly  2130 PWNVFDFLLVLASIFGILMEDIMIDLPISPTLLRVVRVFRIGRILRLIKAAKGIRKLLFALVVSL 2194

Human  1668 PALFNIGLLLFLVMFIYAIFGMSNFAYVKREVGIDDMFNFETFGNSMICLFQITTSAGWDGLLAP 1732
            |||||||.||.|:.|||||.|||.|..||.:..:|||.||:|||.||..||::.|||||:.:|..
  Fly  2195 PALFNIGALLGLITFIYAILGMSLFGNVKLQGALDDMVNFQTFGRSMQLLFRLMTSAGWNDVLES 2259

Human  1733 ILNSKPPDCDP---NKVNPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVATE 1794
            :: .:||||||   ...|      |:||:|.:.|.:|.|:||||:::|:|||||:|||||:.|.:
  Fly  2260 LM-IQPPDCDPFIHGHTN------GNCGHPLLAITYFTSFIIISYMIVINMYIAIILENFNQAHQ 2317

Human  1795 ESAEPLSEDDFEMFYEVWEKFDPDATQFMEFEKLSQFAAALEPPLNLPQPNKLQLIAMDLPMVSG 1859
            |....:.|||.||||..|.|:||.||||:.|.:||.|.|:|:|||.:.:||.:.|::.:||:..|
  Fly  2318 EEEIGIVEDDLEMFYIRWSKYDPHATQFIHFSQLSDFIASLDPPLGISKPNNVALVSFNLPISKG 2382

Human  1860 DRIHCLDILFAFTKRVLGESGEMD---ALRIQMEERFMASNPSKVSYQPITTTLKRKQEEVSAVI 1921
            ::|||||||.|..|.|||...|.|   .|:.||:.:|....|::...:.:::|...|::|.:|..
  Fly  2383 NKIHCLDILHALVKHVLGHVEETDNFKQLQEQMDVKFKKQFPTRKELEIVSSTRIWKRQEKAAKT 2447

Human  1922 IQRAYRRHLLKRTVKQAS 1939
            ||..::.:|.::..|:.|
  Fly  2448 IQTGWKEYLRRKREKERS 2465

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SCN1ANP_001159435.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 28..60 3/10 (30%)
I. /evidence=ECO:0000305 110..454 150/343 (44%)
Ion_trans 127..433 CDD:306908 142/305 (47%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 455..529 18/83 (22%)
Na_trans_cytopl 510..705 CDD:314757 32/200 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 584..627 3/42 (7%)
II. /evidence=ECO:0000305 750..1022 141/277 (51%)
Ion_trans 767..980 CDD:306908 117/215 (54%)
Na_trans_assoc 1006..1213 CDD:310839 67/824 (8%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1129..1163 11/173 (6%)
III. /evidence=ECO:0000305 1200..1514 176/315 (56%)
Ion_trans 1217..1492 CDD:306908 159/274 (58%)
Na_channel_gate 1484..1536 CDD:240441 32/53 (60%)
IV. /evidence=ECO:0000305 1523..1821 153/300 (51%)
Ion_trans 1540..1796 CDD:306908 133/258 (52%)
S1-S2 loop of repeat IV. /evidence=ECO:0000250|UniProtKB:A2APX8 1561..1571 4/9 (44%)
S3b-S4 loop of repeat IV. /evidence=ECO:0000250|UniProtKB:A2APX8 1619..1636 4/16 (25%)
GPHH 1800..1863 CDD:318993 30/62 (48%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1986..2009
NaCP60ENP_001261172.1 Ion_trans 152..371 CDD:278921 113/240 (47%)
Ion_trans 705..902 CDD:278921 106/200 (53%)
Ion_trans 1768..2019 CDD:278921 155/258 (60%)
Na_channel_gate 2009..2063 CDD:240441 32/53 (60%)
Ion_trans 2085..2320 CDD:278921 125/241 (52%)
GPHH 2331..2386 CDD:293510 25/54 (46%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D37221at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100419
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.820

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