Sequence 1: | NP_001159435.1 | Gene: | SCN1A / 6323 | HGNCID: | 10585 | Length: | 2009 | Species: | Homo sapiens |
---|---|---|---|---|---|---|---|---|---|
Sequence 2: | NP_001261172.1 | Gene: | NaCP60E / 37981 | FlyBaseID: | FBgn0085434 | Length: | 2896 | Species: | Drosophila melanogaster |
Alignment Length: | 2553 | Identity: | 810/2553 - (31%) |
---|---|---|---|
Similarity: | 1173/2553 - (45%) | Gaps: | 794/2553 - (31%) |
- Green bases have known domain annotations that are detailed below.
Human 49 PKPNSDLEAGKNLPFIYGDIPPEMVSEPLEDLDPYYINKKTFIVLNK---GKAIFRFSATSALYI 110
Human 111 LTPFNPLRKIAIKILVHSLFSMLIMCTILTNCVFMTMSNPPDWTKNVEYTFTGIYTFESLIKIIA 175
Human 176 RGFCLEDFTFLRDPWNWLDFTVITFAYVTEFVDLGNVSALRTFRVLRALKTISVIPGLKTIVGAL 240
Human 241 IQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCIQWPPTNASLEEHSIEKNITVNYNGTLI 305
Human 306 NETVFEFDWKSYIQDSRYHYFLEGFLDALLCGNSSDAGQCPEGYMCVKAGRNPNYGYTSFDTFSW 370
Human 371 AFLSLFRLMTQDFWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLINLILAVVAMAYEEQNQATLE 435
Human 436 EAEQKEAEFQQMIEQLKKQQEAAQQAATATASEHSREPSAAGRLSDSSSEASKLSSK------SA 494
Human 495 KERRNRRKKRKQKEQSG----GEEKDEDEFQKSESEDSIRRKGFRFSIEGNRLTYEKRYSSPHQS 555
Human 556 LLSIRGSLFSPRRNS--RTSLFSFRGRAKDVGSENDFADDEHSTFEDNESRRDSLFVPRRHGERR 618
Human 619 NSNLSQTSRSSRMLAVFPANGKMHSTVDCNGVVSLVGGPSVPTSPVGQLLPEVIIDKPATDDNGT 683
Human 684 TTETEMRKRRSSSFHVSMDFLEDPSQRQRAM----SIASILTNTVEELEES------------RQ 732
Human 733 KCPPCWYKFSNIFLIWDCSPY--WLKVKHVVNLVVMDPFVDLAITICIVLNTLFMAMEHYPMTDH 795
Human 796 FNNVLTVGNLVFTGIFTAEMFLKIIAMDPYYYFQEGWNIFDGFIVTLSLVELGLANVEGLSVLRS 860
Human 861 FRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKDCVCKIAS 925
Human 926 DCQLPRWHMNDFFHSFLIVFRVLCGEWIETMWDCM---EVAGQAMCLTVFMMVMVIGNLVVLNLF 987
Human 988 LALLLSSFSADNLAATDDD-NEMNNLQIAVDRMHKGVAYVK--------RKIYEFIQQSFIRKQK 1043
Human 1044 ---------------------ILDEIK-----------------------PLDD----------- 1053
Human 1054 ------------------------------------------LN--------------------- 1055
Human 1056 -----------------------------------------------NKKDSCMSNHTAEIG--- 1070
Human 1071 --------------------KDLDYLKDVNGTTSGI------------GTGSSVEKYIIDESDYM 1103
Human 1104 SFINN----------------------------------------PSLTVTVP---IAVGESDFE 1125
Human 1126 NLNTEDFSSE--------SDLEESKEKLNESSSSSEGSTVDI--------GA------------- 1161
Human 1162 ----------------------------------------------------------------- 1161
Human 1162 ----------------------------------------------PVEEQPV------------ 1168
Human 1169 ---------------------------------------------------VE------------ 1170
Human 1171 ------------------------------------------------PEETLE----------- 1176
Human 1177 ----------------------------------------------------------------- 1176
Human 1177 --------------------PEACFTEGCVQR--FKC-----CQINVEEGRGKQWWNLRRTCFRI 1214
Human 1215 VEHNWFETFIVFMILLSSGALAFEDIYIDQRKTIKTMLEYADKVFTYIFILEMLLKWVAYGYQTY 1279
Human 1280 FTNAWCWLDFLIVDVSLVSLTANALGYSELGAIKSLRTLRALRPLRALSRFEGMRVVVNALLGAI 1344
Human 1345 PSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCINTTTGDRFDIEDVNNHTDCLKLIERNETARWK 1409
Human 1410 NVKVNFDNVGFGYLSLLQVATFKGWMDIMYAAVDSRNVELQPKYEESLYMYLYFVIFIIFGSFFT 1474
Human 1475 LNLFIGVIIDNFNQQKKKFGG--QDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPGNKFQGMVFDF 1537
Human 1538 VTRQVFDISIMILICLNMVTMMVETDDQSEYVTTILSRINLVFIVLFTGECVLKLISLRHYYFTI 1602
Human 1603 GWNIFDFVVVILSIVGMFLAELIEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSL 1667
Human 1668 PALFNIGLLLFLVMFIYAIFGMSNFAYVKREVGIDDMFNFETFGNSMICLFQITTSAGWDGLLAP 1732
Human 1733 ILNSKPPDCDP---NKVNPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVATE 1794
Human 1795 ESAEPLSEDDFEMFYEVWEKFDPDATQFMEFEKLSQFAAALEPPLNLPQPNKLQLIAMDLPMVSG 1859
Human 1860 DRIHCLDILFAFTKRVLGESGEMD---ALRIQMEERFMASNPSKVSYQPITTTLKRKQEEVSAVI 1921
Human 1922 IQRAYRRHLLKRTVKQAS 1939 |
Gene | Sequence | Domain | Region | External ID | Identity |
---|---|---|---|---|---|
SCN1A | NP_001159435.1 | Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 28..60 | 3/10 (30%) | |
I. /evidence=ECO:0000305 | 110..454 | 150/343 (44%) | |||
Ion_trans | 127..433 | CDD:306908 | 142/305 (47%) | ||
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 455..529 | 18/83 (22%) | |||
Na_trans_cytopl | 510..705 | CDD:314757 | 32/200 (16%) | ||
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 584..627 | 3/42 (7%) | |||
II. /evidence=ECO:0000305 | 750..1022 | 141/277 (51%) | |||
Ion_trans | 767..980 | CDD:306908 | 117/215 (54%) | ||
Na_trans_assoc | 1006..1213 | CDD:310839 | 67/824 (8%) | ||
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 1129..1163 | 11/173 (6%) | |||
III. /evidence=ECO:0000305 | 1200..1514 | 176/315 (56%) | |||
Ion_trans | 1217..1492 | CDD:306908 | 159/274 (58%) | ||
Na_channel_gate | 1484..1536 | CDD:240441 | 32/53 (60%) | ||
IV. /evidence=ECO:0000305 | 1523..1821 | 153/300 (51%) | |||
Ion_trans | 1540..1796 | CDD:306908 | 133/258 (52%) | ||
S1-S2 loop of repeat IV. /evidence=ECO:0000250|UniProtKB:A2APX8 | 1561..1571 | 4/9 (44%) | |||
S3b-S4 loop of repeat IV. /evidence=ECO:0000250|UniProtKB:A2APX8 | 1619..1636 | 4/16 (25%) | |||
GPHH | 1800..1863 | CDD:318993 | 30/62 (48%) | ||
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 1986..2009 | ||||
NaCP60E | NP_001261172.1 | Ion_trans | 152..371 | CDD:278921 | 113/240 (47%) |
Ion_trans | 705..902 | CDD:278921 | 106/200 (53%) | ||
Ion_trans | 1768..2019 | CDD:278921 | 155/258 (60%) | ||
Na_channel_gate | 2009..2063 | CDD:240441 | 32/53 (60%) | ||
Ion_trans | 2085..2320 | CDD:278921 | 125/241 (52%) | ||
GPHH | 2331..2386 | CDD:293510 | 25/54 (46%) | ||
Blue background indicates that the domain is not in the aligned region. |
Tool | Simple Score | Weighted Score | Original Tool Information | |||
---|---|---|---|---|---|---|
BLAST Result | Score | Score Type | Cluster ID | |||
Compara | 0 | 0.000 | Not matched by this tool. | |||
Domainoid | 0 | 0.000 | Not matched by this tool. | |||
eggNOG | 0 | 0.000 | Not matched by this tool. | |||
Hieranoid | 0 | 0.000 | Not matched by this tool. | |||
Homologene | 0 | 0.000 | Not matched by this tool. | |||
Inparanoid | 0 | 0.000 | Not matched by this tool. | |||
Isobase | 0 | 0.000 | Not matched by this tool. | |||
OMA | 0 | 0.000 | Not matched by this tool. | |||
OrthoDB | 1 | 1.010 | - | - | D37221at33208 | |
OrthoFinder | 0 | 0.000 | Not matched by this tool. | |||
OrthoInspector | 0 | 0.000 | Not matched by this tool. | |||
orthoMCL | 1 | 0.900 | - | - | OOG6_100419 | |
Panther | 0 | 0.000 | Not matched by this tool. | |||
Phylome | 1 | 0.910 | - | - | ||
RoundUp | 0 | 0.000 | Not matched by this tool. | |||
SonicParanoid | 0 | 0.000 | Not matched by this tool. | |||
SwiftOrtho | 0 | 0.000 | Not matched by this tool. | |||
TreeFam | 0 | 0.000 | Not matched by this tool. | |||
User_Submission | 0 | 0.000 | Not matched by this tool. | |||
3 | 2.820 |