Sequence 1: | NP_001159435.1 | Gene: | SCN1A / 6323 | HGNCID: | 10585 | Length: | 2009 | Species: | Homo sapiens |
---|---|---|---|---|---|---|---|---|---|
Sequence 2: | NP_001259619.1 | Gene: | para / 32619 | FlyBaseID: | FBgn0285944 | Length: | 2145 | Species: | Drosophila melanogaster |
Alignment Length: | 2089 | Identity: | 938/2089 - (44%) |
---|---|---|---|
Similarity: | 1289/2089 - (61%) | Gaps: | 276/2089 - (13%) |
- Green bases have known domain annotations that are detailed below.
Human 14 FNFFTRESLAAIERRIAEEKAKNPKPDKK----------------------DDDENGPKPNSDLE 56
Human 57 AGKNLPF-IYGDIPPEMVSEPLEDLDPYYINKKTFIVLNKGKAIFRFSATSALYILTPFNPLRKI 120
Human 121 AIKILVHSLFSMLIMCTILTNCVFMTMSNPPDWTKNVEYTFTGIYTFESLIKIIARGFCLEDFTF 185
Human 186 LRDPWNWLDFTVITFAYVTEFVDLGNVSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDV 250
Human 251 MILTVFCLSVFALIGLQLFMGNLRNKCIQWPPTNASLEEHSIEKNITVNYNGTLINETVFEFDWK 315
Human 316 SYIQDSRYHYFLEGFLDALLCGNSSDAGQCPEGYMCVKA-GRNPNYGYTSFDTFSWAFLSLFRLM 379
Human 380 TQDFWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLINLILAVVAMAYEE-QNQATLEEAEQKEAE 443
Human 444 FQQMIEQLKKQQEAAQQAATATASEHSREPSAAGRLSDSSSEASKLSSKSAKERRNRRKKRKQKE 508
Human 509 QS--------GGEEKDEDEFQKSESEDSIRRKGFRFSIEGNRLTYEKRYSSP---HQSL------ 556
Human 557 ---LSIRGSLFSPRRNSRTS----LFSFRGRAKDVGSEN---------------DFADDEHSTFE 599
Human 600 DNESRRDSLFVPRRHGERRNSNLSQTSRSSRMLAVFPANGKMHSTVDCNGVVSLV---------- 654
Human 655 ---------GGPSV-----------------PTSPVGQLLPEVIIDKPATDDNGTTTETEMRKRR 693
Human 694 SSSFHVSMDFLEDPSQR-----QRAMSIASILTNTVEELEES----RQKCPPCWYKFSNIFLIWD 749
Human 750 CSPYWLKVKHVVNLVVMDPFVDLAITICIVLNTLFMAMEHYPMTDHFNNVLTVGNLVFTGIFTAE 814
Human 815 MFLKIIAMDPYYYFQEGWNIFDGFIVTLSLVELGLANVEGLSVLRSFRLLRVFKLAKSWPTLNML 879
Human 880 IKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKDCVCKIASDCQLPRWHMNDFFHSFLIV 944
Human 945 FRVLCGEWIETMWDCMEVAGQAMCLTVFMMVMVIGNLVVLNLFLALLLSSFSADNLAATDDDNEM 1009
Human 1010 NNLQIAVDRMHKGVAYVKRKIYEFIQQSFIRKQKILDEI--KPLDDLNNK--------KDSCM-- 1062
Human 1063 ----SNHTAEIGKDLDYLKD-------VNGTTSGIGTGSSVE---------------KYIIDESD 1101
Human 1102 --------YMSFINNPSLTVTVPIAVGESDFENLNTEDFSSESDLEESK------EKLNESSSSS 1152
Human 1153 EGSTVDIGAPVEEQPVV--EPEETLE--PEACFTEGCVQRFKCCQINVEEGRGKQWWNLRRTCFR 1213
Human 1214 IVEHNWFETFIVFMILLSSGALAFEDIYIDQRKTIKTMLEYADKVFTYIFILEMLLKWVAYGYQT 1278
Human 1279 YFTNAWCWLDFLIVDVSLVSLTANALGYSELGAIKSLRTLRALRPLRALSRFEGMRVVVNALLGA 1343
Human 1344 IPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCINTTTGDRFDIEDVNNHTDCLKLIERNETARW 1408
Human 1409 KNVKVNFDNVGFGYLSLLQVATFKGWMDIMYAAVDSRNVELQPKYEESLYMYLYFVIFIIFGSFF 1473
Human 1474 TLNLFIGVIIDNFNQQKKKFGGQ-DIFMTEEQKKYYNAMKKLGSKKPQKPIPRPGNKFQGMVFDF 1537
Human 1538 VTRQVFDISIMILICLNMVTMMVETDDQSEYVTTILSRINLVFIVLFTGECVLKLISLRHYYFTI 1602
Human 1603 GWNIFDFVVVILSIVGMFLAELIEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSL 1667
Human 1668 PALFNIGLLLFLVMFIYAIFGMSNFAYVKREVGIDDMFNFETFGNSMICLFQITTSAGWDGLLAP 1732
Human 1733 ILNSKPPDCDPNKVNPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVATEESA 1797
Human 1798 EPLSEDDFEMFYEVWEKFDPDATQFMEFEKLSQFAAALEPPLNLPQPNKLQLIAMDLPMVSGDRI 1862
Human 1863 HCLDILFAFTK-------RVLGESGEMDALRIQMEERFMASNPSKVSYQPITTTLKRKQEEVSAV 1920
Human 1921 IIQRAYRRH 1929 |
Gene | Sequence | Domain | Region | External ID | Identity |
---|---|---|---|---|---|
SCN1A | NP_001159435.1 | Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 28..60 | 13/53 (25%) | |
I. /evidence=ECO:0000305 | 110..454 | 192/345 (56%) | |||
Ion_trans | 127..433 | CDD:306908 | 175/307 (57%) | ||
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 455..529 | 18/81 (22%) | |||
Na_trans_cytopl | 510..705 | CDD:314757 | 53/269 (20%) | ||
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 584..627 | 11/57 (19%) | |||
II. /evidence=ECO:0000305 | 750..1022 | 167/271 (62%) | |||
Ion_trans | 767..980 | CDD:306908 | 137/212 (65%) | ||
Na_trans_assoc | 1006..1213 | CDD:310839 | 49/262 (19%) | ||
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 1129..1163 | 9/39 (23%) | |||
III. /evidence=ECO:0000305 | 1200..1514 | 187/314 (60%) | |||
Ion_trans | 1217..1492 | CDD:306908 | 164/274 (60%) | ||
Na_channel_gate | 1484..1536 | CDD:240441 | 36/52 (69%) | ||
IV. /evidence=ECO:0000305 | 1523..1821 | 174/297 (59%) | |||
Ion_trans | 1540..1796 | CDD:306908 | 154/255 (60%) | ||
S1-S2 loop of repeat IV. /evidence=ECO:0000250|UniProtKB:A2APX8 | 1561..1571 | 2/9 (22%) | |||
S3b-S4 loop of repeat IV. /evidence=ECO:0000250|UniProtKB:A2APX8 | 1619..1636 | 11/16 (69%) | |||
GPHH | 1800..1863 | CDD:318993 | 29/62 (47%) | ||
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 1986..2009 | ||||
para | NP_001259619.1 | Ion_trans | 165..436 | CDD:278921 | 166/290 (57%) |
Na_trans_cytopl | 515..648 | CDD:288761 | 32/140 (23%) | ||
Ion_trans | 835..1028 | CDD:278921 | 124/194 (64%) | ||
Na_trans_assoc | 1054..1296 | CDD:284034 | 49/262 (19%) | ||
Ion_trans | 1318..1571 | CDD:278921 | 157/258 (61%) | ||
Na_channel_gate | 1561..1613 | CDD:240441 | 35/51 (69%) | ||
Ion_trans | 1636..1871 | CDD:278921 | 144/238 (61%) | ||
GPHH | 1880..1930 | CDD:293510 | 23/49 (47%) | ||
Blue background indicates that the domain is not in the aligned region. |
Tool | Simple Score | Weighted Score | Original Tool Information | |||
---|---|---|---|---|---|---|
BLAST Result | Score | Score Type | Cluster ID | |||
Compara | 0 | 0.000 | Not matched by this tool. | |||
Domainoid | 1 | 1.000 | 342 | 1.000 | Domainoid score | I1069 |
eggNOG | 0 | 0.000 | Not matched by this tool. | |||
Hieranoid | 1 | 1.000 | - | - | ||
Homologene | 0 | 0.000 | Not matched by this tool. | |||
Inparanoid | 1 | 1.050 | 1621 | 1.000 | Inparanoid score | I82 |
Isobase | 0 | 0.000 | Not matched by this tool. | |||
OMA | 1 | 1.010 | - | - | QHG52281 | |
OrthoDB | 1 | 1.010 | - | - | D37221at33208 | |
OrthoFinder | 1 | 1.000 | - | - | FOG0000268 | |
OrthoInspector | 1 | 1.000 | - | - | otm41716 | |
orthoMCL | 1 | 0.900 | - | - | OOG6_100419 | |
Panther | 1 | 1.100 | - | - | O | PTHR10037 |
Phylome | 1 | 0.910 | - | - | ||
RoundUp | 0 | 0.000 | Not matched by this tool. | |||
SonicParanoid | 1 | 1.000 | - | - | X214 | |
SwiftOrtho | 0 | 0.000 | Not matched by this tool. | |||
TreeFam | 0 | 0.000 | Not matched by this tool. | |||
User_Submission | 0 | 0.000 | Not matched by this tool. | |||
11 | 10.980 |