DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment SCN1A and nca-2

DIOPT Version :9

Sequence 1:NP_001159435.1 Gene:SCN1A / 6323 HGNCID:10585 Length:2009 Species:Homo sapiens
Sequence 2:NP_498054.2 Gene:nca-2 / 175674 WormBaseID:WBGene00003558 Length:1785 Species:Caenorhabditis elegans


Alignment Length:2192 Identity:416/2192 - (18%)
Similarity:755/2192 - (34%) Gaps:758/2192 - (34%)


- Green bases have known domain annotations that are detailed below.


Human    47 NGPKPNSDLEAGKNLPFIYGDIPPEMVSEPLEDLDPYYINKKTFIVLNKGKAIF--RFSATSALY 109
            :|.|...:...|:::...:.|:                ||.:...::||...:.  ||       
 Worm    32 DGTKTERNRRRGESIGGAFTDM----------------INIEPTSIINKSTELLHERF------- 73

Human   110 ILTPFNPLRKIAIKILVHSLFSMLIMC---------------TILTNCVFMTMSNPPDWTKNVEY 159
                   ||.:   :.|..|.||:.:|               .||.|.|.:|:            
 Worm    74 -------LRDM---VRVACLLSMISLCLHTPETIKMWPPLNYIILANDVIVTL------------ 116

Human   160 TFTGIYTFESLIKIIARGFCLEDFTFLRDPWNWLD----------------------FTVITFAY 202
                |:..|:.:.|...|......::|||.|...:                      |..:.|.|
 Worm   117 ----IFIGEAAVTINQNGLFDNQNSYLRDRWYQFEFFLLINHILSCVIHIYELCSIWFPALNFVY 177

Human   203 VTEFVDLGNVSALRTFRVLRALKTISVIPGLKTIVGALI-QSVKKLSDVMILTVFCLSVFALIGL 266
               :..||.:.:.|.|..||.:::|......|..:..:| :|.:::.:|.|..:|.:..:|::|:
 Worm   178 ---YPWLGALRSARPFIFLRFIRSIVRFKLPKNRIKLIIKRSSQQIQNVTIFFMFFVFSYAIMGV 239

Human   267 QLFMGNLRNKCIQWPPTNASLEEHSIEKNITVNYNGTLINE-TVFEFDWKSYIQDSRYHYFLEGF 330
            ||| |.|...|:                     .|||..|. |:.:.    .|.|:         
 Worm   240 QLF-GRLNYHCV---------------------VNGTDPNNVTIADL----AIPDT--------- 269

Human   331 LDALLCGNSSDAG-QCPEGYMCVKAGRNPN----YGYTSFDTFSWAFLSLFRLMTQDFWEN-LYQ 389
                :|......| :||...:|::....|.    ||  .|..|:.:..:::...:|:.|.. ||.
 Worm   270 ----MCSQKGAGGYECPGNMVCMRLQLKPQEEGFYG--QFSDFASSLFTVYLAASQEGWVYVLYD 328

Human   390 LTLRAAGKTYMIFFVLVIFLGSFYLINLILAVVAMAYEEQNQATLEEAEQKEAEFQQMIEQLKKQ 454
            ............:||.:||..::.:.|:.:||:...:               ||.:....::.:.
 Worm   329 CLDSLPSFLAFFYFVTLIFFLAWLVKNVFIAVITETF---------------AEIRVQFSEMWQT 378

Human   455 QEAAQQAATATASEHSREPSAAGRLSDSSSEASKLSSKSAKERRNRRKKRKQKEQSGGEEKDEDE 519
            :||        .::|              ....||                        ||||| 
 Worm   379 REA--------TTDH--------------VYTQKL------------------------EKDED- 396

Human   520 FQKSESEDSIRRKGFRFSIEGNRLTYEKRYSSPHQSLLSIRGSLFSPRRNSRTSLFSFRGRAKDV 584
                                |.:|....:|:..|                |..|||         
 Worm   397 --------------------GWKLVEVDKYNRAH----------------SNNSLF--------- 416

Human   585 GSENDFADDEHSTFEDNESRRDSLFVPRRHGERRNSNLSQTSRSSRMLAVFPANGKMHSTVDCNG 649
                                                                    :|:.|    
 Worm   417 --------------------------------------------------------LHTIV---- 421

Human   650 VVSLVGGPSVPTSPVGQLLPEVIIDKPATDDNGTTTETEMRKRRSSSFHVSMDFLEDPSQRQRAM 714
                       ||...|.:.:::|                  ..::.||.:..|..|.|.:.|.:
 Worm   422 -----------TSTAFQTVMQLLI------------------LANAIFHATFVFYHDESDQIRKI 457

Human   715 SIASILTNTVEELEESRQKCPPCWYKFSNIFLIWDCSPYWLKVKHVVNLVVMDPFVDLAITICIV 779
                                   ||             |:::|.                     
 Worm   458 -----------------------WY-------------YYVEVG--------------------- 465

Human   780 LNTLFMAMEHYPMTDHFNNVLTVGNLVFTGIFTAEMFLKIIAMDPYYYFQEGWNIFDGFIVTLSL 844
                                       ||.:|..|:.:||.|.....|...|.:.||..:...|.
 Worm   466 ---------------------------FTILFNTEVIIKIYAFGWKAYIARGQHKFDCILCVGSS 503

Human   845 VELGLANVEGLSVLRSFRLLRVFKLAKSWPTL-NMLIKIIGNSVGALGNLTLVLAIIVFIFAVVG 908
            :.......| .::...|::.|:.:|.|:.|.| :.:.||.|.. ..||.|.:...|::.:.:.:.
 Worm   504 LNAIWVLYE-TNIFTYFQVFRIARLIKASPMLEDFVYKIFGPG-KKLGGLVIFTGILLIVTSAIS 566

Human   909 MQLFGKSYKDCVCKIASDCQLPRWH-MNDFFHSFLIVFRVLCGE-W----IETMWDCMEVAGQAM 967
            :|||              |.:|:.: ..:|..:|:.:|:::..| |    ||.:..|.|.|...:
 Worm   567 LQLF--------------CYVPKLNKFTNFAVAFMSMFQIITQEGWTDVVIEILRACNEQAVPFV 617

Human   968 CLTVFMMVMVIGNLVVLNLFLALLLSSFSAD-------NLAATDDDNEMNNLQIAVDRMHK---- 1021
            .: .|:...::..|.||:||:|::|.:...|       .|.|.:.|.....|.:.:...::    
 Worm   618 AI-YFVAYHLLVTLFVLSLFVAVILDNLEMDEELKKVKQLKAREQDTIKTTLPMRLRIFNRFPTA 681

Human  1022 -GVAYVKRKIYEF----IQQSFIRKQKILDEIKPLDDLNNKKDSCMSNHTAEIGKDLDYLKDVNG 1081
             .:..:|:...||    |:.||.|  :..||.....|                    |.::::..
 Worm   682 PTMVTMKKVSSEFPLPKIRDSFTR--QFADEFVETSD--------------------DTIQEIGF 724

Human  1082 TTSGI--GTGSSVEKYIIDESDYMSFINNPSLTVTVPIAVGESDFENLNTEDFSSESDLEESKEK 1144
            ....:  |.|.|.|..|.....::..::|.::..::   :.||   |.|...||..:....|..:
 Worm   725 KVRSMLSGRGPSKETRITTTIRHVGQLSNKTILTSM---LTES---NRNRALFSESNQHLASLTR 783

Human  1145 LNESSSSSEGSTVDIG--------APVEEQPVVE---------PEETLEPEACFTEGCVQR---- 1188
            .|.||...:...:...        |.::.:.:||         ||:|...        |::    
 Worm   784 SNTSSKHGKSGALSTNSRSRTRGLASLKGKHMVEGFKENGDLRPEDTARK--------VEKHGEI 840

Human  1189 -FKCCQI----------NVEE----------------GRGKQWWNLRRTCFRIVEH--------- 1217
             ||..|:          .:||                ||..   :|||.| :::.|         
 Worm   841 DFKALQMKRAHAEITRNRIEEEMRENHPMFDRPLFLVGRES---SLRRMC-QLIAHSRHSYDQND 901

Human  1218 -------NWFETFIVFMILLSSGALAFEDIYIDQRKTIKT------------------------- 1250
                   |.::.|..|:.:::         |:|....:.|                         
 Worm   902 GQHRKHSNKYKQFHDFLAIMT---------YMDWTMVLVTTLSCCSMLWESPWPTTGENLIFNNF 957

Human  1251 MLEYADKVFTYIFILEMLLKWVAYGYQTYFTNAWCWLDFLIVDVSLVSLTANAL-------GYSE 1308
            .|:.|:.:|..:...|:::|.:|.|  .:||......|  :.|:..:.:...:|       .:.|
 Worm   958 YLQIAEYIFVLVMSFELIVKCIANG--LFFTPKALVTD--VGDILTIFIYITSLMFLIWMPNHIE 1018

Human  1309 LGA-IKSLRTLRALRPLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGK 1372
            :.: .:.|...||:||||..:....:|.||..|......|:.|.::.::...||:..||.|..||
 Worm  1019 INSWAQLLMVCRAMRPLRVYALIPHIRRVVVELCRGFREILLVTILLVVLMFIFASFGVQLVGGK 1083

Human  1373 FYHC---INTTTGDRFDIEDVNNHTDCLKLIERNETAR---------WKNVK-VNFDNVGFGYLS 1424
            ...|   :.|:..:...:.||......:::..:|:...         |.|.: .|||::|...|:
 Worm  1084 LASCNDPMITSRENCTGLYDVKLFVTRMEVYGKNDNLMHPSIIVPRVWTNPRNFNFDHIGNAMLA 1148

Human  1425 LLQVATFKGW---MDIMYAAVDSRNVELQPKYEESLYMYLYFVIFIIFGSFFTLNLFIGVIIDNF 1486
            |.:..::|||   .|::|             .....:..|:..|::..|....|.||:||::.|:
 Worm  1149 LFETLSYKGWNVVRDVLY-------------LRHGAWAVLFIHIYVFIGCMIGLTLFVGVVVANY 1200

Human  1487 NQQKKKFGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRP--GNKFQGMVFDFVTRQVFDISIMI 1549
            .:.:     ....:|.:|:::::...:|...:|....|:|  ..|.:..::|..|.:.|.....:
 Worm  1201 TENR-----GTALLTVDQRRWHDLKARLKMAQPLHVPPKPPESAKLRCYLYDLTTSRWFKQLFAV 1260

Human  1550 LICLNMVTMMV-----ETDDQSEYVTTILSRINLVFIVLFTGECVLKLISLRHYYFTIG--W--- 1604
            |:.:|..|:::     |..|:..:: ..|:.|:.:..:|||.||:||:|:     ||:.  |   
 Worm  1261 LVVVNSFTLVIPWNVSEEQDRKTFL-LCLTVISAICNILFTLECLLKMIA-----FTLSGFWQSR 1319

Human  1605 -NIFDFVVVILS---IVGMFLAELIEKYFVSPTL----------FRVIRLARIGRILRL--IKGA 1653
             |..||::.||.   ||..||.:| ..||.....          :.|:       |||.  |.|.
 Worm  1320 RNRIDFIITILGINWIVFHFLFQL-PAYFAGGITEWKRLTYTYGYLVV-------ILRFFTIAGR 1376

Human  1654 KG-IRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFAYVKREVGIDDMFNFETFGNSMICL 1717
            |. ::.|:..::||:.....|...:||::..||..|:..|..||....:....||.....:::.|
 Worm  1377 KSTLKMLMLTVVMSMVRSSFIIAAMFLLVLFYANAGVVLFGMVKYGQAVGKHVNFRNGREALVVL 1441

Human  1718 FQITTSAGWDGLLAPILNSKPPDCDPNKVNPGSSV-KGDCGNPSVGIFFFVSYIIISFLVVVNMY 1781
            |:..|...|:.::...:.: ||.|:   .:||.|. :.||||....|.:|.|:.:|...:|:|:.
 Worm  1442 FRSVTGEDWNDIMHDCMRA-PPFCN---WHPGLSYWQTDCGNYVGAIVYFCSFYLIITYIVLNLL 1502

Human  1782 IAVILENFSV--ATEESAEPLSEDDFEMFYEVWEKFDPDATQFMEFEKLSQFAAALEPPLNLPQP 1844
            :|:|:||||:  ::||.| .||..|...|..||...|                  :|...::|  
 Worm  1503 VAIIMENFSLFYSSEEDA-LLSYADIRNFQLVWNMVD------------------IEQKRSIP-- 1546

Human  1845 NKLQLIAMDLPMVSGDRIHCLDILFAFTKRVLGESGEMDAL--RIQMEERFMASNPSKVSYQPIT 1907
                             :..:..|....|..|..:.|.|.|  :....|.....|...||:..:.
 Worm  1547 -----------------VRRVKFLLRLLKGRLEVNDESDGLLFKHMCHEMERLHNGDDVSFHDVL 1594

Human  1908 TTLKRKQEEVS-----AVIIQRAYRRHLLKRTV-KQASFTYNKNKIKGGANLLIKEDMIIDRINE 1966
            ..|..:..::.     ..::||....::::..| |.....:.:|.:|   |:..|         :
 Worm  1595 NMLSYRSVDIRKSLQLEELLQREELEYIIEEEVAKHTIRAWLENCLK---NIKAK---------Q 1647

Human  1967 NSITEKTDLTMSTAACPPSYDRVTKPIV----EKHEQEGKDEKAKGK 2009
            |:...|.....||.|.|.|.:.:||.:|    ...|...:.:|..||
 Worm  1648 NNTLGKMSSIGSTFAFPQSQEVLTKGVVLTEASPEEDSLQGDKGSGK 1694

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SCN1ANP_001159435.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 28..60 3/12 (25%)
I. /evidence=ECO:0000305 110..454 74/388 (19%)
Ion_trans 127..433 CDD:306908 69/350 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 455..529 10/73 (14%)
Na_trans_cytopl 510..705 CDD:314757 22/194 (11%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 584..627 0/42 (0%)
II. /evidence=ECO:0000305 750..1022 56/290 (19%)
Ion_trans 767..980 CDD:306908 42/219 (19%)
Na_trans_assoc 1006..1213 CDD:310839 47/265 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1129..1163 7/41 (17%)
III. /evidence=ECO:0000305 1200..1514 74/378 (20%)
Ion_trans 1217..1492 CDD:306908 67/339 (20%)
Na_channel_gate 1484..1536 CDD:240441 8/53 (15%)
IV. /evidence=ECO:0000305 1523..1821 93/329 (28%)
Ion_trans 1540..1796 CDD:306908 79/285 (28%)
S1-S2 loop of repeat IV. /evidence=ECO:0000250|UniProtKB:A2APX8 1561..1571 2/9 (22%)
S3b-S4 loop of repeat IV. /evidence=ECO:0000250|UniProtKB:A2APX8 1619..1636 5/26 (19%)
GPHH 1800..1863 CDD:318993 9/62 (15%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1986..2009 5/26 (19%)
nca-2NP_498054.2 Ion_trans 95..371 CDD:278921 67/350 (19%)
Ion_trans 444..649 CDD:278921 58/305 (19%)
Ion_trans 959..1202 CDD:278921 60/259 (23%)
Ion_trans 1288..1518 CDD:278921 72/246 (29%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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