DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SCN1A and scn1a

DIOPT Version :9

Sequence 1:	NP_001159435.1	Gene:	SCN1A / 6323	HGNCID:	10585	Length:	2009	Species:	Homo sapiens
Sequence 2:	XP_012826731.2	Gene:	scn1a / 100488621	XenbaseID:	XB-GENE-978019	Length:	2020	Species:	Xenopus tropicalis

Alignment Length:	2028	Identity:	1670/2028 - (82%)
Similarity:	1825/2028 - (89%)	Gaps:	34/2028 - (1%)

- Green bases have known domain annotations that are detailed below.

Human     1 MEQTVLVPPGPDSFNFFTRESLAAIERRIAEEKAKNPKPD-KKDDDENGPKPNSDLEAGKNLPFI 64
            |.|..|||||||||.:|:||||.|||:||||||||.||.: :.|||:|||||:|||||||:||||
Frog     1 MAQARLVPPGPDSFRYFSRESLEAIEKRIAEEKAKKPKQEHRDDDDDNGPKPSSDLEAGKSLPFI 65

Human    65 YGDIPPEMVSEPLEDLDPYYINKKTFIVLNKGKAIFRFSATSALYILTPFNPLRKIAIKILVHSL 129
            ||||||.|||||||||||||:|:|||||||:||||||||||||||||||||||||:|||:|||||
Frog    66 YGDIPPGMVSEPLEDLDPYYMNQKTFIVLNRGKAIFRFSATSALYILTPFNPLRKVAIKVLVHSL 130

Human   130 FSMLIMCTILTNCVFMTMSNPPDWTKNVEYTFTGIYTFESLIKIIARGFCLEDFTFLRDPWNWLD 194
            ||||||||||||||||||||||:|||||||||||||||||||||:|||||||.||||||||||||
Frog   131 FSMLIMCTILTNCVFMTMSNPPEWTKNVEYTFTGIYTFESLIKILARGFCLEKFTFLRDPWNWLD 195

Human   195 FTVITFAYVTEFVDLGNVSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLS 259
            |:||..|||||||:|||||||||||||||||||||||||||||||||||||||||||||||||||
Frog   196 FSVIVMAYVTEFVNLGNVSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLS 260

Human   260 VFALIGLQLFMGNLRNKCIQWPPTNASLEEHSIEKNITVNYNGTLI------NETVFEFDWKSYI 318
            ||||||||||||:|||||:||||.     ::....||....|||:.      |.|...|||:.||
Frog   261 VFALIGLQLFMGHLRNKCLQWPPI-----DYFPLINIPPILNGTMNIHDPFGNTTNSTFDWEEYI 320

Human   319 QDSRYHYFLEGFLDALLCGNSSDAGQCPEGYMCVKAGRNPNYGYTSFDTFSWAFLSLFRLMTQDF 383
            .|..:.|.|||..|.||||||||:||||:||:|||.|:||||||||||||||||||||||||||:
Frog   321 TDKNHFYKLEGQKDFLLCGNSSDSGQCPKGYICVKTGKNPNYGYTSFDTFSWAFLSLFRLMTQDY 385

Human   384 WENLYQLTLRAAGKTYMIFFVLVIFLGSFYLINLILAVVAMAYEEQNQATLEEAEQKEAEFQQMI 448
            |||||||||||||||||||||||||||||||:||||||||||||||||||||||||||||||||:
Frog   386 WENLYQLTLRAAGKTYMIFFVLVIFLGSFYLVNLILAVVAMAYEEQNQATLEEAEQKEAEFQQML 450

Human   449 EQLKKQQEAAQQAATAT---ASEHSREPSAAGRLSDSSSEASKLSSKSAKERRNRRKKRKQKEQS 510
            ||||||||.||.||.|.   :.|:| |....|.||:||||||||||||||:||||:|||||||..
Frog   451 EQLKKQQEEAQAAAVAALNMSREYS-EDGGFGPLSESSSEASKLSSKSAKDRRNRKKKRKQKELG 514

Human   511 GGEEKDEDE-FQKSESEDSIRRKGFRFSIEGNRLTYEKRYSSPHQSLLSIRGSLFSPRRNSRTSL 574
            ...||.:|| |.|||||.||:||||||||||||||||.::||||||||||||||||||||||.||
Frog   515 EEYEKGDDEKFPKSESETSIKRKGFRFSIEGNRLTYENKFSSPHQSLLSIRGSLFSPRRNSRASL 579

Human   575 FSFRGRAKDVGSENDFADDEHSTFEDNESRRDSLFVPRRHGERRNSNLSQTSRSSRMLAVFPANG 639
            ||||.||||||||||||||||||||||||||.|||||.|||||||||:||.|:||:.:.|.||||
Frog   580 FSFRNRAKDVGSENDFADDEHSTFEDNESRRGSLFVPNRHGERRNSNISQVSKSSKTMTVLPANG 644

Human   640 KMHSTVDCNGVVSLVGGPSVPTSPVGQLLPEVIIDKPATDDNGTTTETEMRKRRSSSFHVSMDFL 704
            ||||||||||||||:|||||||||||.||||||:||||:||||||||||:|||:||.:.|.||.|
Frog   645 KMHSTVDCNGVVSLLGGPSVPTSPVGLLLPEVIVDKPASDDNGTTTETEIRKRKSSCYQVPMDLL 709

Human   705 EDPSQRQRAMSIASILTNTVEELEESRQKCPPCWYKFSNIFLIWDCSPYWLKVKHVVNLVVMDPF 769
            |||:.||||:|:|||||||||||||||||||||||||:|.||||||...||.|||:|.|:|||||
Frog   710 EDPTARQRALSVASILTNTVEELEESRQKCPPCWYKFANTFLIWDCCENWLTVKHIVKLIVMDPF 774

Human   770 VDLAITICIVLNTLFMAMEHYPMTDHFNNVLTVGNLVFTGIFTAEMFLKIIAMDPYYYFQEGWNI 834
            ||||||||||||||||||||||||..||:||::|||||||||||||..|:||:||||||||||||
Frog   775 VDLAITICIVLNTLFMAMEHYPMTKEFNDVLSIGNLVFTGIFTAEMVFKLIALDPYYYFQEGWNI 839

Human   835 FDGFIVTLSLVELGLANVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAI 899
            |||.||:|||:||||||||||||||||||||||||||||||||||||||||||||||||||||||
Frog   840 FDGIIVSLSLMELGLANVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAI 904

Human   900 IVFIFAVVGMQLFGKSYKDCVCKIASDCQLPRWHMNDFFHSFLIVFRVLCGEWIETMWDCMEVAG 964
            ||||||||||||||||||:||||||.:|:||||||||||||||||||||||||||||||||||||
Frog   905 IVFIFAVVGMQLFGKSYKECVCKIAENCELPRWHMNDFFHSFLIVFRVLCGEWIETMWDCMEVAG 969

Human   965 QAMCLTVFMMVMVIGNLVVLNLFLALLLSSFSADNLAATDDDNEMNNLQIAVDRMHKGVAYVKRK 1029
            |:|||.|||:||||||||||||||||||||||:|||.|||||||||||||||.|:.:|:.|||:.
Frog   970 QSMCLLVFMLVMVIGNLVVLNLFLALLLSSFSSDNLTATDDDNEMNNLQIAVGRIQRGIDYVKKT 1034

Human  1030 IYEFIQQSFIRKQKILDEIKPLDDLNNKKDSCMSNHTA-EIGKDLDYLKDVNGTTSGIGTGSSVE 1093
            |.|.||::|::|||.|||||||::|:||::||:.||.| ||.|.|||.|..||||||:  |||||
Frog  1035 IRECIQKAFVKKQKGLDEIKPLEELHNKRESCLFNHNAVEINKVLDYHKGDNGTTSGV--GSSVE 1097

Human  1094 KYIIDESDYMSFINNPSLTVTVPIAVGESDFENLNTEDFSSESDLEESKEKLNESSSSSEGSTVD 1158
            ||||||:||||||:||||||||||||||||||||||||||||||||||||||| .:|||||||||
Frog  1098 KYIIDENDYMSFIHNPSLTVTVPIAVGESDFENLNTEDFSSESDLEESKEKLN-MTSSSEGSTVD 1161

Human  1159 IGAP-----VEEQPV-VEPEETLEPEACFTEGCVQRFKCCQINVEEGRGKQWWNLRRTCFRIVEH 1217
            |..|     .|.:|: :|.||.|||:||||||||:||..|.:|:||.:||.||..|:||:.||||
Frog  1162 IRPPGVVAEGEGEPIDIESEEALEPDACFTEGCVKRFPICYVNIEENKGKLWWTFRKTCYTIVEH 1226

Human  1218 NWFETFIVFMILLSSGALAFEDIYIDQRKTIKTMLEYADKVFTYIFILEMLLKWVAYGYQTYFTN 1282
            |||||||:|||||||||||||||||:||||||||||||||||||||||||||||||||:..||||
Frog  1227 NWFETFIIFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTYIFILEMLLKWVAYGFVKYFTN 1291

Human  1283 AWCWLDFLIVDVSLVSLTANALGYSELGAIKSLRTLRALRPLRALSRFEGMRVVVNALLGAIPSI 1347
            |||||||||||||||||.||||||||||||||||||||||||||||||||||||||||:||||||
Frog  1292 AWCWLDFLIVDVSLVSLVANALGYSELGAIKSLRTLRALRPLRALSRFEGMRVVVNALIGAIPSI 1356

Human  1348 MNVLLVCLIFWLIFSIMGVNLFAGKFYHCINTTTGDRFDIEDVNNHTDCLKLIERNETARWKNVK 1412
            |||||||||||||||||||||||||:|||:|||||:......|||.:|||.|   ||:|||||||
Frog  1357 MNVLLVCLIFWLIFSIMGVNLFAGKYYHCVNTTTGEMLLDTQVNNRSDCLHL---NESARWKNVK 1418

Human  1413 VNFDNVGFGYLSLLQVATFKGWMDIMYAAVDSRNVELQPKYEESLYMYLYFVIFIIFGSFFTLNL 1477
            |||||||.|||:|||||||||||||||||||||.||.||:||::|||||||||||||||||||||
Frog  1419 VNFDNVGAGYLALLQVATFKGWMDIMYAAVDSRKVEEQPRYEDNLYMYLYFVIFIIFGSFFTLNL 1483

Human  1478 FIGVIIDNFNQQKKKFGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPGNKFQGMVFDFVTRQV 1542
            |||||||||||||||||||||||||||||||||||||||||||||||||.||:||:||||||:|.
Frog  1484 FIGVIIDNFNQQKKKFGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPPNKYQGLVFDFVTKQA 1548

Human  1543 FDISIMILICLNMVTMMVETDDQSEYVTTILSRINLVFIVLFTGECVLKLISLRHYYFTIGWNIF 1607
            |||.|||||||||||||:|||:||:.:...|..||||||:||||||:||:|||||||||||||||
Frog  1549 FDIIIMILICLNMVTMMIETDEQSQDMENNLYWINLVFIILFTGECILKIISLRHYYFTIGWNIF 1613

Human  1608 DFVVVILSIVGMFLAELIEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFN 1672
            |||||||||||||||::||||||||||||||||||||||||||||||||||||||||||||||||
Frog  1614 DFVVVILSIVGMFLADMIEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFN 1678

Human  1673 IGLLLFLVMFIYAIFGMSNFAYVKREVGIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSK 1737
            ||||||||||||||||||||||||:|.|||||||||||||||||||||||||||||||||||||.
Frog  1679 IGLLLFLVMFIYAIFGMSNFAYVKKESGIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSG 1743

Human  1738 PPDCDPNKVNPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVATEESAEPLSE 1802
            .|||||...:|||||||||||||||||||||||||||||||||||||||||||||||||||||.|
Frog  1744 APDCDPQMEHPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVATEESAEPLGE 1808

Human  1803 DDFEMFYEVWEKFDPDATQFMEFEKLSQFAAALEPPLNLPQPNKLQLIAMDLPMVSGDRIHCLDI 1867
            ||||||||||||||||||||:|:.|||.||.||:|||.:.:||::||||||||||||||||||||
Frog  1809 DDFEMFYEVWEKFDPDATQFIEYSKLSNFADALDPPLRIAKPNRVQLIAMDLPMVSGDRIHCLDI 1873

Human  1868 LFAFTKRVLGESGEMDALRIQMEERFMASNPSKVSYQPITTTLKRKQEEVSAVIIQRAYRRHLLK 1932
            |||||||||||..||||||:.||||||||||||.||:|||:||:|||||:|.|||||.:|::||:
Frog  1874 LFAFTKRVLGEGDEMDALRLPMEERFMASNPSKASYEPITSTLRRKQEELSVVIIQRCFRKYLLR 1938

Human  1933 RTVKQASFTYNKNKIKGGANLL-IKEDMIIDRINENSITEKTDLTMSTAACPPSYDRVTKPIVEK 1996
            :|:|:||:.|.|.|:  |.|.| |||||:||::|.||.|||||:|.||.: |||||.||||..||
Frog  1939 KTIKKASYLYKKEKL--GVNSLPIKEDMVIDKLNGNSTTEKTDMTPSTTS-PPSYDSVTKPEKEK 2000

Human  1997 HEQEGKDEKAKGK 2009
            ||::..:::.|.|
Frog  2001 HEKDKAEKENKSK 2013

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SCN1A	NP_001159435.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	28..60		24/32 (75%)
		I. /evidence=ECO:0000305	110..454		291/349 (83%)
		Ion_trans	127..433	CDD:306908	256/311 (82%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	455..529		48/77 (62%)
		Na_trans_cytopl	510..705	CDD:314757	159/195 (82%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	584..627		38/42 (90%)
		II. /evidence=ECO:0000305	750..1022		240/271 (89%)
		Ion_trans	767..980	CDD:306908	193/212 (91%)
		Na_trans_assoc	1006..1213	CDD:310839	148/213 (69%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1129..1163		29/38 (76%)
		III. /evidence=ECO:0000305	1200..1514		276/313 (88%)
		Ion_trans	1217..1492	CDD:306908	244/274 (89%)
		Na_channel_gate	1484..1536	CDD:240441	48/51 (94%)
		IV. /evidence=ECO:0000305	1523..1821		267/297 (90%)
		Ion_trans	1540..1796	CDD:306908	229/255 (90%)
		S1-S2 loop of repeat IV. /evidence=ECO:0000250\|UniProtKB:A2APX8	1561..1571		5/9 (56%)
		S3b-S4 loop of repeat IV. /evidence=ECO:0000250\|UniProtKB:A2APX8	1619..1636		14/16 (88%)
		GPHH	1800..1863	CDD:318993	49/62 (79%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1986..2009		11/22 (50%)
scn1a	XP_012826731.2	Ion_trans	128..435	CDD:395416	256/311 (82%)
		Na_trans_cytopl	515..723	CDD:403218	168/207 (81%)
		Ion_trans	772..985	CDD:395416	193/212 (91%)
		Na_trans_assoc	1011..1222	CDD:399489	148/213 (69%)
		Ion_trans	1226..1498	CDD:395416	244/274 (89%)
		Na_channel_gate	1490..1542	CDD:240441	48/51 (94%)
		Ion_trans	1547..1802	CDD:395416	229/254 (90%)
		GPHH	1814..1861	CDD:407139	34/46 (74%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	535	1.000	Domainoid score	I3173
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	3389	1.000	Inparanoid score	I173
NCBI	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG52281
OrthoDB	1	1.010	-	-		D10241at32523
OrthoFinder	1	1.000	-	-		FOG0000268
OrthoInspector	1	1.000	-	-		otm54109
Panther	1	1.100	-	-	O	PTHR10037
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X214
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	10.080