DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment SERPINB3 and Spn42Dd

DIOPT Version :9

Sequence 1:	NP_008850.1	Gene:	SERPINB3 / 6317	HGNCID:	10569	Length:	390	Species:	Homo sapiens
Sequence 2:	NP_001163067.1	Gene:	Spn42Dd / 49808	FlyBaseID:	FBgn0028988	Length:	372	Species:	Drosophila melanogaster

Alignment Length:	381	Identity:	140/381 - (36%)
Similarity:	208/381 - (54%)	Gaps:	32/381 - (8%)

- Green bases have known domain annotations that are detailed below.

Human    14 DLFQQFRKSKEN-NIFYSPISITSALGMVLLGAKDNTAQQIKKVLHFDQVTENTTGKAATYHVDR 77
            :::|...||..| |:..||:||.:.|.||.:||:.:||::::..|...  :|:....||.|..
  Fly    20 EIYQLLSKSHTNQNLVVSPVSIETILSMVFMGAEGSTAKELQSALGLP--SEDKEAVAARYGA-- 80

Human    78 SGNVHHQFQKLLTEFNKSTDAYELKIANKLFGEKTYLFLQEYLDAIKKFYQTSVESVDFANAPEE 142
                      ||.:.....:...||:||:::....|...|.|..|:::.:::..||:...|.| .
  Fly    81 ----------LLNDLQGQEEGPILKLANRIYVNDQYSLNQNYNLAVREPFKSEAESISLTNGP-V 134

Human   143 SRKKINSWVESQTNEKIKNLIPEGNIGSNTTLVLVNAIYFKGQWEKKFNKEDTKEEKFWPNKNTY 207
            :.::||.||..||:.|||.:|..|::.|:...:||||||||||||.||:...|:...|....|..
  Fly   135 AAERINQWVLDQTSGKIKGMIDPGSMTSDVKALLVNAIYFKGQWESKFDPAKTRASTFQVTANKS 199

Human   208 KSIQMMRQYTSFHFASLEDVQAKVLEIPYKGKDLSMIVLLPNEIDGLQKLEEKLT--AEKLMEWT 270
            ..:|||.|..:|......|:.|:|:|:||...:|||.:.||.|::||..||||:.  |..|:
  Fly   200 VPVQMMAQMGTFRANYFRDLDAQVIELPYLNSNLSMTIFLPREVEGLSALEEKIVGFARPLV--- 261

Human   271 SLQNMRETRVDLHLPRFKVEESYDLKDTLRTMGMVDIFNGDADLSGMTGSR-GLVLSGVLHKAFV 334
                  ...|.|.||:||:|...:||:||..:|:.::|...:||||:...: |..:|.|.||||:
  Fly   262 ------AKEVYLKLPKFKIEFRDELKETLEKLGIRELFTDKSDLSGLFADKSGGKVSQVSHKAFL 320

Human   335 EVTEEGAEAAAATAVVGFGSSPTSTNEEFHCNHPFLFFIRQNKTNSILFYGRFSSP 390
            ||.|||||||.||:|.....:..||  ....:|||.|.||.  .|:|.|.||..||
  Fly   321 EVNEEGAEAAGATSVAVTNRAGFST--FLMADHPFAFVIRD--ANTIYFQGRVVSP 372

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SERPINB3	NP_008850.1	serpinB3_B4_SCCA1_2	1..390	CDD:381030	138/379 (36%)
Spn42Dd	NP_001163067.1	SERPIN	16..369	CDD:238101	137/376 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	221	1.000	Domainoid score	I2614
eggNOG	1	0.900	-	-		E33208_3BBFJ
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	222	1.000	Inparanoid score	I3541
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57242
OrthoDB	1	1.010	-	-		D556621at33208
OrthoFinder	1	1.000	-	-		FOG0000050
OrthoInspector	1	1.000	-	-		mtm8652
orthoMCL	1	0.900	-	-		OOG6_100128
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X28
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	11	10.780