DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment ATXN2 and PBP1

DIOPT Version :9

Sequence 1:NP_001359503.1 Gene:ATXN2 / 6311 HGNCID:10555 Length:1155 Species:Homo sapiens
Sequence 2:NP_011694.3 Gene:PBP1 / 853089 SGDID:S000003410 Length:722 Species:Saccharomyces cerevisiae


Alignment Length:963 Identity:187/963 - (19%)
Similarity:300/963 - (31%) Gaps:392/963 - (40%)


- Green bases have known domain annotations that are detailed below.


Human    32 AAANVRKPGGSGLLASPAAAPSPSSSSVSSSSATAPSSVVAATSGGGRPGLGRGRNSNKGLPQST 96
            ::.|.||.|.|....:....|:.::||:...:                             |:.|
Yeast    10 SSTNSRKGGNSDSNYTNGGVPNQNNSSMFYEN-----------------------------PEIT 45

Human    97 ISFDGIYANMRMVHILTSVVGSKCEVQVKNGGIYEGVFKTYSPKCDL--------------VLDA 147
            .:||.     |..::|.:.:||...|.|.:|..|.|:..:    |:|              |.|:
Yeast    46 RNFDD-----RQDYLLANSIGSDVTVTVTSGVKYTGLLVS----CNLESTNGIDVVLRFPRVADS 101

Human   148 AHEKSTESSSGPKREEIMESILFKCSDFVVVQFKDMDSSY------AKRDAFTDSAIS---AKVN 203
            ....|.:..:    :.:.|::|....|...::.|::|.|.      :|....|.:..:   .:||
Yeast   102 GVSDSVDDLA----KTLGETLLIHGEDVAELELKNIDLSLDEKWENSKAQETTPARTNIEKERVN 162

Human   204 GEH-------------------KEKDLEPWDAGELTANEEL---EALENDVSNGWDPNDMFRYNE 246
            ||.                   ||:.||.|...|...:.::   :|||:| |..|   |.|..||
Yeast   163 GESNEVTKFRTDVDISGSGREIKERKLEKWTPEEGAEHFDINKGKALEDD-SASW---DQFAVNE 223

Human   247 ENYGVVSTYDSSLSSYTVPLERDNSEEFLKREARANQLAEEIESS--------AQYKARVALEND 303
            :.:||.||:|..|  ||..:.:|: ..:.||...|.::|:||||.        |:.:. :.:::.
Yeast   224 KKFGVKSTFDEHL--YTTKINKDD-PNYSKRLQEAERIAKEIESQGTSGNIHIAEDRG-IIIDDS 284

Human   304 DRSEEEKYTAVQRNSSE-----REGHSINTRE-NKYIPPGQRNREVISWGSGRQNSPRMGQPGSG 362
            ...||:.|:.|.|...|     :.....|:.: |:|:||..|.:            |....|...
Yeast   285 GLDEEDLYSGVDRRGDELLAALKSNSKPNSNKGNRYVPPTLRQQ------------PHHMDPAII 337

Human   363 SMPSRSTSHTSDFNPNSGSDQRVVNGGVPWPSPCPSPSSRPPSRYQSGPNSLPPRAA-------- 419
            |            :.||..::..|:.....|:...:|..:||.:......||..:.|        
Yeast   338 S------------SSNSNKNENAVSTDTSTPAAAGAPEGKPPQKTSKNKKSLSSKEAQIEELKKF 390

Human   420 -----TP-----------TRPPSRPPSRPSRPPSHPSAHGSPAPVSTMPKRMSSEGPPRMSPKAQ 468
                 .|           .|..|...|..|.||.         |:|..|...:      :||..|
Yeast   391 SEKFKVPYDIPKDMLEVLKRSSSTLKSNSSLPPK---------PISKTPSAKT------VSPTTQ 440

Human   469 RHPRNHRVSAGRGSISSGLEFVSHNPPSEAATPPVARTSPSGGTWSSVVSGVPRLSPKTHRPRSP 533
                   :|||:                          |.|..:.|::..|              
Yeast   441 -------ISAGK--------------------------SESRRSGSNISQG-------------- 458

Human   534 RQNSIGNTPSGPVLASPQAGIIPTEAVAMPIPAASPTPASPASNRAVTPSSEAKDSRLQDQRQNS 598
             |:|.|:|                                       |.||    :.|:.:...|
Yeast   459 -QSSTGHT---------------------------------------TRSS----TSLRRRNHGS 479

Human   599 PAGNKENIKPNETSPSFSKAENKGISPVVSEHRKQIDDLKKFKNDFRLQPSSTSESMDQLLNKNR 663
            ..|.|.....:.....|.|:.|..|.      .|:..|.||..:|       .||:|:..     
Yeast   480 FFGAKNPHTNDAKRVLFGKSFNMFIK------SKEAHDEKKKGDD-------ASENMEPF----- 526

Human   664 EGEKSRDLIKDKIEPSAKDSFIENSSSNCTSGSSKPNSPSISPSILSNTEHKRGPEVTSQGVQTS 728
                                |||           ||.  ..:|:.|:..|         :..:|.
Yeast   527 --------------------FIE-----------KPY--FTAPTWLNTIE---------ESYKTF 549

Human   729 SPACKQEKDDKEEKKDAAEQVRKSTLNPNAKEFNPRSFSQPKPSTTPTSPR------------PQ 781
            .|      |:....::|..:.::..||         |.....|...|....            |.
Yeast   550 FP------DEDTAIQEAQTRFQQRQLN---------SMGNAVPGMNPAMGMNMGGMMGFPMGGPS 599

Human   782 AQPSPSMVGHQQPT-----PVYTQPVCFAPNM--MYPVPVSPGVQ-------------------- 819
            |.|:|.|.|....:     |...||:.:.|:|  |.||..|.|.:                    
Yeast   600 ASPNPMMNGFAAGSMGMYMPFQPQPMFYHPSMPQMMPVMGSNGAEEGGGNISPHVPAGFMAAGPG 664

Human   820 -PL----YP--IPM--------TPMPVNQAKTYRAGKVPNMPQQRQDQHHQSA 857
             |:    ||  ||.        :.||.|.:..:..|...|..|.....||.|:
Yeast   665 APMGAFGYPGGIPFQGMMGSGPSGMPANGSAMHSHGHSRNYHQTSHHGHHNSS 717

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ATXN2NP_001359503.1 SM-ATX 105..181 CDD:373069 17/89 (19%)
PBP1 194..>339 CDD:227507 50/183 (27%)
LsmAD 249..310 CDD:369058 20/68 (29%)
PRK12323 <408..599 CDD:237057 31/214 (14%)
PAM2 750..765 CDD:336618 2/14 (14%)
PHA03247 <769..1087 CDD:223021 32/143 (22%)
PBP1NP_011694.3 PBP1 3..722 CDD:227507 187/963 (19%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C159047265
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0001866
OrthoInspector 1 1.000 - - otm52751
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR12854
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R2220
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
76.970

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