DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ATXN2 and atxn2

DIOPT Version :9

Sequence 1:	NP_001359503.1	Gene:	ATXN2 / 6311	HGNCID:	10555	Length:	1155	Species:	Homo sapiens
Sequence 2:	NP_001121821.1	Gene:	atxn2 / 569210	ZFINID:	ZDB-GENE-060526-217	Length:	1112	Species:	Danio rerio

Alignment Length:	1164	Identity:	713/1164 - (61%)
Similarity:	835/1164 - (71%)	Gaps:	95/1164 - (8%)

- Green bases have known domain annotations that are detailed below.

Human    31 PAAANVRKPGGSGLLASPAAAPSPSSSSVSSSSATAPSSVVAATSGGGRPGLGRGRNSNKGLPQS 95
            |.|...|||||                  |:|.|.|.|....|..|.||..:|||||:.|| |.:
Zfish     5 PQAGGNRKPGG------------------SNSGAAAASGTGGAGGGVGRQNMGRGRNNAKG-PST 50

Human    96 TISFDGIYANMRMVHILTSVVGSKCEVQVKNGGIYEGVFKTYSPKCDLVLDAAHEKSTESSSGPK 160
            .::|:|:||||||||:||||||:|||::||||.|||||||||.|:||:||||||.||.|.::||:
Zfish    51 AVAFNGVYANMRMVHVLTSVVGTKCELKVKNGLIYEGVFKTYGPECDIVLDAAHRKSVEPNAGPR 115

Human   161 REEIMESILFKCSDFVVVQFKDMDSSYAKRDAFTDSAISAKVNGEHKEKDLEPWDAGELTANEEL 225
            ||:|:|||:||.||.|||.|||:|.:|||:|.|||||:||:||||||||||||||.||...:..:
Zfish   116 REDIVESIIFKSSDVVVVHFKDVDLNYAKKDNFTDSAVSARVNGEHKEKDLEPWDGGEQHISGSM 180

Human   226 EALENDVSNGWDPNDMFRYNEENYGVVSTYDSSLSSYTVPLERDNSEEFLKREARANQLAEEIES 290
            |:|:.|:||||||::||:||||.|||.|||||||||||||||||||||||||||||:|||||||:
Zfish   181 ESLDTDLSNGWDPDEMFKYNEETYGVKSTYDSSLSSYTVPLERDNSEEFLKREARASQLAEEIEA 245

Human   291 SAQYKARVALENDDRSEEEKYTAVQRNSSEREGHSINTRENKYIPPGQRNREV-ISWGSGRQNSP 354
            ||.|||||||||||||||||||||.|  .|||.||:| ||||||||.|||||. :|||:|||.||
Zfish   246 SATYKARVALENDDRSEEEKYTAVVR--GERELHSLN-RENKYIPPSQRNREAGMSWGAGRQVSP 307

Human   355 RMGQPGSGSMPSRSTSHTSDFNPNSGSDQRVVNGGV-PWPSPCPSPSSRPPSRYQSGP-NSLPPR 417
            |:.|..||....||..|  |:|.   .||||||||. ||||.|||||||||||||||| ||||||
Zfish   308 RLVQCSSGPPTPRSGPH--DYNT---IDQRVVNGGAQPWPSRCPSPSSRPPSRYQSGPTNSLPPR 367

Human   418 AATPTRPPSRPPSRPSRPPSHPSAHGSPAPVSTMPKRMSSEGPPRMSPKAQRHPRNHRVSAGRGS 482
            ||||||||||||||||||.|||||||:..|:|.||||:|||||||||||:||.||.|||::.||.
Zfish   368 AATPTRPPSRPPSRPSRPLSHPSAHGTSGPLSNMPKRLSSEGPPRMSPKSQRTPRPHRVASCRGG 432

Human   483 ISSGLEFVSHNPPSEAATPPVARTSPSGGTWSSVVSGVPRLSPKTHRPRSPRQNSI-GNTPSGPV 546
            .....:::|.....|.:.||..|.|||||||||||||       .||||||||||| |..|:...
Zfish   433 GPPPSDYMSQGASVEVSAPPPTRNSPSGGTWSSVVSG-------AHRPRSPRQNSIGGEAPNSSC 490

Human   547 LASPQAGIIPTEAVAMPIPAASPTPASPASNRAVTPSSEAKDSRLQDQRQNSPAGNKENIKPNET 611
            |:|||||.:|.::|.....|.|||.|:||:|...:|..|||:||:.:.|||||..||||:||.|.
Zfish   491 LSSPQAGTVPVDSVTASTTATSPTAANPATNLEASPIEEAKESRVLETRQNSPNANKENVKPIEA 555

Human   612 SPSFSKAENKGISPVVSEHRKQIDDLKKFKNDFRLQPSSTSESMDQLLNKN--RE-GEKSRDLIK 673
            ||..:::..||...:.|:||||||:||||...|||||||:|:...:.:...  |: |||.:|...
Zfish   556 SPGIARSIGKGSPSMASDHRKQIDNLKKFSAAFRLQPSSSSDPGFEAMGTKPPRDLGEKPKDQAA 620

Human   674 DK-------IEPSAKDSFIENSSS--NCTSGSSKPNSPSISPSILSNTEHKRGPEVTSQGVQTSS 729
            :|       ::.|.:.|..|.:||  :.||..||..:||:||| .:..|.||||:||||||||:|
Zfish   621 EKGSVDSTGLKASTESSISEETSSPVSVTSAGSKAGTPSLSPS-SAVPEQKRGPDVTSQGVQTTS 684

Human   730 P---ACKQEKDDKEEKKD-AAEQVRKSTLNPNAKEFNPRSF-SQPKPSTTPTSPRPQAQPSPSMV 789
            |   |..::||:||:|.| .||.||||||||||||||||.| |.|||:||||..|||.|||||:|
Zfish   685 PLANAVTKDKDEKEDKNDPVAESVRKSTLNPNAKEFNPRVFCSPPKPATTPTLTRPQGQPSPSIV 749

Human   790 GHQQPTPVYTQPVCFAPNMMYPV-PVSPGVQP--LYPIPMTPMPVNQAKTYRAGKVPNMPQQRQD 851
            ..|.|| ||.|.:.    .|||: ||||||||  :|.:.:..|.::|.|:||:|||.||||||.|
Zfish   750 VQQPPT-VYGQTMF----QMYPLTPVSPGVQPPAMYHVQVPHMTMSQTKSYRSGKVQNMPQQRPD 809

Human   852 QHH---QSAMMHPASAAGPPIAATPPAYSTQYVAYSPQQFPNQPLVQHVPHYQSQHPHVYSPVIQ 913
            |||   .|.|||.|:||||||.|..|||||||...|||||.:|||||.:||||||..||:|||||
Zfish   810 QHHPPGTSTMMHSATAAGPPIVAPSPAYSTQYFTCSPQQFASQPLVQQMPHYQSQAQHVFSPVIQ 874

Human   914 GNARMMAPPTHAQPGLVSSSATQYGAHEQTHAMYACPKLP--YNKETSPSFYFAISTGSLAQQYA 976
            |:|||:.|||||||.|||||.||||  ||||.||. ...|  ..|...|::    || .:.||:.
Zfish   875 GSARMITPPTHAQPSLVSSSTTQYG--EQTHTMYG-KNFPSTMTKLNKPTY----ST-PIPQQFP 931

Human   977 HPNATLHPHTPHPQPSATPTGQQQ--SQHGGSHPAPSPVQHHQHQ-----AAQALHLASPQQQSA 1034
            ||::|||||..|||||||||||.|  :||||||||||||||.|||     ||||:||.:||||.
Zfish   932 HPSSTLHPHPQHPQPSATPTGQPQQGTQHGGSHPAPSPVQHQQHQAAAAAAAQAIHLGNPQQQQ- 995

Human  1035 IYHAGLAPTPPSMTPASNTQSPQNSFPAAQQTVFTIHPSHVQPAYTNPPHMAHVPQAHVQSGMVP 1099
             .::.||.|||||||..|.||||.|||:|||.|: |||.|   .| ||.|||||.|||:||||||
Zfish   996 -MYSALAATPPSMTPGPNPQSPQASFPSAQQAVY-IHPQH---GY-NPNHMAHVQQAHMQSGMVP 1054

Human  1100 SH--PTAHAP-MMLMTTQPPGGPQAALAQSALQPIPVSTTAHFPYMTHPSVQAHHQQQL 1155
            .|  ..:|.| ||||.||.|.|||.||.|..|.|||||:..|| |.|...|||||||||
Zfish  1055 PHHGNPSHPPTMMLMATQAPAGPQPALPQGTLNPIPVSSGTHF-YSTLTPVQAHHQQQL 1112

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ATXN2	NP_001359503.1	SM-ATX	105..181	CDD:373069	55/75 (73%)
		PBP1	194..>339	CDD:227507	114/144 (79%)
		LsmAD	249..310	CDD:369058	56/60 (93%)
		PRK12323	<408..599	CDD:237057	117/192 (61%)
		PAM2	750..765	CDD:336618	14/14 (100%)
		PHA03247	<769..1087	CDD:223021	203/332 (61%)
atxn2	NP_001121821.1	SM-ATX	62..131	CDD:291131	50/68 (74%)
		LsmAD	204..265	CDD:284215	56/60 (93%)
		PAM2	708..724	CDD:284542	15/15 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C194338186
Domainoid	1	1.000	445	1.000	Domainoid score	I3680
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2234
Inparanoid	1	1.050	1272	1.000	Inparanoid score	I1419
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG54638
OrthoDB	1	1.010	-	-		D121375at7742
OrthoFinder	1	1.000	-	-		FOG0001866
OrthoInspector	1	1.000	-	-		oto50843
orthoMCL	1	0.900	-	-		OOG6_114721
Panther	1	1.100	-	-	LDO	PTHR12854
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2220
SonicParanoid	1	1.000	-	-		X8608
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	1	1.500	-	-
	17	17.440