Protein Alignment ATXN2 and SPBC21B10.03c

DIOPT Version :9

• Sequence 1: NP_001359503.1
• Gene: ATXN2 / 6311
• HGNCID: 10555
• Length: 1155
• Species: Homo sapiens
• Sequence 2: NP_595684.1
• Gene: SPBC21B10.03c / 2540677
• PomBaseID: SPBC21B10.03c
• Length: 791
• Species: Schizosaccharomyces pombe
• Alignment Length: 1065
• Identity: 210/1065 - (19%)
• Similarity: 345/1065 - (32%)
• Gaps: 347/1065 - (32%)

Human    49 AAAPSPSSSSVSSSSATAPSSVVAATSGGGRPGLGRGRNSNKGLPQSTISFDGIYANMRMVHILT 113
            ||:|:.:..:...|:..|..|.:|.::....    |...|.|.:|::.:
pombe    15 AASPNKTQGAKKWSAVAARGSKIAQSATNDH----RNVESIKVVPENRV---------------- 59

Human   114 SVVGSKCEVQVKNGGIYEGVFKTYSPKCDLVLDAAHEKSTESSSGPKREEIMESILFKCSDFVVV 178
                        .||:   ..|......::...|:.|::..|.||..:....:..::|
pombe    60 ------------RGGV---AAKATDSSSNVTSLASSEENVSSVSGSAKSNNSQQRVWK------- 102

Human   179 QFKDMDSSYAKRDAFTDSAISAKVNGEHKEKDLEPWDAGELTANEELEALENDVSN-GWDPNDMF 242
                           ||.||||:...|.::::|..|......|...|..||....| .|   |.|
pombe   103 ---------------TDVAISAEKRTETRQRELRRWMPDPEDAGVPLAGLEESTDNVEW---DQF 149

Human   243 RYNEENYGVVSTYDSSLSSYTVPLERDNSEEFLKREARANQLAEEIESSAQYKARVA----LEND 303
            ..||:.:||.|.:|..|  ||..::|.: .::.::|..|:::|:|||.:......:|    |:.|
pombe   150 ATNEKLFGVKSHFDEDL--YTSRIDRSH-PKYKEKEQEADRIAKEIEGTVTNNIHIAEERGLKVD 211

Human   304 DR--SEEEKYTAVQRNSSEREGHSINTRENKYIPPGQRNREVISWGSGRQNSPRMGQPGSGSMPS 366
            |.  .||:.|:.|.|:......:   ||.|.|
pombe   212 DSGLDEEDLYSGVHRSIDVVRNY---TRSNAY--------------------------------- 240

Human   367 RSTSHTSDFNPNSGSDQRVVNGGVPWPSPCPSPSSRPPSRYQSGPNSLPPRAATPTRPPSRPPSR 431
                     |.|: .||:                   |..::: |:..|.:...|...|:....|
pombe   241 ---------NKNN-KDQK-------------------PKNHEA-PHQHPQQKVVPPDDPAIVSHR 275

Human   432 PSRPPSHPSAHGSPAPVSTMPKRMSSEGPPRMSPKAQRHPRNHRVSAGR----GSISSGLEFVSH 492
                  |.:...:|.|.|...:|.       .:.:.:..|.:.|...|:    ...|..|:..|.
pombe   276 ------HLALPRAPGPDSRAAERF-------FNARRKAGPLSRREKEGQIKEFMQFSQSLKIGSL 327

Human   493 NPPSEAATPPVARTSPSGGTWSSVVSGVPRLSPKTHRPRSPRQNSIGNTPSGPVLASPQAGIIPT 557
            :....::|..||..               :::.:...|.                ||.||
pombe   328 DSKQPSSTKSVAEV---------------KVADEKQLPD----------------ASSQA----- 356

Human   558 EAVAMPIPAASPTPASPASNRAVTPSSEAKDSRLQDQRQNSPAGNKENIKPNETSPSFSKAENKG 622
                  .||.|..|....:.:.||.::|....:::....|:.:.:||..||: |.|.
pombe   357 ------TPADSKEPRKEEAEKPVTSATEVSSEKVEKVDGNTSSPSKEEEKPS-TEPE-------- 406

Human   623 ISPVVSEHRKQIDDLKKFKNDFRLQPSSTSESMDQLLNKNREGEK----------SRDLIKDKIE 677
             .|.|...||:                :|...:...||......|          .:..|..|..
pombe   407 -KPSVVTQRKE----------------TTGTKLGTKLNAKAISFKPNVAAPVFTPGKFTIPSKPA 454

Human   678 P-SAKDSFIENSSSNCTSGSSKPNSPSISPSILSNTEHKRGPEVTSQGVQTSSPA-----CKQEK 736
            | :|....:...|:|  |.:|.|::...|||::||.|:|          .:|||.     ...||
pombe   455 PVNASRPMMPQQSNN--SEASIPSTTPQSPSVVSNGENK----------PSSSPVFFNGPVSSEK 507

Human   737 D----------DKEEKKDAAEQVRKSTLNPNAKEFNPRSFSQ----PKPSTTPTSPRPQAQPSPS 787
            :          :..|:...|||:.|....|......|.|..|    .:|.....|.:..|..:|.
pombe   508 EPILDNFNVFKNVGEEHQGAEQIDKPFSCPPTWNTGPNSLQQTIANSRPEGNSGSAKKAAAANPM 572

Human   788 MVGHQQPTPVYTQPVCFAPNMMYPVPVSPGVQPLYPIPMTP-MPVNQAKTYRAGKVPN-MPQQRQ 850
            :                 |:::.|....|...|:||.|..| :||..       .||. .|..|.
pombe   573 I-----------------PSIVLPNSAMPSAMPMYPTPTMPYIPVGY-------PVPGYTPYMRN 613

Human   851 DQHHQSAMMHPASAAGPPIAATPPAYSTQYVAY-SPQQFPNQPLVQHVPHYQSQHPHVYSPVIQG 914
            ...|.|....|   .|.|.:.......:..:.| :||..|        |:...|.|.      .|
pombe   614 PSQHTSVAPSP---NGTPTSGNSSTVGSPMIGYMAPQFIP--------PYAMPQFPP------SG 661

Human   915 NAR-MMAPPTHAQPGLVSSSATQYGAHEQTHAMYACPKLPYNKETSPSFYFAISTGSLAQQYAHP 978
            |.| ..||.|:..|        |.|.           .:.|.....|..|         .|||..
pombe   662 NGRGASAPATYFVP--------QMGG-----------MMAYTMNGVPPMY---------GQYAPN 698

Human   979 NATLHPHTPHPQPSATPTGQQQSQHGGSHPAPSPVQHHQHQAAQALHLASPQQQSAIYHAGLAPT 1043
            |..::.|  :|....:.....|.....|:...|.| |..:.|:.....::....|::..|
pombe   699 NGMMNMH--YPMYGDSRRSNSQRSFNSSNGKRSNV-HKNNNASNTFSHSNASTSSSLNAA----- 755

Human  1044 PPSMTPASNTQS--PQNSFPAAQQT 1066
             |:.|..|::|:  |.:...|.::|
pombe   756 -PNTTAKSSSQTAPPVSKGDATEKT 779

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ATXN2	NP_001359503.1	SM-ATX	105..181	CDD:373069	9/75 (12%)
		PBP1	194..>339	CDD:227507	46/151 (30%)
		LsmAD	249..310	CDD:369058	20/66 (30%)
		PRK12323	<408..599	CDD:237057	32/194 (16%)
		PAM2	750..765	CDD:336618	3/14 (21%)
		PHA03247	<769..1087	CDD:223021	63/304 (21%)
SPBC21B10.03c	NP_595684.1	PBP1	1..739	CDD:227507	201/1017 (20%)
		LsmAD	156..220	CDD:284215	20/66 (30%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	62	1.000	Inparanoid score	I2195
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001866
OrthoInspector	1	1.000	-	-		oto147017
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12854
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2220
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	6.180